highlights
Kev siv tshuaj Ascorbic Acid (Vitamin C) ntau heev rau kev tso tshuaj nrog rau kev siv tshuaj xws li FOLFOX thiab FOLFIRI, nyob rau hauv cov neeg mob ua nqaj qaum lossis mob qog nqaij hlav hauv lub plab, tuaj yeem siv ua kom nyab xeeb tsis muaj tshuaj lom. Kev noj cov tshuaj muaj txiaj ntsig zoo Vitamin C lossis suav nrog Vitamin C cov zaub mov muaj txiaj ntsig yog ib feem ntawm cov khoom noj cov neeg mob mob cancer ntshav qab zib nrog rau kev siv tshuaj khomob tuaj yeem txhim kho tag nrho cov lus teb thiab txo cov tshuaj khomob cuam tshuam rau kev mob qog noj ntshav lossis mob plab. cancer.
Vitamin C / Ascorbic Acid
Ascorbic Acid (Vitamin C) yog ib qho tshuaj tiv thaiv kab mob antioxidant thiab kev tiv thaiv ntuj. Txawm li cas los xij, nws lub luag haujlwm hauv cancer kev tiv thaiv thiab kev kho mob tau muaj teeb meem. Txawm hais tias qee cov ntaub ntawv pov thawj qhia tau hais tias noj cov zaub mov nplua nuj vitamin C txo qis kev pheej hmoo ntawm mob qog noj ntshav, cov pov thawj los ntawm kev cuam tshuam, randomized soj ntsuam kev sim nrog qhov ncauj ascorbate tsis pom muaj txiaj ntsig. Tab sis nyob rau hauv cov kev tshawb fawb preclinical tsis ntev los no nrog cov koob tshuaj ntau heev ascorbic acid raug nrog cov tshuaj intravenous infusion xaiv tua cov qog nqaij hlav cancer, thiab pom muaj kev cuam tshuam nrog cov tshuaj cytotoxic. Cov koob tshuaj ntau heev ntawm ascorbic acid tsuas yog ua tiav nrog kev txhaj tshuaj hauv cov hlab ntsha thiab ntawm qhov koob tshuaj no, ascorbic acid tuaj yeem muaj cov teebmeem oxidant, ua rau muaj kev puas tsuaj DNA ntau ntxiv, uas tuaj yeem ua rau mob qog noj ntshav. Tsis tas li ntawd, muaj cov pov thawj hauv kev kho mob ua ntej sau qhia tias cov koob tshuaj ascorbic acid tuaj yeem muaj kev nyab xeeb nrog rau cov tshuaj cytotoxic xws li gemcitabine, paclitaxel thiab carboplatin (Ma Y li al, Sci. Txhais lus. Med., 2014; Welsh JL li al, Cancer Cheem Pharmacol, 2013)
Cov zaub mov noj tom qab kuaj mob qog noj ntshav!
Tsis muaj ob yam mob qog noj ntshav zoo ib yam. Mus dhau qhov txheej txheem kev noj zaub mov zoo rau txhua tus thiab txiav txim siab tus kheej txog zaub mov thiab tshuaj ntxiv nrog kev ntseeg siab.
