Which Foods are Recommended for Oropharynx Squamous Cell Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Oropharynx Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Oropharynx Squamous Cell Carcinoma because of FBXW7 and CDKN2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Oropharynx Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Garland Chrysanthemum” or “Can I take Thunder God and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OROPHARYNX SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Oropharynx Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR OROPHARYNX SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Oropharynx Squamous Cell Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Oropharynx Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Oropharynx Squamous Cell Carcinoma are in ages between 39 to 71 with an average age of 58. 85.9% of males and 14.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 193; the top genes with mutations and other abnormalities for Oropharynx Squamous Cell Carcinoma include genes TERT, KMT2C, ATRX, CDKN2A and FBXW7. The occurrence frequency distribution for these genes respectively is 12.1%, 6.9%, 6.9%, 6.9% and 6.9%. These tumor genetic details of Oropharynx Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Oropharynx Squamous Cell Carcinoma.

Significance of Nutrition for Oropharynx Squamous Cell Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Oropharynx Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Modified Citrus Pectin, Oleic Acid, Beta-sitosterol, Vitamin C and others. And Apple contains active ingredients Modified Citrus Pectin, Phloretin, Fisetin, Cianidanol, Caffeic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Oropharynx Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Oropharynx Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OROPHARYNX SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Oropharynx Squamous Cell Carcinoma undergoing chemotherapy treatment

In Oropharynx Squamous Cell Carcinoma – the genes TERT, KMT2C, ATRX, CDKN2A and FBXW7 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Oropharynx Squamous Cell Carcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Quercetin, Butein, Daidzein, Oleic Acid, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Oropharynx Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Cianidanol in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR OROPHARYNX SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Garland Chrysanthemum?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Oleic Acid, Beta-sitosterol, Vitamin C, Brassinin, Sulforaphane among others. While the active ingredients contained in Garland Chrysanthemum are Vitamin C, Vitamin A, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Brassinin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Vitamin A can manipulate biochemical pathways TGFB Signaling and Focal Adhesion. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and MAPK Signaling. And so on.

When treating Oropharynx Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Garland Chrysanthemum. This is because the active ingredients Vitamin A and Folic Acid in Garland Chrysanthemum interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR OROPHARYNX SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Apple or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Apple are Modified Citrus Pectin, Phloretin, Fisetin, Cianidanol, Caffeic Acid among others. While the active ingredients contained in Apricot are Quercetin, Modified Citrus Pectin, Oleic Acid, Beta-sitosterol, Vitamin C and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Modified Citrus Pectin has biological action on biochemical pathways TGFB Signaling, JAK-STAT Signaling and MYC Signaling.

Rutin can manipulate biochemical pathways Oxidative Stress and Focal Adhesion. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Oropharynx Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Apple are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Modified Citrus Pectin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: APPLE IS RECOMMENDED OVER APRICOT FOR OROPHARYNX SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Oleic Acid, Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Beta-carotene, Vitamin C, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.

When treating Oropharynx Squamous Cell Carcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR OROPHARYNX SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Oropharynx Squamous Cell Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FBXW7 and CDKN2A are two genes whose abnormalities are risk factors for Oropharynx Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Oropharynx Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Oropharynx Squamous Cell Carcinoma gene FBXW7 has causative impact on biological pathways like Antigen Presentation and Post Translation Modification. And CDKN2A has a causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FBXW7 and CDKN2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FBXW7 and CDKN2A should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Ferulic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints and Cell Cycle. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Oropharynx Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and CDKN2A – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF OROPHARYNX SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND CDKN2A

Eat more vegetables, Giant Butterbur or Chicory?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Betulinic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Oropharynx Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and CDKN2A – Foods like Giant Butterbur are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF OROPHARYNX SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND CDKN2A

Eat more fruits, Feijoa or Raspberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Vitamin C, Quercetin, Salicylic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Oropharynx Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and CDKN2A – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF OROPHARYNX SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND CDKN2A

Eat more nuts, Pecan Nut or Chestnut?

The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Vitamin C, Quercetin, Oleic Acid, Linolenic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Oropharynx Squamous Cell Carcinoma due to abnormalities in genes FBXW7 and CDKN2A – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF OROPHARYNX SQUAMOUS CELL CARCINOMA DUE TO GENES FBXW7 AND CDKN2A

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Oropharynx Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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