Amfanin Clinical na Indole-3-Carbinol (I3C) a cikin Ciwon daji

labarai

Wani bincike na baya-bayan nan da aka yi a cikin 2018 ya nuna cewa indole-3-carbinol (I3C) na iya samun fa'idodi a matsayin maganin kulawa a cikin ci gaban ciwon daji na ovarian kuma wani binciken da ya gabata ya sami babban koma baya na Cervical Intra-epithelial Neoplasia (CIN) a cikin marasa lafiya da aka bi da su tare da I3C. Koyaya, ana buƙatar ingantaccen bincike don tabbatar da yuwuwar chemoprevention da tasirin cutar kansa na Indole-3-Carbinol (I3C) da metabolite Diindolylmethane (DIM) a cikin ciwon nono, kamar yadda DIM na iya yuwuwar yin hulɗa tare da ma'aunin kula da maganin hormonal. , Tamoxifen. Cin abincin da ke ɗauke da indole-3-carbinol (I3C) abinci mai wadataccen abinci irin su kayan lambu na cruciferous ana iya fifita su don ragewa. ciwon daji kasada, maimakon cinye waɗannan abubuwan kari ba da gangan ba, sai dai idan an ba da shawarar tare da bayanin kimiyya.

Indole-3-Carbinol (I3C) da Tushen Abincinsa

Abincin mai wadataccen kayan marmari mai ƙayatarwa koyaushe ana ɗaukarsa mai gina jiki da lafiya. Karatuttukan karatu daban daban sun kuma tallafawa yuwuwar waɗannan kayan lambu wajen rage haɗarin cututtukan daji da dama.

Indole-3-carbinol (I3C) mahadi ne wanda aka kirkira daga wani abu da ake kira glucobrassicin, wanda galibi ana samun sa a cikin kayan marmari na giciye kamar:

• broccoli 
• brussels sun tsiro
• kabeji
• farin kabeji
• kale
• bok choy
• kohlrabi
• doki
• arugula
• turnips
• abin wuya
• radishes
• ruwan wanka
• wasabi
• mustard 
• rutabagas

Indole-3-carbinol (I3C) yawanci ana samu ne lokacin da aka yanke, an tauna ko aka dafa shi. Ainihin, yankan, murkushewa, taunawa ko dafa waɗannan kayan lambu yana lalata ƙwayoyin ƙwayoyin suna barin glucobrassicin ya haɗu da wani enzyme da ake kira myrosinase wanda ya haifar da hydrolysis zuwa indole-3-carbinol (I3C), glucose da thiocyanate. Shan MG 350 zuwa 500 MG na Indole-3-carbinol (I3C) na iya zama daidai da cin kusan gram 300 zuwa gram 500 na ɗanyen kabeji ko tsiron Brussels. 

I3C na iya ƙarfafa motsa enzymes a cikin hanta da hanta. 

Indole-3-carbinol (I3C) yana da matukar rashin ƙarfi a cikin ruwan ciki kuma saboda haka ana inganta shi zuwa dimer mai aiki da ake kira Diindolylmethane (DIM). DIM, samfurin sanadin Indole-3-carbinol (I3C) an tsame shi daga karamin hanji.

Fa'idodin Kiwan Lafiya na Indole-3-Carbinol (I3C)

• Mafi yawan anti-cancer, anti-inflammatory, antioxidant da anti-estrogenic Properties na kayan marmari na gicciye ana iya danganta su ga indole-3-carbinol (I3C) da sulforaphane. 
• Yawancin abubuwan da suka gabata a cikin vitro da in vivo karatu sun ba da shawarar fa'idodi masu fa'ida na indole-3-carbinol (I3C) a cikin cututtukan kansa kamar huhu, hanji, prostate, da ciwon nono kuma ƙila ma haɓaka ayyukan wasu magungunan ƙwayoyi. Koyaya, ya zuwa yanzu, babu gwajin gwaji na ɗan adam wanda ya inganta tasirin sa akan cutar kansa. 
• Studiesananan binciken gwaji / lab sun kuma ba da shawarar yiwuwar Indole-3-carbinol (I3C) mai fa'ida a cikin ayyukan rigakafi da ayyukan rigakafin ƙwayoyin cuta, duk da haka, karatun ɗan adam ba shi da wannan gaba.
• Mutane suna amfani da I3C don magance lupus erythematosus na tsarin (SLE), fibromyalgia da maimaita numfashi (laryngeal) papillomatosis, duk da haka, babu kyakkyawar shaidar kimiyya don tallafawa waɗannan amfani.