Siv Vitamin C / Ascorbic Acid nrog rau Kev Kho Mob Hauv Kev Xog Pob Ntseg thiab Khees Xaws Mob Cancer
Txhawm rau ntsuas qhov kev nyab xeeb thiab qhov siab tshaj plaws (MTD) ntawm ascorbic acid / Vitamin C uas tuaj yeem muab nrog rau kev sib xyaw cytotoxic chemotherapy xws li FOLFOX thiab FOLFIRI, cov kws tshawb fawb los ntawm Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University hauv Suav teb puas tau ib tug yav tom ntej Phase 1 soj ntsuam sim (NCT02969681) nyob rau hauv metastatic colorectal (mCRC) los yog gastric cancer (mGC) cov neeg mob. FOLFOX yog ib qho tshuaj khomob ua ke nrog 3 cov tshuaj: leucovorin (Folinic acid), Fluorouracil thiab oxaliplatin. Hauv kev tswj hwm FOLFIRI, 4 cov tshuaj cytotoxic - Folinic acid, Fluorouracil, Irinotecan thiab Cetuximab yog siv. (Wang F li al, BMC Cancer, 2019)
36 cov neeg mob Suav tau kuaj pom nrog koob tshuaj nce qib ntawm cov leeg ntshav acid los ntawm 0.2-1.5 g / kg rau 3 teev kev lis ntshav, ib zaug ib hnub, rau hnub 1-3, nrog rau FOLFOX lossis FOLFIRI hauv 14 hnub voj voog, kom txog thaum MTD tiav. Ntawm 36 cov neeg mob cuv npe, 24 (23 nrog mCRC thiab 1 nrog mGC) tau raug ntsuas rau cov lus teb qog. Cov lus teb tau zoo tshaj plaws suav nrog cov lus teb ib nrab hauv plaub tus neeg mob (58.35%), kab mob ruaj khov hauv cuaj (37.5%), nrog kev tswj tus kab mob ntawm 95.8%. Cov kws tshawb nrhiav tau tshaj tawm tias tsis muaj MTD tau mus txog thiab lawv tsis pom muaj cov tshuaj noj tsis haum lub cev los ntawm kev kuaj mob nce ntxiv. Feem ntau cov kev mob tshwm sim los ntawm qhov muaj ntau cov tshuaj ascorbic acid suav nrog kev mob taub hau, lub teeb taub hau, lub qhov ncauj qhuav thiab qee qhov mob plab zom mov vim muaj cov leeg ntshav. Qhov kev tshawb nrhiav no tseem qhia tau txo qis rau cov neeg mob pob txha caj qaum thiab mob plab zom mov ua rau muaj kev cuam tshuam nrog kev siv tshuaj khomob thaum muaj cov tshuaj ascorbic acid ntau ntxiv nrog rau kev siv tshuaj kho mob.
Qhov uas nrhiav tau ntawm txoj kev tshawb pom no qhia tias "cov tshuaj ascorbic acid / Vitamin C ntawm 1.5 g / kg ib hnub ib hnub rau peb hnub sib law liag tuaj yeem muaj kev saib xyuas zoo nrog FOLFOX lossis FOLFIRI kev kho tshuaj hauv ib lub sijhawm 14-hnub." (Wang F li al, BMC Cancer, 2019)
xaus
Kev noj tshuaj ntau Vitamin C thiab / lossis kev noj haus / khoom noj khoom haus nplua nuj nyob rau hauv Vitamin C muab nrog rau cov tshuaj khomob tuaj yeem txhim kho tag nrho cov lus teb thiab txo cov kws khomob cuam tshuam rau kev mob qog noj ntshav lossis mob plab. cancer.
Yam zaub mov twg koj noj thiab cov khoom noj uas koj noj yog qhov kev txiav txim siab koj ua. Koj qhov kev txiav txim siab yuav tsum suav nrog kev txiav txim siab ntawm kev hloov pauv noob caj noob ces, uas mob qog noj ntshav, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua qhov ua xua, qhia txog kev ua neej nyob, hnyav, qhov siab thiab tus cwj pwm.
Kev npaj zaub mov noj rau mob qog noj ntshav los ntawm addon tsis yog los ntawm kev tshawb fawb hauv internet. Nws siv qhov kev txiav txim siab rau koj raws li kev tshawb fawb molecular siv los ntawm peb cov kws tshawb fawb thiab software engineers. Tsis hais seb koj puas mob siab rau nkag siab cov hauv paus txheej txheem biochemical molecular lossis tsis - rau kev npaj zaub mov noj rau mob qog noj ntshav uas xav tau kev nkag siab.
Pib tam sim no nrog koj cov phiaj xwm kev noj zaub mov zoo los ntawm kev teb cov lus nug ntawm lub npe mob qog noj ntshav, kev hloov pauv caj ces, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua yam kev ua xua, tus cwj pwm, lub neej, pab pawg hnub nyoog thiab poj niam txiv neej.
Khoom noj khoom haus tus kheej rau Cancer!
Cancer hloov nrog lub sijhawm. Kho thiab hloov kho koj cov khoom noj khoom haus raws li kev qhia mob qog noj ntshav, kev kho mob, kev ua neej, kev nyiam zaub mov, kev ua xua thiab lwm yam.
Cov neeg mob cancer feem ntau yuav tsum tau ua nrog sib txawv kev kho mob tshuaj phiv uas cuam tshuam rau lawv lub neej zoo thiab saib rau lwm cov kev kho mob qog noj ntshav. Noj cov khoom noj khoom haus zoo thiab pabcuam ntxiv raws li kev txiav txim siab science (tsis txhob twv ua haujlwm thiab xaiv random) yog qhov kev kho zoo tshaj plaws rau cancer thiab kev kho mob muaj feem cuam tshuam.