highlights
Cov khoom noj khoom haus zoo li Retinol muaj ntau yam txiaj ntsig kev noj qab haus huv thiab tau siv dav los ntawm cov neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo ntawm kev mob qog noj ntshav. Tab sis, nws puas muaj kev nyab xeeb los noj cov tshuaj Retinol rau txhua hom mob qog noj ntshav thiab tsis xav txog kev kho mob txuas ntxiv thiab lwm yam kev ua neej nyob? Ib qho kev ntseeg tab sis tsuas yog ib qho lus dab neeg xwb yog tias txhua yam ntuj tsim tau tsuas yog pab tau kuv lossis tsis muaj kev phom sij. Raws li ib qho piv txwv, kev siv txiv kab ntxwv qaub nrog qee yam tshuaj tsis pom zoo. Lwm qhov piv txwv, kev siv spinach nrog qee cov tshuaj ua kom ntshav ntshav tuaj yeem ua rau muaj kev cuam tshuam tsis zoo thiab yuav tsum zam. Rau cancer, khoom noj khoom haus uas suav nrog cov khoom noj thiab cov khoom siv ntuj tsim tau pom tias muaj kev cuam tshuam cov txiaj ntsig. Yog li cov lus nug uas nquag nug los ntawm cov neeg mob qog noj ntshav rau cov kws kho mob thiab kws kho mob yog "Kuv yuav tsum noj dab tsi thiab kuv yuav tsum tsis txhob?".
Noj cov khoom noj khoom haus Retinol tuaj yeem pab cov neeg mob Non-Hodgkin Lymphoma ntawm kev kho mob qog noj ntshav Vorinostat. Tab sis zam cov tshuaj Retinol yog nyob rau ntawm Paclitaxel kho rau Adenoid Cystic Carcinoma. Ib yam li ntawd, noj cov khoom noj khoom haus ntxiv Retinol tuaj yeem muaj txiaj ntsig zoo rau cov tib neeg noj qab haus huv uas muaj kev pheej hmoo ntawm kev mob qog noj ntshav vim kev hloov pauv ntawm cov noob CDKN1B. Tab sis tsis txhob noj zaub mov ntxiv Retinol thaum muaj kev pheej hmoo ntawm kev mob qog noj ntshav vim kev hloov pauv ntawm cov noob CHEK2.
Kev noj qab haus huv - koj tus kheej cov ntsiab lus yuav cuam tshuam koj qhov kev txiav txim siab yog tias cov khoom noj khoom haus Retinol muaj kev nyab xeeb lossis tsis zoo. Thiab tseem hais tias qhov kev txiav txim siab no yuav tsum tau rov mus xyuas tas li thaum muaj xwm txheej hloov. Cov xwm txheej zoo li hom mob qog noj ntshav, kev kho mob tam sim no thiab tshuaj ntxiv, hnub nyoog, poj niam txiv neej, qhov hnyav, qhov siab, kev ua neej thiab txhua yam kev hloov pauv caj ces tau txheeb xyuas qhov teeb meem. Yog li cov lus nug raug cai rau koj kom nug txog cov lus pom zoo ntawm cov khoom noj thiab cov khoom siv ntuj yog li cas nws cuam tshuam rau koj tus kheej cov ntsiab lus.
Saib me me hais
Khoom noj khoom haus - cov vitamins, tshuaj ntsuab, minerals, probiotics, thiab lwm yam tshwj xeeb pawg yog nce. Cov tshuaj ntxiv yog qhov muaj siab ntawm cov khoom xyaw nquag uas tseem muaj nyob hauv cov khoom noj sib txawv. Qhov sib txawv yog cov khoom noj muaj ntau tshaj ib qho khoom muaj nyob rau hauv qis diffused concentrations. Nco ntsoov tias txhua yam ntawm cov khoom xyaw no muaj nws tus kheej kev tshawb fawb thiab kev siv tshuaj lom neeg ntawm qib molecular - yog li xaiv qhov sib xyaw ua ke ntawm cov tshuaj xws li Retinol raws li cov ntsiab lus ntawm tus kheej thiab cov xwm txheej.
