Ihe ọụcoụ na-aba n'anya na-egbu egbu na ihe egwu nke ọrịa kansa

Isi

Meta-nyocha nke ọmụmụ nlegharị anya dị iche iche na-egosi na ị drinkingụ mmanya na-ebute nsonaazụ na-adịghị mma dị ka ịbawanye n'ihe egwu nke ụdị ọrịa kansa dị ka ọrịa kansa na olu gụnyere cancer ọnụ na pharyngeal, kansa esophageal, cancer thyroid na kansa nke nkọlọ, yana colorectal, ọrịa imeju na ara, na -agbanyeghị, ma mmanya ọ na -ebute kansa akpa ume yana kansa prostate enweghị ihe ọ bụla.

Ọrịa cancer bụ otu n'ime ihe na-ebute ọnwụ n'ụwa niile. Ihe ize ndụ nke ịmalite ọrịa kansa na-adabere n'ọtụtụ ihe ndị na-adịghị n'okpuru anyị gụnyere mmụgharị mkpụrụ ndụ ihe nketa, afọ, akụkọ ihe mere eme ezinụlọ. cancer na ihe gbasara gburugburu ebe obibi dị ka ikpughe radieshon. Otú ọ dị, e nwere ọtụtụ ihe ndị ọzọ na-akpata/na-enye aka dị ukwuu na mmepe nke ụdị ọrịa cancer dị iche iche (dị ka ara, ngụgụ, prostate, colorectal, isi na olu cancer na ndị ọzọ) ma dị n'okpuru anyị, dị ka àgwà nri gụnyere gụnyere nri nri gụnyere. ịṅụ mmanya na-aba n'anya, iji ụtaba , iri anụ uhie, anụ a na-edozi na nri ndị a na-edozi nke ọma yana usoro ndụ dịka enweghị mmega ahụ na mgbatị ahụ na ụbara ibu / oke ibu. 

A na-ele mmanya na-aba n'anya anya dị ka akụkụ dị mkpa nke ememe, nnọkọ oriri na ọ socialụ socialụ na mmekọrịta mmadụ na ibe ya. Ọ bụ ezie na ọtụtụ ndị na-a alcoholụ mmanya na-egbu egbu na oke mmanya dịka akụkụ nke "ị drinkingụ mmanya na-elekọta mmadụ", ọnụ ọgụgụ dị ịrịba ama nke ndị mmadụ na-a highụ nnukwu mmanya na-aba n'anya mgbe niile, nke na-emecha pụta na nsonaazụ na-adịghị mma gụnyere ọrịa dị iche iche na-eyi ndụ egwu na ihe mberede okporo ụzọ. Enwere ike ịsị ọtụtụ ọnwụ ọnwụ (n'oge dị obere na ndụ) maka ị alcoholụbiga mmanya na-aba n'anya, na-eduga n'ihe dịka 13.5% ọnwụ n'etiti ndị nọ n'agbata 20 ruo afọ 39. (World Health Organization) 

Alumptionụ mmanya na-aba n'anya ọ nwere ike ịkpata kansa?

Dị ka Òtù Ahụ Ike Ụwa si kwuo, ihe dị ka 1 n'ime mmadụ 20 nwụrụ (ihe dị ka pasent 5.3 nke ọnwụ ụwa) bụ n'ihi ịṅụ mmanya na-aba n'anya na 1 n'ime ọnwụ 6 bụ n'ihi ọrịa cancer n'ụwa nile. N'ihi ya, ndị nchọpụta na-eme nchọpụta dị iche iche n'ụwa nile iji nyochaa njikọ dị n'etiti mmanya na-aba n'anya na cancer. Ọmụmaatụ ụfọdụ meta-nyocha nke mụọ ma mmanya nwere ike ịkpata ụdị ọrịa cancer dị iche iche (dị ka isi na olu, ara, ngụgụ, prostate na colorectal) na blọgụ a. 

