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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Small Intestine Adenocarcinoma!

Jul 30, 2023

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Introduction

Foods for Small Intestine Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Adenocarcinoma of the small intestine, a relatively rare form of gastrointestinal cancer, presents unique challenges in diagnosis and treatment. Pathology outlines of small intestine adenocarcinoma reveal specific cellular characteristics, essential for accurate diagnosis. Patients may experience a range of symptoms, including abdominal pain, weight loss, and gastrointestinal bleeding, often leading to a delay in diagnosis due to their nonspecific nature. The survival rate for small intestine adenocarcinoma varies, depending on factors such as the stage at diagnosis and the patient’s overall health. Imaging techniques in radiology, such as CT scans or MRIs, play a crucial role in the diagnosis and staging of this cancer, providing valuable information on the tumor’s size, location, and potential spread. The prognosis of small intestine adenocarcinoma depends on various factors, including the tumor’s response to treatment, which typically involves chemotherapy. Immunohistochemistry is also used in the diagnostic process, helping to identify specific markers that can guide treatment decisions. The overall approach to managing small intestine adenocarcinoma requires a multidisciplinary effort to optimize outcomes and improve the survival rate for affected individuals.



For Small Intestine Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Small Intestine Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Small Intestine Adenocarcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Chinese Broccoli? Does it make any difference if fruit Sapodilla is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Butternut over Cashew Nut and for pulses like Gram Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Small Intestine Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Small Intestine Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Small Intestine Adenocarcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Small Intestine Adenocarcinoma. Biochemical pathways like DNA Repair, Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Small Intestine Adenocarcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Sapodilla contains active ingredients Curcumin, Formononetin, Myricetin, Phloretin, Daidzein. And Black Mulberry contains active ingredients Quercetin, Curcumin, Formononetin, Myricetin, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Small Intestine Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Small Intestine Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Small Intestine Adenocarcinoma?

Personalized nutrition for cancers like Small Intestine Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Small Intestine Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Small Intestine Adenocarcinoma

All cancers like Small Intestine Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Small Intestine Adenocarcinoma. Biochemical pathways like DNA Repair, Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Small Intestine Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Small Intestine Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Small Intestine Adenocarcinoma when taking cancer treatment Temozolomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

APC, TERT, PIK3R1, KAT6A and PTCH1 are the top ranked reported genes for Small Intestine Adenocarcinoma. APC is reported in 8.4 % of the representative patients across all clinical trials. And TERT is reported in 5.3 %. The combined population patient data cover ages from to . 66.0 % of the patient data are identified as men. The Small Intestine Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Small Intestine Adenocarcinoma!

Food and Supplements for Small Intestine Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or CHINESE BROCCOLI?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Quercetin, Curcumin, Formononetin, Myricetin, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, DNA Repair and Focal Adhesion and others. New Zealand Spinach is recommended for Small Intestine Adenocarcinoma when ongoing cancer treatment is Temozolomide. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in vegetable Chinese Broccoli are Curcumin, Formononetin, Myricetin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like Oncogenic Histone Methylation, PI3K-AKT-MTOR Signaling and Oxidative Stress and others. Chinese Broccoli is not recommended for Small Intestine Adenocarcinoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER CHINESE BROCCOLI FOR Small Intestine Adenocarcinoma AND TREATMENT Temozolomide.

Choose Fruit BLACK MULBERRY or SAPODILLA?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Formononetin, Myricetin, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Epithelial to Mesenchymal Transition and Cell Survival and others. Black Mulberry is recommended for Small Intestine Adenocarcinoma when ongoing cancer treatment is Temozolomide. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in fruit Sapodilla are Curcumin, Formononetin, Myricetin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Extracellular Matrix Remodelling, Focal Adhesion and Oxidative Stress and others. Sapodilla is not recommended for Small Intestine Adenocarcinoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER SAPODILLA FOR Small Intestine Adenocarcinoma AND TREATMENT Temozolomide.

Choose Nut BUTTERNUT or CASHEW NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Formononetin, Myricetin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, P53 Signaling and Microtubule Dynamics and others. Butternut is recommended for Small Intestine Adenocarcinoma when ongoing cancer treatment is Temozolomide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in Cashew Nut are Quercetin, Curcumin, Formononetin, Myricetin, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Direct Repair and MYC Signaling and others. Cashew Nut is not recommended for Small Intestine Adenocarcinoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CASHEW NUT FOR Small Intestine Adenocarcinoma AND TREATMENT Temozolomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Small Intestine Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or TURNIP?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, MAPK Signaling and MYC Signaling and others. Giant Butterbur is recommended for risk of Small Intestine Adenocarcinoma when associated genetic risk is APC. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Turnip are Curcumin, Quercetin, Lupeol, Ellagic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, WNT Beta Catenin Signaling and MAPK Signaling and others. Turnip is not recommended when risk of Small Intestine Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER TURNIP FOR APC GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Betulinic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, MAPK Signaling and MYC Signaling and others. Nance is recommended for risk of Small Intestine Adenocarcinoma when associated genetic risk is APC. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Lupeol, Naringin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Small Intestine Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR APC GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, P53 Signaling, MAPK Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Small Intestine Adenocarcinoma when associated genetic risk is APC. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Lupeol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and WNT Beta Catenin Signaling and others. European Chestnut is not recommended when risk of Small Intestine Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR APC GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Small Intestine Adenocarcinoma. Small Intestine Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Small Intestine Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Small Intestine Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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