Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Cervical Neuroendocrine Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Cervical Neuroendocrine Tumor because of BRD4 and FAT3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Cervical Neuroendocrine Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Grape” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Tangerine and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CERVICAL NEUROENDOCRINE TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Cervical Neuroendocrine Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CERVICAL NEUROENDOCRINE TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Cervical Neuroendocrine Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Cervical Neuroendocrine Tumor from cBioPortal. The patients enrolled in the studies for Cervical Neuroendocrine Tumor are in ages between 27 to 27 with an average age of 27.From a patient sample size of 1; the top genes with mutations and other abnormalities for Cervical Neuroendocrine Tumor include genes BRD4, FAT3, HKDC1, ITPA and PNPLA6. The occurrence frequency distribution for these genes respectively is 100.0%, 100.0%, 100.0%, 100.0% and 100.0%. These tumor genetic details of Cervical Neuroendocrine Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Cervical Neuroendocrine Tumor.
Significance of Nutrition for Cervical Neuroendocrine Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Cervical Neuroendocrine Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Grape includes active ingredients Lupeol, Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C and others. And Graviola contains active ingredients Emodin, Lycopene, Vitamin E, Daidzein, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Cervical Neuroendocrine Tumor, activation or inhibition of selected biochemical pathways like Cell Cycle, Cell Cycle Checkpoints, DNA Repair, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Cervical Neuroendocrine Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CERVICAL NEUROENDOCRINE TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Cervical Neuroendocrine Tumor undergoing chemotherapy treatment
In Cervical Neuroendocrine Tumor – the genes BRD4, FAT3, HKDC1, ITPA and PNPLA6 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Cervical Neuroendocrine Tumor are Cell Cycle, Cell Cycle Checkpoints, Apoptosis and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Linolenic Acid, Stigmasterol, Vitamin C, Vitexin, Quercetin among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Ferulic Acid and others.
Stigmasterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways Apoptosis, Cell Cycle and Cell Cycle Checkpoints.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Cervical Neuroendocrine Tumor with chemotherapy Cisplatin – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Stigmasterol and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR CERVICAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Sweet Potato or Bell Pepper?
Vegetables are an important part of many diets. The active ingredients contained in Sweet Potato are Beta-sitosterol, Linolenic Acid, Vitamin C, Quercetin, Oleic Acid among others. While the active ingredients contained in Bell Pepper are Capsaicin, Vitamin E, P-coumaric Acid, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin A has biological action on biochemical pathways Apoptosis, Cell Cycle and MYC Signaling.
Capsaicin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways P53 Signaling, MYC Signaling and Apoptosis. And so on.
When treating Cervical Neuroendocrine Tumor with chemotherapy Cisplatin – Foods like Sweet Potato are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Sweet Potato support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SWEET POTATO IS RECOMMENDED OVER BELL PEPPER FOR CERVICAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Graviola or Grape?
Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Lycopene, Vitamin E, Daidzein, Beta-sitosterol among others. While the active ingredients contained in Grape are Lupeol, Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C and others.
Emodin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Cinnamic Acid has biological action on biochemical pathways Apoptosis, Cell Cycle and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pterostilbene has biological action on biochemical pathways DNA Repair. And so on.
When treating Cervical Neuroendocrine Tumor with chemotherapy Cisplatin – Foods like Graviola are recommended compared to Grape. This is because the active ingredients Resveratrol and Pterostilbene in Grape interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Cinnamic Acid contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER GRAPE FOR CERVICAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin B3 among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Apoptosis, Cell Cycle and Cell Cycle Checkpoints.
Lauric Acid can manipulate biochemical pathways MYC Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, P53 Signaling and Apoptosis. And so on.
When treating Cervical Neuroendocrine Tumor with chemotherapy Cisplatin – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR CERVICAL NEUROENDOCRINE TUMOR ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Cervical Neuroendocrine Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRD4 and FAT3 are two genes whose abnormalities are risk factors for Cervical Neuroendocrine Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Cervical Neuroendocrine Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Cervical Neuroendocrine Tumor gene BRD4 has causative impact on biological pathways like Chromatin Remodeling, DNA Repair and Epithelial to Mesenchymal Transition. And FAT3 has a causative impact on biological pathways like Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRD4 and FAT3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRD4 and FAT3 should be avoided.
Eat more pulses, Yellow Wax Bean or Pigeon Pea?
The active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Ferulic Acid, Palmitic Acid, