labarai
Immunotherapy wani nau'i ne na maganin ciwon daji wanda ke motsa jiki da kuma amfani da tsarin rigakafi na jiki don yaki da ciwon daji. Coffee, ɗaya daga cikin shahararrun abubuwan sha a duk faɗin duniya, yana da yuwuwar haɓaka rigakafin cutar kansa da haɓaka hanyoyin rigakafi iri-iri masu tasowa na pharmacological. Coffee yana haɓaka rigakafin cutar kansa kuma yana haɓaka rigakafi ta hanyar sake kunna tsarin rigakafi kusa da ciwace-ciwacen ƙwayar cuta, rage sabbin samuwar jini da hana ƙari shiga yanayin gyara lokacin da lalacewa ta ciwon daji jiyya.
Kofi shine ɗayan mashahuran abubuwan sha a Amurka da ko'ina cikin duniya. Babban mahimmin kofi shine maganin kafeyin na psychostimulant, wannan ma muhimmin abu ne a cikin abubuwan sha mai sha, sodas, kara kuzari da sauran abubuwan sha na lafiya. Bayan maganin kafeyin, kofi yana da wasu abubuwa masu yawa na jiki tare da abubuwan da ke haifar da kumburi da antioxidant. Akwai sama da karatu 15,000 da suka yi nazarin tasirin shan kofi kuma gabaɗaya sun gano cewa yana da lafiya fiye da cutarwa, lokacin da ba a amfani da shi fiye da kima.
Kofi ya nuna cewa yana da fa'idodi masu yawa kamar na kiwon lafiya kamar rage ramuka, da haɓaka wasannin motsa jiki, da inganta yanayi, da rage ciwon kai. Hakanan an nuna tasirin kofi don rage haɗarin cututtuka daban-daban na yau da kullun da masu haɗari irin su ciwon sukari na 2, kansar hanji, kansar hanta, gallstones, cirrhosis na hanta da Cutar Parkinson. (Hong et al, Nutrients, 2020; Contaldo et al, Curr Opin Clin Nutr Metab Care, 2019; Kolb H et al, Kayan abinci, 2020)
A cikin wannan rukunin yanar gizon, za mu bincika hanyoyin da kofi zai iya haɓaka rigakafin cutar kansa da haɓaka hanyoyin da ke tattare da maganin rigakafin magunguna. Zamuyi bayani a takaice kan yadda cutar daji take taimakawa tsarin garkuwar jiki don saukaka ci gabanta da kuma rayuwa tare da samar da taƙaitaccen bayani kan fitowar sabon tunani kan amfani da tsarinmu na rigakafi don magancewa da sarrafa kansa ta hanyar ci gaba ta hanyoyi daban-daban na rigakafi, domin haskaka tasirin kofi.
Ciwon Immunology 101
Kamar yadda aka sani, cutar sankara cuta ce da ake samu sakamakon rashin girma da yaduwar wasu kwayoyin halitta a jikinmu wadanda suka zama marasa kyau kuma suka zama haywire. Akwai dalilai da yawa da ke haifar da cutar kansa wanda ya bambanta daga samun saukin kamuwa da kwayoyin halitta da abubuwan haɗarin dangi, zuwa salon rayuwa da dalilan muhalli. Tsufa, kiba da sauran abubuwan da ke haifar da kumburi da yanayin suma suna ƙara haɗarin cutar kansa.
Jikinmu sanye yake da kayan kariya na kanmu wanda shine tsarin garkuwar jiki. Ya ƙunshi nau'ikan salula daban-daban waɗanda suka haɗa da macrophages, ƙwayoyin T, ƙwayoyin B, ƙwayoyin dendritic, ƙwayoyin kisa na halitta, ƙwayoyin cuta da sauransu waɗanda ke mai da hankali kan kare jiki daga kamuwa da cuta. Tsarin garkuwar jiki a cikin lafiyayyen mutum yana da sa-ido don gano duk wani abu da yake baƙon, kamar ƙwayoyin cuta na ƙwayoyin cuta da ƙwayoyin cuta, ko suka lalace, saboda rauni ko kuma saboda wasu ƙwayoyin jikinmu da suka kamu da cutar kansa, da share su. Dukkanmu an yi mana alurar riga kafi tun muna yara don kamuwa da cututtuka daban-daban kamar cutar shan inna, ƙarami, kyanda, kumburi da sauransu don inganta tsarin garkuwar jiki don sanin waɗannan ƙananan ƙwayoyin cuta masu cutarwa kuma a shirye su yi yaƙi da su lokacin da ake buƙata.
