Zifukwa 3 Zapamwamba Zomwe Mungapangire Khansa ya Genomic

Mfundo

Kusanthula kwa Cancer genome / DNA kumatha kuthandizira kudziwa bwino za khansa, kulosera zamtsogolo komanso kuzindikira njira zamankhwala zomwe mungasankhe malinga ndi mikhalidwe ya khansa. Komabe, ngakhale kutchuka ndikunyengerera kwakubwera pokhudzana ndi phindu komanso kagwiritsidwe ntchito kake kotsata khansa, pali ochepa chabe odwala omwe amapindula ndi izi.

Kwa munthu yemwe wapezeka ndi matendawa posachedwa khansa ndi kuthana ndi kugwedezeka kwa matendawa, pali mafunso ambiri okhudza momwe, chiyani, chifukwa chiyani ndi masitepe otsatirawa. Amalemedwa ndi mawu ambiri omveka komanso mawu omveka, amodzi mwa iwo kukhala kutsata ma genomic a khansa komanso chithandizo chamunthu payekha.

Kodi Tumor Genomic Sequigation ndi Chiyani?

Kutupa kwamatenda amtundu ndi njira yopezera mtundu wa sikani ya mamolekyu ya DNA yotengedwa m'maselo otupa otengedwa ku fanizo la biopsy kapena m'magazi kapena m'mafupa a wodwalayo. Izi zimapereka tsatanetsatane wa zomwe zigawo za chotupa za DNA zimasiyana ndi DNA yopanda chotupa komanso kutanthauzira kwa ma genomic sequencing data kumapereka chidziwitso cha majini ofunikira ndi oyendetsa. khansa. Pakhala kupita patsogolo kodabwitsa muukadaulo wotsatizana zomwe zapangitsa kuti chidziwitso chamtundu wa chotupacho chikhale chotsika mtengo komanso chosavuta kugwiritsa ntchito kuchipatala. Mapulojekiti angapo ofufuza omwe amathandizidwa ndi maboma osiyanasiyana padziko lonse lapansi akuphatikiza zidziwitso za kuchuluka kwa odwala omwe ali ndi khansa, komanso mbiri yawo yachipatala, tsatanetsatane wamankhwala ndi zotsatira zachipatala, zomwe zaperekedwa kuti ziwunikidwe m'magulu a anthu. monga: The Cancer Genome Atlas (TCGA), Genomic England, cBIOPortal ndi ena ambiri. Kuwunika kopitilira muyeso kwa kuchuluka kwa anthu omwe ali ndi khansa kwapereka zidziwitso zazikulu zomwe zikusintha mawonekedwe a njira zamankhwala padziko lonse lapansi:

1. Khansa yamtundu winawake wa khansa monga khansa yonse ya m'mawere kapena khansa yonse yam'mapapo, yomwe poyamba idaganiziridwa kuti ndi yofanana komanso yothandizidwa chimodzimodzi, masiku ano amadziwika kuti ndiosiyana kwambiri ndipo amagawidwa m'magulu ang'onoang'ono am'magazi omwe amafunika kuthandizidwa mosiyanasiyana.
2. Ngakhale mkati mwa kamululu kakang'ono ka khansa, mawonekedwe a chotupa cha anthu aliwonse ndi osiyana komanso osiyana.
3. Kusanthula kwa khansa ya khansa kumapereka chidziwitso pazovuta zazikulu zamtundu (zomwe zasintha) zomwe zimayambitsa matendawa ndipo ambiri mwa iwo ali ndi mankhwala omwe adapangidwira kuti aletse zomwe akuchita.
4. Zovuta za DNA ya khansa zikuthandizira kumvetsetsa bwino zomwe zimayambira momwe khansa imagwiritsira ntchito kukulira ndikukula mwachangu ndikufalikira, ndipo izi zikuthandizira kupezeka kwa mankhwala atsopano komanso olunjika.

Chifukwa chake, zikafika ku matenda ngati khansa, omwe amathandizidwa ndi zoyipa komanso zakupha, chidziwitso chilichonse chomwe chimathandiza kumvetsetsa za khansa ya munthu chimathandiza.

Chifukwa chiyani Odwala Khansa Ayenera Kuganiza Zotupa za Genomic Sequicing?

