Foods for Squamous Cell Carcinoma Of The Vulva Or Vagina!

Introduction

Foods for Squamous Cell Carcinoma Of The Vulva Or Vagina should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Squamous Cell Carcinoma Of The Vulva Or Vagina does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Squamous Cell Carcinoma Of The Vulva Or Vagina does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Squamous Cell Carcinoma Of The Vulva Or Vagina?

For example does it matter if vegetable Common Mushroom is consumed more compared to Sweet Potato? Does it make any difference if fruit Common Chokecherry is preferred over Rabbiteye Blueberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Moth Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Squamous Cell Carcinoma Of The Vulva Or Vagina!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Common Chokecherry contains active ingredients Curcumin, Apigenin, Lupeol, Myricetin, Beta-sitosterol. And Rabbiteye Blueberry contains active ingredients Quercetin, Eugenol, Linalool, Ferulic Acid, P-coumaric Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Squamous Cell Carcinoma Of The Vulva Or Vagina – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Squamous Cell Carcinoma Of The Vulva Or Vagina.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Squamous Cell Carcinoma Of The Vulva Or Vagina?

Personalized nutrition for cancers like Squamous Cell Carcinoma Of The Vulva Or Vagina consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Squamous Cell Carcinoma Of The Vulva Or Vagina biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Squamous Cell Carcinoma Of The Vulva Or Vagina

All cancers like Squamous Cell Carcinoma Of The Vulva Or Vagina can be characterized by a unique set of biochemical pathways – the signature pathways of Squamous Cell Carcinoma Of The Vulva Or Vagina. Biochemical pathways like Cell Cycle, Extracellular Matrix Remodelling, G-protein-coupled Receptor Signaling, Focal Adhesion are part of the signature definition of Squamous Cell Carcinoma Of The Vulva Or Vagina. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Squamous Cell Carcinoma Of The Vulva Or Vagina need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when taking cancer treatment Paclitaxel, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MAML2, F5, NRG1, KMT2B and CASP8 are the top ranked reported genes for Squamous Cell Carcinoma Of The Vulva Or Vagina. MAML2 is reported in 33.3 % of the representative patients across all clinical trials. And F5 is reported in 16.7 %. The combined population patient data cover ages from 45 to 83. 0.0 % of the patient data are identified as men. The Squamous Cell Carcinoma Of The Vulva Or Vagina biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Squamous Cell Carcinoma Of The Vulva Or Vagina

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable COMMON MUSHROOM or SWEET POTATO?

Vegetable Common Mushroom contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Myricetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Cell Survival, Inflammation and Microtubule Dynamics and others. Common Mushroom is recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when ongoing cancer treatment is Paclitaxel. This is because Common Mushroom modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Paclitaxel.

Some of the active ingredients or bioactives in vegetable Sweet Potato are Quercetin, Curcumin, Lupeol, Beta-sitosterol, Formononetin. These active ingredients manipulate various biochemical pathways like Focal Adhesion, Heat Stress Response and NFKB Signaling and others. Sweet Potato is not recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when ongoing cancer treatment is Paclitaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE COMMON MUSHROOM IS RECOMMENDED OVER SWEET POTATO FOR Squamous Cell Carcinoma Of The Vulva Or Vagina AND TREATMENT Paclitaxel.

Choose Fruit RABBITEYE BLUEBERRY or COMMON CHOKECHERRY?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Eugenol, Linalool, Ferulic Acid, P-coumaric Acid. These active ingredients manipulate various biochemical pathways like Cell Cycle, Inflammation, Microtubule Dynamics and MYC Signaling and others. Rabbiteye Blueberry is recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when ongoing cancer treatment is Paclitaxel. This is because Rabbiteye Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Paclitaxel.

