Amfanin Clinical na Milk Thistle / Silymarin a Ciwon daji

labarai

Milk Thistle Extract/Silymarin da mahimmin sashinsa Silibinin suna da fa'idodin kiwon lafiya da yawa masu ban sha'awa saboda antioxidant, anti-inflammatory and anti-cancer Properties. Daban-daban in vitro / in vivo da nazarin dabbobi sun bincika amfanin lafiyar lafiyar ƙwayar nono madara da kuma ikonsa na hana ciwon daji iri-iri kuma sun sami sakamako mai ban sha'awa. Gwajin ɗan adam kaɗan kuma sun ba da shawarar cewa ƙwayar madara da kayan aikin sa na iya zama da fa'ida wajen rage wasu illolin haɗari na chemotherapy da radiotherapy kamar su cardiotoxicity, hepatotoxicity da edema na kwakwalwa a wasu takamaiman. ciwon daji nau'ikan da aka bi da su da takamaiman chemo.

Menene Milist Thistle?

Milist thistle shuki ne mai furanni wanda aka yi amfani dashi tsawon ƙarni a matsayin magani na halitta don magance cutar hanta da bile galibi a ƙasashen Turai. Ana samun sarƙa madara a matsayin ƙarin abincin abincin. Milist thistle ya samo sunansa daga ruwan madara wanda ke fitowa daga ganye idan ya karye. 

Maballin Ingantaccen Maɗaukaki na Milk Thistle

Babban mahimman abubuwan da ke samar da busassun 'ya'yan itacen madara sune flavonolignans (abubuwanda suka hada da halitta flavonoid da wani bangare na lignan) wadanda suka hada da:

• Silibin (silybin)
• isosilybin
• Silychristin
• Silydianin.

Cakuda waɗannan flavonolignans da aka samo daga ƙwayoyin sarƙaƙƙen madara ana kiranta Silymarin gabaɗaya. Silibinin wanda aka fi sani da silybin, shine babban mahimmin aiki na silymarin. Silymarin yana da antioxidant, antiviral da anti-mai kumburi Properties. Milk Thistle / Silymarin yana nan a matsayin kari na abincin abin ci kuma ana amfani da shi sau da yawa don kaddarorinsa masu amfani wajen magance rikicewar hanta. Yawancin kari kuma an daidaita su bisa ga silibinin ɗin su. Hakanan akwai wasu tsari na musamman na silymarin ko silibinin wanda zai iya ƙara yawan kwazon su ta hanyar haɗawa da phosphatidylcholine.

Janar Amfanin Lafiyar Milk Thistle

Yawancin karatun dabba da 'yan karatun asibiti an gudanar dasu don kimanta fa'idar sarƙar madara. Wasu daga cikin fa'idar amfanin lafiyayyar madara sune:

1. Zai iya taimakawa cikin matsalolin Hanta sun hada da cirrhosis, jaundice, hepatitis
2. Zai iya taimakawa cikin cututtukan mafitsara na Gall
3. Idan aka haɗe shi tare da jiyya na al'ada, yana iya inganta ciwon sukari
4. Zai iya taimakawa inganta matakan cholesterol a cikin masu fama da ciwon sukari
5. Zai iya taimakawa da zafin ciki da rashin narkewar abinci
6. Zai iya taimakawa tare da hana kansar

Fa'idodi da Madarar Kashi a Cancer

A cikin shekaru ashirin da suka gabata, an sami karuwar sha'awar fahimtar fa'idodin asibiti na sarƙar nono a cikin ciwon daji. Wasu daga cikin in vitro / in vivo / dabba / ɗan adam binciken da suka kimanta aikace-aikace / illolin nono a ciki. ciwon daji an taƙaita a ƙasa:

A cikin Vitro / A cikin Vivo / Nazarin Dabbobi

1. Mai Iya hana Ciwon Cutar Pancreatic & Rage Ciwon Cutar Sanda-Cachexia / Rashin ƙarfi

Karatuttukan in vitro sun nuna cewa silibinin mai sarƙar madara yana da damar hana haɓakar kwayar cutar ciwon sanƙara a cikin hanyar dogaro. Sauran in vivo studies kuma suna ba da shawarar cewa silibinin yana rage ci gaban tumo da yaɗuwar cutar sankara kuma yana iya taimakawa hana ɓarna nauyin jiki da tsoka. (Shukla SK et al, Oncotarget., 2015)

A takaice, in vitro da nazarin dabbobi sun ba da shawarar cewa sarƙaƙƙen madara / silibinin na iya fa'ida wajen rage haɓakar cutar sankara da ciwon sankara-Rashin Cachexia / rauni. Ana buƙatar gwaji na asibiti don kafa iri ɗaya a cikin mutane. 