Shan Indole-3-Carbinol (I3C) wadataccen abinci kamar su kayan marmari ana gasa shi saboda haka ana ɗaukarsa da fa'idodin kiwon lafiya da yawa. Baya ga waɗannan wadatattun abinci na Indole-3-Carbinol (I3C), ana samun kari na Indole-3-carbinol a kasuwa wanda yawanci ana ɗaukar sahihanci don ɗaukar adadi mai yawa wanda bai wuce 400 MG ba a kowace rana. A wasu mutane, yana iya haifar da wasu illoli kamar su fatar jiki da gudawa. Koyaya, guji yawan cin abinci mai yawa ko na I3C mafi girma saboda yana iya haifar da sakamako masu illa kamar matsaloli na daidaito, rawar jiki, da tashin zuciya.

Da fatan za a kuma lura cewa akwai karancin nazarin dabba wanda ya ba da shawarar cewa I3C na iya inganta ci gaban tumo. Saboda haka, ana buƙatar karatu don kimanta tasirin indole-3-carbinol (I3C) abinci mai yalwa da kari a cikin mutane. Don fa'idodin kiwon lafiyar gaba ɗaya, cinye abinci mai Indole-3-carbinol an fifita shi akan abubuwan I3C.

Amfani da Indole-3-carbinol (I3C) a Ciwon daji

Nazarin kulawa daban-daban da na abinci ya tallafawa ƙungiyar tsakanin yawan cin abinci mai kayan lambu mai gishiri da rage kasadar cutar kansa. Wannan tasirin mai hana yaduwar sinadarai na wadannan abinci mai indole-3-carbinol (I3C) maiyuwa ana iya danganta shi ne da aikin antitumor na I3C da kuma na Diindolylmethane (DIM), da sulforaphane. Koyaya, babu karatun da yawa waɗanda suka kimanta haɗin tsakanin indole-3-carbinol (I3C) da haɗarin cutar kansa. A ƙasa, mun ba da cikakkun bayanai game da wasu nazarin da ya shafi I3C da ciwon daji.

Fa'idodi na Indole-3-carbinol (I3C) da Epigallocatechin gallate (EGCG) a cikin Ciwon Marasa Lafiya na Ciwan Ovarian

A duk duniya, cutar sankarar jakar kwai ita ce ta takwas mafi yawan cutar kansa a cikin mata da kuma ta 18 mafi yawan cutar kansa gabaɗaya, tare da kusan sabbin 300,000 a cikin 2018. (Asusun Binciken Cancer na Duniya) Kimanin kashi 1.2 na mata za a kamu da cutar sankarar jakar kwai a wani lokaci yayin rayuwarsu. , tsakanin 5-30% don ci gaban cututtukan ƙwayar mace. 5-12% na waɗannan marasa lafiyar waɗanda aka kula da su tare da daidaitaccen kulawar sake dawo da cutar sankara a cikin watanni 42 zuwa 60 wanda ya haifar da buƙatar ci gaba da maganin ƙwaƙwalwar, a ƙarshe ya sa ƙari ya zama mai jure cutar.

Saboda haka, masu bincike daga Jami'ar Abota ta Jama'a ta Rasha, Cibiyar Kimiyyar Kimiyyar Rasha ta Roentgenoradiology (RSCRR) da MiraxBioPharma a Rasha da Jami'ar Jihar ta Wayne a Amurka sun gudanar da gwaji na gwaji don kimanta ingancin aikin kula da dogon lokaci tare da indole-3 -carbinol (I3C), da kuma maganin kulawa tare da indole-3-carbinol (I3C) da epigallocatechin-3-gallate (EGCG) a cikin masu fama da cutar sankarar jakar kwai. Epigallocatechin gallate (EGCG) shine maɓallin keɓaɓɓen aiki wanda ke cikin koren shayi tare da abubuwan da ke da kumburi da antioxidant. (Vsevolod I Kiselev et al, BMC Ciwon daji., 2018)

Nazarin a RSCRR ya haɗa da ƙungiyoyi 5 (kamar yadda aka bayyana a ƙasa) na jimlar mata 284 masu shekaru ≥ 39 shekaru tare da mataki na III-IV mai saurin kamuwa da cutar sankarar jakar kwai, waɗanda suka shiga tsakanin Janairu 2004 da Disamba 2009, waɗanda suka karɓi haɗin gwiwa ciki har da neoadjuvant platinum-taxane chemotherapy, tiyata, da adjuvant platinum-taxane chemotherapy. 

