highlights
Mannitol, ib yam khoom ntuj, yog siv los ua diuretic kom cov zis muaj ntau ntxiv rau cov neeg uas muaj lub raum tsis ua haujlwm (chemo phiv). Cov kev tshawb fawb pom tau hais tias siv mannitol nrog rau Cisplatin kev kho mob ua kom tsis txhob mob Cisplatin vim raug mob raum, qhov tshwm sim tsis zoo tshwm sim hauv ib feem peb ntawm cov neeg mob kho nrog Cisplatin. Cov tshuaj Mannitol nrog rau Cisplatin tuaj yeem yog nephroprotective.
Cisplatin Cov Tshuaj Kho Mob Cov Teeb Meem
Cisplatin yog ib qho tshuaj khomob uas siv los kho ntau cov qog nqaij hlav thiab cov qauv kev saib xyuas rau cov qog nqaij hlav ntawm lub zais zis, lub taub hau thiab caj dab, cov cell me thiab lub ntsws tsis zoo. Cancer, zes qe menyuam, ncauj tsev menyuam thiab qog nqaij hlav cancer thiab ntau lwm yam. Cisplatin muaj txiaj ntsig zoo hauv kev tshem tawm cov qog nqaij hlav cancer los ntawm kev ua kom muaj zog oxidative kev nyuaj siab thiab DNA puas tsuaj, yog li ua rau mob qog noj ntshav tuag. Txawm li cas los xij, kev siv Cisplatin tseem cuam tshuam nrog ntau yam kev mob tshwm sim tsis zoo xws li kev tsis haum tshuaj, kev tiv thaiv kab mob qis, mob plab hnyuv, cardiotoxicity thiab teeb meem rau lub raum hnyav. Ib feem peb ntawm cov neeg mob kho nrog Cisplatin muaj kev puas tsuaj rau lub raum tom qab kev kho thawj zaug (Yao X, li al, Am J Med. Sib., 2007). Kev puas tsuaj rau lub raum lossis nephrotoxicity tshwm sim los ntawm Cisplatin tau lees paub tias yog qhov tshwm sim tsis zoo (Aw, Gi-Su, et al. Electrolyte Blood Press, 2014)). Ib qho ntawm cov laj thawj tseem ceeb rau kev siab dua nephrotoxicity nrog Cisplatin yog vim tias muaj cov tshuaj ntau dua rau hauv lub raum yog li ua rau ntau lub raum puas tsuaj.
Cov zaub mov noj tom qab kuaj mob qog noj ntshav!
Tsis muaj ob yam mob qog noj ntshav zoo ib yam. Mus dhau qhov txheej txheem kev noj zaub mov zoo rau txhua tus thiab txiav txim siab tus kheej txog zaub mov thiab tshuaj ntxiv nrog kev ntseeg siab.
Mannitol yog dab tsi?
Mannitol, tseem hu ua cawv cawv, muaj nyob hauv ntau qhov chaw ntuj xws li nceb, txiv pos nphuab, celery, dos, taub dag, taub dag thiab algae hiav txwv. Nws kuj tseem lees paub tias yog cov khoom muaj kev nyab xeeb los ntawm FDA (Food and Drug Administration), thiab yog siv dav hauv cov khoom lag luam tshuaj.
Cov txiaj ntsig/Siv Cov Tshuaj Mannitol
Nram qab no yog qee qhov kev siv ntau ntawm mannitol:
- Mannitol feem ntau yog siv los ua cov tshuaj diuretic kom nce cov zis hauv cov neeg uas mob raum tsis ua haujlwm.
- Mannitol kuj tseem siv hauv cov tshuaj yuav tshuaj kom txo qis thiab o hauv lub hlwb ib yam nkaus.
- Mannitol tuaj yeem pab txhim kho kev tswj ntshav qab zib
Cov Teeb Meem Ntawm Cov Tshuaj Mannitol
Nram qab no yog qee qhov tshwm sim tshwm sim ntawm cov tshuaj mannitol:
- Zau Zaus
- Ntxiv plawv dhia
- mob taub hau
- Kauj taub hau
- lub cev qhuav dej
Mannitol rau Cisplatin Chemo Side Effect- Mob Raug Mob
Ib txoj hauv kev los txo qis cov tshuaj chemo-phiv zoo li nephrotoxicity, thaum kho nrog Cisplatin, uas tau tshuaj xyuas los ntawm chaw kho mob yog siv Mannitol nrog rau Cisplatin tshuaj kho mob.