Yog li cov lus nug yog koj yuav tsum noj cov tshuaj Retinol ntxiv? Koj yuav tsum noj nws thaum muaj kev pheej hmoo ntawm kev mob qog noj ntshav rau kev hloov pauv ntawm cov noob CHEK2? Koj yuav tsum noj nws thaum muaj kev pheej hmoo ntawm kev mob qog noj ntshav rau kev hloov pauv ntawm cov noob CDKN1B? Koj yuav tsum noj nws thaum kuaj tau Adenoid Cystic Carcinoma? Koj puas yuav tsum noj Retinol ntxiv thaum kuaj pom tias tsis yog-Hodgkin Lymphoma? Koj yuav tsum noj nws thaum kho Paclitaxel? Koj puas yuav tsum tau noj ntxiv yog tias koj hloov koj txoj kev kho mob los ntawm Paclitaxel rau Vorinostat? Yog li cov lus piav qhia dav dav zoo li - nws yog ntuj lossis nws nce kev tiv thaiv kab mob yuav tsis txaus thiab txaus rau xaiv Retinol.
cancer
Mob qog noj ntshav tseem yog ib qho teeb meem tsis daws teeb meem. Kev txhim kho muaj kev kho tus kheej thiab kev saib xyuas mob qog noj ntshav ntawm cov ntshav thiab qaub ncaug yog qhov tseem ceeb los txhim kho cov txiaj ntsig. Qhov kev cuam tshuam ua ntej - qhov zoo dua qhov cuam tshuam ntawm qhov tshwm sim. Kev ntsuam xyuas noob caj noob ces muaj peev xwm los ntsuas qhov kev pheej hmoo mob qog noj ntshav thiab kev raug mob ntxov. Tab sis dhau li kev saib xyuas tsis tu ncua nyob rau hauv feem ntau tsis muaj cov kev xaiv kho mob muaj. Tom qab kuaj mob nrog mob qog noj ntshav xws li Adenoid Cystic Carcinoma lossis Non-Hodgkin Lymphoma, cov kev kho mob tau txais tus kheej rau cov qog genomics thiab yam xws li kev kis tus kab mob, hnub nyoog thiab poj niam txiv neej. Thaum lub sij hawm kho mob qog noj ntshav (tom qab kev kho mob tiav) - kev soj ntsuam yog siv rau kev ntsuam xyuas ntawm ib qho kev rov qab los thiab txiav txim siab raws li cov kauj ruam tom ntej. Feem coob ntawm cov neeg mob qog noj ntshav thiab cov uas muaj kev pheej hmoo noj cov khoom noj khoom haus zoo li Retinol.
Yog li cov lus nug yog tias txhua yam kev hloov pauv caj ces muaj feem cuam tshuam thiab hom mob qog noj ntshav yuav suav tias yog ib qho thaum txiav txim siab siv Retinol? Puas yog txoj hauv kev biochemical cuam tshuam txog kev pheej hmoo ntawm caj ces rau mob qog noj ntshav vim kev hloov pauv ntawm cov noob CHEK2 tib yam li vim kev hloov pauv ntawm cov noob CDKN1B? Puas yog qhov cuam tshuam ntawm Adenoid Cystic Carcinoma tib yam li Non-Hodgkin Lymphoma? Puas yog ib qho thiab tib yam yog tias koj tau kho nrog Paclitaxel lossis ntawm Vorinostat?
Retinol - Ib qho khoom noj khoom haus ntxiv
Retinol los yog vitamin A1 yog ib tug rog soluble vitamin uas belongs rau lub vitamin A tsev neeg. Nws muaj nyob rau hauv cov khoom noj sib txawv thiab tseem siv los ua kev noj haus ntxiv. Kev noj cov tshuaj Retinol txhawb nqa cov tawv nqaij, qhov muag, thiab kev noj qab haus huv ntawm cov menyuam yaus, kev loj hlob zoo hauv cov menyuam yaus, muab kev tiv thaiv kab mob xws li mob khaub thuas thiab mob khaub thuas, thiab tseem ceeb heev rau kev tiv thaiv kab mob. Txawm li cas los xij, kev siv ntau ntawm retinol tuaj yeem ua rau lub siab loj, tawv nqaij qhuav, lossis hypervitaminosis A.
