Which Foods are Recommended for Epithelioid Trophoblastic Tumor?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Epithelioid Trophoblastic Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Epithelioid Trophoblastic Tumor because of DNMT3A and TET2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Epithelioid Trophoblastic Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Rambutan in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Vitamin C and Sulforaphane supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EPITHELIOID TROPHOBLASTIC TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Epithelioid Trophoblastic Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EPITHELIOID TROPHOBLASTIC TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Epithelioid Trophoblastic Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Epithelioid Trophoblastic Tumor from cBioPortal. The patients enrolled in the studies for Epithelioid Trophoblastic Tumor are in ages between 23 to 58 with an average age of 35. 53.8% of males and 46.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 13; the top genes with mutations and other abnormalities for Epithelioid Trophoblastic Tumor include genes DNMT3A and TET2. The occurrence frequency distribution for these genes respectively is 50.0% and 50.0%. These tumor genetic details of Epithelioid Trophoblastic Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Epithelioid Trophoblastic Tumor.

Significance of Nutrition for Epithelioid Trophoblastic Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Epithelioid Trophoblastic Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Vitamin C, Bergapten, Beta-sitosterol, Lupeol, Palmitic Acid and others. And Rambutan contains active ingredients Vitamin C, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Epithelioid Trophoblastic Tumor, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Amino Acid Metabolism plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Epithelioid Trophoblastic Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EPITHELIOID TROPHOBLASTIC TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Epithelioid Trophoblastic Tumor undergoing chemotherapy treatment

In Epithelioid Trophoblastic Tumor – the genes DNMT3A and TET2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Epithelioid Trophoblastic Tumor are Oncogenic Cancer Epigenetics, Amino Acid Metabolism and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Black-eyed Pea or Hyacinth Bean?

Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Vitamin C, Beta-carotene, Genistein, Oleic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Palmitic Acid and others.

Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Beta-carotene has biological action on biochemical pathways Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Epithelioid Trophoblastic Tumor with chemotherapy Fluorouracil – Foods like Black-eyed Pea are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER HYACINTH BEAN FOR EPITHELIOID TROPHOBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more vegetables, Turnip or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Turnip are Sulforaphane, Vitamin C among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin and others.

Sulforaphane can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Epithelioid Trophoblastic Tumor with chemotherapy Fluorouracil – Foods like Turnip are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Sulforaphane and Vitamin C contained in Turnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TURNIP IS RECOMMENDED OVER CAROB FOR EPITHELIOID TROPHOBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more fruits, Rambutan or Fig?

Fruits are an important part of many diets. The active ingredients contained in Rambutan are Vitamin C, Oleic Acid among others. While the active ingredients contained in Fig are Vitamin C, Bergapten, Beta-sitosterol, Lupeol, Palmitic Acid and others.

Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Oleic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Epithelioid Trophoblastic Tumor with chemotherapy Fluorouracil – Foods like Rambutan are recommended compared to Fig. This is because the active ingredients Palmitic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Oleic Acid contained in Rambutan support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RAMBUTAN IS RECOMMENDED OVER FIG FOR EPITHELIOID TROPHOBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Vitamin C, Ellagic Acid, Oleic Acid, Quercetin among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid and others.

Ellagic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Epithelioid Trophoblastic Tumor with chemotherapy Fluorouracil – Foods like Chestnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER MACADAMIA NUT FOR EPITHELIOID TROPHOBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Foods for Genetic Risk of Epithelioid Trophoblastic Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. DNMT3A and TET2 are two genes whose abnormalities are risk factors for Epithelioid Trophoblastic Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Epithelioid Trophoblastic Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Epithelioid Trophoblastic Tumor gene DNMT3A has causative impact on biological pathways like Oncogenic Cancer Epigenetics and Amino Acid Metabolism. And TET2 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like DNMT3A and TET2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes DNMT3A and TET2 should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Glucaric Acid, Oleic Acid, Kaempferol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Genistein, Linoleic Acid and others.

Quercetin can manipulate biochemical pathways Oncogenic Cancer Epigenetics, RAS-RAF Signaling and Hypoxia. Vitamin C has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Epithelioid Trophoblastic Tumor due to abnormalities in genes DNMT3A and TET2 – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF EPITHELIOID TROPHOBLASTIC TUMOR DUE TO GENES DNMT3A AND TET2

Eat more vegetables, Cassava or Chicory?

The active ingredients contained in Cassava are Vitamin C, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Quercetin, Protocatechuic Acid, Vitamin C, Lupeol and others.

Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, RAS-RAF Signaling and Hypoxia. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Epithelioid Trophoblastic Tumor due to abnormalities in genes DNMT3A and TET2 – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF EPITHELIOID TROPHOBLASTIC TUMOR DUE TO GENES DNMT3A AND TET2

Eat more fruits, Star Fruit or Cranberry?

The active ingredients contained in Star Fruit are Vitamin C, Oleic Acid, Epigallocatechin Gallate, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Cranberry are Resveratrol, Quercetin, Vitamin C, Ellagic Acid, Myricetin and others.

Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, RAS-RAF Signaling and Hypoxia. Epigallocatechin Gallate has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Myricetin can manipulate biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Epithelioid Trophoblastic Tumor due to abnormalities in genes DNMT3A and TET2 – Foods like Star Fruit are recommended compared to Cranberry. This is because the active ingredients Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Epigallocatechin Gallate contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF EPITHELIOID TROPHOBLASTIC TUMOR DUE TO GENES DNMT3A AND TET2

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways RAS-RAF Signaling, Hypoxia and MAPK Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and MYC Signaling. And so on.

For genetic risk of Epithelioid Trophoblastic Tumor due to abnormalities in genes DNMT3A and TET2 – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF EPITHELIOID TROPHOBLASTIC TUMOR DUE TO GENES DNMT3A AND TET2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Epithelioid Trophoblastic Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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