• Rukuni na 1 sun karɓi haɗin gwiwa haɗe da I3C
• Rukuni na 2 sun sami haɗin gwiwa haɗe da I3C da Epigallocatechin gallate (EGCG)
• Rukuni na 3 sun sami haɗin gwiwa haɗe da I3C da Epigallocatechin gallate (EGCG) tare da dogon lokaci na sinadarin platinum-taxane chemotherapy
• Controlungiyar kulawa ta 4 ta haɗu da magani ita kadai ba tare da neoadjuvant platinum-taxane chemotherapy ba
• Controlungiyar sarrafawa 5 haɗuwa da magani shi kaɗai

Wadannan sune mahimman abubuwan binciken:

• Bayan bin shekaru biyar, matan da suka sami maganin gyarawa tare da indole-3-carbinol, ko I3C tare da Epigallocatechin gallate (EGCG), suna da Ci gaba mai Girma na Tsira da Ci gaba Gabaɗaya idan aka kwatanta da mata a cikin ƙungiyoyin kulawa. 
• Yawan Rayuwa ta Tsakiya ya kasance watanni 60.0 a cikin Rukuni na 1, watanni 60.0 a Rukuni na 2 da 3 waɗanda suka karɓi maganin kulawa yayin watanni 46.0 a Rukuni na 4, da watanni 44.0 a Rukuni na 5. 
• Ci gaban Rayuwa na Median Progressive Free ya kasance watanni 39.5 a Rukuni na 1, watanni 42.5 a Rukuni na 2, watanni 48.5 a Rukuni na 3, watanni 24.5 a Rukuni na 4, watanni 22.0 a Rukuni na 5. 
• Adadin marasa lafiya da ke fama da cutar sankarar mahaifa tare da hawan ascites bayan an gama hada su ya ragu sosai a cikin kungiyoyin wadanda suka sami maganin gyarawa tare da indole-3-carbinol ko I3C tare da Epigallocatechin gallate (EGCG), idan aka kwatanta da kungiyoyin sarrafawa.

Masu binciken sun yanke shawarar cewa amfani da indole-3-carbinol (I3C) da kuma Epigallocatechin gallate (EGCG) na iya inganta sakamakon magani (game da ci gaban kashi 73.4% kamar yadda aka gani a cikin binciken) a cikin cututtukan da ke fama da cutar sankarar jakar kwai kuma suna iya zama mai tabbatar da ci gaba far ga waɗannan marasa lafiya.

Fa'idodin Indole-3-carbinol (I3C) a cikin Marasa lafiya tare da Cervical Intra-epithelial Neoplasia (CIN)

Cervical Intra-epithelial Neoplasia (CIN) ko Cerp dysplasia wani yanayi ne mai kyau wanda ake samun ci gaban kwayar halitta mara kyau a saman rufin bakin mahaifa ko mashin din endocervical wanda shine buɗewa tsakanin mahaifa da farji. Cervical Intra-epithelial Neoplasia galibi ana kula da shi ta hanyar tiyata ko maganin zubar da ciki don lalata ƙwayar mahaukaci. 

Maimakon magance cutar sankarar mahaifa bayan gano cutar kansa, yana da kyau koyaushe a gano shi a matakin farko ko matakin da ya dace kuma a shiga tsakani a baya ta amfani da roba ko mahaɗan halitta kamar indole-3-carbinol (I3C) da hana ci gaban cigaban cuta mai cin zali. Tare da wannan a zuciyarsu, masu binciken daga Cibiyar Kiwon Lafiya ta Jami'ar Jihar Louisiana-Shreveport a Amurka, sun kimanta indole-3-carbinol (I3C) da aka ba da baki don magance mata da Cervical Intra-epithelial Neoplasia (CIN), a matsayin magani na CIN . (MC Bell et al, Gynecol Oncol., 2000)

Nazarin ya haɗa da duka marasa lafiya 30 waɗanda ko dai suka karɓi placebo ko 200, ko 400 mg / day na indole na baka-3-carbinol (I3C). 

