Mfundo
Ngakhale zakudya zokhala ndi lignans (gwero la zakudya za phytoestrogen zomwe zili ndi mapangidwe ofanana ndi estrogen) atha kukhala ndi mankhwala ofunikira omwe angathandize kuchepetsa chiopsezo cha mitundu ingapo ya khansa, mgwirizano wapakati pa plasma enterolactone komanso chiopsezo cha khansa sichidziwikiratu . Kafukufuku waposachedwa adapeza kuti milingo yayikulu ya enterolactone imatha kukhala ndi chiopsezo chocheperako cha kufa kwamankhwala okhudzana ndi khansa pakati pa akazi komanso chiopsezo chowonjezeka chakufa pakati pa amuna. Kafukufuku wina yemwe adayesa momwe mphamvu ya plasma enterolactone imakhudzira khansa ya m'mawere, prostate ndi ma endometrial sanapeze mgwirizano kapena amathera ndi zotsutsana. Chifukwa chake, pakadali pano, palibe umboni wowoneka bwino womwe ukuwonetsa kuti milingo yayikulu kwambiri ya enterolactone imatha kupereka zoteteza ku chiopsezo cha khansa yokhudzana ndi mahomoni.
Lignans ndi chiyani?
Lignans ndi ma polyphenols komanso ndiwo chakudya chachikulu cha phytoestrogen (chomera chophatikizika chofanana ndi estrogen), chomwe chimapezeka kwambiri mu zakudya zosiyanasiyana zopangidwa ndi mbewu monga mbewu za fulakesi ndi nthangala za sesame komanso zocheperako mtedza, mbewu zonse, zipatso ndi masamba. Zakudya zolemera izi za lignan nthawi zambiri zimagwiritsidwa ntchito ngati gawo la chakudya chopatsa thanzi. Zina mwazomwe zimayambitsa lignan zomwe zimapezeka muzakudya zopangidwa ndi chomera ndi secoisolariciresinol, pinoresinol, lariciresinol ndi matairesinol.
Enterolactone ndi chiyani?
Zomera lignans zomwe timadya zimasandulika mwazowonjezera ndi mabakiteriya am'mimba omwe amatsogolera pakupanga mankhwala omwe amatchedwa Enterolignans. Ma enterolignans awiri akulu omwe amayenda mthupi lathu ndi awa:
a. Enterodiol ndi
b. Kulowera
Enterolactone ndi amodzi mwamayimbidwe ambiri am'mayi. Enterodiol amathanso kusandulika kukhala enterolactone ndi mabakiteriya am'matumbo. (Meredith AJ Hullar et al, Cancer Epidemiol Biomarkers Prev., 2015) Onse enterodiol ndi enterolactone, amadziwika kuti ali ndi zochitika zochepa za estrogenic.
Kuphatikiza pa kuchuluka kwa kudya kwa lignans wazomera, milingo ya enterolactone mu seramu ndi mkodzo imatha kuwonetsanso zomwe mabakiteriya am'matumbo amachita. Komanso, kugwiritsa ntchito maantibayotiki kumalumikizidwa ndi kuchepa kwa serum enterolactone.
Pankhani ya phytoestrogen (chomera chophatikizika chofanana ndi estrogen) - zakudya zopatsa thanzi, soya isoflavones nthawi zambiri imawonekera, komabe, ma lignans ndiye omwe amapangira phytoestrogens makamaka m'ma Western.
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
Kuzindikira kwa Plasma Enterolactone ndi Kuopsa kwa Khansa
Ngakhale zakudya zokhala ndi ma lignans (gwero lazakudya za phytoestrogen zokhala ndi mawonekedwe ofanana ndi estrogen) zimawonedwa kuti ndi zathanzi ndipo zimakhala ndi zinthu zosiyanasiyana zomwe zingathandize kuchepetsa chiopsezo cha mitundu yosiyanasiyana ya khansa, mgwirizano pakati pa milingo ya enterolactone ndi chiopsezo cha khansa sizikudziwika bwinobwino.