Ihe ọcoụcoụ na-aba n'anya na-aba n'anya nwere ike ibute Ọrịa Isi na Ọrịa

1. Nnyocha e mere na omume nchịkwa mmadụ, usoro nyocha ụzọ ndụ tupu nchoputa yana data ahụike sitere n'ọmụmụ ihe ise n'ime International Head na Neck Cancer Epidemiology (INHANCE) Consortium, nke gụnyere ndị ọrịa 4759 isi na olu (HNC) chọpụtara na, tupu ịkọwa mmanya ịụ mmanya bụ ihe na-egosi na ọ ga - adị ndụ na ndụ HNC maka ndị ọrịa nwere ọrịa larynx. (L (Giraldi et al, Ann Oncol., 2017)
2. N'ime nnyocha e bipụtara na 2017, ndị na-eme nchọpụta jiri data ị alcoholụ mmanya na-egbu ndị ọrịa 811 isi na olu (HNC) na njikwa 940 si Taiwan iji nyochaa mkpakọrịta dị n'etiti mmanya na HNC site na saịtị ụfọdụ wee chọpụta na ị alcoholụ mmanya na-aba n'anya na-arịwanye elu HNC nwere nsogbu kachasị na-ahụ maka ọrịa kansa hypopharyngeal, yana ọrịa cancer oropharyngeal na laryngeal. Achọpụtakwara ihe egwu a dị elu karịa ndị mmadụ n'otu n'otu na-eji nwayọ ethanol metabolism. (Cheng-Chih Huang et al, Sci Rep., 2017) Ọgwụgwọ
3. Meta-nyocha nke data enwetara site na nyocha Pubmed ruo Septemba 2009 nke gụnyere njikwa ikpe 43 na ọmụmụ ihe abụọ gụnyere ngụkọta nke 17,085 cancer na pharyngeal cancer (OPC) chọpụtara na ndị na-a alcoholụbiga mmanya na-egbu egbu jikọtara nnukwu ihe ize ndụ nke kansa na ihe ize ndụ ahụ mụbara na usoro ịdabere na ọgwụ. Nnyocha ahụ chọpụtakwara na usoro> r = 1 ọ doseụ drinkụ ma ọ bụ 10g ethanol / ụbọchị nwekwara ike jikọta ya na ọnụọgụ OPC. (Irene Tramacere et al, Oral Oncol., 2010)
4. Nnyocha nke data enwetara site na nyocha akwụkwọ na ọdụ data gụnyere Embase, Latin American na Caribbean Health Sciences (LILACS), PubMed, Science Direct, na Web of Science) rue July 2018, nke gụnyere isiokwu 15, chọpụtara na ị consumptionụ mmanya na ụtaba na-arịwanye elu ihe ize ndụ nke carcinoma cell squamous cell. (Fernanda Weber Mello et al, Clin Oral Investig., 2019)
5. A nyochaa usoro nyocha na meta-nyocha nke data enwetara site na nyocha akwụkwọ na PubMed na ọdụ data Embase ruo July 2012 nke gụnyere ndị otu 8 / ndị bi na ya na usoro nyocha nke 11 chọpụtara na ị thatụ mmanya na-a inụ ndị ọrịa nwere oke ikuku elu (oghere ọnụ, pharynx, larynx, na esophagus) a na - ejikọ kansa kansa na ọnụọgụ nke ọrịa cancer nke abụọ. (Nathalie Druesne-Pecollo et al, Ọrịa Cancer Epidemiol Biomarkers Na-aga. 2014)

Ihe ọmụmụ ndị a dị n’elu na-egosi na ị intakeụ mmanya na-aba n’anya nke ukwuu nwere ike ibute ọrịa kansa dị n’isi na n’olu dịka kansa ọnụ na ọnụ, ọrịa kansa pharyngeal na ọrịa kansa nke nkọlọ. (Harindra Jayasekara, Mmanya na-aba n'anya na-egbu egbu., 2016; V Bagnardi, Br J Cancer., 2015)

