highlights
Curcumin yog qhov tseem ceeb ua cov khoom noj uas nquag xyaw Turmeric. Piperine, cov khoom xyaw tseem ceeb ntawm Cov kua txob Dub feem ntau muaj nyob hauv Curcumin cov qauv los txhim kho nws txoj kev nyab xeeb. Coob tus neeg mob cancer mis tau kho nrog tus txheej txheem ntawm kev saib xyuas kev kho tshuaj hormones hu ua Tamoxifen. Nrog rau cov qauv kev kho mob zoo li no, cov neeg mob cancer mis feem ntau nyiam saib cov tshuaj ntsuab zoo ib yam li Curcumin (los ntawm Turmeric) nrog cov tshuaj tiv thaiv, muaj zog tiv thaiv thiab mob qog nqaij hlav los txhim kho lawv qhov kev tiv thaiv, kho kom ua tau haujlwm zoo, muaj lub neej zoo lossis txo cov kev mob tshwm sim. Txawm li cas los xij, qee qhov ntawm cov tshuaj tiv thaiv no tuaj yeem ua rau raug mob rau kev kho mob. Cov kev tshawb fawb soj ntsuam sib tham hauv cov blog no pom xws li kev sib tham tsis sib haum ntawm Tamoxifen tshuaj kho mob thiab Curcumin uas tau muab rho tawm los ntawm Turmeric. Kev noj tshuaj Curcumin ntxiv thaum nyob rau Tamoxifen txoj kev kho tuaj yeem txo cov theem ntawm cov tshuaj metabolite ntawm Tamoxifen thiab cuam tshuam nrog kev kho mob ntawm cov tshuaj hauv cov neeg mob cancer mis. Li no, ib qho yuav tsum tsis txhob suav nrog Curcumin tshuaj ntxiv ua ib feem ntawm lub mis cov neeg mob mob cancer ntshav qab zib Yog tias tau txais kev kho mob Tamoxifen. Tsis tas li ntawd, nws yog ib qho tseem ceeb rau tus kheej cov khoom noj khoom haus rau qhov tshwj xeeb cancer thiab kev kho kom tau txais txiaj ntsig siab tshaj plaws los ntawm kev noj zaub mov zoo thiab muaj kev nyab xeeb.
Tamoxifen Rau Cancer Mis
Tus mob cancer mis yog qhov feem ntau paub hais tias mob cancer thiab yog ib qho ua rau mob cancer ploj tuag rau cov poj niam thoob ntiaj teb. Ib qho ntawm cov subtypes mob cancer ntawm lub mis ntau tshaj qhov sib deev hormone, estrogen (ER) thiab progesterone (PR) receptor zoo thiab tib neeg phaum mob loj ntxiv 2 (ERBB2, tseem hu ua HER2) tsis zoo - (ER + / PR + / HER2- subtype) Cov. Cov tshuaj hormones zoo ntawm cov mob cancer ntawm lub mis tau txais txoj kev raug zoo nrog qhov kev phom sij siab heev 5 xyoo ntawm 94-99% (Waks thiab Winer, JAMA, 2019). Cov neeg mob uas kuaj pom tias muaj cov qog nqaij hlav cancer mis zoo yog kho nrog kev kho mob endocrine xws li Tamoxifen rau kev tiv thaiv kab mob qog noj ntshav thiab rov tshwm sim dua, tom qab lawv txoj kev phais thiab kev kho mob hluav taws xob. Tamoxifen ua raws li kev xaiv tshuaj estrogen receptor modulator (SERM), qhov uas nws inhibits cov tshuaj hormones receptors hauv cov ntaub so ntswg cancer ntawm lub mis kom txo tau txoj sia nyob. cancer cov hlwb thiab txo kev pheej hmoo ntawm kev rov qab los.