Wadannan sune mahimman abubuwan binciken.

• Daga cikin marasa lafiya 10 a cikin rukuni waɗanda suka karɓi placebo, babu wanda ya sami cikakken koma baya na Cervical Intra-epithelial Neoplasia (CIN). 
• 4 daga cikin marasa lafiya 8 a cikin rukunin da suka karɓi 200 mg / rana na indole na baka-3-carbinol (I3C) sun sami cikakkiyar koma baya na Cervical Intra-epithelial Neoplasia (CIN). 
• 4 daga cikin marasa lafiya 9 a cikin rukunin da suka karɓi 400 mg / rana na indole na baka-3-carbinol (I3C) sun sami cikakkiyar koma baya na Cervical Intra-epithelial Neoplasia (CIN). 

A takaice, masu binciken sun sami gagarumar koma baya na Cervical Intra-epithelial Neoplasia (CIN) a cikin marasa lafiyar da aka kula da su da indole-3-carbinol (I3C) a baki idan aka kwatanta da waɗanda suka karɓi placebo. 

Hanyoyin Canjin Chemo na Indole-3-Carbinol (I3C) a cikin Ciwon Nono

Dangane da wata takarda da masu binciken daga Cibiyar Rigakafin Cutar Canji ta Strang da ke New York, Amurka suka buga a 1997, matan 60 da ke cikin haɗarin kamuwa da cutar sankarar mama an sanya su cikin gwajin sarrafa wuribo don kimanta yiwuwar hana yaduwar cutar ta I3C. Daga cikin wadannan, mata 57 masu kimanin shekaru 47 sun kammala binciken. (GY Won et al, J Cell Biochem Gudanar., 1997)

Waɗannan matan an haɗa su a ɗayan ƙungiyoyi 3 (dalla-dalla a ƙasa) waɗanda ko dai suka karɓi maganin kwantaccen wuribo ko indole-3-carbinol (I3C) kwantena kowace rana don jimlar makonni 4. 

• Controlungiyar sarrafawa ta karɓi kwantaccen placebo
• Doseananan rukuni sun karɓi 50, 100, da 200 MG na I3C
• Babban rukuni ya karɓi 300 da 400 MG na I3C

Matsayi na ƙarshe wanda aka yi amfani dashi a cikin wannan binciken shine haɓakar haɓakar haɓakar hawan estrogen na 2-hydroxyestrone zuwa 16 alpha-hydroxyestrone.

Binciken ya gano cewa mafi girman canjin canjin matsayi na mata a cikin babban rukuni ya fi na matan da ke cikin kulawa da ƙananan ƙungiyoyi ta hanyar adadin da yake da alaƙa da yanayin asali.

Sakamakon binciken ya kuma nuna cewa indole-3-carbinol (I3C) a mafi ƙarancin tasiri na 300 MG kowace rana na iya zama wakili mai ban sha'awa don rigakafin ciwon nono. Koyaya, ana buƙatar ƙarin ingantaccen ingantaccen nazarin asibiti don tabbatar da waɗannan binciken kuma don fito da mafi kyawun kashi na I3C don nono na dogon lokaci. ciwon daji maganin rigakafi.

Diindolylmethane a cikin Ciwon Nono a cikin Marasa lafiya shan Tamoxifen

Dangane da yiwuwar yaduwar kayan lambu na gishiri da gyambon ciki na tasirin Indole-3-carbinol (I3C) a cikin cutar sankarar mama, akwai sha'awar a kimanta ko Diindolylmethane, babban abin da ke cikin Indole-3-carbinol (I3C), yana da fa'idodi a cutar kansa. (Cynthia A Thomson et al, Maganin Ciwon Cutar Canji., 2017)

Masu bincike daga Jami'ar Arizona, Jami'ar Arizona Cibiyar Ciwon daji, Jami'ar Stony Brook da Jami'ar Hawaii Cibiyar Ciwon daji a Amurka sun gudanar da gwaji na asibiti don kimanta aiki da amincin amfani da Diindolylmethane (DIM) tare da Tamoxifen a cikin nono. ciwon daji marasa lafiya.