Ihe ọụholụ na-aba n'anya na-aba n'anya nwere ike ibute ọrịa kansa thyroid

N'ime nnyocha e bipụtara na 2016, ndị nchọpụta si China nyochara data enwetara site na ọdụ data PubMed na EMBASE nke gụnyere ọmụmụ 24 na 9,990 ọrịa kansa thyroid ikpe ma chọpụta na ị consumptionụbiga mmanya ókè nwere ike jikọta ya na mmụba nke ọrịa Thyroid. (Xiaofei Wang et al, Oncotarget. 2016)

Ọmụmụ ihe ahụ na-egosi na ị alcoholụbiga mmanya ókè nwere ike ibute ọrịa kansa. 

Ihe ọcoụholụ na-aba n'anya na-aba n'anya nwere ike ibute Ọrịa Cancer Esophageal

1. N'ime nnyocha e bipụtara na 2014, ndị nchọpụta si Mahadum Michigan Medical School, Michigan nyochara data enwetara site na nyocha akwụkwọ na ọdụ data gụnyere MEDLINE, nyocha EBM, EMBASE, ISI Web of Knowledge na BIOSIS nke gụnyere amaokwu 5 wee chọpụta na mmanya na ụtaba oriri synergistically ụba ihe ize ndụ nke oria esophageal. (Anoop Prabhu et al, Am J Gastroenterol., 2014)
2. Nyocha nyocha na usoro nyocha site na iji 40 ikpe-njikwa na nchịkọta 13 / ọnụ ọgụgụ mmadụ gụnyere 17 ọmụmụ sitere na America, 22 si Asia, 1 si Australia na 13 si Europe, chọpụtara na ị moderateụbiga mmanya oke na mmanya dị elu nwere ike jikọta ya na mmụba ihe egwu nke kansar. Nnyocha ahụ chọpụtakwara na ị alcoholụ mmanya na-egbu egbu nwere ike jikọta ya na ọrịa cancer esophageal na Asia, na-atụ aro ọrụ nwere ike ịnweta mkpụrụ ndụ ihe nketa. (Farhad Islami et al, Int J Cancer. 2011)

Ihe ọmụmụ ndị a na-egosi na ị alcoholụbiga mmanya oke na-egbu egbu nwere ike ibute ọrịa kansa. (V Bagnardi, Br J Cancer., 2015)

Ihe ọcoụholụ na-aba n'anya na-aba n'anya nwere ike ibute Ọrịa ara ara

1. Ntụle meta nke ndị nyocha nke Mahadum Lanzhou, China ji mee ihe nyocha nke iri abụọ na ise gosiri na enwere mmekọrịta-dose-nzaghachi n'etiti ị alcoholụbiga mmanya na ọnwu ọrịa ara ara na nlọghachi. Ha chọpụtakwara na ị alcoholụ mmanya na-egbu ihe karịrị 25 g / ụbọchị nwere ike jikọta ya na ọnụọgụ ọnwu nke ọrịa ara ure. (Yun-Jiu Gou et al, Asia Pac J Cancer Na Mbụ, 20)
2. Ihe nyocha nke gunyere otutu ihe omuma ihe omuma nke sitere na ihe omumu nke 6 na ihe omume 200 nke oria ara ubara site na Canada, Netherlands, Sweden, na United States choputara na i alcoholu mmanya na-aba n'anya na mmetuta nke oria ara ụmụ nwanyị. Nnyocha ahụ kwukwara na n'etiti ụmụ nwanyị na-a consumedụ mmanya oge niile, belata ị ,ụ mmanya na-aba n'anya nwere ike inye aka n'ibelata ihe ize ndụ kansa kansa. (SA Smith-Warner et al, JAMA, 1998) Nkeji edemede

Ihe ọmụmụ ndị a na-egosi na ị alcoholụ mmanya na-aba n'anya nke ukwuu nwere ike ibute ọrịa kansa. (V Bagnardi, Br J Cancer., 2015)

