Foods for Stomach Signet Ring Cell Carcinoma!

Introduction

Foods for Stomach Signet Ring Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Stomach Signet Ring Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Stomach Signet Ring Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Stomach Signet Ring Cell Carcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Arrowhead? Does it make any difference if fruit Grapefruit is preferred over European Cranberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Black-eyed Pea over Winged Bean. And if what I eat matters – then how does one identify foods which are recommended for Stomach Signet Ring Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Stomach Signet Ring Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Naringenin, Hesperetin, Delphinidin, Formononetin. And European Cranberry contains active ingredients Curcumin, Ellagic Acid, Quercetin, Delphinidin, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Stomach Signet Ring Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Stomach Signet Ring Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Stomach Signet Ring Cell Carcinoma?

Personalized nutrition for cancers like Stomach Signet Ring Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Stomach Signet Ring Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Stomach Signet Ring Cell Carcinoma

All cancers like Stomach Signet Ring Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Stomach Signet Ring Cell Carcinoma. Biochemical pathways like Growth Factor Signaling, Netrin Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling are part of the signature definition of Stomach Signet Ring Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Stomach Signet Ring Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Stomach Signet Ring Cell Carcinoma when taking cancer treatment Trifluridine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

CDH10, MUC16, SMARCA4, PLK1 and BCOR are the top ranked reported genes for Stomach Signet Ring Cell Carcinoma. CDH10 is reported in 20.0 % of the representative patients across all clinical trials. And MUC16 is reported in 20.0 %. The combined population patient data cover ages from 46 to 77. 47.6 % of the patient data are identified as men. The Stomach Signet Ring Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Stomach Signet Ring Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or ARROWHEAD?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Quercetin, Delphinidin, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition, Hypoxia and Growth Factor Signaling and others. New Zealand Spinach is recommended for Stomach Signet Ring Cell Carcinoma when ongoing cancer treatment is Trifluridine. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trifluridine.

Some of the active ingredients or bioactives in vegetable Arrowhead are Curcumin, Delphinidin, Formononetin, Phloretin, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and TGFB Signaling and others. Arrowhead is not recommended for Stomach Signet Ring Cell Carcinoma when ongoing cancer treatment is Trifluridine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER ARROWHEAD FOR Stomach Signet Ring Cell Carcinoma AND TREATMENT Trifluridine.

Choose Fruit EUROPEAN CRANBERRY or GRAPEFRUIT?

Fruit European Cranberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Delphinidin, Formononetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition, Hypoxia and JAK-STAT Signaling and others. European Cranberry is recommended for Stomach Signet Ring Cell Carcinoma when ongoing cancer treatment is Trifluridine. This is because European Cranberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trifluridine.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Naringenin, Hesperetin, Delphinidin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and TGFB Signaling and others. Grapefruit is not recommended for Stomach Signet Ring Cell Carcinoma when ongoing cancer treatment is Trifluridine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EUROPEAN CRANBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Stomach Signet Ring Cell Carcinoma AND TREATMENT Trifluridine.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Delphinidin, Formononetin, Juglone, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Hypoxia, Growth Factor Signaling and MYC Signaling and others. Butternut is recommended for Stomach Signet Ring Cell Carcinoma when ongoing cancer treatment is Trifluridine. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trifluridine.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Ellagic Acid, Quercetin, Delphinidin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and Epithelial to Mesenchymal Transition and others. European Chestnut is not recommended for Stomach Signet Ring Cell Carcinoma when ongoing cancer treatment is Trifluridine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Stomach Signet Ring Cell Carcinoma AND TREATMENT Trifluridine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Stomach Signet Ring Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or DAIKON RADISH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Giant Butterbur is recommended for risk of Stomach Signet Ring Cell Carcinoma when associated genetic risk is BCOR. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle and Epithelial to Mesenchymal Transition and others. Daikon Radish is not recommended when risk of Stomach Signet Ring Cell Carcinoma when associated genetic risk is BCOR because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER DAIKON RADISH FOR BCOR GENETIC RISK OF CANCER.

Choose Fruit NANCE or FOX GRAPE?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Nance is recommended for risk of Stomach Signet Ring Cell Carcinoma when associated genetic risk is BCOR. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Fox Grape are Apigenin, Curcumin, Lupeol, Quercetin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle and Epithelial to Mesenchymal Transition and others. Fox Grape is not recommended when risk of Stomach Signet Ring Cell Carcinoma when associated genetic risk is BCOR because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER FOX GRAPE FOR BCOR GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Quercetin, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Common Hazelnut is recommended for risk of Stomach Signet Ring Cell Carcinoma when associated genetic risk is BCOR. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle and Epithelial to Mesenchymal Transition and others. Chestnut is not recommended when risk of Stomach Signet Ring Cell Carcinoma when associated genetic risk is BCOR because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR BCOR GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Stomach Signet Ring Cell Carcinoma. Stomach Signet Ring Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Stomach Signet Ring Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Stomach Signet Ring Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pancan Pcawg 2020
• Pan-cancer analysis of whole genomes.
• Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway.
• Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
• Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells.
• Effects and significance of formononetin on expression levels of HIF-1α and VEGF in mouse cervical cancer tissue.
• Anti-Metastatic Effects of Lupeol via the Inhibition of MAPK/ERK Pathway in Lung Cancer.
• Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma.
• Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells.