Nutritional supplements and extracts like Pterostilbene have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Pterostilbene supplement and why should not take them?
Is it okay to take Pterostilbene extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.
A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.
To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.
Taking Pterostilbene extracts or nutritional supplements may benefit Primary Head and Neck Squamous Cell Carcinoma patients on Docetaxel treatment over Apple nutritional supplements. But Pterostilbene supplements or Pterostilbene extracts offer less benefit if on Radiation treatment for Primary Sinonasal Adenocarcinoma compared to Clove. Similarly, taking nutritional supplements Pterostilbene may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene JAK2 over Apple. But avoid nutritional supplements Pterostilbene when at genetic risk of cancer due to mutation of gene NOTCH1.
The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Pterostilbene beneficial and should not be taken? Why should Pterostilbene be not taken? Who should not take Pterostilbene? What are side effects of Pterostilbene with Radiation chemotherapy? What are the benefits of Pterostilbene for cancer? Can Pterostilbene help fight cancer and so on.
Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.
Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.
These are some example questions which nutrition planning should help answer for you. Should you take supplements Pterostilbene? Should you take it when at genetic risk of cancer for mutation of gene JAK2? Should you take it when at genetic risk of cancer for mutation of gene NOTCH1? Should you take it when diagnosed with Primary Sinonasal Adenocarcinoma? Should you take it when diagnosed with Primary Head and Neck Squamous Cell Carcinoma? Should you take it when on Docetaxel treatment? Should you continue taking it if you change your treatment from Docetaxel to Radiation? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Pterostilbene extracts and nutritional supplements.
Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Head and Neck Squamous Cell Carcinoma or Primary Sinonasal Adenocarcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Pterostilbene.
So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Pterostilbene extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene JAK2 the same as due to mutation of gene NOTCH1? Are the implications of Primary Head and Neck Squamous Cell Carcinoma the same as Primary Sinonasal Adenocarcinoma? Is it one and the same if you are on treatment with Radiation or Docetaxel?
Pterostilbene – An Extract or Nutritional Supplement
Pterostilbene is a natural derivative of Resveratrol with structural resemblance. It has a powerful antioxidant effect and prevents the cells from the damaging effects of reactive oxygen species. The use of Pterostilbene supplement may lead to the following health benefits: (Hyunsook Kim at al, J Agric Food Chem. 2020)
- May control high cholesterol level
- May help in weight management
- May show anti-inflammatory and neuroprotective effects (Pablo Peñalver et al, J Agric Food Chem. 2020)
- May prevent cancer progression (Denise McCormack et al, J Surg Res. 2012)
- May control high blood sugar (Yu Jing Zhang et al, Biomed Environ Sci. 2020)
- May prevent atherosclerosis (Wei Wang et al, J Agric Food Chem. 2019)
Pterostilbene supplements contain many active ingredients including Pterostilbene at different concentration levels. The molecular pathways which are regulated by Pterostilbene include JAK-STAT Signaling, Notch Signaling and Cytokine Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Pterostilbene individually or in combination is an important decision to be made. When making decisions on the use of supplement Pterostilbene over other nutritional supplements – do consider all these factors.
Who Should not take Pterostilbene Supplements and Why?
There is no easy way to answer the question “For which cancers should I not choosePterostilbene nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Pterostilbene in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Pterostilbene should be avoided or not and why.
1. Will Pterostilbene Supplements benefit Primary Sinonasal Adenocarcinoma patients undergoing Radiation treatment?
Primary Sinonasal Adenocarcinoma is characterized and driven by specific genetic mutations like ATRX, NOTCH1 and PTPRD leading to biochemical pathway changes in Notch Signaling and RUNX Signaling. A cancer treatment like Radiation works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Pterostilbene supplement should not be taken for Primary Sinonasal Adenocarcinoma along with treatment Radiation. Pterostilbene supplement impacts the biochemical pathway called Notch Signaling which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any
2. Will Pterostilbene Supplements benefit Primary Head and Neck Squamous Cell Carcinoma Patients undergoing Docetaxel Treatment?
Primary Head and Neck Squamous Cell Carcinoma is characterized and driven by specific genetic mutations like FRG1BP, TP53 and PCDH11X leading to biochemical pathway changes in JAK-STAT Signaling, Cell Cycle Checkpoints and Apoptosis. A cancer treatment like Docetaxel works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Pterostilbene supplements should be considered for Primary Head and Neck Squamous Cell Carcinoma along with the treatment Docetaxel. Pterostilbene supplement impacts pathways/processes like JAK-STAT Signaling which either obstruct drivers of Primary Head and Neck Squamous Cell Carcinoma and/or improve Docetaxel treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. What about Pterostilbene Supplements for Healthy Individuals with NOTCH1 Mutation associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. NOTCH1 is one of the genes generally available in panels for cancer risk testing.
NOTCH1 mutation causes biochemical pathways/processes like Notch Signaling and RUNX Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pterostilbene should not be taken when the genetic panel identifies mutation of NOTCH1 for Chronic Lymphocytic Leukemia. Pterostilbene impacts pathways/processes like Notch Signaling and creates adverse conditions with NOTCH1.
4. What about Pterostilbene Supplements for Healthy Individuals with JAK2 Mutation associated Genetic Risk?
JAK2 is one of the genes available in panels for cancer risk testing. JAK2 mutation causes biochemical pathways/processes like Cytokine Signaling, JAK-STAT Signaling and Immune Checkpoints to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pterostilbene supplements may be considered when the genetic panel identifies mutations in JAK2 for Myeloproliferative Neoplasms. Pterostilbene impacts pathways/processes like Cytokine Signaling and creates a canceling effect in those individuals with JAK2 mutation.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Pterostilbene are chosen by you and can influence outcomes.
“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.
The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
- Targeting Notch to overcome radiation resistance.
- Pterostilbene exerts antitumor activity via the Notch1 signaling pathway in human lung adenocarcinoma cells.
- Pan-cancer analysis of whole genomes.
- Antitumor Activity of Pulvomycin via Targeting Activated-STAT3 Signaling in Docetaxel-Resistant Triple-Negative Breast Cancer Cells.
- cBioPortal for Cancer Genomics
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.
- cBioPortal for Cancer Genomics
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.