Introduction
Zakudya za Acral Melanoma ziyenera kukhala zamunthu aliyense payekha komanso zimayenera kusintha ngati chithandizo cha khansa kapena chotupa chikusintha. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.
Acral melanoma, mtundu wapadera wa melanoma, umawonekera m'manja, mapazi, ndi pansi pa misomali, kuwonetsa zizindikiro monga kusintha kwa mtundu wa misomali kapena zotupa pakhungu. Mtundu wa melanoma uwu ukhoza kuwunikidwa kudzera mu dermoscopy, ndi acral lentiginous melanoma yomwe nthawi zambiri imawonedwa pamapazi, ndi zithunzi za mawonetseredwe awa zimathandizira kumvetsetsa. Ma pathology a acral melanoma, kuphatikiza mafomu a situ, ndi ofunikira kuti azindikire molondola, komanso kachitidwe ka ICD-10 kamene kamapereka gulu lake. Kuchiza kumasiyana malinga ndi siteji ndi mtundu wa masinthidwe, ndi momwe zimakhalira komanso momwe moyo umakhalira kutengera zinthu monga momwe melanoma imafalira komanso kuopsa kwake. Mapulatifomu a pa intaneti ngati Reddit amapereka zokambirana zapagulu pazokumana nazo komanso zambiri. Kumvetsetsa momwe acral melanoma imawonekera komanso chomwe imayambitsa, ndikofunikira kuti muzindikire msanga ndi kuwongolera bwino, chifukwa mtundu wa melanoma uwu ukhoza kuchitika m'malo omwe nthawi zambiri sakhala ndi dzuwa.
Kwa Acral Melanoma, kodi zili ndi masamba, zipatso, mtedza, mbewu zomwe munthu amadya?
Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - la khansa ngati Acral Melanoma, kodi zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira khansa ngati Acral Melanoma?
Mwachitsanzo, kodi zilibe kanthu ngati masamba a Kabichi amadyedwa kwambiri poyerekeza ndi Broccoli waku China? Kodi pamakhala kusiyana kulikonse ngati chipatso cha Malus (nkhanu Apple) chimakondedwa kuposa Black Mulberry? Komanso ngati kusankha kofananako kumapangidwira mtedza/mbewu monga Common Hazelnut pa European Chestnut komanso zamasamba monga Gram Bean pa Moth Bean. Ndipo ngati zomwe ndimadya zili ndi vuto - ndiye kuti munthu angadziwe bwanji zakudya zomwe zimalimbikitsidwa ku Acral Melanoma ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha chibadwa?
Inde! Zakudya zomwe mumadya ndizofunikira za Acral Melanoma!
Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.
Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.
Mwachitsanzo Malus (nkhanu Apple) ili ndi zosakaniza zogwira ntchito Lupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. Ndipo Black Mabulosi ali ndi zosakaniza zomwe zimagwira ntchito monga Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol ndipo mwina ena.
Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya zoyenera kudya za Acral Melanoma - ndikuwunika zomwe zasankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungathe kusankha zosakaniza muzakudya ndi zowonjezera kuti mupange chisankho cha Acral Melanoma.
INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.
Maluso Ofunika Pakukonda Chakudya Chake kwa Acral Melanoma?
Zakudya zamakhansa monga Acral Melanoma zimakhala ndi zakudya / zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.
Kusankha zakudya zomwe zimalangizidwa kapena ayi ndizovuta kwambiri, zomwe zimafuna ukadaulo wa Acral Melanoma biology, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe chithandizocho chingasiye kugwira ntchito.
ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Makhalidwe a khansa monga Acral Melanoma
Makhansa onse ngati Acral Melanoma amatha kudziwika ndi njira zapadera za biochemical - njira zosainira za Acral Melanoma. Njira zama biochemical monga Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, PI3K-AKT-MTOR Signaling, MAPK Signaling ndi gawo la tanthauzo la Acral Melanoma. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.
Chithandizo chomwe chili chothandiza kwa Acral Melanoma chiyenera kuzindikirika ndi ma signature a biochemical omwe amalumikizana nawo kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa kwa Acral Melanoma mukamamwa chithandizo cha khansa Checkpoint Pdl1, ndipo zakudya zina ndi zowonjezera sizimalimbikitsidwa.
Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.