Raws li tau hais ua ntej, Retinol yog cov khoom muaj nyob hauv ntau yam khoom noj. Cov khoom noj xws li Barley, Pob Kws thiab Quinoa muaj Retinol ntawm cov qib sib txawv nrog rau lwm cov khoom xyaw nquag. Txoj hauv kev molecular uas tswj hwm los ntawm Retinol suav nrog Focal Adhesion, Inflammation, Estrogen Signaling, Cell Cycle thiab NFKB Signaling. Cov txheej txheem ntawm tes no ncaj qha lossis ncaj qha tswj cov kab mob qog noj ntshav tshwj xeeb xws li kev loj hlob, kis thiab tuag. Vim tias cov kev cai lom neeg no - rau kev noj zaub mov zoo rau mob qog noj ntshav, kev xaiv txoj cai ntawm cov tshuaj xws li Retinol ib leeg lossis ua ke yog qhov kev txiav txim siab tseem ceeb. Thaum txiav txim siab txog kev siv cov tshuaj Retinol ntxiv rau kev mob qog noj ntshav - xav txog tag nrho cov xwm txheej no thiab cov lus piav qhia. Vim tias tsuas yog muaj tseeb rau kev kho mob qog noj ntshav - kev siv Retinol tsis tuaj yeem yog ib qho kev txiav txim siab rau txhua hom qog noj ntshav.
Xaiv Retinol Ntxiv rau Koj Cov Mob Cancer
Yog vim li cas tsis muaj txoj hauv kev yooj yim los teb cov lus nug "Thaum twg kuv yuav tsum zam Retinol rau Cancer" yog vim "Nws nyob ntawm!". Ib yam li tib txoj kev kho mob tsis ua haujlwm rau txhua tus neeg mob qog noj ntshav, raws li koj tus kheej cov ntsiab lus, Retinol tuaj yeem tsim kev puas tsuaj lossis nyab xeeb. Nrog rau cov kab mob qog noj ntshav thiab cov caj ces cuam tshuam - cov kev kho mob tsis tu ncua, tshuaj ntxiv, kev ua neej nyob, BMI thiab kev ua xua yog txhua yam txiav txim siab seb Retinol yuav tsum zam lossis tsis yog vim li cas.
1. Cov tshuaj Retinol puas yuav pab tau Adenoid Cystic Carcinoma/Cancer Cov neeg mob uas tau txais kev kho mob Paclitaxel?
Adenoid Cystic Carcinoma yog tus yam ntxwv thiab tau tsav los ntawm kev hloov pauv caj ces tshwj xeeb xws li NFIB thiab MYB ua rau kev hloov pauv hauv biochemical hauv Focal Adhesion, PI3K-AKT-MTOR Signaling, Notch Signaling thiab Cholesterol Metabolism. A cancer Kev kho mob zoo li Paclitaxel ua haujlwm los ntawm txoj hauv kev tshwj xeeb ntawm kev ua haujlwm. Lub hom phiaj yog kom muaj kev sib tshooj zoo ntawm kev kho mob thiab kev mob qog noj ntshav rau txoj hauv kev ntawm tus kheej uas muaj txiaj ntsig zoo. Nyob rau hauv cov xwm txheej zoo li no, txhua yam zaub mov lossis khoom noj khoom haus ntxiv uas muaj qhov cuam tshuam rau kev kho lossis txo qhov sib tshooj yuav tsum zam. Ua piv txwv, Retinol yuav tsum zam rau Adenoid Cystic Carcinoma nrog rau kev kho Paclitaxel. Retinol cuam tshuam txoj hauv kev Focal Adhesion uas yog txhawb cov neeg tsav tsheb ntawm tus kab mob thiab / lossis tshem tawm cov nyhuv kho. Tsis tas li ntawd, cov tshuaj Retinol muaj CYP3A4 (cov tshuaj metabolizing enzyme) cuam tshuam nrog kev kho Paclitaxel, thiab yog li yuav tsum zam los ntawm cov neeg mob qog noj ntshav uas tau kho qhov no. (Kun Wang li al, Biochem Pharmacol., 2008; Pius S Fasinu li al, Front Oncol., 2019) Qee yam uas yuav tau txiav txim siab xaiv thaum xaiv khoom noj yog hom mob qog noj ntshav, kev kho mob thiab tshuaj noj uas tau siv tam sim no (yog tias muaj), hnub nyoog, tub los ntxhais, BMI, kev ua neej thiab cov ntaub ntawv hloov caj ces (yog tias muaj).