Tsarin na rigakafi ya daidaita sosai. Lokacin da aka wuce gona da iri, zai iya kai hari kan 'kai' kuma ya haifar da cututtukan ƙwayar cuta irin su cututtukan zuciya na rheumatoid, sclerosis da yawa da sauransu. Lokacin da lura da garkuwar jiki yayi danshi, yakan haifar da cututtuka kamar su kansar da sauran cututtukan cututtuka masu tsanani. Lafiyayyen tsarin garkuwar jiki yana tasiri ta yanayin rayuwarmu mai matukar wahala, abincinmu mara kyau, tare da tsarin tsufa na halitta wanda ke rage karfin faɗaɗa tsarin garkuwar jiki.
Don haka kwayoyin cutar kansar zasu iya girma da bunƙasa lokacin da suka tsere daga lura da garkuwar jiki. Bugu da kari, cutar sankara tana hade da garkuwar jiki ba don kare ta ba kawai, amma tana amfani da injina masu kare garkuwar jiki don saukaka ci gaban cutar ta hanyar girmanta da yaduwa cikin jiki. Kwayoyin cutar kansa suma suna da ikon rage sa ido akan garkuwar jiki a kewayenta (microenvironment) kuma suna bunƙasa a cikin yanayin kariya.
Abincin da Zai Ci Bayan Bayanan Ciwon Cutar Kansa!
Babu cutar kansa guda biyu iri daya. Wuce ka'idojin abinci mai gina jiki na kowa don kowa kuma yanke hukunci na musamman game da abinci da kari tare da ƙarfin gwiwa.
Immunotherapy Tushen
Dangane da zurfin bincike na kimiyya da kuma fahimtar muhimmiyar rawar da garkuwar jiki ke takawa wajen tallafawa kansar, akwai sabunta hankali akan hanyoyin maganin magunguna daban-daban don motsawa da amfani da tsarin garkuwar jiki don yaƙi da cutar kansa. (Waldman AD et al, Nature Reviews Immunology, 2020) Wannan nau'i na maganin kansar da ke amfani da garkuwar jiki don magance kansar ana kiransa immunotherapy. Akwai hanyoyi daban-daban na rigakafin rigakafin rigakafi da nufin rage rigakafin rigakafin cuta a cikin ƙananan ƙwayar cuta da haɓaka kulawar rigakafi da kunna ƙwayoyin ƙwayoyin cuta. Wadannan sun hada da:
- Yin jiyya tare da masu shiga tsakani na rigakafi (cytokines) don kunna ƙwayoyin rigakafi don kai hari ciwon daji.
- Dakatar da siginar da ke ciki (masu hana shingen bincike) waɗanda ke nan don hana ƙwayoyin rigakafi daga kai hari, waɗanda ciwon daji ya haɗa su don hana a gane su mara kyau kuma a hallaka su.
- Yin amfani da ƙwayoyin rigakafin marasa lafiya waɗanda aka ɗebo daga jikinsu kuma aka shirya su a waje don ganewa da kai hari kan ƙwayoyin kansa a hanyar da ake kira farfaɗɗen ƙwayar ƙwayar cuta. CAR T (Chimeric antigen receptor T cells) ya nuna nasara wajen magance cututtukan ƙwayoyin B.
- Alurar rigakafin cutar sankara wata hanya ce da ake bincika.