2. Zai Iya Hana Ciwon Ciwon Nono

Nazarin in vitro ya nuna cewa silibinin ya hana ci gaban kwayar cutar kansar nono da haifar da apoptosis / mutuwar kwayar halitta a cikin kwayoyin cutar sankarar mama. Nemo daga karatu daban-daban ya nuna cewa silibinin yana da tasirin mallakar cutar sankarar mama. (Tiwari P et al, Ciwon daji Cancer., 2011)

3. Iya hana Ciwon Ciwon Ciwon Marasa Hankali

A wani binciken kuma, an kimanta tasirin silibinin na cutar kansa a cikin haɗin haɗin gwiwa tare da DOX / Adriamycin. A cikin wannan binciken, an kula da kwayoyin sankarar sankara da silibinin da DOX a hade.Gano binciken ya nuna cewa silibinin-DOX hadewa ya haifar da hana 62-69% na ci gaba a cikin kwayoyin da aka kula. (Prabha Tiwari da Kaushala Prasad Mishra, kan iyakokin binciken kansar., 2015)

4. Iya hana Ciwon Sankarar fata

Hakanan an gudanar da karatu da yawa don kimanta tasirin Silkinin mai aiki na Milib Thistle akan cutar kansa. Nemo daga waɗannan nazarin in vitro ya nuna cewa magani na Silibinin na iya samun tasiri na rigakafi a cikin ƙwayoyin kansa na jikin mutum. Wani bincike a cikin rayuwa ya gano cewa Silibinin zai iya hana cutar kankara ta sanadiyar UVB kuma zai iya taimakawa wajen gyara lalacewar DNA a cikin fatar bera. (Prabha Tiwari da Kaushala Prasad Mishra, kan iyakokin bincike na kansar., 2015)

Wadannan karatun suna da alƙawarin kuma suna ba da shawarar cewa madarar sarƙaƙƙiya / silibinin na iya zama lafiya da fa'ida ga fata ciwon daji.

5. Zai Iya hana Ciwon Cancer Na Bazara

Wasu daga cikin in-vitro binciken sun nuna cewa Silibinin na iya haifar da mutuwar kwayar halitta a cikin kwayar cutar kansar ta mutum. Nazarin in vitro kuma ya gano cewa maganin Silibinin na 24h na iya rage haɓakar ƙwayoyin kansa da 30-49%. (Prabha Tiwari da Kaushala Prasad Mishra, kan iyakokin binciken kansar., 2015)

An kuma kimanta fa'idodin Milk Thistle / Silibinin a haɗe tare da wasu hanyoyin kwantar da hankali kamar masu hana maganin histone-deacetylase (HDAC). Haɗin ya nuna tasirin synergistic a cikin ƙwayoyin launi.

6. Zai iya hana Ciwon Canji

Nazarin in vitro ya nuna cewa Silibinin na iya samun tasirin hanawa a cikin layin kwayar cutar kanjamau ta ɗan adam. Nazarin ya kuma nuna cewa Silibinin a hade tare da DOX ya hana ci gaban kwayar cutar sankarar huhu a cikin vitro. Silibinin tare da indole-3-carbinol kuma ya haifar da tasirin antiproliferative fiye da wakilan mutum. (Prabha Tiwari da Kaushala Prasad Mishra, kan iyakokin binciken kansar., 2015)

Waɗannan binciken sun nuna cewa Silibinin mai aiki da madara na iya samun fa'ida ta maganin huhu na huhu.

