Foods for Lung Neuroendocrine Tumors!

Introduction

Foods for Lung Neuroendocrine Tumors should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Lung Neuroendocrine Tumors does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Lung Neuroendocrine Tumors does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Lung Neuroendocrine Tumors?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Cardoon? Does it make any difference if fruit Lime is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Gram Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Lung Neuroendocrine Tumors and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Lung Neuroendocrine Tumors!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Lime contains active ingredients Curcumin, Lupeol, Daidzein, Naringin, Formononetin. And Red Raspberry contains active ingredients Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Lung Neuroendocrine Tumors – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Lung Neuroendocrine Tumors.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Lung Neuroendocrine Tumors?

Personalized nutrition for cancers like Lung Neuroendocrine Tumors consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Lung Neuroendocrine Tumors biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Lung Neuroendocrine Tumors

All cancers like Lung Neuroendocrine Tumors can be characterized by a unique set of biochemical pathways – the signature pathways of Lung Neuroendocrine Tumors. Biochemical pathways like Apoptosis, Cell Cycle, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling are part of the signature definition of Lung Neuroendocrine Tumors. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Lung Neuroendocrine Tumors need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Lung Neuroendocrine Tumors when taking cancer treatment Eribulin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3CG, PIK3CA, PTEN, FLT4 and MET are the top ranked reported genes for Lung Neuroendocrine Tumors. PIK3CG is reported in 12.9 % of the representative patients across all clinical trials. And PIK3CA is reported in 8.1 %. The combined population patient data cover ages from 44 to 76. 54.9 % of the patient data are identified as men. The Lung Neuroendocrine Tumors biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Lung Neuroendocrine Tumors

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or CARDOON?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Curcumin, Lupeol, Indole-3-carbinol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for Lung Neuroendocrine Tumors when ongoing cancer treatment is Eribulin. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Eribulin.

Some of the active ingredients or bioactives in vegetable Cardoon are Curcumin, Apigenin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Cardoon is not recommended for Lung Neuroendocrine Tumors when ongoing cancer treatment is Eribulin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER CARDOON FOR Lung Neuroendocrine Tumors AND TREATMENT Eribulin.

Choose Fruit RED RASPBERRY or LIME?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Growth Factor Signaling, Microtubule Dynamics and Apoptosis and others. Red Raspberry is recommended for Lung Neuroendocrine Tumors when ongoing cancer treatment is Eribulin. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Eribulin.

Some of the active ingredients or bioactives in fruit Lime are Curcumin, Lupeol, Daidzein, Naringin, Formononetin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics and Epithelial to Mesenchymal Transition and others. Lime is not recommended for Lung Neuroendocrine Tumors when ongoing cancer treatment is Eribulin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER LIME FOR Lung Neuroendocrine Tumors AND TREATMENT Eribulin.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, Microtubule Dynamics and Apoptosis and others. Butternut is recommended for Lung Neuroendocrine Tumors when ongoing cancer treatment is Eribulin. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Eribulin.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Curcumin, Quercetin, Apigenin, Myricetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Lung Neuroendocrine Tumors when ongoing cancer treatment is Eribulin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Lung Neuroendocrine Tumors AND TREATMENT Eribulin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Lung Neuroendocrine Tumors or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or ROCKET SALAD (SSP.)?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Catechol, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for risk of Lung Neuroendocrine Tumors when associated genetic risk is FLT4. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Rocket Salad (ssp.) are Quercetin, Curcumin, Apigenin, Catechol, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling and others. Rocket Salad (ssp.) is not recommended when risk of Lung Neuroendocrine Tumors when associated genetic risk is FLT4 because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER ROCKET SALAD (SSP.) FOR FLT4 GENETIC RISK OF CANCER.

Choose Fruit EVERGREEN BLACKBERRY or PUMMELO?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Ellagic Acid, Linalool, Myricetin, Methyleugenol, Eugenol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Evergreen Blackberry is recommended for risk of Lung Neuroendocrine Tumors when associated genetic risk is FLT4. This is because Evergreen Blackberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Apigenin, Catechol, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended when risk of Lung Neuroendocrine Tumors when associated genetic risk is FLT4 because it increases the signature pathways of it.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER PUMMELO FOR FLT4 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Catechol, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Insulin Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Lung Neuroendocrine Tumors when associated genetic risk is FLT4. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Apigenin, Catechol, Myricetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Lung Neuroendocrine Tumors when associated genetic risk is FLT4 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR FLT4 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Lung Neuroendocrine Tumors. Lung Neuroendocrine Tumors patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Lung Neuroendocrine Tumors, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Lung Neuroendocrine Tumors?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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