Ihe ọụholụ na-aba n'anya na-aba n'anya nwere ike ịkpata ọrịa Cancer 

1. Ntụle meta nke ndị nyocha nke Mahadum Zhejiang University of Health, China jiri data ha nwetara site na nchọta akwụkwọ na PubMed na Web of Science site na Jenụwarị 1966 ruo June 2013 nke gunyere ọmụmụ ndị otu 9 chọpụtara na ị drinkingụbiga mmanya na-egbu egbu kwekọrọ na ≥50 g / ụbọchị ethanol nwere ike ime ka ohere ịnwụ nke ọrịa kansa na-egbu egbu. (Shaofang Cai et al, Eur J Cancer Prev., 2014)
2. Usoro nyocha ọzọ yiri nke data sitere na ndị otu 27 na ọmụmụ ihe gbasara 34 nke achọpụtara site na nyocha akwụkwọ Pubmed chọpụtara na ị drinkingụ mmanya na-egbu mmanya> 1 ihe ọ /ụ /ụ / ụbọchị nwere ike jikọta ya na ọnụọgụ nke kansa cancer. (V Fedirko et al, Ann Oncol., 2011)
3. Meta-analysis nke 16 ọmụmụ nke gụnyere 14,276 colorectal cancer ikpe na 15,802 njikwa si 5 ikpe-njikwa na 11 nested ikpe-akara ọmụmụ chọpụtara na ị heavyụbiga mmanya ókè (karịa ihe ọ drinksụ drinksụ 3 / ụbọchị) nwere ike jikọta ya na mmụba dị ukwuu nke eriri afọ. (Sarah McNabb, Int J Ọrịa Cancer., 2020)

Ihe ọmụmụ ndị a na-egosi na ị ofụbiga mmanya ókè nwere ike ibute ọrịa kansa. (Harindra Jayasekara, Alcohol Alcohol. 2016; V Bagnardi, Br J Cancer., 2015)

Ihe ọụholụ na-aba n’anya na-aba n’anya nwere ike ịkpata Ọrịa Cancer 

1. Ntụle meta emere site na iji data enwetara site na nyocha akwụkwọ na PubMed rue Mee 2014 nke gụnyere akwụkwọ 112 chọpụtara na otu mmanya na-egbu egbu kwa ụbọchị (~ 12 g / ụbọchị) nwere ike jikọta ya na oge 1.1 dị elu nke ọrịa cancer imeju. Nnyocha ahụ tụkwara aro mmekọrịta mmekọrịta nke ị alcoholụ mmanya na ịba ọcha n'anya yana ọrịa shuga na ihe egwu nke ọrịa imeju, agbanyeghị, ha atụ aro maka ịmụtakwu ọmụmụ iji guzobe otu. (Shu-Chun Chuang et al, Ọrịa Cancer Na-akpata., 2015)
2. Ihe nyocha yiri nke a mere site na iji data enwetara site na nyocha akwụkwọ na PubMed na EMBASE ruo Eprel 2013 nke gụnyere isiokwu 16 (19 cohorts) na ikpe 4445 na ọnwụ 5550 site na ọrịa cancer imeju, achọtara 46% atụmatụ oke ọrịa cancer ọrịa imeju 50 g nke ethanol kwa ụbọchị na 66% maka 100 g kwa ụbọchị. Nyocha a tụrụ aro ka ị drinkingụbiga mmanya oke (ị ofụ 3 ma ọ bụ karịa mmanya na-egbu egbu kwa ụbọchị) na ọrịa kansa imeju, yana enweghị mkpakọrịta na ị moderateụbiga mmanya oke.