Muaj ntau qhov kev tshawb fawb uas lawv tau tshuaj xyuas cov txiaj ntsig ntawm kev siv Mannitol nrog rau Cisplatin tshuaj kho mob ntawm nephrotoxicity (chemo side-effect) cov cim xws li qib creatinine hauv ntshav:
- Kev tshawb nrhiav rov qab los ntawm University of Minnesota Health-Fairview system tau tshuaj xyuas 313 cov neeg mob kho nrog Cisplatin (95 kho nrog mannitol thiab 218 yam tsis muaj), pom tias cov pab pawg uas siv Mannitol muaj qhov nruab nrab nce hauv cov ntshav creatinine ntau dua li cov pab pawg uas tsis siv. Mannitol. Nephrotoxicity tshwm sim tsawg zaus hauv cov neeg mob uas tau txais Mannitol dua li cov uas tsis tau - 6-8% nrog Mannitol vs. 17-23% tsis muaj Mannitol (Hmong / Williams RP Jr et al, J Oncol Tus Kws Tshuaj., 2017).
- Lwm qhov kev tshawb fawb los ntawm Emory University koom nrog saib daim duab qhia txog kev soj ntsuam txhua tus neeg mob tau txais cisplatin nrog hluav taws xob sib tshooj rau cov npluag ntsej muag cell carcinoma ntawm lub taub hau thiab lub caj dab. Kev tsom xam cov ntaub ntawv los ntawm 139 cov neeg mob (88 nrog Mannitol thiab 51 nrog saline ib leeg) pom tias Mannitol pawg muaj tsawg dua cov ntshav creatinine qhia tias muaj nephrotoxicity qis dua (McKibbin T et al, Txhawb Kev Kho Mob Cancer, 2016).
- Ib qho chaw kawm ib leeg los ntawm Rigshospitalet thiab Herlev tsev kho mob, Denmark, kuj tau lees paub qhov nephroprotective cuam tshuam ntawm Mannitol siv hauv taub hau thiab caj dab. cancer Cov neeg mob tau txais kev kho cisplatin hauv ib pawg ntawm 78 tus neeg mob (Hagerstrom E, li al, Clin Med Insights Oncol., 2019).
xaus
Cov ntaub ntawv pov thawj kho mob saum toj no txhawb kev siv cov khoom muaj kev nyab xeeb, ntuj zoo li mannitol, kom txo qis cisplatin vim qhov tseem ceeb thiab muaj kev cuam tshuam loj ntawm nephrotoxicity hauv cancer cov neeg mob.
Yam zaub mov twg koj noj thiab cov khoom noj uas koj noj yog qhov kev txiav txim siab koj ua. Koj qhov kev txiav txim siab yuav tsum suav nrog kev txiav txim siab ntawm kev hloov pauv noob caj noob ces, uas mob qog noj ntshav, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua qhov ua xua, qhia txog kev ua neej nyob, hnyav, qhov siab thiab tus cwj pwm.
Kev npaj zaub mov noj rau mob qog noj ntshav los ntawm addon tsis yog los ntawm kev tshawb fawb hauv internet. Nws siv qhov kev txiav txim siab rau koj raws li kev tshawb fawb molecular siv los ntawm peb cov kws tshawb fawb thiab software engineers. Tsis hais seb koj puas mob siab rau nkag siab cov hauv paus txheej txheem biochemical molecular lossis tsis - rau kev npaj zaub mov noj rau mob qog noj ntshav uas xav tau kev nkag siab.
Pib tam sim no nrog koj cov phiaj xwm kev noj zaub mov zoo los ntawm kev teb cov lus nug ntawm lub npe mob qog noj ntshav, kev hloov pauv caj ces, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua yam kev ua xua, tus cwj pwm, lub neej, pab pawg hnub nyoog thiab poj niam txiv neej.
Khoom noj khoom haus tus kheej rau Cancer!
Cancer hloov nrog lub sijhawm. Kho thiab hloov kho koj cov khoom noj khoom haus raws li kev qhia mob qog noj ntshav, kev kho mob, kev ua neej, kev nyiam zaub mov, kev ua xua thiab lwm yam.
Cov neeg mob cancer feem ntau yuav tsum tau ua nrog sib txawv kev kho mob tshuaj phiv uas cuam tshuam rau lawv lub neej zoo thiab saib rau lwm cov kev kho mob qog noj ntshav. Noj cov khoom noj khoom haus zoo thiab pabcuam ntxiv raws li kev txiav txim siab science (Tsis txhob twv thiab xaiv xaiv) yog cov tshuaj zoo tshaj plaws rau kev mob qog noj ntshav thiab kev kho mob ntsig txog phiv.