7. Zai iya hana Ciwon Maziyyi

Karatun in vitro ya nuna cewa Silibinin ya haifar da mutuwar apoptosis / cell na kwayoyin cutar kansar mafitsara. Karatun kuma ya nuna cewa Silibinin na iya danne hijirar da yaduwar kwayoyin cutar kansa na mafitsara. (Prabha Tiwari da Kaushala Prasad Mishra, kan iyakokin binciken kansar., 2015)

8. Zai iya hana Ciwon Ciki

Karatun in vitro ya nuna cewa silibinin na iya hana ci gaban kwayar cutar kansar dan adam, kuma ya haifar da mutuwar apoptosis / cell. Nazarin ya kuma gano cewa Silibinin na iya haɓaka ƙwan ƙwarin ƙwayoyin ƙwayoyin kwai ga PTX (Onxal). Silibinin lokacin amfani dashi tare da PTX (Onxal) yana iya haɓaka apoptosis / cell cell. (Prabha Tiwari da Kaushala Prasad Mishra, kan iyakokin binciken kansar., 2015)

Wadannan binciken sun nuna cewa za a iya amfani da silibinin a zaman wani bangare na hanyoyin hada maganin kansar kwai.

9. Zai iya hana Ciwon Mara

Nazarin ya nuna cewa Silibinin na iya hana yaduwar kwayoyin halittar mahaifa na dan adam. Bugu da kari, silibinin tare da MET, sanannen wakilin yaki da ciwon sukari, suna nuna tasirin aiki tare kan hana kwayoyin cutar sankarar mahaifa da mutuwar kwayar halitta. Don haka, silibinin na iya zama mai tasiri a matsayin wakili na kariya daga cutar sankarar mahaifa. Arin karatu yakamata a gano yiwuwar samar da ingantattun hanyoyin dabarun magance cutar sankarar mahaifa.

Nazarin Clinical a cikin Mutane

Bari muyi la'akari da karatun asibiti daban-daban don fahimtar ko ya hada da sarƙaƙƙen madara a matsayin ɓangare na abincin marasa lafiya yana da amfani ko a'a.

1. Fa'idar Milist Thistle a rage Cardiotoxicity a Ciwon Lymphoblastic Leukemia Yara da aka Kula da DOX (Adriamycin)

Silymarin, ɗayan mahimman abubuwan aiki na ƙaya na madara, an nuna gwaji don samun tasirin kwayar halitta lokacin da aka bayar tare da DOX. Silymarin na iya rage yawan kumburin gajiya, asalin abin da ke haifar da cutar zuciya. Yana da antioxidant kuma zai iya rage lalacewar membranes da sunadarai ta hanyar nau'in mai amsawa, waɗanda aka kirkira a matsayin wani ɓangare na aikin DOX na aiki, ta hanyar hana ɓarkewar kayan aikin antioxidant na ƙwayoyin rai. (Roskovic A et al, Kwayoyin Halitta 2011)

Nazarin asibiti daga Jami'ar Tanta a Misira ya kimanta tasirin kwayar cutar Silymarin daga Milk Thistle a cikin yara tare da Acute Lymphoblastic Leukemia (ALL), waɗanda aka kula da su da DOX. Nazarin ya yi amfani da bayanai daga yara 80 tare da DUK, daga cikinsu an ba marasa lafiya 40 tare da DOX tare da Silymarin a 420 mg / rana kuma sauran 40 ana bi da su kawai tare da DOX (ƙungiyar placebo). Binciken ya gano cewa a cikin rukunin Silymarin, akwai 'raguwar farkon DOX wanda ya haifar da rikicewar aikin hagu na hagu' akan rukunin placebo. Wannan binciken na asibiti, kodayake tare da ƙananan ALLan yara duka, yana ba da tabbaci game da tasirin kwayar cutar Silymarin kamar yadda aka gani a cikin sifofin gwajin gwaji. (Adel A Hagag et al, Ciwon Cutar Cutar Cutar., 2019)

2. Fa'idojin sarƙaƙƙen madara wajen rage yawan cutar hanta a cikin Childrenananan yara masu cutar sankarar bargo wanda aka yi wa magani tare da Chemotherapy

Maganin yara masu fama da cutar sankarar bargo (ALL) ta amfani da magunguna don yawanci ana katsewa saboda cututtukan hanta / hanta da ƙwayoyin cuta ke haifarwa. Wannan rikice-rikicen kawar da cutar kansa ta amfani da magunguna na chemotherapy da ma'amala da mawuyacin sakamako kuma wasu lokuta mahimmancin tasirin waɗannan kwayoyi lamari ne mai ci gaba a cikin cutar kansa. Saboda haka, akwai ci gaba da ƙoƙari don nemo hanyoyin da zasu iya taimakawa rage ko kare mai haƙuri daga mummunar illa.