M'munsimu muli zifukwa zitatu zomwe zimapangitsa kuti odwala azilingalira za DNA yawo ndi akatswiri azakafukufuku ndi zotsatira zawo:

Kusanthula kwa Khansa ku helps ndi Kuzindikira Koyenera

Nthawi zambiri, tsambalo komanso chomwe chimayambitsa khansa yoyamba sichidziwikiratu ndipo kusanthula kwa chotupa cha DNA kumatha kuthandizira kuzindikira bwino malo opangira zotupa ndi majeremusi ofunikira a khansa, potero zimapereka chidziwitso chokwanira. Pazifukwa zotere za khansa kapena khansa zomwe zimapezeka mochedwa ndipo zafalikira kudzera m'ziwalo zosiyanasiyana, kumvetsetsa khansa kumatha kuthandizira kudziwa njira zoyenera zochiritsira.

Kusanthula Kwa Khansa Kwambiri helps ndi Kulosera Kwabwinoko

Kuchokera pazotsatira zotsatizana wina amatenga mbiri ya genomic ya khansa DNA. Kutengera kuwunika kwa kuchuluka kwa anthu a khansa, machitidwe azovuta zosiyanasiyana adalumikizidwa ndi kuuma kwa matenda komanso kuyankha kwamankhwala. Mwachitsanzo. Kusowa kwa jini ya MGMT kumaneneratu kuyankha bwino ndi TMZ (Temodal) kwa odwala omwe ali ndi khansa ya muubongo glioblastoma multiforme. (Hegi ME et al, New Engl J Med, 2005Kupezeka kwa kusintha kwa majini kwa TET2 kumawonjezera mwayi woyankha gulu linalake la mankhwala omwe amatchedwa hypomethylating agents mu odwala khansa ya m'magazi. (Bejar R, Magazi, 2014) Izi zimapereka chidziwitso pakuwopsa kwa matendawa ndikuthandizira posankha mankhwala okhwima kapena owopsa.

Kusanthula Kwa Khansa Kwambiri helps ndi Kupeza Njira Yosankhira Yokha

Kwa ambiri khansa odwala omwe salabadira chithandizo chamankhwala chamankhwala a chemotherapy, kutsata chotupacho kumathandiza kuzindikira zolakwika zazikulu zomwe zitha kuthandizidwa ndi mankhwala omwe apangidwa posachedwapa ndipo angagwiritsidwe ntchito pokhapokha ngati kuli kofunikira. khalidwe. M'makhansa ambiri ouma khosi, obwerera m'mbuyo komanso osamva bwino, kuwunika kwamtundu wa chotupa cha DNA kumathandizira kupeza ndikulembetsa mayeso azachipatala kuyesa mankhwala atsopano komanso opangidwa mwaluso kapena kupeza njira zina zapadera zopangira mankhwala (mankhwala) kutengera mawonekedwe a khansa.

Kutsiliza

Chofunikira ndichakuti kutsatizana kwa ma genome kukuchulukirachulukira kwa odwala omwe ali nawo khansa lero. Monga zojambula zatsatanetsatane zomwe mmisiri wamanga amapanga asanayambe ntchito yomanga, deta ya genomic ndiye chizindikiro cha khansa ya wodwala ndipo imatha kuthandizira sing'angayo kuti azitha kusankha yekha chithandizocho potengera momwe khansayo imakhalira ndipo ikuyembekezeka kukhala yopindulitsa ku khansa. chithandizo. Kufufuza zenizeni za momwe alili ndi zodabwitsa za kutsata chotupa ndi mbiri ya khansa zafotokozedwa bwino m'nkhani yaposachedwapa ya David H. Freedmen mu 'Newsweek' pa 7/16/19. Iye akuchenjeza kuti ngakhale achita bwino kulunjika chotupa cha wodwala aliyense kudzera mumankhwala olondola, pali odwala ochepa omwe amapindula ndi izi. (https://www.newsweek.com/2019/07/26/targeting-each-patients-unique-tumor-precision-medicine-crushing-once-untretable-cancers-1449287.html)

Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.

Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.

Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.

Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.

• Zowona Zotsata Khansa Genomic ndi Njira Zambiri Momwe Zingakhalire Zothandiza
• Kufufuza kwa Mimba ndi Kuchiza Khansa Yanu
• Chakudya Chamtundu Wokha cha Khansa ya M'mawere ya Metastatic
• Ubwino Wogwiritsa Ntchito Tiyi Popewa Khansa
• Kuzungulira kwa Tumor DNA (ctDNA) Kufufuza kumatha kukhala Chizindikiro Chodziimira Chokha cha Khansa Yapamwamba