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Liquid biopsy gwajin ne wanda ke keɓe da kuma yin nazarin ƙwayar ƙwayar cuta ta DNA daga jini ko samfuran fitsari ta hanyar jeri, kuma yana iya ba da bayanai kan yuwuwar maye gurbi da ɓarna masu alaƙa da ciwon daji. Duk da yake wannan dabarar tana da fa'idodi don sauƙaƙe kulawar cutar, yana da yuwuwar haɓakar ƙarya kuma a halin yanzu ba ta da daidaituwa a cikin tarin samfuri da bincike.
Lokacin da aka gano mutum yana da ciwon daji, daya daga cikin gwaje-gwajen shine biopsy na nama don ciwace-ciwacen ciwace-ciwacen daji da ƙwayar kasusuwa don ciwon daji na jini, duka hanyoyin da za a iya yi ta hanyar allura, endoscopy ko tiyata, wasu kuma ba za su kasance ba. zai yiwu idan wurin da ciwon ya kasance ba zai iya isa ba. Sakamakon nazarin kwayoyin halitta daga waɗannan kwayoyin halitta suna ba da cikakkun bayanai game da nau'i, mataki da tsinkaye na ciwon daji. A cikin 'yan lokutan baya-bayan nan kuma tare da fasahar ci gaba, masana kimiyya sun sami damar gano kwayar cutar tumor DNA (ctDNA) da ke yawo da kwayoyin tumor (CTCs) a cikin jini, fitsari da samfurin salwa. Sakamakon biopsy na ruwa shine samfurin jinin majiyyaci ko wasu samfurori masu sauƙi da mara amfani don ganewa, tsinkaye da dalilai na sa ido.
Liquid biopsy yana dogara ne akan yanayin cewa ƙwayoyin kansa masu girma cikin sauri a cikin jiki suna sakin DNA ɗin su cikin jini. Akwai dabaru don ganowa da cire ƙananan adadin ctDNA daga babban bangon DNA na yau da kullun a cikin jini ko fitsari. Bincike da nazarin wannan ctDNA ta hanyar gwaje-gwaje daban-daban ciki har da jeri, na iya ba da bayanai game da halayen ƙwayar cuta. Gano gyare-gyaren kwayoyin halitta kamar ciwon daji maye gurbi masu alaƙa, wasu canje-canje na chromosomal kamar haɓakawa, gogewa, jujjuyawar, jujjuyawar ɓangarori masu tasiri ga kwayoyin cutar kansa, suna ba da haske game da halayen ƙwayoyin cuta na kansa - bayanai masu mahimmanci da yuwuwar aiki don keɓance nau'in da tsarin jiyya (Elazezy da Joosse, Kayan Fasahar Fasaha Biotechnol J., 2018).
Abincin da Zai Ci Bayan Bayanan Ciwon Cutar Kansa!
Babu cutar kansa guda biyu iri daya. Wuce ka'idojin abinci mai gina jiki na kowa don kowa kuma yanke hukunci na musamman game da abinci da kari tare da ƙarfin gwiwa.
Menene fa'idodi da rashin amfanin Liquid Biopsy?
Fa'idodin biopsy na ruwa a cikin Cancer
Da aka jera a ƙasa wasu mahimman fa'idodi ne na yin biopsy na ruwa a cikin kansa.
- Za a iya yi akan samfuran kamar jini waɗanda ke da sauƙin isa kuma amfani da su akai-akai don gwajin awon. Bai dogara da ciwo ba, hanyoyin mamayewa da tsada kamar yadda ake buƙata don nama ko ƙashin ƙashi.
- Yana ba da damar sa ido kan amsawa ta hanyar tantance matakan ctDNA.
- Yana ba da damar lura da sake dawowa cutar ta hanyar yin nazari na lokaci-lokaci na matakan da halaye na ctDNA da zarar mai haƙuri ya kammala magani kuma yana cikin gafara. Ana kuma kiran wannan lura da kimantawar cutar da ta rage (MRD).
- Don cuta mai ci gaba ko ci gaba, saka idanu ta hanyar biopsy na ruwa na ctDNA zai ba da haske game da yadda ciwon ya samo asali daga ainihin halayensa kuma zai iya taimakawa tare da canji a cikin dabarun magani don magance ci gaba da cutar kansa.
Rashin amfani na biopsy na ruwa
Wasu daga cikin rashin amfanin biopsy na ruwa sun haɗa da:
- Hannun ƙwayar DNA (ctDNA) mai yaduwa na iya zama mai rauni ƙwarai a cikin babban asalin al'ada na DNA da ke zagayawa saboda haka tsarin biopsy na ruwa na iya rasa ganowa sabili da haka bayar da rahoton sakamako mara kyau.