Maganizo a Plasma Enterolactone ndi Imfa Yam'mimba Yam'mimba
Mu kafukufuku wofalitsidwa mu 2019 ndi ofufuza ochokera ku Denmark, adawunika mgwirizano pakati pa kuchuluka kwa plasma kwa enterolactone (the main lignan metabolite) asanazindikire khansa, komanso kupulumuka pambuyo pa colorectal. khansa, kutengera deta kuchokera kwa amayi a 416 ndi amuna a 537 omwe adapezeka ndi khansa ya colorectal, omwe adachita nawo Phunziro la Danish Diet, Cancer and Health cohort Study. Munthawi yotsatila, azimayi 210 ndi amuna 325 adamwalira, mwa azimayi 170 ndi amuna 215 adamwalira chifukwa cha khansa yapakhungu. (Cecilie Kyrø et al, Br J Nutriti., 2019)
Zotsatira za phunziroli zinali zosangalatsa kwambiri. Kafukufukuyu adawona kuti kuchuluka kwa Enterolactone kumalumikizidwa ndi kufa kwamankhwala otsika kwambiri a khansa pakati pa akazi, makamaka kwa iwo omwe sanagwiritse ntchito maantibayotiki. Kuwonjezeka kwa kuchuluka kwa plasma enterolactone mwa amayi kumalumikizidwa ndi chiopsezo chochepa cha 12% chaimfa chifukwa cha khansa yoyipa. Komanso, azimayi omwe ali ndi plasma yolimba kwambiri ya enterolactone anali ndi 37% ya anthu ochepa omwe amafa chifukwa cha khansa yoyipa, poyerekeza ndi omwe ali ndi plasma yotsika kwambiri ya enterolactone. Komabe, mwa amuna, kuchuluka kwa enterolactone kumalumikizidwa ndi kufa kwamtundu wamatenda okhwima okhudzana ndi khansa. M'malo mwake, mwa amuna, kuchuluka kwa plasma enterolactone kumalumikizidwa ndi chiopsezo chachikulu cha 10% chaimfa chifukwa cha khansa yoyipa.
Izi zikugwirizana ndi kafukufuku wakale yemwe adawonetsa kuti estrogen, mahomoni azimayi ogonana, amalumikizana mosiyana ndi chiopsezo cha kufa kwa khansa yamatenda (Neil Murphy et al, J Natl Cancer Inst., 2015). Enterolactone imawerengedwa kuti ndi phytoestrogen. Phytoestrogens ndi mankhwala omwe amapangidwa ndi mapangidwe ofanana ndi estrogen, ndipo zakudya zopangidwa ndi lignan ndizo chakudya chawo chachikulu.
Mwachidule, ofufuzawo adazindikira kuti milingo yayikulu ya enterolactone imatha kukhala ndi chiopsezo chocheperako cha kufa kwamankhwala okhudzana ndi khansa pakati pa akazi komanso chiopsezo chowonjezeka chaimfa mwa amuna.
Kuzindikira kwa Plasma Enterolactone ndi Kuopsa kwa Khansa ya Endometrial
Kukhazikika kwa Enterolactone ndi Kuopsa kwa Khansa ya Endometrial ku Women ku Denmark
Pakafukufuku wofalitsidwa ndi ofufuza a Danish Cancer Society Research Center ku Denmark, adawunika mgwirizano womwe ulipo pakati pa plasma enterolactone ndi kuchuluka kwa khansa ya endometrial, kutengera zomwe zachitika ku 173 endometrial milandu ndi akazi 149 osankha mwachidwi azimayi aku Danish omwe adalembetsa ku ' Kafukufuku wamagulu azakudya, Cancer ndi Health pakati pa 1993 ndi 1997 ndipo anali azaka zapakati pa 50 ndi 64. (Julie Aarestrup et al, Br J Nutriti., 2013)
Kafukufukuyu anapeza kuti amayi omwe ali ndi 20 nmol / l apamwamba m'magazi a enterolactone atha kukhala ndi chiopsezo chochepa cha khansa ya endometrial. Komabe, kuchepetsa sikunali kofunikira kwambiri. Kafukufukuyu adawunikiranso bungweli atatha kupatula chidziwitso kuchokera kwa azimayi omwe ali ndi zovuta zochepa za enterolactone chifukwa chogwiritsa ntchito maantibayotiki ndipo adapeza kuti bungweli lidalimba pang'ono, komabe, lidakhalabe losafunikira. Kafukufukuyu sanapezenso kusiyana kulikonse mgwirizanowu chifukwa cha kutha msinkhu, mankhwala othandizira mahomoni kapena BMI.
Ofufuzawo adazindikira kuti kuchuluka kwa plasma enterolactone kumachepetsa chiopsezo cha khansa ya endometrial, koma zovuta zake sizikhala zazikulu.
