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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Monoclonal Gammopathy of Undetermined Significance!

Jul 24, 2023

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Introduction

Foods for Monoclonal Gammopathy of Undetermined Significance should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Monoclonal Gammopathy of Undetermined Significance (MGUS) is a hematological condition that often presents without specific symptoms, making its diagnosis a challenge. Characterized by the presence of abnormal proteins in the blood, MGUS is diagnosed based on specific diagnostic criteria, including lab tests and pathology outlines. While it is often asymptomatic, MGUS requires monitoring due to its potential progression to more serious conditions like multiple myeloma. The ICD-10 coding system classifies MGUS for healthcare tracking and research purposes. Treatment is typically not required for MGUS itself but focuses on regular monitoring and managing any associated symptoms or complications. Understanding MGUS is vital, particularly in distinguishing it from more serious hematological disorders, and ongoing research in the NHS and other healthcare systems continues to explore its nature and implications for patient care.



For Monoclonal Gammopathy Of Undetermined Significance does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Monoclonal Gammopathy Of Undetermined Significance does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Monoclonal Gammopathy Of Undetermined Significance?

For example does it matter if vegetable Cauliflower is consumed more compared to Radish? Does it make any difference if fruit Elderberry is preferred over Kiwi? Also if similar choices are made for nuts/seeds like Butternut over Chestnut and for pulses like Broad Bean over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Monoclonal Gammopathy Of Undetermined Significance and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Monoclonal Gammopathy Of Undetermined Significance!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Monoclonal Gammopathy Of Undetermined Significance can be characterized by a unique set of biochemical pathways - the signature pathways of Monoclonal Gammopathy Of Undetermined Significance. Biochemical pathways like NFKB Signaling, Angiogenesis, PI3K-AKT-MTOR Signaling, Hypoxia are part of the signature definition of Monoclonal Gammopathy Of Undetermined Significance.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Elderberry contains active ingredients Quercetin, Apigenin, Isoliquiritigenin, Catechol, Myricetin. And Kiwi contains active ingredients Kaempferol, Isoliquiritigenin, Catechol, Melatonin, Luteolin and possibly others.

A common mistake made when deciding and choosing foods to eat for Monoclonal Gammopathy Of Undetermined Significance – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Monoclonal Gammopathy Of Undetermined Significance.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Monoclonal Gammopathy Of Undetermined Significance?

Personalized nutrition for cancers like Monoclonal Gammopathy Of Undetermined Significance consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Monoclonal Gammopathy Of Undetermined Significance biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Monoclonal Gammopathy Of Undetermined Significance

All cancers like Monoclonal Gammopathy Of Undetermined Significance can be characterized by a unique set of biochemical pathways – the signature pathways of Monoclonal Gammopathy Of Undetermined Significance. Biochemical pathways like NFKB Signaling, Angiogenesis, PI3K-AKT-MTOR Signaling, Hypoxia are part of the signature definition of Monoclonal Gammopathy Of Undetermined Significance. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Monoclonal Gammopathy Of Undetermined Significance need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Monoclonal Gammopathy Of Undetermined Significance when taking cancer treatment Lenalidomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

LATS2, LCP1, IRS2, CUL4A and RB1 are the top ranked reported genes for Monoclonal Gammopathy Of Undetermined Significance. LATS2 is reported in 30.3 % of the representative patients across all clinical trials. And LCP1 is reported in 30.3 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Monoclonal Gammopathy Of Undetermined Significance biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Monoclonal Gammopathy Of Undetermined Significance!

Food and Supplements for Monoclonal Gammopathy Of Undetermined Significance

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or RADISH?

Vegetable Cauliflower contains many active ingredients or bioactives such as Isoliquiritigenin, Catechol, Melatonin, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, WNT Beta Catenin Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for Monoclonal Gammopathy Of Undetermined Significance when ongoing cancer treatment is Lenalidomide. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenalidomide.

Some of the active ingredients or bioactives in vegetable Radish are Quercetin, Apigenin, Kaempferol, Isoliquiritigenin, Catechol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling and others. Radish is not recommended for Monoclonal Gammopathy Of Undetermined Significance when ongoing cancer treatment is Lenalidomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER RADISH FOR Monoclonal Gammopathy Of Undetermined Significance AND TREATMENT Lenalidomide.

Choose Fruit KIWI or ELDERBERRY?

Fruit Kiwi contains many active ingredients or bioactives such as Kaempferol, Isoliquiritigenin, Catechol, Melatonin, Luteolin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Hypoxia and PI3K-AKT-MTOR Signaling and others. Kiwi is recommended for Monoclonal Gammopathy Of Undetermined Significance when ongoing cancer treatment is Lenalidomide. This is because Kiwi modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenalidomide.

Some of the active ingredients or bioactives in fruit Elderberry are Quercetin, Apigenin, Isoliquiritigenin, Catechol, Myricetin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics and WNT Beta Catenin Signaling and others. Elderberry is not recommended for Monoclonal Gammopathy Of Undetermined Significance when ongoing cancer treatment is Lenalidomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT KIWI IS RECOMMENDED OVER ELDERBERRY FOR Monoclonal Gammopathy Of Undetermined Significance AND TREATMENT Lenalidomide.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Kaempferol, Isoliquiritigenin, Catechol, Myricetin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics, WNT Beta Catenin Signaling, RAS-RAF Signaling and NFKB Signaling and others. Butternut is recommended for Monoclonal Gammopathy Of Undetermined Significance when ongoing cancer treatment is Lenalidomide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Lenalidomide.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Kaempferol, Isoliquiritigenin, Catechol, Myricetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended for Monoclonal Gammopathy Of Undetermined Significance when ongoing cancer treatment is Lenalidomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR Monoclonal Gammopathy Of Undetermined Significance AND TREATMENT Lenalidomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Monoclonal Gammopathy Of Undetermined Significance or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CHICORY LEAVES?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Monoclonal Gammopathy Of Undetermined Significance when associated genetic risk is CUL4A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chicory Leaves are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Insulin Signaling and others. Chicory Leaves is not recommended when risk of Monoclonal Gammopathy Of Undetermined Significance when associated genetic risk is CUL4A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY LEAVES FOR CUL4A GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Monoclonal Gammopathy Of Undetermined Significance when associated genetic risk is CUL4A. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Insulin Signaling and others. Pummelo is not recommended when risk of Monoclonal Gammopathy Of Undetermined Significance when associated genetic risk is CUL4A because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR CUL4A GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Monoclonal Gammopathy Of Undetermined Significance when associated genetic risk is CUL4A. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Monoclonal Gammopathy Of Undetermined Significance when associated genetic risk is CUL4A because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR CUL4A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Monoclonal Gammopathy Of Undetermined Significance. Monoclonal Gammopathy Of Undetermined Significance patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Monoclonal Gammopathy Of Undetermined Significance, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Monoclonal Gammopathy Of Undetermined Significance?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.