Which Foods are Recommended for Sinonasal Undifferentiated Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sinonasal Undifferentiated Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Sinonasal Undifferentiated Carcinoma because of GATA1 and POLE gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Sinonasal Undifferentiated Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Coconut” or “Include fruit Pear in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Vitamin C and Lingonberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SINONASAL UNDIFFERENTIATED CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Sinonasal Undifferentiated Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SINONASAL UNDIFFERENTIATED CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Sinonasal Undifferentiated Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Sinonasal Undifferentiated Carcinoma from cBioPortal. From a patient sample size of 2; the top genes with mutations and other abnormalities for Sinonasal Undifferentiated Carcinoma include genes GATA1, POLE, ASXL1, FOXL2 and IDH2. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Sinonasal Undifferentiated Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sinonasal Undifferentiated Carcinoma.

Significance of Nutrition for Sinonasal Undifferentiated Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sinonasal Undifferentiated Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Coconut includes active ingredients Beta-sitosterol, Vitamin E, Capric Acid, Palmitic Acid and others. And Pear contains active ingredients Vitamin C, Caffeic Acid, Isoliquiritigenin, Chlorogenic Acid, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Sinonasal Undifferentiated Carcinoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, Suppressive Histone Methylation, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sinonasal Undifferentiated Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SINONASAL UNDIFFERENTIATED CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Sinonasal Undifferentiated Carcinoma undergoing chemotherapy treatment

In Sinonasal Undifferentiated Carcinoma – the genes GATA1, POLE, ASXL1, FOXL2 and IDH2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sinonasal Undifferentiated Carcinoma are Oncogenic Cancer Epigenetics, Chromatin Remodeling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Soy Bean or Yellow Wax Bean?

Pulses are an important part of many diets. The active ingredients contained in Soy Bean are Vitamin C, Quercetin, Caffeic Acid, Genistein, Folic Acid among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Folic Acid, Cianidanol, Butyric Acid, Palmitic Acid and others.

Genistein can manipulate biochemical pathways Hypoxia and Oncogenic Cancer Epigenetics. Beta-sitosterol has biological action on biochemical pathways Hypoxia and Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Energy Metabolism, Oncogenic Cancer Epigenetics and mRNA Splicing. Butyric Acid has biological action on biochemical pathways mRNA Splicing. And so on.

When treating Sinonasal Undifferentiated Carcinoma with chemotherapy Radiation – Foods like Soy Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Butyric Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Genistein and Beta-sitosterol contained in Soy Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SOY BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR SINONASAL UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Mexican Groundcherry or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Carob are Quercetin, Folic Acid, Gallic Acid, Myricetin, Palmitic Acid and others.

Vitamin C can manipulate biochemical pathways Hypoxia, Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. Vitamin B3 has biological action on biochemical pathways Hypoxia.

Palmitic Acid can manipulate biochemical pathways Energy Metabolism, Oncogenic Cancer Epigenetics and mRNA Splicing. Myricetin has biological action on biochemical pathways Oncogenic Histone Methylation and Oncogenic Cancer Epigenetics. And so on.

When treating Sinonasal Undifferentiated Carcinoma with chemotherapy Radiation – Foods like Mexican Groundcherry are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER CAROB FOR SINONASAL UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Pear or Coconut?

Fruits are an important part of many diets. The active ingredients contained in Pear are Vitamin C, Caffeic Acid, Isoliquiritigenin, Chlorogenic Acid, Folic Acid among others. While the active ingredients contained in Coconut are Beta-sitosterol, Vitamin E, Capric Acid, Palmitic Acid and others.

Caffeic Acid can manipulate biochemical pathways Hypoxia and Oncogenic Histone Methylation. Chlorogenic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Hypoxia.

Capric Acid can manipulate biochemical pathways Energy Metabolism. Palmitic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics, mRNA Splicing and Energy Metabolism. And so on.

When treating Sinonasal Undifferentiated Carcinoma with chemotherapy Radiation – Foods like Pear are recommended compared to Coconut. This is because the active ingredients Capric Acid and Palmitic Acid in Coconut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Caffeic Acid and Chlorogenic Acid contained in Pear support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PEAR IS RECOMMENDED OVER COCONUT FOR SINONASAL UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Vitamin C, Quercetin, Ellagic Acid, Folic Acid, Betulin among others. While the active ingredients contained in Macadamia Nut are Folic Acid, Beta-sitosterol, Palmitic Acid and others.

Ellagic Acid can manipulate biochemical pathways Hypoxia and Oncogenic Cancer Epigenetics. Betulin has biological action on biochemical pathways Hypoxia.

Palmitic Acid can manipulate biochemical pathways Energy Metabolism, Oncogenic Cancer Epigenetics and mRNA Splicing. And so on.

When treating Sinonasal Undifferentiated Carcinoma with chemotherapy Radiation – Foods like Chestnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Betulin contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER MACADAMIA NUT FOR SINONASAL UNDIFFERENTIATED CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Sinonasal Undifferentiated Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GATA1 and POLE are two genes whose abnormalities are risk factors for Sinonasal Undifferentiated Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sinonasal Undifferentiated Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Sinonasal Undifferentiated Carcinoma gene GATA1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics and Oncogenic Cancer Epigenetics. And POLE has a causative impact on biological pathways like Chromatin Remodeling, DNA Repair and Mismatch Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GATA1 and POLE should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GATA1 and POLE should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Vitamin C, Linolenic Acid, Stigmasterol, Vitexin, Quercetin among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Genistein and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and Hypoxia. Stigmasterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis.

Folic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Sinonasal Undifferentiated Carcinoma due to abnormalities in genes GATA1 and POLE – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF SINONASAL UNDIFFERENTIATED CARCINOMA DUE TO GENES GATA1 AND POLE

Eat more vegetables, Giant Butterbur or Heart Of Palm?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and Hypoxia. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Energy Metabolism and Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Sinonasal Undifferentiated Carcinoma due to abnormalities in genes GATA1 and POLE – Foods like Giant Butterbur are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF SINONASAL UNDIFFERENTIATED CARCINOMA DUE TO GENES GATA1 AND POLE

Eat more fruits, Star Fruit or Grape?

The active ingredients contained in Star Fruit are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Grape are Vitamin C, Lupeol, Vitamin E, Pterostilbene, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and Hypoxia. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Oncogenic Cancer Epigenetics.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Sinonasal Undifferentiated Carcinoma due to abnormalities in genes GATA1 and POLE – Foods like Star Fruit are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF SINONASAL UNDIFFERENTIATED CARCINOMA DUE TO GENES GATA1 AND POLE

Eat more nuts, Hazelnut or Cashew Nut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Palmitic Acid, Gallic Acid, Butyric Acid and others.

Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and Hypoxia. Quercetin has biological action on biochemical pathways MYC Signaling, P53 Signaling and Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Energy Metabolism and Oncogenic Cancer Epigenetics. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Sinonasal Undifferentiated Carcinoma due to abnormalities in genes GATA1 and POLE – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF SINONASAL UNDIFFERENTIATED CARCINOMA DUE TO GENES GATA1 AND POLE

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Sinonasal Undifferentiated Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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