Muchidimbu
Mannitol, chigadzirwa chechisikigo, chinoshandiswa sedhiureti kuwedzera kugadzirwa kweweti kune vanhu vane itsvo inotadza (chemo mhedzisiro). Zvidzidzo zvekiriniki zvakaratidza kuti kushandisa mannitol pamwe neCisplatin chemotherapy kunoderedza kukuvara kweitsvo yeCisplatin-inokonzeresa, yakashata-mhedzisiro inoonekwa mune chetatu chevarwere vanorapwa neCisplatin. Mannitol kushandiswa pamwe neCisplatin inogona kuve nephroprotective.
Cisplatin Chemotherapy Side Mhedzisiro
Cisplatin ndeye chemotherapy inoshandiswa kurapa mamota akawanda akasimba uye chiyero chekutarisira kenza dzedundira, musoro nemutsipa, sero diki uye isiri-diki sero mapapu. kanzira, magomarara emuchibereko, emuchibereko nema testicular nemamwe akawanda. Cisplatin inoshanda mukubvisa maseru egomarara kuburikidza nekukonzera kuwedzera oxidative kusagadzikana uye kukuvara kweDNA, zvichikonzera kufa kwegomarara. Nekudaro, kushandiswa kweCisplatin kunobatanidzwawo nezvakawanda zvisingadiwe mhedzisiro zvinosanganisira allergic reaction, kudzikiswa kusadzivirirwa, kusagadzikana kwegastrointestinal, cardiotoxicity uye matambudziko akaomarara eitsvo. Chikamu chimwe muzvitatu chevarwere vanobatwa neCisplatin vanoona kukuvara kwetsvo mushure mekutanga kurapwa (Yao X, et al, Am J Med. Sci., 2007) Kukuvara kweitsvo kana nephrotoxicity inokonzerwa neCisplatin yave ichizivikanwa sechiitiko chakakosha chakashata (Ah, Gi-Su, nevamwe. Electrolyte Blood Press, 2014). Chimwe chezvikonzero zvakakosha chekukwirisa nephrotoxicity neCisplatin imhaka yekuti kune kuwanda kukuru kwechirwere muitsvo nokudaro zvichikonzera kukuvara kwetsvo.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Chii chinonzi Mannitol?
Mannitol, inozivikanwawo seshuga doro, inowanikwa munzvimbo zhinji dzepanyama senge howa, mastrawberry, celery, hanyanisi, manhanga uye algae algae. Iyo inozivikanwa zvakare seyakachengeteka chigadzikiso neDFA (Chikafu neDrug Administration), uye chinhu chinoshandiswa zvakanyanya muzvinhu zvekurapa.
Zvakanakira / Zvishandiso zveMannitol Zvinowedzera
Kutevera ndeimwe yemashandisirwo akajairwa mannitol:
- Mannitol inowanzo shandiswa sedhiureti kuwedzera weti kugadzirwa mune vanhu vane chakakomba itsvo kutadza.
- Mannitol inoshandiswawo mumishonga yemishonga yekuderedza kumanikidza uye kuzvimba muuropi futi.
- Mannitol inogona kubatsira kugadzirisa shuga yeropa mutemo
Side-Mhedzisiro yeMannitol Supplements
Zvinotevera ndezvimwe zvakajairika mhedzisiro-mhedzisiro yemanitol yekuwedzera:
- Kakawanda Urination
- Kuwedzera kwenhamba yemwoyo
- Headaches
- Chizutu
- nemvura
Mannitol yeCisplatin Chemo Side Mhedzisiro- Itsvo Kukuvara
Imwe nzira yekudzora chemo-mhedzisiro senge nephrotoxicity, kana ichirapwa neCisplatin, iyo yakaongororwa kiriniki iri kushandisa Mannitol pamwe neCisplatin chemotherapy.
Pakave paine ongororo dzinoverengeka kwavakaongorora zvinoitika zvekushandisa kweMannitol pamwe neCisplatin chemotherapy pane nephrotoxicity (chemo side-athari) mamaki senge serum creatinine mazinga:
- Ongororo yakadzokororwa kubva kuYunivhesiti yeMinnesota Health-Fairview system yakaongorora varwere ve313 vakabatwa neCisplatin (95 yakarapwa mannitol uye 218 vasina), yakawana kuti boka rakashandisa Mannitol raive neavhareji yekuwedzera kweserum creatinine mazinga pane boka risina kushandisa. Mannitol. Nephrotoxicity yakaitika zvishoma nezvishoma kune varwere vakagamuchira Mannitol pane avo vasina - 6-8% neMannitol vs. 17-23% pasina Mannitol (Williams RP Jr nevamwe, J Oncol Pharm Pract., 2017).
- Chimwe chidzidzo kubva kuYunivhesiti yeEmory chakabatanidza kudzokorodza chati kunoongorora kwevarwere vese vanogamuchira cisplatin nemagetsi akabatana e squamous cell carcinoma yemusoro nemutsipa. Kuongororwa kwedhata kubva kuvarwere ve139 (88 ine Mannitol uye makumi mashanu neshanu ine saline chete) kwakaratidza kuti boka reMannitol raive nekuwedzera kwakaderera muSerum creatinine inoratidza yakaderera nephrotoxicity (McKibbin T et al, Tsigira Kuchengeta Kenza, 2016).
- Imwe nzvimbo yekudzidza kubva kuRigshospitalet uye Herlev hospital, Denmark, yakasimbisawo nephroprotective mhedzisiro yeMannitol kushandiswa mumusoro nemutsipa. kenza varwere vanowana cisplatin therapy muboka revarwere ve78 (Hagerstrom E, et al, Clin Med Kunzwisisa Oncol., 2019).
mhedziso
Uchapupu hwekiriniki huri pamusoro hunotsigira kushandiswa kwechinhu chakachengeteka, chakasikwa semannitol, kuderedza cisplatin-induced yakakosha uye yakakomba mhedzisiro yenephrotoxicity mu. kenza varwere.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.