2. Cov tshuaj Retinol puas puas muaj txiaj ntsig rau cov neeg mob uas tsis yog Hodgkin Lymphoma uas tau txais kev kho mob qog noj ntshav Vorinostat?
Non-Hodgkin Lymphoma yog tus yam ntxwv thiab tau tsav los ntawm kev hloov pauv caj ces xws li KMT2D thiab CREBBP ua rau kev hloov pauv hauv biochemical hauv Inflamation, NFKB Signaling, Endoplasmic Reticulum Stress, PI3K-AKT-MTOR Signaling thiab P53 Signaling. Kev kho mob qog noj ntshav zoo li Vorinostat ua haujlwm los ntawm cov txheej txheem tshwj xeeb. Lub hom phiaj yog kom muaj kev sib tshooj zoo ntawm kev kho mob thiab kev mob qog noj ntshav rau txoj hauv kev rau tus kheej. Nyob rau hauv cov xwm txheej zoo li no ib qho khoom noj los yog khoom noj khoom haus ntxiv uas muaj txiaj ntsig zoo rau kev kho mob lossis txo qhov sib tshooj yuav tsum tau txiav txim siab. Ua piv txwv, Retinol ntxiv yuav tsum raug txiav txim siab rau Non-Hodgkin Lymphoma nrog rau kev kho mob Vorinostat. Retinol ntxiv cuam tshuam rau txoj hauv kev Inflamation thiab NFKB Signaling uas cuam tshuam cov neeg tsav tsheb ntawm tus kab mob (Non-Hodgkin Lymphoma) thiab / lossis txhim kho kev kho mob.
Cov zaub mov noj tom qab kuaj mob qog noj ntshav!
Tsis muaj ob yam mob qog noj ntshav zoo ib yam. Mus dhau qhov txheej txheem kev noj zaub mov zoo rau txhua tus thiab txiav txim siab tus kheej txog zaub mov thiab tshuaj ntxiv nrog kev ntseeg siab.
3. Puas yog cov tshuaj Retinol muaj kev nyab xeeb rau cov tib neeg noj qab haus huv nrog CHEK2 Mutation Associated Genetic Risk?
Cov tuam txhab sib txawv muab cov noob caj noob ces los kuaj xyuas cov kev pheej hmoo ntawm caj ces rau cov qog nqaij hlav sib txawv. Cov vaj huam sib luag no npog cov noob uas cuam tshuam nrog cov qog nqaij hlav ntawm lub mis, zes qe menyuam, tsev menyuam, prostate, thiab plab hnyuv thiab lwm yam. Kev ntsuam xyuas cov noob caj noob ces tuaj yeem lees paub qhov kev kuaj mob thiab pab qhia kev kho mob thiab kev tswj xyuas kev txiav txim siab. Kev txheeb xyuas tus kab mob sib txawv kuj tseem tuaj yeem qhia kev kuaj thiab kuaj xyuas cov txheeb ze uas pheej hmoo. CHEK2 yog ib qho ntawm cov noob feem ntau muaj nyob rau hauv panels rau kev kuaj mob qog noj ntshav.
CHEK2 kev hloov pauv ua rau biochemical pathways Estrogen Signaling, DNA Kho, Stem Cell Signaling, P53 Signaling thiab Cell Cycle kom muaj kev cuam tshuam. Cov kev no yog cov tsav tsheb ncaj qha lossis tsis ncaj qha ntawm cancer molecular endpoints. Retinol yuav tsum raug zam thaum lub genetic vaj huam sib luag txheeb xyuas kev hloov pauv ntawm CHEK2 rau Cancer Lub Cev. Retinol cuam tshuam txoj hauv kev Estrogen Signaling thiab DNA Kho thiab tsim cov teebmeem tsis zoo nrog CHEK2 thiab lwm yam mob.