Curcumin- Cov khoom xyaw nquag ntawm Turmeric
Kev kuaj mob cancer ua rau muaj kev pauv hloov pauv loj hauv cov tib neeg suav nrog ib qho qauv ntawm kev siv cov khoom siv dag zog ntawm tsob ntoo uas paub tias muaj tshuaj los tiv thaiv tus mob cancer, txhawb kev tiv thaiv thiab kev nyab xeeb. Cov txiaj ntsig ntawm kev tshawb nrhiav tsis ntev los no tau pom tias ntau dua 80% ntawm cov neeg mob qog nqaij hlav siv tshuaj ntxiv nrog rau kev ntxiv tshuaj thiab lwm cov tshuaj (Richardson MA li al, J Clin Oncol., 2000). Curcumin, cov nquag ua los ntawm curry txuj lom turmeric, yog ib qho xws li ntuj ntxiv uas yog nrov ntawm cov neeg mob qog nqaij hlav thiab muaj txoj sia nyob rau nws tshuaj tiv thaiv kab mob thiab anti-inflammatory lub zog. Yog li, qhov ntxim nyiam ntawm cov neeg mob cancer mis noj Curcumin pab txhawb ntxiv (rho tawm los ntawm Turmeric) thaum nyob rau Tamoxifen txoj kev kho yog siab. Curcumin tau paub tias muaj kev nqus tsis zoo hauv lub cev thiab vim li ntawd nws yog feem ntau siv hauv cov qauv nrog piperine, ib qho kev txuam ntawm cov kua txob dub, uas pab txhawb nws txoj kev lom neeg kom txausShoba G li al, Planta Med, 1998).
Cov zaub mov noj tom qab kuaj mob qog noj ntshav!
Tsis muaj ob yam mob qog noj ntshav zoo ib yam. Mus dhau qhov txheej txheem kev noj zaub mov zoo rau txhua tus thiab txiav txim siab tus kheej txog zaub mov thiab tshuaj ntxiv nrog kev ntseeg siab.
Curcumin (los ntawm Turmeric) & Tamoxifen Tshuaj Sib Tsoo hauv Kev Mob Cancer Mis
Qhov ncauj tshuaj Tamoxifen yog metabolized nyob rau hauv lub cev mus rau nws cov tshuaj pharmacologically active metabolites los ntawm cytochrome P450 enzymes hauv daim siab. Endoxifen yog qhov tshuaj lom neeg muaj mob nyob rau hauv niaj hnub tshuaj ntawm Tamoxifen, uas yog tus neeg sib kho tseem ceeb ntawm kev ua tau zoo ntawm kev kho tamoxifen (Del Re M et al, Pharmacol Res., 2016). Qee qhov kev kawm ua ntej dhau los ntawm cov nas tau pom tias muaj kev sib txuam tshuaj-tshuaj sib xyaw ntawm Curcumin (los ntawm Turmeric) thiab Tamoxifen vim tias Curcumin inhibited cytochrome P450 mediated metabolism ntawm tamoxifen hloov mus rau nws daim ntawv nquag (Cho YA li al, Pharmazie, 2012)). Ib tug nyuam qhuav luam tawm yav dhau los kev tshawb nrhiav (EudraCT 2016-004008-71 / NTR6149) los ntawm Erasmus MC Cancer Institute hauv tebchaws Netherlands, kuaj qhov kev sib cuam tshuam ntawm Curcumin thiab Tamoxifen hauv cov neeg mob cancer mis (Hussaarts KGAM et al, Khees Xaws (Basel), 2019).
Hauv txoj kev tshawb no lawv tau sim cov txiaj ntsig ntawm Curcumin ib leeg thiab Curcumin nrog nws cov bio-enhancer Piperine thaum noj nrog Tamoxifen hauv 16 lub mis ntsuas. cancer cov neeg mob. Cov neeg mob tau muab Tamoxifen rau 28 hnub ua ntej txoj kev tshawb fawb los xyuas kom meej cov theem ntawm Tamoxifen nyob rau hauv txhua qhov kev kawm. Tom qab ntawd cov neeg mob tau tswj hwm 3 lub voj voog hauv 2 pawg sib cais sib txawv nrog cov kab sib txawv ntawm cov voj voog. Tamoxifen tau muab rau ntawm qhov koob tshuaj tas li ntawm 20-30 mg thaum lub sijhawm 3 lub voj voog. 3 lub voj voog suav nrog Tamoxifen ib leeg, Tamoxifen nrog 1200 mg Curcumin noj peb zaug ib hnub, lossis Tamoxifen nrog 1200 mg Curcumin thiab 10 mg Piperine noj peb zaug ib hnub. Qib ntawm Tamoxifen thiab Endoxifen tau muab piv nrog thiab tsis muaj Curcumin ib leeg thiab nrog ntxiv ntawm bio-enhancer Piperine.