Kukhazikika kwa Enterolactone ndi Kuopsa kwa Khansa ya Endometrial mwa azimayi aku US
Ofufuza ku New York University School of Medicine ku US adachitapo kafukufuku wofananako yemwe adawunika mgwirizano womwe ulipo pakati pa khansa ya endometrium komanso ma enterolactone oyenda. Zambiri za phunziroli zidapezeka kuchokera ku maphunziro a 3 cohort ku New York, Sweden ndi Italy. Pambuyo pakutsatiridwa kwakanthawi kwa zaka 5.3, milandu yonse ya 153 idapezeka, yomwe idaphatikizidwa mu kafukufukuyu pamodzi ndi zowongolera 271 zofanana. Kafukufukuyu sanapeze gawo loteteza kufalitsa enterolactone motsutsana ndi khansa ya endometrial mwa azimayi a premenopausal kapena postmenopausal. (Anne Zeleniuch-Jacquotte et al, Int J Cancer., 2006)
Maphunzirowa samapereka umboni uliwonse wakuti enterolactone amateteza khansa ya endometrial.
Maganizo a Plasma Enterolactone ndi Imfa ya Khansa ya Prostate
Mu kafukufuku wofalitsidwa mu 2017 ndi ofufuza ochokera ku Denmark ndi Sweden, adawunika mgwirizano pakati pa kukhazikika kwa enterolactone ndi kufa pakati pa amuna aku Danish omwe ali ndi prostate. khansa. Kafukufukuyu adaphatikizanso zambiri kuchokera kwa amuna a 1390 omwe adapezeka ndi khansa ya prostate omwe adalembetsa ku Danish Diet, Cancer and Health cohort Study. (AK Eriksen et al, Eur J Clin Nutr., 2017)
Kafukufukuyu sanapeze mgwirizano uliwonse pakati pa 20 nmol / l apamwamba m'magazi a enterolactone ndi kumwalira kwa amuna aku Danish omwe ali ndi khansa ya prostate. Kafukufukuyu sanapezenso kusiyana kulikonse mgululi chifukwa cha zinthu monga kusuta, cholozera thupi kapena masewera, komanso nkhanza za khansa ya prostate.
Mwachidule, kafukufukuyu sanapeze mgwirizano pakati pa kulowa kwa enterolactone ndi kufa pakati pa amuna aku Danish omwe amapezeka ndi khansa ya prostate.
Kutengera ndi kuchuluka kwakanthawi, palibe umboni wotsimikizira kuyanjana pakati pa lignan (gwero la phytoestrogen yodyera yofanana ndi estrogen) -kudya zakudya zambiri, kuchuluka kwa serum enterolactone komanso chiopsezo cha khansa ya prostate.
Maganizo a Plasma Enterolactone ndi Khansa ya m'mawere
Kukhazikika kwa Enterolactone ndi Matenda a Khansa ya M'mawere ku Danish Postmenopausal Women
Pakafukufuku wofalitsidwa mu 2018 ndi ofufuza a Danish Cancer Society Research Center ndi University of Aarhus ku Denmark, adawunika kuyanjana komwe kulipo pakati pa matenda a plasma a enterolactone ndi khansa ya m'mawere azimayi omwe amapezeka pambuyo pake amwalira monga kubwereza, kufa kwa khansa ya m'mawere ndi zonse-zimayambitsa imfa. Kafukufukuyu anaphatikizira zambiri kuchokera ku 1457 za khansa ya m'mawere yochokera ku Danish Diet, Cancer ndi Health cohort Study. Munthawi yotsatira yotsatira yazaka 9, azimayi okwana 404 adamwalira, mwa iwo 250 adamwalira ndi khansa ya m'mawere, ndipo 267 adabweranso. (Cecilie Kyrø et al, Clin Nutr., 2018)
Kafukufukuyu anapeza kuti plasma yayikulu enterolactone imangoyanjana pang'ono ndi omwe amafa ndi khansa ya m'mawere azimayi omwe amapezeka pambuyo popha msinkhu, komanso osagwirizana ndi zomwe zimayambitsa kufa komanso kubwereza pambuyo poganizira zinthu monga kusuta, maphunziro, BMI, zolimbitsa thupi komanso kugwiritsa ntchito mahomoni otha msinkhu. Zotsatira sizinasinthe pambuyo pazinthu monga zamankhwala ndi chithandizo.
Kafukufukuyu adatsimikiza kuti panalibe mgwirizano wowoneka bwino pakati pa kuchuluka kwa plasma m'matenda a enterolactone ndi kufalikira kwa khansa ya m'mawere mwa amayi omwe atha msambo.