Duka matan 98 da ke fama da cutar sankarar mama waɗanda aka ba su tare da tamoxifen ko dai sun karɓi DIM (mata 47) ko placebo (mata 51). Binciken ya gano cewa yau da kullum DIM yana amfani da sauye-sauye masu dacewa a cikin kwayar halittar estrogen da kuma yaduwar matakan jima'i na jima'i-daura globulin (SHBG). Koyaya, matakan plasma tamoxifen metabolites masu aiki ciki har da endoxifen, 4-OH tamoxifen, da N-desmethyl-tamoxifen sun ragu a cikin matan da suka karɓi DIM, suna ba da shawarar cewa DIM na iya samun damar rage tasirin Tamoxifen. (NCT01391689).  

Arin bincike yana da garantin don tantance ko DIM (samfurin ƙanshin Indole-3-Carbinol (I3C)) wanda ya haɗu da raguwa a cikin tamoxifen metabolites kamar endoxifen, yana haɓaka faɗin asibiti na tamoxifen. Har zuwa wannan, tunda bayanan asibiti suna nuna yanayin hulɗa tsakanin DIM da maganin tamoxifen na hormonal, marasa lafiya na kansar nono yayin da suke kan maganin tamoxifen ya kamata su bi ta gefen taka tsantsan kuma su guji shan ƙarin DIM.

Kammalawa

Indole-3-carbinol (I3C) na iya samun magungunan anti-tumo kamar yadda shawarar in vitro da ta gabata ta nuna, a cikin rayuwa da nazarin dabbobi da kuma yin tunani bisa ga binciken da aka gudanar wanda ya nuna cewa yawan amfani da kayan marmarin gicciye a cikin abincin yana da alaƙa da ma'ana rage haɗarin cutar kansa. Koyaya, babu karatun da yawa a cikin mutane don kafa waɗannan binciken. 

Wani bincike na baya-bayan nan a cikin 2018 ya gano cewa yin amfani da dogon lokaci na indole-3-carbinol (I3C) na iya samun fa'idodi azaman maganin kulawa da haɓaka sakamakon jiyya a cikin ci gaban ciwon daji na ovarian da wani binciken da ya gabata ya sami babban koma baya na Cervical Intra-epithelial. Neoplasia (CIN) a cikin marasa lafiya da aka bi da su tare da I3C. Koyaya, ana buƙatar ingantaccen bincike don tabbatarwa akan yuwuwar chemoprevention da tasirin cutar kansa na Indole-3-Carbinol (I3C) da metabolite Diindolylmethane (DIM) a cikin nono. ciwon daji, kamar yadda DIM na iya yuwuwar yin hulɗa tare da ma'aunin kula da maganin hormonal tamoxifen kuma ya rage matakan aikin sa na endoxifen, wanda zai iya rinjayar tasirin maganin tamoxifen. Don haka, an fi son cin abinci mai ɗauke da abinci kamar kayan lambu masu ɗimbin yawa a cikin Indole-3-Carbinol (I3C) maimakon kari, sai dai idan mai kula da lafiyar ku ya ba ku shawara.

Abincin da kuke ci kuma wanne kari kuke ɗauka shine yanke shawara. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ciwon daji, wanda cutar kansa, jiyya da ci gaba da gudana, duk wani rashin lafiyan, bayanin salon rayuwa, nauyi, tsayi da halaye.

Tsarin abinci mai gina jiki don cutar kansa daga addon baya dogara ne akan binciken intanet. Yana sarrafa muku yanke shawara ta atomatik dangane da kimiyyar kwayoyin da masana kimiyya da injiniyoyin software suka aiwatar. Ba tare da la’akari da ko kuna kula da fahimtar hanyoyin hanyoyin kwayoyin halittar biochemical ko a'a - don shirin abinci mai gina jiki don cutar kansa wanda ake buƙatar fahimta.

Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.

Marasa lafiya masu cutar kansa sau da yawa dole su magance daban-daban illar illa na chemotherapy wanda ke shafar ingancin rayuwarsu da kuma neman wasu hanyoyin magance cutar kansa. Shan da madaidaicin abinci mai gina jiki da kari bisa la'akari na kimiyya (gujewa zato da zabin bazuwar) shine mafi kyawun maganin halitta don cutar kansa da cututtukan da suka shafi magani.

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