Ndi khansa iti yomwe ingapindule pophatikiza Bingu la Mulungu muzakudya zawo?

Mfundo

Bingu Mulungu amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa ndi omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Bingu Mulungu kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Bingu la Mulungu likhoza kupindulitsa iwo omwe ali ndi Primary Mucinous colorectal adenocarcinoma omwe akudwala Cetuximab. Kuphatikiza apo, ngakhale Bingu la Mulungu limatha kuthandiza anthu omwe ali ndi vuto la "KIT", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana "ASXL1". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Bingu la Mulungu kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Bingu la Mulungu ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Bingu Mulungu m'malo mowunika chilichonse chogwira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta likubuka: Kodi muyenera kuphatikiza Bingu la Mulungu muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndi bwino kudya Bingu la Mulungu ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya KIT? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ASXL1? Kodi ndizopindulitsa kuphatikiza Bingu la Mulungu muzakudya zanu ngati mwapezeka ndi Primary Mucinous colorectal adenocarcinoma? Komanso, kodi kugwiritsa ntchito Bingu Mulungu kukuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Cetuximab kapena ngati dongosolo lanu lamankhwala likuchoka ku Cetuximab? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Bingu la Mulungu ndi lachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Bingu la Mulungu limalimbitsa chitetezo cha mthupi' sizokwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Bingu la Mulungu muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Bingu la Mulungu muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zotsatira za biochemical pazosakaniza zonse, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, majini. mayendedwe, ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale ndi kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Mucinous colorectal adenocarcinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Bingu la Mulungu. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa KIT chimakhala ndi njira yofananira ndi kusintha kwa ASXL1? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Mucinous colorectal adenocarcinoma chikufanana ndi khansa ina? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akulandira chithandizo china monga omwe amalandira Cetuximab? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Bingu Mulungu - Chowonjezera Chakudya

Bingu lowonjezera la Bingu Mulungu limaphatikizapo zinthu zingapo zogwira ntchito, kuphatikiza Celastrol ndi Triptolide, iliyonse ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka MAPK Signaling, Suppressive Histone Methylation ndi PI3K-AKT-MTOR Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Popeza chikoka chachilengedwechi, kusankha zowonjezera zoyenera monga Bingu la Mulungu, payekha kapena kuphatikiza, kumakhala chisankho chovuta pankhani yazakudya za khansa. Poganizira kugwiritsa ntchito Bingu la Mulungu kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Bingu la Mulungu si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala payekha.

Kusankha Bingu Mulungu Zowonjezera

Kuyankha funso loti 'Kodi ndipewe liti Bingu la Mulungu munkhani ya Khansa' ndizovuta chifukwa yankho limakhala la munthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Bingu la Mulungu zimasiyana malinga ndi zochitika zaumwini. Zinthu monga mtundu weniweni wa khansa, chibadwa, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Bingu la Mulungu ndiloyenera kapena liyenera kupeŵedwa, kutsindika kufunikira kwa kulingalira kwaumwini. muzosankha zotero.

1. Kodi Bingu la Mulungu Zowonjezera Zingapindulitse Odwala a Primary Mucinous colorectal adenocarcinoma omwe akulandira Chithandizo cha Cetuximab?

Primary Mucinous colorectal adenocarcinoma imadziwika ndi kusintha kwa majini, monga TTN, APC ndi KRAS, zomwe zimabweretsa kusintha kwa njira za biochemical, makamaka MAPK Signaling, Angiogenesis, G-protein-coupled Receptor Signaling ndi Growth Factor Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Cetuximab, kumatsimikiziridwa ndi kulumikizana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, Bingu la Mulungu lowonjezera ndi njira yabwino kwa iwo omwe ali ndi Primary Mucinous colorectal adenocarcinoma omwe akukumana ndi Cetuximab. Izi zili choncho chifukwa Bingu la Mulungu limakhudza njira monga MAPK Signaling, zomwe zingalepheretse zinthu zomwe zimayendetsa Primary Mucinous colorectal adenocarcinoma kapena kupindulitsa mphamvu ya Cetuximab.

2. Kodi Bingu la Mulungu Limawonjezera Zotetezedwa kwa Anthu Athanzi Amene Ali ndi ASXL1 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ASXL1 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ASXL1 kumakhudza njira zama biochemical kapena njira, monga Oncogenic Cancer Epigenetics ndi Suppressive Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ASXL1 komwe kumakhudzana ndi chiopsezo chowonjezereka cha Chronic Myelomonocytic Leukemia, zomveka za sayansi zimasonyeza kupeŵa kugwiritsa ntchito Bingu la Mulungu. Izi ndichifukwa choti Bingu lothandizira Mulungu limakhudza njira ngati Suppressive Histone Methylation, zomwe zitha kubweretsa zovuta pakusintha kwa ASXL1 ndi zovuta zina za khansa.

3. Kodi Bingu la Mulungu Limawonjezera Zotetezedwa kwa Anthu Athanzi Amene Ali ndi KIT Mutation Associated Genetic Risk?

KIT imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa KIT kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza PI3K-AKT-MTOR Signaling ndi Growth Factor Signaling, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe mu KIT okhudzana ndi Gastric Cancer, lingalirani zophatikizira Bingu la Mulungu muzakudya zanu. Zowonjezera izi zitha kulimbikitsa njira ngati PI3K-AKT-MTOR Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a KIT ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya, kuphatikizapo chakudya ndi zowonjezera monga Bingu Mulungu, ndi chida chothandiza chomwe chingathe kulamulidwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Kuletsa kwachindunji kwa c-Myc-Max heterodimers ndi celastrol ndi celastrol-inspired triterpenoids.
• Triptolide Imalimbikitsa Senescence ya Maselo a Khansa ya Prostate Kupyolera mu Histone Methylation ndi Heterochromatin Mapangidwe.
• Pan-cancer kusanthula ma genomes onse.
• Ntchito ya Antitumor ya ZD6474, vascular endothelial growth factor receptor tyrosine kinase inhibitor, m'maselo a khansa ya anthu omwe amapeza kukana kwa antiepidermal growth factor receptor therapy.
• cBioPortal ya Cancer Genomics
• Zotsatira za deoxyribonuclease I pa chiwerengero ndi kutalika kwa maunyolo a poly(ADP-ribose) opangidwa, mu vitro.