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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Sinonasal Undifferentiated Carcinoma!

Jul 30, 2023

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Introduction

Foods for Sinonasal Undifferentiated Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and aggressive cancer that arises in the nasal cavity and paranasal sinuses. The pathology outlines of SNUC are crucial for diagnosis, as it typically lacks distinctive features in histopathology. Patients with SNUC often present with symptoms like nasal obstruction and epistaxis, and radiology plays a key role in assessing the extent of the disease. The prognosis of SNUC depends on the stage at diagnosis, with survival rates being generally lower for advanced stages, such as stage 3 to 4. Treatment typically involves a combination of surgery, chemotherapy, and sometimes radiation therapy. The ICD-10 classification system provides a standardized coding for SNUC, aiding in healthcare documentation and research. The p16 protein may play a role in its pathology, and ongoing research is focused on understanding the causes and improving the management of SNUC. Despite its aggressive nature, the incidence rate of SNUC is low, but early detection and comprehensive treatment are essential for improving life expectancy and outcomes for affected individuals.



For Sinonasal Undifferentiated Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Sinonasal Undifferentiated Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Sinonasal Undifferentiated Carcinoma?

For example does it matter if vegetable Cauliflower is consumed more compared to {food_veg1_nr1}? Does it make any difference if fruit {food_fruit1_nr1} is preferred over Common Grape? Also if similar choices are made for nuts/seeds like Walnut over {food_nut1_nr1} and for pulses like Black-eyed Pea over {food_pulse1_nr1}. And if what I eat matters – then how does one identify foods which are recommended for Sinonasal Undifferentiated Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Sinonasal Undifferentiated Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Skin Adnexal Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Skin Adnexal Carcinoma. Biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Skin Adnexal Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example {food_fruit1_nr1} contains active ingredients {food_fruit1_nr1_ing}. And Common Grape contains active ingredients Vitamin C, Geraniin, Catechol, Melatonin, Kaempferol and possibly others.

A common mistake made when deciding and choosing foods to eat for Sinonasal Undifferentiated Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Sinonasal Undifferentiated Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Sinonasal Undifferentiated Carcinoma?

Personalized nutrition for cancers like Sinonasal Undifferentiated Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Sinonasal Undifferentiated Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Sinonasal Undifferentiated Carcinoma

All cancers like Sinonasal Undifferentiated Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Sinonasal Undifferentiated Carcinoma. Biochemical pathways like Hypoxia, Oncogenic Cancer Epigenetics, Chromatin Remodeling, Suppressive Histone Methylation are part of the signature definition of Sinonasal Undifferentiated Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Sinonasal Undifferentiated Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Sinonasal Undifferentiated Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

GATA1, POLE, ASXL1, FOXL2 and IDH2 are the top ranked reported genes for Sinonasal Undifferentiated Carcinoma. GATA1 is reported in 50.0 % of the representative patients across all clinical trials. And POLE is reported in 50.0 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Sinonasal Undifferentiated Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Sinonasal Undifferentiated Carcinoma!

Food and Supplements for Sinonasal Undifferentiated Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER?

Vegetable Cauliflower contains many active ingredients or bioactives such as Vitamin C, Catechol, Melatonin, Allicin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Hypoxia and others. Cauliflower is recommended for Sinonasal Undifferentiated Carcinoma when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

VEGETABLE CAULIFLOWER IS RECOMMENDED FOR Sinonasal Undifferentiated Carcinoma AND TREATMENT Radiation.

Choose Fruit COMMON GRAPE?

Fruit Common Grape contains many active ingredients or bioactives such as Vitamin C, Geraniin, Catechol, Melatonin, Kaempferol. These active ingredients manipulate various biochemical pathways like Hypoxia and others. Common Grape is recommended for Sinonasal Undifferentiated Carcinoma when ongoing cancer treatment is Radiation. This is because Common Grape modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

FRUIT COMMON GRAPE IS RECOMMENDED FOR Sinonasal Undifferentiated Carcinoma AND TREATMENT Radiation.

Choose Nut WALNUT?

Walnut contains many active ingredients or bioactives such as Vitamin C, Catechol, Melatonin, Kaempferol, Apigenin. These active ingredients manipulate various biochemical pathways like Hypoxia and others. Walnut is recommended for Sinonasal Undifferentiated Carcinoma when ongoing cancer treatment is Radiation. This is because Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

WALNUT IS RECOMMENDED FOR Sinonasal Undifferentiated Carcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Sinonasal Undifferentiated Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CUCUMBER?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Vitamin C, Apigenin, Curcumin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, Hypoxia, Angiogenesis and MYC Signaling and others. Giant Butterbur is recommended for risk of Sinonasal Undifferentiated Carcinoma when associated genetic risk is ASXL1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Cucumber are Curcumin, Resveratrol, Lupeol, Genistein, Beta-carotene. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Cucumber is not recommended when risk of Sinonasal Undifferentiated Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CUCUMBER FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or GRAPEFRUIT?

Fruit Nance contains many active ingredients or bioactives such as Vitamin C, Apigenin, Curcumin, Lupeol, Genistein. These active ingredients manipulate various biochemical pathways like Hypoxia, Angiogenesis and MYC Signaling and others. Nance is recommended for risk of Sinonasal Undifferentiated Carcinoma when associated genetic risk is ASXL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lycopene, Lupeol, Naringin, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Grapefruit is not recommended when risk of Sinonasal Undifferentiated Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER GRAPEFRUIT FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Genistein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, Hypoxia, Angiogenesis and Glutathione Metabolism and others. Butternut is recommended for risk of Sinonasal Undifferentiated Carcinoma when associated genetic risk is ASXL1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Delphinidin, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, Angiogenesis and MYC Signaling and others. Flaxseed is not recommended when risk of Sinonasal Undifferentiated Carcinoma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR ASXL1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Sinonasal Undifferentiated Carcinoma. Sinonasal Undifferentiated Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Sinonasal Undifferentiated Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Sinonasal Undifferentiated Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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