Foods for Myxoid Liposarcoma!

Introduction

Foods for Myxoid Liposarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Myxoid Liposarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Myxoid Liposarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Myxoid Liposarcoma?

For example does it matter if vegetable Garden Tomato is consumed more compared to Agave? Does it make any difference if fruit Pummelo is preferred over Apricot? Also if similar choices are made for nuts/seeds like Almond over Macadamia Nut and for pulses like Black-eyed Pea over Yellow Wax Bean. And if what I eat matters – then how does one identify foods which are recommended for Myxoid Liposarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Myxoid Liposarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Apigenin, Lupeol, Allicin, Daidzein. And Apricot contains active ingredients Curcumin, Oleic Acid, Lupeol, Allicin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Myxoid Liposarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Myxoid Liposarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Myxoid Liposarcoma?

Personalized nutrition for cancers like Myxoid Liposarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Myxoid Liposarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Myxoid Liposarcoma

All cancers like Myxoid Liposarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Myxoid Liposarcoma. Biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling, Apoptosis, Inositol Phosphate Signaling are part of the signature definition of Myxoid Liposarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Myxoid Liposarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Myxoid Liposarcoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TERT, PIK3CA, PTEN, TP53 and KMT2A are the top ranked reported genes for Myxoid Liposarcoma. TERT is reported in 65.7 % of the representative patients across all clinical trials. And PIK3CA is reported in 31.4 %. The combined population patient data cover ages from to . 59.1 % of the patient data are identified as men. The Myxoid Liposarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Myxoid Liposarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GARDEN TOMATO or AGAVE?

Vegetable Garden Tomato contains many active ingredients or bioactives such as Curcumin, Oleic Acid, Lupeol, Allicin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Garden Tomato is recommended for Myxoid Liposarcoma when ongoing cancer treatment is Radiation. This is because Garden Tomato modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Agave are Curcumin, Apigenin, Lupeol, Allicin, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Agave is not recommended for Myxoid Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GARDEN TOMATO IS RECOMMENDED OVER AGAVE FOR Myxoid Liposarcoma AND TREATMENT Radiation.

Choose Fruit APRICOT or PUMMELO?

Fruit Apricot contains many active ingredients or bioactives such as Curcumin, Oleic Acid, Lupeol, Allicin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Apricot is recommended for Myxoid Liposarcoma when ongoing cancer treatment is Radiation. This is because Apricot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lupeol, Allicin, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Myxoid Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT APRICOT IS RECOMMENDED OVER PUMMELO FOR Myxoid Liposarcoma AND TREATMENT Radiation.

Choose Nut ALMOND or MACADAMIA NUT?

Almond contains many active ingredients or bioactives such as Curcumin, Oleic Acid, Lupeol, Allicin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Almond is recommended for Myxoid Liposarcoma when ongoing cancer treatment is Radiation. This is because Almond modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Macadamia Nut are Curcumin, Apigenin, Oleic Acid, Lupeol, Allicin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and MYC Signaling and others. Macadamia Nut is not recommended for Myxoid Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR Myxoid Liposarcoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Myxoid Liposarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GREEN BELL PEPPER or WELSH ONION?

Vegetable Green Bell Pepper contains many active ingredients or bioactives such as Curcumin, Quercetin, Resveratrol, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like Insulin Signaling, P53 Signaling, Inositol Phosphate Signaling and Angiogenesis and others. Green Bell Pepper is recommended for risk of Myxoid Liposarcoma when associated genetic risk is KMT2A. This is because Green Bell Pepper increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Welsh Onion are Curcumin, Catechol, Formononetin, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Insulin Signaling and Cell Cycle Checkpoints and others. Welsh Onion is not recommended when risk of Myxoid Liposarcoma when associated genetic risk is KMT2A because it increases the signature pathways of it.

VEGETABLE GREEN BELL PEPPER IS RECOMMENDED OVER WELSH ONION FOR KMT2A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or GRAPEFRUIT?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Catechol, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, Insulin Signaling and MYC Signaling and others. Java Plum is recommended for risk of Myxoid Liposarcoma when associated genetic risk is KMT2A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Catechol, Formononetin, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Grapefruit is not recommended when risk of Myxoid Liposarcoma when associated genetic risk is KMT2A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER GRAPEFRUIT FOR KMT2A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or HICKORY NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Catechol, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling and Insulin Signaling and others. Butternut is recommended for risk of Myxoid Liposarcoma when associated genetic risk is KMT2A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Catechol, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Hickory Nut is not recommended when risk of Myxoid Liposarcoma when associated genetic risk is KMT2A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER HICKORY NUT FOR KMT2A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Myxoid Liposarcoma. Myxoid Liposarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Myxoid Liposarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Garden Tomato contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Myxoid Liposarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Daidzein exerts anti-tumor activity against bladder cancer cells via inhibition of FGFR3 pathway.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
• Eriodictyol exerts potent anticancer activity against A549 human lung cancer cell line by inducing mitochondrial-mediated apoptosis, G2/M cell cycle arrest and inhibition of m-TOR/PI3K/Akt signalling pathway.
• Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells.