Foods for Adenoid Cystic Breast Cancer!

Introduction

Foods for Adenoid Cystic Breast Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Adenoid cystic breast cancer, a rare subtype of breast cancer also known as adenoid cystic carcinoma of the breast, presents unique challenges in terms of diagnosis, treatment, and prognosis. This type of breast cancer is characterized by its distinct cellular arrangement, resembling adenoid structures. The treatment for adenoid cystic breast cancer often involves a combination of surgery, radiation therapy, and, in some cases, chemotherapy, depending on the extent and characteristics of the tumor. The prognosis of patients with adenoid cystic carcinoma of the breast is generally more favorable compared to other types of breast cancer, owing to its typically slow-growing nature and lower tendency for metastasis. However, like all cancers, the prognosis can vary based on the cancer’s stage at diagnosis and the patient’s overall health. The management of adenoid cystic breast cancer requires a tailored approach, considering the tumor’s unique pathology and the patient’s individual circumstances, to optimize treatment outcomes and enhance the quality of life for those affected by this rare cancer subtype.

For Adenoid Cystic Breast Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Adenoid Cystic Breast Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Adenoid Cystic Breast Cancer?

For example does it matter if vegetable Kai-lan is consumed more compared to Daikon Radish? Does it make any difference if fruit Grapefruit is preferred over Sweet Rowanberry? Also if similar choices are made for nuts/seeds like Common Hazelnut over Brazil Nut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Adenoid Cystic Breast Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Adenoid Cystic Breast Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Isoliquiritigenin, Curcumin, Luteolin, Phloretin, Lupeol. And Sweet Rowanberry contains active ingredients Quercetin, Isoliquiritigenin, Caffeine, Curcumin, Apigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Adenoid Cystic Breast Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Adenoid Cystic Breast Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Adenoid Cystic Breast Cancer?

Personalized nutrition for cancers like Adenoid Cystic Breast Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Adenoid Cystic Breast Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Adenoid Cystic Breast Cancer

All cancers like Adenoid Cystic Breast Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Adenoid Cystic Breast Cancer. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, TGFB Signaling are part of the signature definition of Adenoid Cystic Breast Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Adenoid Cystic Breast Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Adenoid Cystic Breast Cancer when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

NOTCH1, CREBBP, MED12, FAT3 and PTEN are the top ranked reported genes for Adenoid Cystic Breast Cancer. NOTCH1 is reported in 17.1 % of the representative patients across all clinical trials. And CREBBP is reported in 17.1 %. The combined population patient data cover ages from 52 to 78. 2.2 % of the patient data are identified as men. The Adenoid Cystic Breast Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Adenoid Cystic Breast Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable KAI-LAN or DAIKON RADISH?

Vegetable Kai-lan contains many active ingredients or bioactives such as Quercetin, Isoliquiritigenin, Caffeine, Curcumin, Apigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Kai-lan is recommended for Adenoid Cystic Breast Cancer when ongoing cancer treatment is Radiation. This is because Kai-lan modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Isoliquiritigenin, Myricetin, Curcumin, Apigenin, Luteolin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, TGFB Signaling and DNA Repair and others. Daikon Radish is not recommended for Adenoid Cystic Breast Cancer when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE KAI-LAN IS RECOMMENDED OVER DAIKON RADISH FOR Adenoid Cystic Breast Cancer AND TREATMENT Radiation.

Choose Fruit SWEET ROWANBERRY or GRAPEFRUIT?

Fruit Sweet Rowanberry contains many active ingredients or bioactives such as Quercetin, Isoliquiritigenin, Caffeine, Curcumin, Apigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Sweet Rowanberry is recommended for Adenoid Cystic Breast Cancer when ongoing cancer treatment is Radiation. This is because Sweet Rowanberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Grapefruit are Isoliquiritigenin, Curcumin, Luteolin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Grapefruit is not recommended for Adenoid Cystic Breast Cancer when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SWEET ROWANBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Adenoid Cystic Breast Cancer AND TREATMENT Radiation.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Isoliquiritigenin, Caffeine, Myricetin, Curcumin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Common Hazelnut is recommended for Adenoid Cystic Breast Cancer when ongoing cancer treatment is Radiation. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Brazil Nut are Isoliquiritigenin, Ellagic Acid, Curcumin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling and Epithelial to Mesenchymal Transition and others. Brazil Nut is not recommended for Adenoid Cystic Breast Cancer when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR Adenoid Cystic Breast Cancer AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Adenoid Cystic Breast Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or AMERICAN POKEWEED?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, Cell Cycle Checkpoints, Notch Signaling and MYC Signaling and others. Wild Carrot is recommended for risk of Adenoid Cystic Breast Cancer when associated genetic risk is CREBBP. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and Retinoic Acid Signaling and others. American Pokeweed is not recommended when risk of Adenoid Cystic Breast Cancer when associated genetic risk is CREBBP because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER AMERICAN POKEWEED FOR CREBBP GENETIC RISK OF CANCER.

Choose Fruit TAMARIND or NANKING CHERRY?

Fruit Tamarind contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling and Apoptosis and others. Tamarind is recommended for risk of Adenoid Cystic Breast Cancer when associated genetic risk is CREBBP. This is because Tamarind increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Nanking Cherry are Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and Retinoic Acid Signaling and others. Nanking Cherry is not recommended when risk of Adenoid Cystic Breast Cancer when associated genetic risk is CREBBP because it increases the signature pathways of it.

FRUIT TAMARIND IS RECOMMENDED OVER NANKING CHERRY FOR CREBBP GENETIC RISK OF CANCER.

Choose Nut HAZELNUT or PILI NUT?

Hazelnut contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Inositol Phosphate Signaling, PI3K-AKT-MTOR Signaling and Apoptosis and others. Hazelnut is recommended for risk of Adenoid Cystic Breast Cancer when associated genetic risk is CREBBP. This is because Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Pili Nut are Curcumin, Apigenin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and Retinoic Acid Signaling and others. Pili Nut is not recommended when risk of Adenoid Cystic Breast Cancer when associated genetic risk is CREBBP because it increases the signature pathways of it.

HAZELNUT IS RECOMMENDED OVER PILI NUT FOR CREBBP GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Adenoid Cystic Breast Cancer. Adenoid Cystic Breast Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Adenoid Cystic Breast Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Kai-lan contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Adenoid Cystic Breast Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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