Foods for Epithelioid Trophoblastic Tumor!

Introduction

Foods for Epithelioid Trophoblastic Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Epithelioid Trophoblastic Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Epithelioid Trophoblastic Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Epithelioid Trophoblastic Tumor?

For example does it matter if vegetable Broccoli is consumed more compared to Garden Rhubarb? Does it make any difference if fruit Babassu Palm is preferred over Sweet Orange? Also if similar choices are made for nuts/seeds like Pistachio over Japanese Chestnut and for pulses like Green Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Epithelioid Trophoblastic Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Epithelioid Trophoblastic Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Babassu Palm contains active ingredients Curcumin, Genistein, Luteolin, Pelargonidin, Bergapten. And Sweet Orange contains active ingredients Beta-carotene, Vitamin C, Vicenin 2, Curcumin, Hesperidin and possibly others.

A common mistake made when deciding and choosing foods to eat for Epithelioid Trophoblastic Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Epithelioid Trophoblastic Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Epithelioid Trophoblastic Tumor?

Personalized nutrition for cancers like Epithelioid Trophoblastic Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Epithelioid Trophoblastic Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Epithelioid Trophoblastic Tumor

All cancers like Epithelioid Trophoblastic Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Epithelioid Trophoblastic Tumor. Biochemical pathways like Oncogenic Cancer Epigenetics, Amino Acid Metabolism are part of the signature definition of Epithelioid Trophoblastic Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Epithelioid Trophoblastic Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Epithelioid Trophoblastic Tumor when taking cancer treatment Pembrolizumab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A and TET2 are the top ranked reported genes for Epithelioid Trophoblastic Tumor. DNMT3A is reported in 50.0 % of the representative patients across all clinical trials. And TET2 is reported in 50.0 %. The combined population patient data cover ages from 23 to 58. 53.8 % of the patient data are identified as men. The Epithelioid Trophoblastic Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Epithelioid Trophoblastic Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BROCCOLI or GARDEN RHUBARB?

Vegetable Broccoli contains many active ingredients or bioactives such as Sulforaphane, Beta-carotene, Vitamin C, Curcumin, Genistein. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and others. Broccoli is recommended for Epithelioid Trophoblastic Tumor when ongoing cancer treatment is Pembrolizumab. This is because Broccoli modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in vegetable Garden Rhubarb are Curcumin, Genistein, Luteolin, Pelargonidin, Bergapten. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and others. Garden Rhubarb is not recommended for Epithelioid Trophoblastic Tumor when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BROCCOLI IS RECOMMENDED OVER GARDEN RHUBARB FOR Epithelioid Trophoblastic Tumor AND TREATMENT Pembrolizumab.

Choose Fruit SWEET ORANGE or BABASSU PALM?

Fruit Sweet Orange contains many active ingredients or bioactives such as Beta-carotene, Vitamin C, Vicenin 2, Curcumin, Hesperidin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and others. Sweet Orange is recommended for Epithelioid Trophoblastic Tumor when ongoing cancer treatment is Pembrolizumab. This is because Sweet Orange modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in fruit Babassu Palm are Curcumin, Genistein, Luteolin, Pelargonidin, Bergapten. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and others. Babassu Palm is not recommended for Epithelioid Trophoblastic Tumor when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SWEET ORANGE IS RECOMMENDED OVER BABASSU PALM FOR Epithelioid Trophoblastic Tumor AND TREATMENT Pembrolizumab.

Choose Nut PISTACHIO or JAPANESE CHESTNUT?

Pistachio contains many active ingredients or bioactives such as Beta-carotene, Curcumin, Genistein, Pelargonidin, Bergapten. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and others. Pistachio is recommended for Epithelioid Trophoblastic Tumor when ongoing cancer treatment is Pembrolizumab. This is because Pistachio modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in Japanese Chestnut are Curcumin, Genistein, Luteolin, Pelargonidin, Bergapten. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and others. Japanese Chestnut is not recommended for Epithelioid Trophoblastic Tumor when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

PISTACHIO IS RECOMMENDED OVER JAPANESE CHESTNUT FOR Epithelioid Trophoblastic Tumor AND TREATMENT Pembrolizumab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Epithelioid Trophoblastic Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or GROUNDCHERRY?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Vitamin C, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, Hypoxia and MYC Signaling and others. Giant Butterbur is recommended for risk of Epithelioid Trophoblastic Tumor when associated genetic risk is DNMT3A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Groundcherry are Apigenin, Curcumin, Lycopene, Protocatechuic Acid, Catechol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Oncogenic Histone Methylation and others. Groundcherry is not recommended when risk of Epithelioid Trophoblastic Tumor when associated genetic risk is DNMT3A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GROUNDCHERRY FOR DNMT3A GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Vitamin C, Protocatechuic Acid, Catechol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Hypoxia and others. Nance is recommended for risk of Epithelioid Trophoblastic Tumor when associated genetic risk is DNMT3A. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lycopene, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended when risk of Epithelioid Trophoblastic Tumor when associated genetic risk is DNMT3A because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR DNMT3A GENETIC RISK OF CANCER.

Choose Nut BLACK WALNUT or CHINESE CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Protocatechuic Acid, Catechol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle Checkpoints, MYC Signaling and MAPK Signaling and others. Black Walnut is recommended for risk of Epithelioid Trophoblastic Tumor when associated genetic risk is DNMT3A. This is because Black Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chinese Chestnut are Apigenin, Curcumin, Lycopene, Protocatechuic Acid, Catechol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Oncogenic Histone Methylation and others. Chinese Chestnut is not recommended when risk of Epithelioid Trophoblastic Tumor when associated genetic risk is DNMT3A because it increases the signature pathways of it.

BLACK WALNUT IS RECOMMENDED OVER CHINESE CHESTNUT FOR DNMT3A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Epithelioid Trophoblastic Tumor. Epithelioid Trophoblastic Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Epithelioid Trophoblastic Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Broccoli contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Epithelioid Trophoblastic Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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