addonfinal2
What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Melanoma!

Jul 23, 2023

4.2
(70)
Estimated reading time: 12 minutes
Home » Blogs » Foods for Melanoma!

Introduction

Foods for Melanoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Melanoma is a type of skin cancer that originates in the melanocytes, which are cells that produce pigment. It is the most dangerous form of skin cancer and can quickly spread to other parts of the body if left untreated. Melanomas can also form in the eye known as ocular melanoma and inside the nose, mouth, throat, genital or anal area, known as mucosal melanoma. Symptoms of melanoma can include changes in the shape, color, or size of existing moles, the appearance of new moles, or the development of sores that don’t heal. Treatment for melanoma depends on the stage and may involve surgery, radiation therapy, chemotherapy, or targeted therapy. It is important to be aware of the risk factors associated with melanoma, including genetics and sun exposure, and to take precautions such as wearing sunscreen and protective clothing. Regular self-examinations, along with routine check-ups with a dermatologist, can aid in early diagnosis and improve the melanoma survival rate.



For Melanoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Melanoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Melanoma?

For example does it matter if vegetable Cauliflower is consumed more compared to American Pokeweed? Does it make any difference if fruit Malabar Plum is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Broad Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Melanoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Melanoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Melanoma can be characterized by a unique set of biochemical pathways - the signature pathways of Melanoma. Biochemical pathways like RAS-RAF Signaling, Inositol Phosphate Signaling, Extracellular Matrix Remodelling, Focal Adhesion are part of the signature definition of Melanoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Malabar Plum contains active ingredients Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. And Black Mulberry contains active ingredients Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde and possibly others.

A common mistake made when deciding and choosing foods to eat for Melanoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Melanoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Melanoma?

Personalized nutrition for cancers like Melanoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Melanoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Melanoma

All cancers like Melanoma can be characterized by a unique set of biochemical pathways – the signature pathways of Melanoma. Biochemical pathways like RAS-RAF Signaling, Inositol Phosphate Signaling, Extracellular Matrix Remodelling, Focal Adhesion are part of the signature definition of Melanoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Melanoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Melanoma when taking cancer treatment Dabrafenib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MUC16, BRAF, APOB, MGAM and NRAS are the top ranked reported genes for Melanoma. MUC16 is reported in 7.5 % of the representative patients across all clinical trials. And BRAF is reported in 4.9 %. The combined population patient data cover ages from 5 to 90. 62.8 % of the patient data are identified as men. The Melanoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Melanoma!

Food and Supplements for Melanoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or AMERICAN POKEWEED?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Isoliquiritigenin, Cinnamaldehyde, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Amino Acid Metabolism and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for Melanoma when ongoing cancer treatment is Dabrafenib. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dabrafenib.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. American Pokeweed is not recommended for Melanoma when ongoing cancer treatment is Dabrafenib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER AMERICAN POKEWEED FOR Melanoma AND TREATMENT Dabrafenib.

Choose Fruit BLACK MULBERRY or MALABAR PLUM?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Myricetin, Curcumin, Isoliquiritigenin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Growth Factor Signaling and Epithelial to Mesenchymal Transition and others. Black Mulberry is recommended for Melanoma when ongoing cancer treatment is Dabrafenib. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dabrafenib.

Some of the active ingredients or bioactives in fruit Malabar Plum are Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. Malabar Plum is not recommended for Melanoma when ongoing cancer treatment is Dabrafenib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER MALABAR PLUM FOR Melanoma AND TREATMENT Dabrafenib.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Myricetin, Lycopene, Curcumin, Isoliquiritigenin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair and Insulin Signaling and others. Butternut is recommended for Melanoma when ongoing cancer treatment is Dabrafenib. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dabrafenib.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Myricetin, Curcumin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like DNA Repair, WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and Oxidative Stress and others. European Chestnut is not recommended for Melanoma when ongoing cancer treatment is Dabrafenib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Melanoma AND TREATMENT Dabrafenib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Melanoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or TURNIP?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Melanoma when associated genetic risk is APOB. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Turnip are Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Turnip is not recommended when risk of Melanoma when associated genetic risk is APOB because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER TURNIP FOR APOB GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for risk of Melanoma when associated genetic risk is APOB. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Extracellular Matrix Remodelling and others. Pummelo is not recommended when risk of Melanoma when associated genetic risk is APOB because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR APOB GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or MACADAMIA NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Melanoma when associated genetic risk is APOB. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Macadamia Nut are Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Macadamia Nut is not recommended when risk of Melanoma when associated genetic risk is APOB because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR APOB GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Melanoma. Melanoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Melanoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Melanoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 4.2 / 5. Vote count: 70

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?