Kuopsa kwa khansa ya m'mawere ya Enterolactone ndi Postmenopausal ndi estrogen, progesterone ndi herceptin 2 receptor status
Pakuwunika meta kochitidwa ndi ofufuza aku Germany Cancer Research Center, Heidelberg, Germany, adayesa mgwirizano pakati pa serum enterolactone ndi postmenopausal khansa ya m'mawere. Zambiri pakuwunikaku zidapezeka pamilandu ya 1,250 ya khansa ya m'mawere ndi zowongolera 2,164 kuchokera ku kafukufuku wambiri wa anthu. (Aida Karina Zaineddin et al, Int J Cancer., 2012)
Kafukufukuyu adawonetsa kuti kuchuluka kwa serum enterolactone kumalumikizidwa ndi kuchepa kwa khansa ya m'mawere yotha msinkhu wa postmenopausal. Kafukufukuyu adawonetsanso kuti bungweli linali lofunika kwambiri kwa khansa ya m'mawere ya Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) poyerekeza ndi khansa ya m'mawere ya ER + ve / PR + ve. Kuphatikiza apo, mawu a HER2 sanakhudze bungweli.
Kafukufukuyu akuwonetsa kuti kuchuluka kwa serum enterolactone kumatha kuphatikizidwa ndi kuchepa kwa khansa ya m'mawere ya postmenopausal, makamaka ku Estrogen Receptor (ER) -ve / Progesterone Receptor (PR) - khansa ya m'mawere.
Kukhazikika kwa Enterolactone ndi Kuopsa kwa Khansa ya M'mawere ku Women Postmenopausal Women
Kafukufuku wam'mbuyomu wofalitsidwa mu 2007 ndi ofufuza a Institut Gustave-Roussy, France adawunikiranso mayanjano omwe ali pachiwopsezo cha khansa ya m'mawere yotchedwa postmenopausal ndi zakudya zomwe zimapezeka pazomera zinayi za lignans -pinoresinol, lariciresinol, secoisolariciresinol, ndi matairesinol, komanso kupezeka kwa ma enterolignans awiri - enterodiol ndi enterolactone. Kafukufukuyu adagwiritsa ntchito zomwe adalemba kuchokera pafunso lodziyesa lokha lokha lokha lokha la azimayi a ku France a 58,049 omwe atenga magazi kumapeto kwa nthawi omwe samatenga zowonjezera zowonjezera za soy isoflavone. Pakutsatiridwa kwakanthawi kwa zaka 7.7, milandu yonse ya 1469 ya khansa ya m'mawere idapezeka. (Marina S Touillaud Et al, J Natl Cancer Inst., 2007)
Kafukufukuyu adawonetsa kuti poyerekeza ndi azimayi omwe ali ndi lignans otsika kwambiri, omwe ali ndi lignan yokwanira kwambiri yofanana ndi 1395 microg / tsiku, ali ndi chiopsezo chochepa cha khansa ya m'mawere. Kafukufukuyu adapezanso kuti mayanjano osagwirizana pakati pa phytoestrogen omwe amatenga khansa ya m'mawere ndi postmenopausal pachiwopsezo anali ochepa ku Estrogen Receptor (ER) ndi Progesterone Receptor (PR) -ma khansa am'mimba abwino.
Kuchotsa Kwachinsinsi: Pakadali pano, pali zotsatira zotsutsana motero, sitingathe kunena ngati lignan (gwero la phytoestrogen yodyera yomwe ili ndi mapangidwe ofanana ndi estrogen) -kudya zakudya zambiri komanso kuchuluka kwa plasma ya enterolactone kuli ndi zoteteza ku khansa ya m'mawere.
Kutsiliza
Ngakhale kudya zakudya zokhala ndi ma lignans (gwero lazakudya za phytoestrogen zokhala ndi mawonekedwe ofanana ndi estrogen) ndi zathanzi ndipo zitha kukhala ndi mankhwala ofunikira omwe angathandize kuchepetsa chiopsezo cha mitundu yosiyanasiyana ya khansa, mgwirizano pakati pa milingo ya plasma enterolactone ndi chiwopsezo. za khansa zosiyanasiyana sizikudziwika. Kafukufuku wina waposachedwa wasonyeza kuti enterolactone imateteza matenda a khansa ya colorectal mwa amayi, komabe, mayanjanowo anali osiyana ndi amuna. Kafukufuku wina yemwe adawona momwe ndende ya plasma ya enterolactone imakhudzira khansa yokhudzana ndi mahomoni monga khansa ya m'mawere, khansa ya prostate ndi khansa ya endometrial sanapeze kuyanjana kapena kutha ndi zotsatira zotsutsana. Chifukwa chake, pakadali pano, palibe umboni womveka bwino womwe umasonyeza kuti kuchuluka kwa enterolactone komwe kumazungulira kumatha kupereka chitetezo chachikulu ku chiopsezo chokhudzana ndi mahomoni. khansa.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.