Which Foods are Recommended for Adenoid Cystic Breast Cancer?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Adenoid Cystic Breast Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Adenoid Cystic Breast Cancer because of NOTCH1 and CREBBP gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Adenoid Cystic Breast Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Caffeine and Black Seed supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ADENOID CYSTIC BREAST CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Adenoid Cystic Breast Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ADENOID CYSTIC BREAST CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Adenoid Cystic Breast Cancer

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Adenoid Cystic Breast Cancer from cBioPortal. The patients enrolled in the studies for Adenoid Cystic Breast Cancer are in ages between 52 to 78 with an average age of 62. 2.2% of males and 97.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 53; the top genes with mutations and other abnormalities for Adenoid Cystic Breast Cancer include genes NOTCH1, CREBBP, MED12, FAT3 and PTEN. The occurrence frequency distribution for these genes respectively is 17.1%, 17.1%, 14.3%, 11.4% and 8.6%. These tumor genetic details of Adenoid Cystic Breast Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Adenoid Cystic Breast Cancer.

Significance of Nutrition for Adenoid Cystic Breast Cancer

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Adenoid Cystic Breast Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Oleic Acid, Beta-sitosterol, Vitamin C, Salicylic Acid and others. And Apple contains active ingredients Phloretin, Fisetin, Caffeic Acid, Maslinic Acid, Rhamnetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Adenoid Cystic Breast Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, TGFB Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Adenoid Cystic Breast Cancer, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ADENOID CYSTIC BREAST CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Adenoid Cystic Breast Cancer undergoing chemotherapy treatment

In Adenoid Cystic Breast Cancer – the genes NOTCH1, CREBBP, MED12, FAT3 and PTEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Adenoid Cystic Breast Cancer are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lentils?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Oleic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Lentils are Isoliquiritigenin, Ellagic Acid, Daidzein, Oleic Acid, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.

Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. And so on.

When treating Adenoid Cystic Breast Cancer with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lentils. This is because the active ingredients Isoliquiritigenin and Ellagic Acid in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LENTILS FOR ADENOID CYSTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Vitamin C, Isorhamnetin among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Kaempferol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adenoid Cystic Breast Cancer with chemotherapy Radiation – Foods like Cabbage are recommended compared to Endive. This is because the active ingredients Vitamin A and Quercetin in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER ENDIVE FOR ADENOID CYSTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Apple or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Apple are Phloretin, Fisetin, Caffeic Acid, Maslinic Acid, Rhamnetin among others. While the active ingredients contained in Apricot are Quercetin, Oleic Acid, Beta-sitosterol, Vitamin C, Salicylic Acid and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Cell Cycle. Phloretin has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Rutin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adenoid Cystic Breast Cancer with chemotherapy Radiation – Foods like Apple are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Phloretin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: APPLE IS RECOMMENDED OVER APRICOT FOR ADENOID CYSTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Linolenic Acid, Delphinidin, Cianidanol among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Beta-sitosterol, Salicylic Acid, Linolenic Acid, Stigmasterol and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Delphinidin has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Adenoid Cystic Breast Cancer with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR ADENOID CYSTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Adenoid Cystic Breast Cancer

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH1 and CREBBP are two genes whose abnormalities are risk factors for Adenoid Cystic Breast Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Adenoid Cystic Breast Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Adenoid Cystic Breast Cancer gene NOTCH1 has causative impact on biological pathways like Notch Signaling and RUNX Signaling. And CREBBP has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and Immune Evasion Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH1 and CREBBP should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH1 and CREBBP should be avoided.

Eat more pulses, Scarlet Bean or Chickpea?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Adenoid Cystic Breast Cancer due to abnormalities in genes NOTCH1 and CREBBP – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC BREAST CANCER DUE TO GENES NOTCH1 AND CREBBP

Eat more vegetables, Milk Thistle or Beetroot?

The active ingredients contained in Milk Thistle are Vitamin E, Silibinin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C and others.

Silibinin can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and RUNX Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Adenoid Cystic Breast Cancer due to abnormalities in genes NOTCH1 and CREBBP – Foods like Milk Thistle are recommended compared to Beetroot. This is because the active ingredients Vitamin A and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Silibinin and Vitamin E contained in Milk Thistle together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC BREAST CANCER DUE TO GENES NOTCH1 AND CREBBP

Eat more fruits, Cherimoya or Cranberry?

The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Hyperoside, P-coumaric Acid, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Adenoid Cystic Breast Cancer due to abnormalities in genes NOTCH1 and CREBBP – Foods like Cherimoya are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC BREAST CANCER DUE TO GENES NOTCH1 AND CREBBP

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Rhamnetin, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Adenoid Cystic Breast Cancer due to abnormalities in genes NOTCH1 and CREBBP – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC BREAST CANCER DUE TO GENES NOTCH1 AND CREBBP

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Adenoid Cystic Breast Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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