4. Puas yog Retinol Supplements muaj kev nyab xeeb rau cov tib neeg noj qab haus huv nrog CDKN1B Mutation Associated Genetic Risk?
CDKN1B yog ib qho ntawm cov noob muaj nyob rau hauv panels rau cancer kev ntsuam xyuas txaus ntshai. CDKN1B kev hloov pauv ua rau biochemical pathways Cell Cycle, Stem Cell Signaling, FOXO Signaling, PI3K-AKT-MTOR Signaling thiab Cell Cycle Checkpoints kom muaj kev cuam tshuam. Cov kev no yog cov tsav tsheb ncaj qha lossis tsis ncaj ntawm cov kab mob qog noj ntshav. Retinol thaum lub genetic vaj huam sib luag txheeb xyuas kev hloov hauv CDKN1B rau Neuroendocrine Cancer. Retinol cuam tshuam txoj hauv kev Cell Cycle thiab Stem Cell Signaling thiab tsim cov nyhuv ntxiv nrog CDKN1B thiab lwm yam mob.
* Lwm Yam Txheej Txheem kuj tseem muaj xws li BMI, Kev Coj Ua Neej, Kev Kho Mob
Nyob rau hauv Xaus
Ob qho tseem ceeb tshaj plaws uas yuav tsum nco ntsoov yog tias kev kho mob qog noj ntshav thiab noj zaub mov tsis zoo ib yam rau txhua tus. Khoom noj khoom haus uas suav nrog zaub mov thiab khoom noj khoom haus zoo li Retinol, yog cov cuab yeej siv tau zoo uas tuaj yeem tswj tau los ntawm koj, thaum ntsib mob qog noj ntshav.
Yam zaub mov twg koj noj thiab cov khoom noj uas koj noj yog qhov kev txiav txim siab koj ua. Koj qhov kev txiav txim siab yuav tsum suav nrog kev txiav txim siab ntawm kev hloov pauv noob caj noob ces, uas mob qog noj ntshav, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua qhov ua xua, qhia txog kev ua neej nyob, hnyav, qhov siab thiab tus cwj pwm.
Kev npaj zaub mov noj rau mob qog noj ntshav los ntawm addon tsis yog los ntawm kev tshawb fawb hauv internet. Nws siv qhov kev txiav txim siab rau koj raws li kev tshawb fawb molecular siv los ntawm peb cov kws tshawb fawb thiab software engineers. Tsis hais seb koj puas mob siab rau nkag siab cov hauv paus txheej txheem biochemical molecular lossis tsis - rau kev npaj zaub mov noj rau mob qog noj ntshav uas xav tau kev nkag siab.
Pib tam sim no nrog koj cov phiaj xwm kev noj zaub mov zoo los ntawm kev teb cov lus nug ntawm lub npe mob qog noj ntshav, kev hloov pauv caj ces, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua yam kev ua xua, tus cwj pwm, lub neej, pab pawg hnub nyoog thiab poj niam txiv neej.
Khoom noj khoom haus tus kheej rau Cancer!
Cancer hloov nrog lub sijhawm. Kho thiab hloov kho koj cov khoom noj khoom haus raws li kev qhia mob qog noj ntshav, kev kho mob, kev ua neej, kev nyiam zaub mov, kev ua xua thiab lwm yam.
Cov neeg mob cancer feem ntau yuav tsum tau ua nrog sib txawv kev kho mob tshuaj phiv uas cuam tshuam rau lawv lub neej zoo thiab saib rau lwm cov kev kho mob qog noj ntshav. Noj cov khoom noj khoom haus zoo thiab pabcuam ntxiv raws li kev txiav txim siab science (Tsis txhob twv thiab xaiv xaiv) yog cov tshuaj zoo tshaj plaws rau kev mob qog noj ntshav thiab kev kho mob ntsig txog phiv.