Hanyoyin da Kwayoyin Cutar Cancer ke Guji Gane Jiki
- Kwayoyin cututtukan da ba na al'ada ba suna haifar da ƙananan yanayin kewaye da kansu wanda ke da rigakafin rigakafi kuma yana hana kunnawa da aiki na ƙwayoyin cuta.
- Yayinda ciwon daji ke tsiro, ƙwayoyin cuta marasa kyau suna koyon rayuwa akan ƙananan oxygen. Wannan wani yanayi ne da ake kira hypoxia. Hypoxia a cikin kwayoyin cutar kansa yana haifar da canje-canje masu mahimmanci waɗanda ke ƙara inganta rayuwa. Hypoxia tana haifar da yawan samar da matsakaita wanda zai kara samar da jini ga cutar kansa don haka ya samar da karin abinci mai gina jiki, sannan kuma ya samar da wasu masu shiga tsakani kamar adenosine, wadanda ke taimakawa wajen samar da rigakafin rigakafi a kewayenta.
- Kwayoyin cutar kansa suna kara samar da masu toshewa kai tsaye zuwa siginar kunnawa a cikin kwayoyin kariya (wuraren bincike na rigakafi) wadanda ke hana kwayoyin kariya daga lalata kwayoyin cutar kansa.
Yaya Taimakon Kofi tare da Boosting Anti-cancer Immunity?
Wadanda aka ambata a kasa wasu hanyoyi ne da kofi zai iya inganta rigakafin cutar kansa.
Kofi yana sake kunna garkuwar jiki a kusa da ƙari mai girma
Yanayin hypoxia da aka kirkira a cikin cutar sankara saboda rashin isashshen oxygen ya takaita samuwar hanyoyin samar da kuzari kuma yana haifar da tara matsakaicin matsakaicin karfi da ake kira adenosine don tarawa waje a cikin kwayar cutar kansar. Adenosine yana taimakawa wajen canzawar makamashin salula ta hanyar samar da kwayar ATP mai kuzari. Har ila yau, mai shiga tsakani ne mai sigina kuma yana aiki azaman mai hana neurotransmitter a cikin kwakwalwa.
Adenosine yana ɗaure ga masu karɓar Adenosine waɗanda ke da tasiri daban-daban akan nau'ikan ƙwayoyin halitta daban-daban. Adenosine yana hana kunnawa na ƙwayoyin T, ƙwayoyin B, macrophages da ƙwayoyin dendritic amma suna iya kunna etan tsarin T-cells, wanda ke haifar da yanayin rigakafin cuta a kusa da ƙari.
Maganin kafeyin da ke cikin kofi shima yana ɗaure ga masu karɓa guda ɗaya kamar adenosine kuma suna gasa tare da shi, don haka yana ɓata aikin adenosine. Ta wannan hanyar, maganin kafeyin na iya tsoma baki tare da hana adenosine daga hana ƙwayoyin ƙwayoyin cuta waɗanda ake buƙata don ganewa da kuma kawar da ƙwayar ƙwayar mahaifa. (Merighi S et al, Mol. Pharmacol, 2007; Tej GNVC et al, Int. Immunopharmacol., 2019; Jacobson KA et al, Br. J Pharmacol, 2020)
Kofi yana rage sabon samuwar jijiyoyin jini
Adenosine da ke cikin ƙwayar ƙwayar ƙwayar cuta yana ƙaruwa da samar da matsakanci kamar interleukin 8 (IL8) da haɓakar ƙarancin jijiyoyin jijiyoyin jiki (VEGF) wanda ke inganta ƙirƙirar sabbin jijiyoyin jini a cikin wani tsari da ake kira angiogenesis. Wannan yana amfani da ƙwayoyin cutar kansa don karɓar ƙarin abubuwan gina jiki don haɓakar su da rayuwarsu.