- Tare da fasahohin da aka yi amfani da su don nazarin halittu na ruwa inda aka kara yawan adadin ctDNA don nazari, yiwuwar kurakurai da kayayyakin tarihi wadanda ke haifar da sakamako mai kyau na karya yana da girma.
- Fasahohin biopsy na ruwa da gudanawar aiki a yau basu da daidaito a cikin tarin samfuri da samfurin bincike.
- Saboda samfuran samfu daban-daban tsakanin biopsy na nama da kuma biopsy na ruwa, suna iya samar da wani abu wanda baya rufewa da bayanai daban-daban ga mutum daya wanda zai iya rikita zabin maganin.
Wani bincike da ƙungiyar British Columbia ta gudanar ya gano cewa ctDNA ya ba da ƙarin bayani mai amfani ga ƙwayar prostate biopsy a cikin maza waɗanda aka gano tare da ƙwayar prostate. ciwon daji, kuma sun kuma tabbatar da cewa an sami daidaituwar kashi 80 cikin XNUMX a cikin maye gurbi tsakanin ctDNA da biopsy nama na prostate. Hanyar da ta fi dacewa kamar yadda binciken su ya nuna ya ba da shawarar yin amfani da nama da biopsy na ruwa kamar yadda babu wata hanyar da kanta ta kama duk bayanan kwayoyin halitta a cikin duk marasa lafiya.Vandekerkhove G, et al, Yurol, 2019). Wani binciken daga MD Anderson, Texas, ya kuma nuna fa'idar amfani da kwayar halittar ruwa da kuma nazarin ctDNA a cikin cutar sankara ()Bernard V, et al, Gastroenterol., 2019). A taƙaice, biopsy na ruwa yana da damar bayar da bayanai masu amfani yayin matakai daban-daban na maganin kansa da kuma lura yayin da kuma bayan matakan jiyya.
Ga masu ciwon daji masu sha'awar bin gwajin biopsy na ruwa, akwai kamfanoni da yawa da aka kafa a wannan filin. Gwajin biopsy na ruwa ya bambanta dangane da ciwon daji nau'in da jerin kwayoyin halitta da aka rufe, zurfin jerin abubuwan da ke tattare da kwayoyin halitta da hankali da kuma ƙayyadaddun gwaje-gwaje. A cikin Amurka, kamfanoni irin su Guardant Health, Magungunan Gidauniyar, Kiwon Lafiyar Halittu da sauran su suna ba da gwaje-gwajen biopsy na ruwa daban-daban. Kamfanoni da yawa a Indiya kuma suna yin gwajin biopsy na ruwa ciki har da MedGenome, Dr Lal Path Labs, Strand Life Sciences, Datar Cancer Genetics, Redcliffe Life Sciences da sauransu. Gwajin biopsy na ruwa galibi ba su da kuɗaɗen aljihu ga majiyyaci waɗanda inshorar lafiyarsu bai rufe su ba.
Abincin da kuke ci kuma wanne kari kuke ɗauka shine yanke shawara. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ciwon daji, wanda cutar kansa, jiyya da ci gaba da gudana, duk wani rashin lafiyan, bayanin salon rayuwa, nauyi, tsayi da halaye.
Tsarin abinci mai gina jiki don cutar kansa daga addon baya dogara ne akan binciken intanet. Yana sarrafa muku yanke shawara ta atomatik dangane da kimiyyar kwayoyin da masana kimiyya da injiniyoyin software suka aiwatar. Ba tare da la’akari da ko kuna kula da fahimtar hanyoyin hanyoyin kwayoyin halittar biochemical ko a'a - don shirin abinci mai gina jiki don cutar kansa wanda ake buƙatar fahimta.
Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.
Keɓaɓɓen Abinci don Ciwon daji!
Ciwon daji yana canzawa da lokaci. Keɓancewa da canza abincin ku dangane da alamun cutar kansa, jiyya, salon rayuwa, abubuwan da ake so abinci, alerji da sauran dalilai.
Marasa lafiya masu cutar kansa sau da yawa dole su magance daban-daban illar illa na chemotherapy wanda ke shafar rayuwarsu da kuma neman wasu hanyoyin magance cutar kansa madaidaicin abinci mai gina jiki da kari bisa la'akari na kimiyya (guje wa zato da zaɓi bazuwar) shine mafi kyawun maganin ƙasa don cutar kansa da alaƙar magani sakamako masu illa.