N’ọnọdụ ọ bụla, ihe ọmụmụ ndị a na-atụkwa aro na ị intakeụbiga mmanya ókè nwere ike ibute ọrịa cancer nke imeju. (V Bagnardi, Br J Ọrịa., 2015)

Ihe ọcoụholụ na-aba n’anya na-aba n’anya nwere ike ibute Ọrịa Cancer 

1. Usoro nyocha nke usoro nyocha emere site na iji data enwetara site na nyocha Medline tinyere nyocha 10 chọpụtara na ị alcoholụbiga mmanya oke nwere ike jikọta ya na nnukwu ọrịa cancer. Nnyocha ahụ gosikwara na ị drinkingụbiga ihe ọ drinkingụ drinkingụ na ị moderateụbiga mmanya ókè nwere ike jikọta ya na ohere dị ukwuu nke kansa cancer. (Ke Ma et al, Med Sci Monit., 2017)
2. Meta-analysis nke nyocha nke otu 11 nke enwetara site na PUBMED na Ichushi na-enyocha nchekwa data yana nyocha akwụkwọ na ọnụ ọgụgụ ndị Japan chọpụtara na n'ime 9 n'ime ọmụmụ 11 ọ nweghị mkpakọrịta dị n'etiti ị alcoholụ mmanya na ọrịa kansa, n'agbanyeghị, otu nnyocha gosipụtara oke ihe egwu nke afọ cancer na ụmụ nwoke nwere nnukwu mmanya. Ndị nnyocha ahụ tụrụ aro ịmụtakwu banyere ndị bi na Japan iji gosi otu ihe ahụ. (Taichi Shimazu et al, Jpn J Clin Oncol., 2008)

Drinkingụbiga mmanya ókè gụnyere ịgụnye 3 ma ọ bụ karịa mmanya na-aba n'anya kwa ụbọchị nwere ike ibute ọrịa kansa.

Mmanya Na-egbu Mmanya na Akụrụ, Prostate na Lung Cancer Risk

Ọrịa akụrụ

1. Meta-analysis nke data enwetara site na PubMed, EMBASE, na MEDLINE ọdụ data ruo August 2011 nke gụnyere ọmụmụ ikpe-20, ọmụmụ ihe otu 3, yana nyocha 1 nke ndị otu na-achọpụta na, n'ụzọ dị ịtụnanya, ị alcoholụ mmanya na-aba n'anya nwere ike jikọta ya na obere nsogbu. nke akụrụ mkpụrụ ndụ akụrụ, yana oke oriri na-enye nchedo yana oriri dị elu na-enweghị uru ọzọ. (DY Song et al, Br J Cancer. 2012) Nnyocha ahụ tụrụ aro na ị drinkingụbiga ihe ọ moderateụ alcoholụ na-aba n'anya ókè nwere ike inye aka n'ibelata ohere nke ọrịa akwara akụrụ.

2. Otú ọ dị, nyocha ọzọ nke data nke gụnyere ọmụmụ ihe ọmụmụ 20 (otu ìgwè, 4 na-achịkwa 1 na njikwa ikpe 15) nwetara site na nyocha akwụkwọ na PubMed na ọdụ data EMBASE ruo na Nọvemba 2010 chọpụtara na ị moderateụbiga mmanya oke na ị heavyụbiga mmanya ókè nwere ike jikọta ya na ihe ize ndụ dị ukwuu nke akụrụ akwara kansa akwara.  

N'ozuzu ya, njikọ dị n'etiti ị alcoholụ mmanya na akụrụ akụrụ bụ ihe na-enweghị isi.

Ọwara Ọrịa

Ọtụtụ nchọpụta nyochakwara njikọ dị n'etiti mmanya na ọrịa kansa prostate. Agbanyeghị, a hụkwara ihe ndị na -emegiderịta onwe ha n'ọmụmụ ihe ndị a metụtara mkpakọrịta dị n'etiti ị alcoholụ mmanya na ihe egwu kansa prostate (Jinhui Zhao et al, BMC Cancer., 2016; Christine M Velicer et al, Nutr Cancer., 2006; Matteo Rota et al, Eur J Ọrịa Prev., 2012). 