Some of the active ingredients or bioactives in fruit Common Chokecherry are Curcumin, Apigenin, Lupeol, Myricetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Heat Stress Response and others. Common Chokecherry is not recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when ongoing cancer treatment is Paclitaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER COMMON CHOKECHERRY FOR Squamous Cell Carcinoma Of The Vulva Or Vagina AND TREATMENT Paclitaxel.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Inflammation, Heat Stress Response and Microtubule Dynamics and others. Butternut is recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when ongoing cancer treatment is Paclitaxel. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Paclitaxel.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Quercetin, Curcumin, Apigenin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Heat Stress Response and others. European Chestnut is not recommended for Squamous Cell Carcinoma Of The Vulva Or Vagina when ongoing cancer treatment is Paclitaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Squamous Cell Carcinoma Of The Vulva Or Vagina AND TREATMENT Paclitaxel.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Squamous Cell Carcinoma Of The Vulva Or Vagina or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable PEPPER (C. FRUTESCENS) or ROCKET SALAD (SSP.)?

Vegetable Pepper (c. Frutescens) contains many active ingredients or bioactives such as Capsaicin, Cinnamaldehyde, Lupeol, Eriodictyol, Geraniol. These active ingredients manipulate various biochemical pathways like Apoptosis, Growth Factor Signaling and TWEAK Signaling and others. Pepper (c. Frutescens) is recommended for risk of Squamous Cell Carcinoma Of The Vulva Or Vagina when associated genetic risk is CASP8. This is because Pepper (c. Frutescens) increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Rocket Salad (ssp.) are Isorhamnetin, Cinnamaldehyde, Lupeol, Eriodictyol, Geraniol. These active ingredients manipulate various biochemical pathways like Ceramide Signaling and TWEAK Signaling and others. Rocket Salad (ssp.) is not recommended when risk of Squamous Cell Carcinoma Of The Vulva Or Vagina when associated genetic risk is CASP8 because it increases the signature pathways of it.

VEGETABLE PEPPER (C. FRUTESCENS) IS RECOMMENDED OVER ROCKET SALAD (SSP.) FOR CASP8 GENETIC RISK OF CANCER.

Choose Fruit HIGHBUSH BLUEBERRY or FOX GRAPE?

Fruit Highbush Blueberry contains many active ingredients or bioactives such as Cinnamaldehyde, Cianidanol, Phloroglucinol, Lupeol, Eriodictyol. These active ingredients manipulate various biochemical pathways like Apoptosis, Extracellular Matrix Remodelling and Growth Factor Signaling and others. Highbush Blueberry is recommended for risk of Squamous Cell Carcinoma Of The Vulva Or Vagina when associated genetic risk is CASP8. This is because Highbush Blueberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Fox Grape are Cinnamaldehyde, Lupeol, Geraniol, Eriodictyol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Ceramide Signaling and TWEAK Signaling and others. Fox Grape is not recommended when risk of Squamous Cell Carcinoma Of The Vulva Or Vagina when associated genetic risk is CASP8 because it increases the signature pathways of it.

FRUIT HIGHBUSH BLUEBERRY IS RECOMMENDED OVER FOX GRAPE FOR CASP8 GENETIC RISK OF CANCER.

Choose Nut HAZELNUT or CHIA?

Hazelnut contains many active ingredients or bioactives such as Cinnamaldehyde, Lupeol, Geraniol, Eriodictyol, Oleic Acid. These active ingredients manipulate various biochemical pathways like Apoptosis, Growth Factor Signaling and TWEAK Signaling and others. Hazelnut is recommended for risk of Squamous Cell Carcinoma Of The Vulva Or Vagina when associated genetic risk is CASP8. This is because Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chia are Cinnamaldehyde, Lupeol, Eriodictyol, Geraniol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Ceramide Signaling and TWEAK Signaling and others. Chia is not recommended when risk of Squamous Cell Carcinoma Of The Vulva Or Vagina when associated genetic risk is CASP8 because it increases the signature pathways of it.

HAZELNUT IS RECOMMENDED OVER CHIA FOR CASP8 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Squamous Cell Carcinoma Of The Vulva Or Vagina. Squamous Cell Carcinoma Of The Vulva Or Vagina patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Squamous Cell Carcinoma Of The Vulva Or Vagina, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Common Mushroom contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Squamous Cell Carcinoma Of The Vulva Or Vagina?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Vsc Cuk 2018
• Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva.
• Induction of apoptosis of SW480 human colon cancer cells by (-)-epicatechin isolated from Bulnesia sarmienti.
• A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model.
• L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus.
• Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential.
• Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.