A cikin nazarin asibiti, yara masu cutar sankarar bargo (ALL) tare da cutar sanyin hanji an ɗauke su tare da chemotherapy ita kaɗai (placebo) ko kuma haɗuwa da kwayar ƙanƙan madara mai ɗauke da 80 mg na silibinin tare da chemotherapy (MTX / 6-MP / VCR) da baki ( Rukunin Milk Thistle) na tsawon kwanaki 28. An sanya yara 50 daga Mayu 2002 zuwa Agusta 2005 don wannan binciken, tare da batutuwa 26 a cikin rukunin placebo da 24 a cikin Milk Thistle Group. 49 daga cikin yara 50 sun sami kimantawa don binciken. An kula da cutar hanta a duk tsawon lokacin kulawa. (EJ Ladas et al, Ciwon daji., 2010)

Abubuwan da aka samo daga binciken sun nuna cewa shan Milk Thistle tare da chemotherapy ta DUK marasa lafiya na iya haɗuwa da raguwa mai yawa a cikin hanta mai guba. Binciken bai gano wata gubar da ba a zata ba, da bukatar rage allurai na maganin, ko kuma wani jinkiri a magani yayin karin lokacin narkakkiyar madara. Karatun kuma ya nuna cewa sarƙar madara ba ta tasiri tasirin magungunan sinadarai masu amfani da cutar don amfani da DUK magani. 

Masu binciken duk da haka sun ba da shawarar karatu na gaba don gano kwayar cutar Milk Thistle mafi inganci da tasirin ta kan cutar hanta da hanta da kuma rashin cutar sankarar jini.

3. Amfanin Milib Thistle mai aiki na Silibinin don rage kaifin kwakwalwa a cikin Marasa Hankalin Ciwon Cutar Sanda tare da Brain Metastasis

Nazarin ya ba da shawarar cewa yin amfani da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta mai suna Legasil® na iya inganta ƙwaƙwalwar ƙwaƙwalwa daga NSCLC/majin ciwon huhu wanda ya ci gaba bayan jiyya tare da radiotherapy da chemotherapy. Sakamakon waɗannan binciken kuma ya nuna cewa gudanar da silibinin zai iya rage yawan kumburin kwakwalwa. Duk da haka, waɗannan abubuwan hanawa na silibinin akan metastasis na kwakwalwa na iya yin tasiri ga ci gaban ƙwayar cuta ta farko a cikin huhu. ciwon daji marasa lafiya. (Bosch-Barrera J et al, Oncotarget., 2016)

4. Fa'idojin sarkewar madara wajen rage yawan cutar Hanta a cikin Marasa lafiyar Ciwon Kansa

An buga nazarin yanayin kan mai cutar kansar nono wanda aka kula dashi tare da magunguna daban-daban na 5 kuma yana da ci gaba da hanta. Rahoton ya ambata cewa sakamakon gwajin hanta ya tabarbare zuwa matakan da ke barazanar rayuwa bayan hawan keke huɗu na maganin kawance. Daga nan an kara wa mara lafiyar da sinadarin sinadarin na Silibinin mai suna Legasil® wanda aka lura da ci gaban asibiti da hanta, wanda hakan ya taimaka wa mara lafiyar ci gaba da maganin jinya. (Bosch-Barrera J et al, Anticancer Res., 2014)

Wannan binciken ya nuna fa'idar silibinin ta asibiti mai yiwuwa wajen rage yawan cutar hanta a cikin masu cutar sankarar mama wadanda aka kula da su da cutar sankara.