Txoj kev tshawb fawb no qhia tau tias qhov tseem ceeb ntawm cov nquag metabolite Endoxifen poob nrog Curcumin thiab txuas ntxiv nrog Curcumin thiab Piperine noj ua ke. Qhov kev txo qis hauv Endoxifen yog qhov tseem ceeb ntawm no.
xaus
Hauv cov ntsiab lus, yog tias Curcumin ntxiv raug noj nrog Tamoxifen txoj kev kho, nws tuaj yeem txo qhov kev kub siab ntawm cov tshuaj nquag hauv qab no nws qhov cuam tshuam rau kev ua tau zoo thiab muaj peev xwm cuam tshuam nrog kev cuam tshuam nrog tshuaj. Cov kev tshawb fawb xws li cov no tsis tuaj yeem tsis quav ntsej, txawm hais tias tsawg tsawg ntawm cov neeg mob cancer mis, thiab ceeb toom rau cov poj niam noj tamoxifen xaiv cov tshuaj ntsuab uas lawv tau ua tib zoo, uas tsis cuam tshuam rau cov tshuaj tua kabmob kheesxaws (kev kho mob cuam tshuam) hauv ib qho twg txoj kev. Raws li cov ntaub ntawv pov thawj no, Curcumin tsis zoo li yog qhov tsim nyog yuav tau noj nrog Tamoxifen vim nws cuam tshuam nrog kev kho mob kom ua tau zoo.
Yam zaub mov twg koj noj thiab cov khoom noj uas koj noj yog qhov kev txiav txim siab koj ua. Koj qhov kev txiav txim siab yuav tsum suav nrog kev txiav txim siab ntawm kev hloov pauv noob caj noob ces, uas mob qog noj ntshav, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua qhov ua xua, qhia txog kev ua neej nyob, hnyav, qhov siab thiab tus cwj pwm.
Kev npaj zaub mov noj rau mob qog noj ntshav los ntawm addon tsis yog los ntawm kev tshawb fawb hauv internet. Nws siv qhov kev txiav txim siab rau koj raws li kev tshawb fawb molecular siv los ntawm peb cov kws tshawb fawb thiab software engineers. Tsis hais seb koj puas mob siab rau nkag siab cov hauv paus txheej txheem biochemical molecular lossis tsis - rau kev npaj zaub mov noj rau mob qog noj ntshav uas xav tau kev nkag siab.
Pib tam sim no nrog koj cov phiaj xwm kev noj zaub mov zoo los ntawm kev teb cov lus nug ntawm lub npe mob qog noj ntshav, kev hloov pauv caj ces, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua yam kev ua xua, tus cwj pwm, lub neej, pab pawg hnub nyoog thiab poj niam txiv neej.
Khoom noj khoom haus tus kheej rau Cancer!
Cancer hloov nrog lub sijhawm. Kho thiab hloov kho koj cov khoom noj khoom haus raws li kev qhia mob qog noj ntshav, kev kho mob, kev ua neej, kev nyiam zaub mov, kev ua xua thiab lwm yam.
Cov neeg mob cancer feem ntau yuav tsum tau ua nrog sib txawv kev kho mob tshuaj phiv uas cuam tshuam rau lawv lub neej zoo thiab saib rau lwm cov kev kho mob qog noj ntshav. Noj cov khoom noj khoom haus zoo thiab pabcuam ntxiv raws li kev txiav txim siab science (Tsis txhob twv thiab xaiv xaiv) yog cov tshuaj zoo tshaj plaws rau mob qog noj ntshav thiab kho mob cuam tshuam nrog kev phiv.