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Kev siv cov tshuaj folic acid ua ib feem ntawm multivitamin pabcuam ntxiv yog ib qho, tab sis muaj cov ntaub ntawv tsis muaj tseeb ntawm folic acid ntxiv thiab nws lub koom haum nrog kev pheej hmoo mob cancer. Yog tias tsis mob qog nqaij hlav cancer hauv lub cev, Folic acid pom zoo tshwj xeeb kom siv nrog Pemetrexed (Alimta) kev siv tshuaj kho mob, vim nws txo qis Pemetrexed chemo ntxias ua rau muaj tshuaj lom (muaj kev cuam tshuam), raws li kev txhawb los ntawm kev tshawb fawb soj ntsuam.
Dab tsi yog Folic Acid?
Folic acid, tseem hu ua folate lossis Vitamin B9 yog ib txwm muaj nyob hauv ntau cov zaubmov xws li cov zaub ntsuab, zaub ntsuab, zaub paj, zaub cob pob, Zaub pob ntsuab, nplej thiab ntau ntxiv. Nws tseem yog ib qho muaj txiaj ntsig ntawm multivitamin thiab B-complex tshuaj siv los ntawm ntau cov neeg muaj kev noj qab haus huv. Folate deficiency tuaj yeem ua rau mob ntshav tsis txaus thiab ntshav siab, thiab hauv cov poj niam cev xeeb tub, nws tuaj yeem ua rau lub plab me me tsis xws luag; yog li qhov tseem ceeb thiab qhov tseem ceeb rau peb kev nyab xeeb.
Koom Haum ntawm Folic Acid Pab Txhawb Ntxiv thiab Cancer
Muaj ntau qhov tsis meej thiab tsis meej pem ntawm kev koom tes ntawm folic acid supplementation thiab cancer thiab seb nws tiv thaiv lossis txhawb kev mob qog noj ntshav. Hauv kev tshawb fawb los ntawm ib pab pawg neeg Norwegian uas tau ua qhov kev tshuaj ntsuam xyuas ntawm 19 qhov kev tshawb fawb ntawm folic acid supplementation rau tib neeg thiab kev sib raug zoo nrog kev mob qog noj ntshav lossis kev tuag, lawv pom muaj 'txoj kev loj hlob ntawm ntau zaus ntawm kev mob qog noj ntshav hauv pawg folic acid piv rau kev tswj hwm. .' (Wien TN, BMJ Qhib., 2012) Cov koob tshuaj thiab lub sijhawm ntawm kev noj cov tshuaj folic acid tuaj yeem muaj qhov sib txawv. Tsawg heev thiab siab heev ntawm folic acid tau cuam tshuam nrog kev pheej hmoo mob qog noj ntshav. Tsis tas li ntawd, cov tshuaj folic acid ntxiv rau cov tib neeg uas twb tau kuaj mob qog noj ntshav tuaj yeem ua rau muaj kev phom sij tab sis tuaj yeem pab cov uas tsis muaj. cancer. Yog li kev siv cov khoom noj xws li folic acid yuav tsum tau ua tib zoo, tshawb fawb, thiab sab laj nrog kws kho mob tshwj xeeb.
Cov zaub mov noj tom qab kuaj mob qog noj ntshav!
Tsis muaj ob yam mob qog noj ntshav zoo ib yam. Mus dhau qhov txheej txheem kev noj zaub mov zoo rau txhua tus thiab txiav txim siab tus kheej txog zaub mov thiab tshuaj ntxiv nrog kev ntseeg siab.
Folic Acid rau Kev Siv Tshuaj Kho Mob Sab-Los Ntawm Kev Ua Rau Mob / Lom rau hauv cov neeg mob qog nqaij hlav cancer
Txawm hais tias cov ntaub ntawv tsis meej pem txog kev siv Folic acid ntxiv rau cov neeg mob qog noj ntshav, cov kev tshawb fawb tshwj xeeb tau qhia txog nws cov txiaj ntsig zoo thaum siv nrog Pemetrexed (Alimta) kev kho mob hauv cov neeg mob ntsws tsis yog mob ntsws me me (NSCLC) cov neeg mob. Cov kab mob ntsws uas tsis yog kab mob me yog hom mob ntsws uas tshaj plaws thiab ua kom cov neeg tuag thoob ntiaj teb. Kev haus luam yeeb yog qhov tseem ceeb txaus ntshai rau tus kab mob no. Lub sijhawm xyoo dhau los, Pemetrexed, cov tshuaj tua kab mob uas yog cov tshuaj tua kab mob, ua rau cov tshuaj tua kab mob tseem ceeb los ua kev kho mob rau cov neeg mob NSCLC hauv thawj kab thiab tom qab kev teeb tsa (Tomasini P, Ther Adv Med Oncol., 2016). Pemetrexed ua haujlwm los ntawm kev thaiv cov folate metabolism thiab ua rau DNA puas thiab cuam tshuam DNA kho txoj hauv kev, uas pab ua kom lub cev muaj zog. cancer cell muaj kev cuam tshuam ntau dua thaum tuaj yeem muaj qhov cuam tshuam tsis zoo rau kev faib cov hlwb sai hauv lub cev zoo li lub cev tiv thaiv kab mob. Vim li no, myelosuppression, txo qis hauv cov pob txha pob txha tsim cov qe ntshav (RBC, WBC thiab platelets) yog cov tshuaj lom ntau tshaj ntawm pemetrexed (Kim Y, Cancer Epidemiol Biomarkers Dhau Los. Xyoo 2008).
