Vitamini E imathandizira kuyankha kwa Bevacizumab mwa odwala Ovarian Cancer

Mfundo

Vitamini E ndi antioxidant yomwe imapezeka muzakudya kuphatikizapo mafuta a chimanga, mafuta a masamba, mafuta a kanjedza, ma almond, hazelnuts, pine-nuts ndi mbewu za mpendadzuwa. Oncologists nthawi zambiri amagwiritsa ntchito Avastin (Bevacizumab) ngati chithandizo cha ovarian khansa. Kafukufuku wosiyanasiyana awonetsa kuti kudya zakudya zoyenera kuphatikiza zakudya zoyenera komanso zopatsa thanzi kungathandize kupititsa patsogolo chithandizo chamankhwala kwa odwala khansa. Kafukufuku wina wachipatala ku Denmark wasonyeza kuti kugwiritsa ntchito Vitamini E (tocotrienol) pamodzi ndi Avastin (Bevacizumab) kuwirikiza kawiri kuchuluka kwa kupulumuka ndikukhazikitsa matendawa mu 70% ya odwala khansa ya ovarian yolimbana ndi chemotherapy. Izi zikuwonetsa kuti zakudya zokhala ndi Vitamini E zitha kukhala zopindulitsa kwa odwala khansa ya ovarian, chifukwa zitha kusintha kuyankha kwachire kwa Avastin/Bevacizumab. Ndikofunikira kusintha zakudya zamtundu wa khansa komanso chithandizo chopitilira kuti mupindule ndi zakudya komanso kukhala otetezeka.

Vitamini E ndi Zakudya Zake

Vitamini E ndi michere ya antioxidant yomwe imapezeka mu zakudya zosiyanasiyana kuphatikiza mafuta a chimanga, mafuta a masamba, mafuta amanjedza, ma almond, mtedza, mtedza wa paini ndi mbewu za mpendadzuwa, kuphatikiza zipatso ndi ndiwo zamasamba zambiri. Ikupezekanso ngati chowonjezera pazakudya ndipo imadziwika kuti ili ndi zambiri phindu la thanzi kuyambira kusamalira khungu mpaka kusintha kwa mtima ndi thanzi laubongo. Mavitamini antioxidant a Vitamini E amathandiza kuteteza maselo kuti asawonongeke chifukwa chotsitsimutsa kwambiri komanso kupsinjika kwa oxidative.

Katemera wa ovarian

Chifukwa chomwe khansara ya ovari imapha amayi ambiri padziko lonse lapansi ndi chifukwa choti khansa yoyambirira ya khansa imayambitsa matendawa. M'magawo am'mbuyomu a khansa, zizindikilo monga kuonda ndi kupweteka m'mimba, zomwe nthawi zambiri sizimadziwika, zimayamba kuwonekera ndipo nthawi zambiri sizimabweretsa nkhawa. Chifukwa cha izi, azimayi amapezeka kuti ali ndi khansa yamchiberekero pambuyo pake, zomwe zimabweretsa zaka zisanu kupulumuka kwa 47% (American Cancer Society).

Chithandizo cha Bevacizumab cha Khansa ya Ovarian

Imodzi mwamankhwala odziwika kwambiri omwe amagwiritsidwa ntchito pa khansa yamchiberekero ndi bevacizumab, yomwe imadziwikanso ndi dzina loti "Avastin". Bevacizumab sagwira ntchito mwachikhalidwe cha chemo mwa kungolimbana ndi kupha maselo a khansa koma imagwira ntchito pothetsa zotupazo m'malo mwake. Pankhondo, izi zitha kukhala ngati kuzungulira ndi kudzipatula mumzinda podula zofunikira zawo zonse m'malo mongowaukira mopanda nzeru. Imachita izi poletsa puloteni yotchedwa vascular endothelial growth factor (VEGF). Maselo a khansa awonjezera kuchuluka kwa VEGF ndipo kutsekereza puloteni iyi kumathandiza kupewa kukula kwa mitsempha yatsopano yomwe ili yofunikira potumiza michere ku zotupa za khansa.

vitamini E Zowonjezera limodzi ndi Bevacizumab Khansa ya Ovarian

Ngakhale chithandizo cha Bevacizumab limodzi ndi chemotherapy chimavomerezedwa kuchiza khansa ya ovarian, kusankha zakudya zoyenera kutenga ndi avastin mu khansa ya ovarian ndikofunikira. Kafukufuku waposachedwa wopangidwa ndi ofufuza ku chipatala ku Denmark awonetsa mphamvu ya chowonjezera chomwe chimatha kulumikizana ndi Bevacizumab ndikuwongolera kupulumuka kwa odwala khansa ya ovarian. Delta-tocotrienols ndi gulu lapadera la mankhwala omwe angapezeke mu Vitamini E. Kwenikweni, Vitamini E amapangidwa ndi magulu awiri a mankhwala- tocopherols ndi tocotrienols. Dipatimenti ya Oncology mu Chipatala cha Vejle, Denmark, idaphunzira momwe gulu la tocotrienol la vitamini E likuphatikiza ndi bevacizumab mu khansa ya chemo refractory ovarian. Aka kanali koyamba kuyesa kwachipatala kuchitidwa pogwiritsa ntchito kuphatikiza uku kwa ovary osamva zambiri khansa ndipo zotsatira zake zikuwoneka kuti zikulonjeza.

Poyerekeza ndi kupulumuka kwapakatikati kwa Progression Free Survival kwa miyezi 2-4 komanso kupulumuka kwapakatikati kwa miyezi 5-7, kuphatikiza chithandizo cha bevacizumab ndi delta-tocotrienol kudawirikiza kupulumuka, pomwe odwala amafika ku PFS yapakatikati ya miyezi 6.9 ndi OS yapakatikati ya miyezi 10.9, kukhalabe ndi matenda olimba pa 70% opanda poizoni wochepa (Thomsen CB neri Al, PharmacolRes. 2019). Nutrition / Zakudya zomwe zili ndi Vitamini E zitha kukhala zothandiza (mankhwala achilengedwe) kwa chemo omwe sagonjetsedwa ndi khansa ya ovari omwe amathandizidwa ndi Avastin pokweza kuchuluka kwa mayankho.

Kutsiliza

Kafukufukuyu adawonetsa zotsatira zotsutsana ndi khansa ya delta-tocotrienol mu khansa ya ovarian yolimbana ndi matenda ambiri, koma zomwezi sizinakhazikitsidwe kwa tocopherols. Mavitamini ambiri owonjezera a Vitamini E amakhala ochulukirapo mu tocopherols kuposa tocotrienols. Ikamwedwa moyenerera, tocotrienol imawoneka kuti ili ndi maubwino ena ambiri kuyambira pakusamalira khungu kupita ku thanzi la mtima ndi ubongo. Kudya kwachilengedwe kumakhala bwino nthawi zonse ndipo kumatha kupezedwa kuchokera ku mpunga, mafuta a kanjedza, rye, oats, balere. Ponena za kumwa tocotrienol zowonjezera khansa mankhwala, munthu ayenera nthawi zonse kukambirana chimodzimodzi ndi dokotala pamaso ntchito chifukwa nthawi zonse bwino kukhala otetezeka kuposa chisoni.

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

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