5. Fa'idar Milk Thistle a Inganta Sakamakon Tsira a cikin Brain Metastatic Marasa lafiya da aka Kula da Radiotherapy

Nazarin ya nuna cewa sarƙaƙƙen madara na iya amfanar da marasa lafiyar ƙwayoyin cuta masu fama da cutar rediyo. Nazarin na asibiti ya hada da bayanai daga marasa lafiya da ke da metastases na kwakwalwa waɗanda aka kula da su ko dai tare da aikin rediyo shi kaɗai ko kuma aikin rediyo tare da omega 3 fatty acid da silymarin. Binciken ya gano cewa marasa lafiyar da ke shan omega 3 fatty acid da silymarin sun fi tsayi na rayuwa da kuma rage radionecrosis. (Gramaglia A et al, Anticancer Res., 1999)

Kammalawa

Milk Thistle Extract / Silymarin da mabuɗin sashin Silibinin yana da fa'idodi masu yawa na kiwon lafiya saboda abubuwan da ke kare ta, masu kumburin kumburi da na kansar. Cire sarƙaƙƙen madara / Silymarin yawanci ba shi da sakamako masu illa da yawa lokacin da aka sha shi ta baki cikin madaidaitan yawa. Koyaya, a cikin wasu mutane, shan ƙanshin sarƙaƙƙen madara na iya haifar da gudawa, tashin zuciya, gas na hanji, kumburin ciki, cika ko zafi, da kuma rashin cin abinci. Hakanan, tunda cirewar sarƙaƙƙen madara na iya rage matakin sukarin jini a cikin mutanen da ke fama da ciwon sukari, za a iya gyara ƙwayoyin magungunan ciwon suga. Hakanan cirewar tsiron madara na iya samun tasirin estrogenic wanda zai iya haifar da mummunan yanayi mai saurin haɗari, gami da wasu nau'ikan cutar sankarar mama.

Daban-daban invitro / invivo da nazarin dabbobi sun binciki fa'idodin kiwon lafiya na cirewar ƙwayar madara da kuma ikonsa na hana cututtukan daji iri-iri. Yawancin waɗannan binciken sun ba da rahoton sakamako masu ban sha'awa da ke ba da shawarar kariya daga ƙwayar madara a wasu nau'in ciwon daji. Wasu ƙananan gwaje-gwajen ɗan adam kuma suna goyan bayan cewa ƙwayar nono da kayan aikin sa na iya zama da amfani wajen rage wasu haɗari masu haɗari na cututtukan chemotherapy da radiotherapy kamar su cututtukan zuciya, hepatotoxicity da edema na kwakwalwa a cikin wasu nau'in ciwon daji da aka yi da takamaiman chemo. Duk da haka, shan ƙarin na halitta irin su madarar sarƙoƙi mai tsattsauran ra'ayi tare da kowane nau'i na chemotherapy ga kowane ciwon daji ba a ba da shawarar ba saboda yana iya haifar da mummunar hulɗar ganye da magunguna. Don haka, yakamata mutum ya tuntuɓi likitan su koyaushe kafin ya ɗauki duk wani kari na halitta tare da chemotherapy.

Abincin da kuke ci kuma wanne kari kuke ɗauka shine yanke shawara. Ya kamata shawararku ta haɗa da la'akari da maye gurbi na ciwon daji, wanda cutar kansa, jiyya da ci gaba da gudana, duk wani rashin lafiyan, bayanin salon rayuwa, nauyi, tsayi da halaye.

Tsarin abinci mai gina jiki don cutar kansa daga addon baya dogara ne akan binciken intanet. Yana sarrafa muku yanke shawara ta atomatik dangane da kimiyyar kwayoyin da masana kimiyya da injiniyoyin software suka aiwatar. Ba tare da la’akari da ko kuna kula da fahimtar hanyoyin hanyoyin kwayoyin halittar biochemical ko a'a - don shirin abinci mai gina jiki don cutar kansa wanda ake buƙatar fahimta.

Fara NOW tare da shirin abinci mai gina jiki ta hanyar amsa tambayoyi kan sunan cutar kansa, maye gurbi, jiyya mai gudana da kari, duk wani rashin lafiyan, halaye, salon rayuwa, ƙungiyar shekaru da jinsi.

Marasa lafiya masu cutar kansa sau da yawa dole su magance daban-daban illar illa na chemotherapy wanda ke shafar ingancin rayuwarsu da kuma neman wasu hanyoyin magance cutar kansa. Shan da madaidaicin abinci mai gina jiki da kari bisa la'akari na kimiyya (gujewa zato da zabin bazuwar) shine mafi kyawun maganin halitta don cutar kansa da cututtukan da suka shafi magani.

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