Folic acid ntxiv (350-1000 mg / hnub) pom zoo kom muab nrog rau Pemetrexed kev kho mob tshuaj thiab cov lus qhia yog pib folic acid 7 hnub ua ntej pib ntawm Pemetrexed, txuas ntxiv nws thaum tus neeg mob nyob rau txoj kev kho kom txog 21 hnub tom qab kev kho mob tau tas lawm. Qee qhov kev tshawb fawb tsis ntev los no uas muaj kev cuam tshuam txog kev rov qab kho dua ntawm NSCLC cov neeg mob raug kho nrog thawj-kab pemetrexed nrog rau kev kho mob cisplatin tau pom tias folic acid ntxiv qis rau theem ntawm ntshav homocysteine, lub cim rau hematological toxicity (toxicity ntxias los ntawm Pemetrexed chemo), tsis muaj kev txo qis kev ua tau zoo ntawm Pemetrexed tshuaj kho mob (Singh N et al, Am J. Clin Oncol, 2017). Hauv lwm qhov kev cia siab tom ntej hu ua PEMVITASTART (NCT02679443), sijhawm sijhawm folic acid / vitamin B12 ntxiv nrog Pemetrexed hauv kev kho NSCLC cov neeg mob tau ntsuas. Txoj kev tshawb nrhiav pom tias pib folic acid ntxiv ib txhij nrog Pemetrexed hloov 7 hnub ua ntej sib luag txo cov Pemetrexed ntxias hematologic toxicity (kev kho mob rau sab-cov tshuaj) tsis muaj kev cuam tshuam rau kev ua tau zoo ntawm kev siv tshuaj kho mob (Singh N li al, Cancer, 2019).
Hauv kev tshawb fawb dhau los, kev sim qib III EMPHACIS, qhov chaw uas cov neeg mob tau ntxiv nrog 350-1000 mg ntawm folic acid thiab 1000 μg ntawm vitamin B12, nws tau pom tias Qib 3-4 hematologic thiab tsis-hematologic toxicities txo los ntawm 37% ntawm cov neeg mob uas tsis muaj kev txhawb nqa ntxiv rau 6.4% nrog ntxiv (Bunn C et al, Proc Am Soc Clin Oncol., 2001)
xaus
Txoj kev tshawb no qhia tias, nyob rau hauv cov ntaub ntawv ntawm cov neeg mob uas tsis yog-me me cell ntsws cancer, Folic acid yuav siv tau nrog Pemetrexed (Alimta) chemotherapy, kom txo tau Pemetrexed chemo induced toxicity (side-effect). Yog li hauv cov ntsiab lus, supplementation ntawm cov khoom ntuj thiab cov vitamins hauv cancer Cov neeg mob uas tsis tu ncua lossis tau ua tiav kev kho mob yuav tau txais txiaj ntsig yog tias cov tshuaj ntxiv raug xaiv los ntawm kev tshawb fawb. Yog li xaiv cov tshuaj ntxiv yuav tsum tau ua tib zoo ua tib zoo thiab nyob rau hauv kev qhia thiab kev saib xyuas.
Yam zaub mov twg koj noj thiab cov khoom noj uas koj noj yog qhov kev txiav txim siab koj ua. Koj qhov kev txiav txim siab yuav tsum suav nrog kev txiav txim siab ntawm kev hloov pauv noob caj noob ces, uas mob qog noj ntshav, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua qhov ua xua, qhia txog kev ua neej nyob, hnyav, qhov siab thiab tus cwj pwm.
Kev npaj zaub mov noj rau mob qog noj ntshav los ntawm addon tsis yog los ntawm kev tshawb fawb hauv internet. Nws siv qhov kev txiav txim siab rau koj raws li kev tshawb fawb molecular siv los ntawm peb cov kws tshawb fawb thiab software engineers. Tsis hais seb koj puas mob siab rau nkag siab cov hauv paus txheej txheem biochemical molecular lossis tsis - rau kev npaj zaub mov noj rau mob qog noj ntshav uas xav tau kev nkag siab.
Pib tam sim no nrog koj cov phiaj xwm kev noj zaub mov zoo los ntawm kev teb cov lus nug ntawm lub npe mob qog noj ntshav, kev hloov pauv caj ces, kev kho mob txuas ntxiv thiab tshuaj ntxiv, txhua yam kev ua xua, tus cwj pwm, lub neej, pab pawg hnub nyoog thiab poj niam txiv neej.
Khoom noj khoom haus tus kheej rau Cancer!
Cancer hloov nrog lub sijhawm. Kho thiab hloov kho koj cov khoom noj khoom haus raws li kev qhia mob qog noj ntshav, kev kho mob, kev ua neej, kev nyiam zaub mov, kev ua xua thiab lwm yam.
Cov neeg mob cancer feem ntau yuav tsum tau ua nrog sib txawv kev kho mob tshuaj phiv uas cuam tshuam rau lawv lub neej zoo thiab saib rau lwm cov kev kho mob qog noj ntshav. Noj cov khoom noj khoom haus zoo thiab pabcuam ntxiv raws li kev txiav txim siab science (Tsis txhob twv thiab xaiv xaiv) yog cov tshuaj zoo tshaj plaws rau mob qog noj ntshav thiab kho mob cuam tshuam nrog kev phiv.