DNMT3A, TET2, PPM1D, ASXL1 ndi ATM ndi omwe adadziwika bwino kwambiri pamtundu wa Acral Melanoma. DNMT3A imanenedwa mu 31.6 % ya odwala oyimira m'mayesero onse azachipatala. Ndipo TET2 idanenedwa mu 11.8%. Deta yophatikizidwa ya odwala imaphimba zaka kuyambira 5 mpaka 96. 60.8 % ya data ya odwala amadziwika kuti ndi amuna. Biology ya Acral Melanoma pamodzi ndi ma genetics omwe adanenedwa palimodzi amafotokozera kuchuluka kwazomwe zimayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.
ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.
Zalephera kulumikiza ku MySQL: Palibe njira yopezera
Zakudya ndi Zowonjezera za Acral Melanoma
Kwa Odwala Khansa
Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.
Sankhani Kabichi Wamasamba kapena CHINESE BROCCOLI?
Kabichi wamasamba ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Angiogenesis, WNT Beta Catenin Signaling, Natural Killer Cell Activation ndi Interferon Signaling ndi ena. Kabichi amalimbikitsidwa ku Acral Melanoma pamene chithandizo cha khansa chikupitirirabe ndi Checkpoint Pdl1. Izi zili choncho chifukwa Kabichi amasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Checkpoint Pdl1.
Zina mwazinthu zomwe zimagwira ntchito kapena ma bioactive mu masamba a Broccoli aku China ndi Lupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Dendritic Cell Maturation, CD8 T-cell Activation ndi Antigen Presentation ndi ena. Broccoli waku China ndiwosavomerezeka kwa Acral Melanoma pamene chithandizo cha khansa chikupitilira ndi Checkpoint Pdl1 chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisamve kapena kuyankha.
KABIJI WA MASOMPHENYA AMADALITSIDWA PA BROCCOLI YA CHINESE YA Acral Melanoma NDI Checkpoint Pdl1.
Sankhani Chipatso BLACK MULBERRY kapena MALUS (CRAB APPLE)?
Mabulosi Akuda Wakuda ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Macrophage M2, JAK-STAT Signaling, Natural Killer Cell Activation ndi Angiogenesis ndi ena. Black Mabulosi akulimbikitsidwa Acral Melanoma pamene chithandizo cha khansa chikupitirirabe ndi Checkpoint Pdl1. Izi ndichifukwa choti Black Mulberry imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Checkpoint Pdl1.
Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso Malus (nkhanu Apple) ndi Lupeol, Isoliquiritigenin, Formononetin, Catechol, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Dendritic Cell Maturation, CD8 T-cell Activation ndi Antigen Presentation ndi ena. Malus (nkhanu Apple) siyovomerezeka kwa Acral Melanoma pamene chithandizo cha khansa chikupitirirabe ndi Checkpoint Pdl1 chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisawonongeke kapena kuti chisamayankhe.
ZIPATSO ZA BLACK MULBERRY AMAKONZEDWA PA MALUS (CRAB APPLE) PA Acral Melanoma NDI Pdl1.
Sankhani Nut COMMON HAZELNUT kapena EUROPEAN CHESTNUT?
Hazelnut Wamba imakhala ndi zinthu zambiri zomwe zimagwira ntchito kapena bioactives monga Quercetin, Lupeol, Isoliquiritigenin, Formononetin, Catechol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga JAK-STAT Signaling, Angiogenesis, Antigen Presentation ndi T-Regulatory Cell Differentiation ndi ena. Common Hazelnut akulimbikitsidwa Acral Melanoma pamene chithandizo cha khansa chikupitirirabe Checkpoint Pdl1. Izi zili choncho chifukwa Common Hazelnut imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Checkpoint Pdl1.
Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Quercetin, Ellagic Acid, Lupeol, Isoliquiritigenin, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Dendritic Cell Maturation, CD8 T-cell Activation ndi G-protein-coupled Receptor Signaling ndi ena. European Chestnut siyovomerezeka kwa Acral Melanoma pamene chithandizo cha khansa chikupitirirabe ndi Checkpoint Pdl1 chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisamve kapena kuyankha.
HAZELNUT WAMWAMBA IMADALITSIDWA PA CHESTNUT YA KU ULAYA PA Acral Melanoma NDI Pdl1.
Kwa Anthu Amene Ali ndi Genetic Risk of Cancer
Funso lofunsidwa ndi anthu omwe ali ndi chiopsezo cha chibadwa cha Acral Melanoma kapena mbiri ya banja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zosankha zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizili zofanana ndipo zimatengera chibadwa chodziwika ndi Acral Melanoma pathway siginecha - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.
