Ndi khansa iti yomwe ingapindule ndi kuphatikiza Melatonin muzakudya zawo?

Mfundo

Melatonin amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Melatonin kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Melatonin ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe akulandira Radiation for Primary Sclerosing Epithelioid Fibrosarcoma. Kuphatikiza apo, Melatonin ikhoza kuthandiza anthu omwe ali ndi chiopsezo cha chibadwa cha "CDH1", sizingaganizidwe kwa omwe ali ndi chiopsezo chosiyana cha "B2M". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Melatonin kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zochizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Melatonin ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Melatonin m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza Melatonin muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kumwa Melatonin ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CDH1? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya B2M? Kodi ndizopindulitsa kuphatikiza Melatonin muzakudya zanu ngati mwapezeka ndi Primary Sclerosing Epithelioid Fibrosarcoma, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi kumwa kwanu kwa Melatonin kungasinthidwe bwanji ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Radiation? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Melatonin ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Melatonin imalimbitsa chitetezo cha mthupi' ndiyosakwanira pa zosankha za chakudya/zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Melatonin muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Melatonin muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zachilengedwe chonse chazinthu zonse, poganizira zinthu monga mtundu wa khansa, machiritso omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu winawake wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary Sclerosing Epithelioid Fibrosarcoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda. ”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Melatonin. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa CDH1 chimakhala ndi njira yofananira ndi kusintha kwa B2M? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary Sclerosing Epithelioid Fibrosarcoma? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Radiation monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Melatonin - Chowonjezera Chakudya

Melatonin yowonjezera imaphatikizapo zinthu zambiri zogwira ntchito, kuphatikizapo Melatonin, iliyonse yomwe ilipo pamagulu osiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka PI3K-AKT-MTOR Signaling, TGFB Signaling ndi Growth Factor Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zakudya zoyenera monga Melatonin, zokha kapena kuphatikiza, kumakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito Melatonin pa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Melatonin si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera za Melatonin

Kuyankha funso loti 'Ndiyenera kupewa liti Melatonin munkhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Melatonin zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, chibadwa, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Melatonin ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunikira kwa kulingalira payekha. zisankho zotere.

1. Kodi Melatonin Supplements idzathandiza Odwala a Primary Sclerosing Epithelioid Fibrosarcoma omwe akulandira chithandizo cha radiation?

Primary Sclerosing Epithelioid Fibrosarcoma imadziwika ndi kusintha kwa majini, komwe ndi PBRM1, ATRX ndi PIK3C2G, zomwe zimabweretsa kusintha kwa njira zama biochemical, makamaka TGFB Signaling ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Radiation, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Melatonin, chomwe chimakhudza Chizindikiro cha TGFB, sichingakhale chisankho choyenera pankhani ya Primary Sclerosing Epithelioid Fibrosarcoma pamene akudutsa Radiation. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Melatonin Supplements ingapindule Odwala a Primary Penile Squamous Cell Carcinoma omwe akulandira Chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka PI3K-AKT-MTOR Signaling, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Melatonin ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi ndichifukwa choti Melatonin imakhudza njira monga PI3K-AKT-MTOR Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindulitsa mphamvu ya Mitomycin.

3. Kodi Melatonin Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi B2M Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la B2M nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya B2M kumakhudza njira zama biochemical kapena njira, monga TGFB Signaling ndi Antigen Presentation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa B2M komwe kumakhudzana ndi chiwopsezo chowonjezereka cha Diffuse Large B-cell Lymphoma, malingaliro asayansi akuwonetsa kupeŵa kugwiritsa ntchito Melatonin yowonjezera. Izi ndichifukwa choti chowonjezera cha Melatonin chimakhudza njira ngati TGFB Signaling, zomwe zitha kubweretsa zotsatira zoyipa pakusintha kwa B2M ndi zovuta zina za khansa.

4. Kodi Zowonjezera za Melatonin Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi CDH1 Mutation Associated Genetic Risk?

CDH1 imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa CDH1 kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza Kukula kwa Factor Signaling, Adherens junction ndi Epithelial to Mesenchymal Transition, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a CDH1 okhudzana ndi Khansa Yam'mimba, ganizirani kuphatikiza zowonjezera za Melatonin muzakudya zanu. Zowonjezera izi zimatha kukhudza njira monga Kukula kwa Factor Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa CDH1 ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza chakudya ndi zowonjezera monga Melatonin, ndi chida chothandiza chomwe mutha kuwongolera mukakumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Melatonin ndi vitamini D3 synergistically down-regulate Akt ndi MDM2 kutsogolera ku TGFβ-1-odalira kukula kulepheretsa maselo a khansa ya m'mawere.
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• Makhalidwe a epidermal growth factor receptors mu astrocytic glial ndi ma neuronal mu chikhalidwe choyambirira.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Kukana kwawayilesi m'maselo a khansa ya m'mawere kumalumikizidwa kudzera mu chizindikiro cha TGF-β, hybrid epithelial-mesenchymal phenotype ndi ma cell stem cell.
• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.
• Melatonin Attenuates Her-2, p38 MAPK, p-AKT, ndi MTOR Levels mu Ovarian Carcinoma ya Ethanol-Preferring Rats.