Kofi, ta hanyar tsangwama da adawa da aikin adenosine, na iya hana wannan aikin na ciwon angiogenesis. (Gullanki Naga Venkata Charan Tej , Magungunan Biomed., 2018)
Kofi yana hana kumburin shiga yanayin gyara lokacin da cutar kansa ta lalace kamar chemotherapy da radiation radiation
Magungunan ciwon daji kamar chemotherapy da radiation sun daidaita aikin su ta hanyar haifar da lalata DNA mai yawa akan ƙwayoyin cutar kansa, don haka ya sa ƙwayoyin su mutu. Mutuwar ƙwayoyin cuta na iya kunna tsarin garkuwar jiki da ake buƙata don share ƙwayoyin da suka mutu. Kwayoyin cutar kansa suna sake yin injiniya kansu don rayuwa kuma idan akwai lalacewa, gyara fasalin kayan aikin gyara ta hanyar kara samar da kwayoyin halittu masu gyara kamar ATM da ATR.
Caffeine na iya hana sunadaran ATM da ATR kuma su hana gyara lalacewar DNA, saboda haka sa kwayar cutar kanjamau ta zama mai saurin fuskantar barazanar wasu cututtukan. (Li N et al., Biomed Res Int., 2018) Ta hanyar hana ingancin kayan gyaran salula a cikin kwayoyin cutar kansa, maganin kafeyin yana taimakawa tare da dacewa da illar cutar sankarar magani da kuma kulawar radiation har ila yau, tare da ayyukanta kan rage ƙuntataccen rigakafi a cikin ƙananan ƙwayar cuta.
Summary
An ba da haske mai yawa amfanin kofi bisa ga binciken kimiyya. Akwai fitowar mai da hankali kan hanyoyin rigakafin rigakafi daban-daban, ta yin amfani da kariyar rigakafinmu don yin yaƙi ciwon daji, da fahimtar dalilin da yasa aka danne tsarin garkuwar jiki kuma ya kasa gane kwayoyin cutar kansa mara kyau a cikin jiki. Wannan ya haifar da bincike na halitta da amintattun adjuvants waɗanda zasu iya rage juriya na rigakafi da haɓaka sa ido na rigakafi. Hanyoyin gyaran fuska na rigakafi na kofi, ta hanyar adenosine antagonizing a cikin ƙananan ƙwayoyin cuta kuma don haka rage ƙwayar rigakafi, zai iya amfana da haɓaka immunotherapy don sarrafa ciwon daji. Koyaya, duk da yuwuwar fa'idodin kofi wajen haɓaka rigakafin cutar kansa da haɓaka rigakafi, yawan shan maganin kafeyin na iya zama mai mutuwa. Coffee wani psychostimulant ne kuma ya kamata a sha a cikin sarrafawa da matsakaicin adadin don amfani da tasirin sa.
Abincin da kuke ci kuma wanne kari kuke ɗauka shine yanke shawara. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ciwon daji, wanda cutar kansa, jiyya da ci gaba da gudana, duk wani rashin lafiyan, bayanin salon rayuwa, nauyi, tsayi da halaye.
Tsarin abinci mai gina jiki don cutar kansa daga addon baya dogara ne akan binciken intanet. Yana sarrafa muku yanke shawara ta atomatik dangane da kimiyyar kwayoyin da masana kimiyya da injiniyoyin software suka aiwatar. Ba tare da la’akari da ko kuna kula da fahimtar hanyoyin hanyoyin kwayoyin halittar biochemical ko a'a - don shirin abinci mai gina jiki don cutar kansa wanda ake buƙatar fahimta.
Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.
Keɓaɓɓen Abinci don Ciwon daji!
Ciwon daji yana canzawa da lokaci. Keɓancewa da canza abincin ku dangane da alamun cutar kansa, jiyya, salon rayuwa, abubuwan da ake so abinci, alerji da sauran dalilai.
Marasa lafiya masu cutar kansa sau da yawa dole su magance daban-daban illar illa na chemotherapy wanda ke shafar ingancin rayuwarsu da kuma neman wasu hanyoyin magance cutar kansa. Shan da madaidaicin abinci mai gina jiki da kari bisa la'akari na kimiyya (gujewa zato da zabin bazuwar) shine mafi kyawun maganin halitta don cutar kansa da cututtukan da suka shafi magani.