Lung Cancer

Ma mmanya na-aba n'anya na-akpata mmụba nke ọrịa cancer akpa ume bụkwa ihe na-enweghị isi. Ọ bụ ezie na otu nnyocha tụrụ aro na “ihe ize ndụ dịtụ ukwuu nke ngụgụ cancer ejikọtara ya na oriri> ma ọ bụ = 30 g mmanya / ụbọchị ma e jiri ya tụnyere ịṅụ mmanya na-aba n'anya" (Jo L Freudenheim et al, Am J Clin Nutr., 2005), nchọpụta nke abụọ na-atụ aro na ọ dịghị njikọ n'etiti ịṅụ mmanya na-aba n'anya na ọrịa cancer akpa ume. "Ọ dịghị mgbe" ndị na-ese anwụrụ. (V Bagnardi et al, Ann Oncol., 2011)

Ọ dị mkpa ịmụkwu amụ iji chọpụta ma ị alcoholụ mmanya na-akpata ọrịa akpa ume.

Mmanya Na-egbu Mmanya Na Egwu Endometrial na Ovarian Cancer

Ọtụtụ nchọpụta meta-analyses enyochala njikọ dị n'etiti ịṅụ mmanya na endometrial cancer. Otú ọ dị, ọmụmụ ihe ahụ achọpụtaghị njikọ dị ịrịba ama n'etiti abụọ ahụ. Ọtụtụ n'ime ọmụmụ ihe ndị a tụkwara aro na nsonaazụ ya bụ otu n'agbanyeghị ụdị mmanya na-egbu egbu. (Quan Zhou et al, Arch Gynecol Obstet., 2017; Qingmin Sun et al, Asia Pac J Clin Nutr. 2011)

Meta-analysis nke data enwetara site na nyocha akwukwo na PubMed rue Septemba 2011 nke gunyere omumu ihe omumu nke 27, nke 23 bu ihe omumu banyere ihe omumu, ihe omumu nke 3 na otu ndi mmadu na achoputa ihe omumu nke ndi mmadu, tinyere ngụkọta nke 16,554 epithelial ovarian cancer , achọtaghi njikọ dị n'etiti ị alcoholụbiga mmanya na ọrịa cancer ovarian.

mmechi

Ọtụtụ ọmụmụ na meta-nyocha na-egosi na ịṅụ mmanya na-ebuli ihe ize ndụ nke ụdị ọrịa cancer dị iche iche dị ka isi na n'olu cancer gụnyere ọnụ na pharyngeal cancer, esophageal cancer, thyroid cancer, cancer nke larynx; ọrịa cancer colorectal; ọrịa imeju na ọrịa ara ara. Otú ọ dị, meta-analysis nke ọmụmụ dị iche iche tụrụ aro na ịṅụ mmanya nwere ike ọ gaghị ejikọta ya ọrịa cancer dị ka ọrịa cancer endometrial na ovarian, mana maka ọrịa cancer ndị ọzọ dị ka ngụgụ na ọrịa prostate, ọmụmụ ihe adịghị agwụ agwụ. Otú ọ dị, n'agbanyeghị na amabeghị ma mmanya na-akpata ọrịa cancer akpa ume, ọ ka mma izere mmanya na-aba n'anya iji nọgide na-adị mma.

Ihe omumu di elu na ihe omuma nke sayensi n’eme ka odi nkpa iwepu ma obu oburu na ogacho, kwusi / ghara i alcoholu manya i tou mmanya ka ibelata oria kansa. Obere mmanya anyị na-a drinkụ, ọ ka mma maka ọdịnihu dị mma!

Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.

Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.

Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.

Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ usoro ọgwụgwọ kachasị mma maka ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.

• Nri anụ nri / mgbakwunye nke nwere ike ibute / emerụ Ọrịa Cancer
• Akwukwo nri Cruciferous oriri na oria
• Nri tii nwere ike ibuwanye ihe egwu nke akwara
• Gini mere o ji di egwu nye ndi oria cancer ka ha were ogwu ahihia ha na Chemotherapy?
• Kọfị oriri na lanarị na Colorectal Cancer Ọrịa