Sankhani Masamba a CELERY STALKS kapena ROMAINE LETTUCE?
Mapesi a Selari Zamasamba ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Linalool, Lupeol, Lycopene. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Oncogenic Cancer Epigenetics, RAS-RAF Signaling, Cell Cycle Checkpoints ndi Apoptosis ndi ena. Selari Mapesi akulimbikitsidwa pachiwopsezo cha Acral Melanoma pomwe chiwopsezo cha chibadwa ndi ASXL1. Izi ndichifukwa choti Selari mapesi amawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.
Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Romaine Letesi ndi Apigenin, Curcumin, Lupeol, Resveratrol, Protocatechuic Acid. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga P53 Signaling ndi DNA Repair ndi ena. Romaine Letesi si ovomerezeka pamene chiopsezo Acral Melanoma pamene chibadwa chiopsezo ASXL1 chifukwa kumawonjezera siginecha njira Acral Melanoma.
MAPESI A MASAMBA A MASWEREREdwe AMANKHWALA PA RUMIINE LETTUCE PA ASXL1 GENETIC RISK OF CANCER.
Sankhani Chipatso NANCE kapena GRAPEFRUIT?
Zipatso za Nance zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Lupeol, Protocatechuic Acid, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Kukonza kwa DNA, Kuyika kwa RAS-RAF, MYC Signaling ndi Cell Cycle Checkpoints ndi ena. Nance akulimbikitsidwa pachiwopsezo cha Acral Melanoma pomwe chiwopsezo chokhudzana ndi majini ndi ASXL1. Izi ndichifukwa choti Nance amawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.
Zina mwazinthu zomwe zimagwira ntchito kapena ma bioactive mu zipatso za Grapefruit ndi Curcumin, Lupeol, Lycopene, Daidzein, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza DNA ndi zina. Grapefruit sivomerezedwa ngati chiopsezo cha Acral Melanoma chikugwirizana ndi chiopsezo cha chibadwa ndi ASXL1 chifukwa chimawonjezera njira zosayina za Acral Melanoma.
FRUIT NANCE AKUTHANDIZANI KUPANDA GRAPAFRUIT PA ASXL1 GENETIC RISK OF CANCER.
Sankhani Nut BUTTERNUT kapena CHESTNUT?
Butternut imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Juglone, Lupeol, Lycopene. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Oncogenic Cancer Epigenetics, RAS-RAF Signaling, MYC Signaling ndi Cell Cycle Checkpoints ndi ena. Butternut akulimbikitsidwa pachiwopsezo cha Acral Melanoma pomwe chiwopsezo chokhudzana ndi majini ndi ASXL1. Izi ndichifukwa choti Butternut imachulukitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.
Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Chestnut ndi Apigenin, Curcumin, Lupeol, Lycopene, Ellagic Acid. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza DNA ndi zina. Mchere wa Chestnut ndi wosavomerezeka ngati chiopsezo cha Acral Melanoma pamene chiwopsezo cha majini chikugwirizana ndi ASXL1 chifukwa chimawonjezera njira zosayina za Acral Melanoma.
BUTTERNUT AMAKONZEDWA PA CHESTNUT PA ASXL1 GENETIC RISK YA KANSA.
Pomaliza
Zakudya ndi Zowonjezera zomwe zasankhidwa ndi zosankha zofunika pa khansa monga Acral Melanoma. Odwala a Acral Melanoma ndi anthu omwe ali pachiwopsezo cha majini nthawi zonse amakhala ndi funso ili: "Ndi zakudya ziti ndi zakudya zowonjezera zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.
Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Acral Melanoma, iliyonse ili ndi chibadwa chosiyana cha chotupa chokhala ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse monga Kabichi chimakhala ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.
Njira yothetsera makonda a addon imapangitsa kupanga chisankho kukhala kosavuta ndikuchotsa zongoganiza poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha Acral Melanoma?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Zothandizira
2) Tumor mutational load imalosera kupulumuka pambuyo pa immunotherapy pamitundu ingapo ya khansa.
4) Zotsatira za isoliquiritigenin pama cell a khansa ya ovarian.
https://www.ncbi.nlm.nih.gov/books/NBK559113
https://www.cancercenter.com/cancer-types/melanoma/types/acral-lentiginous-melanoma
https://www.healthline.com/health/acral-lentiginous-melanoma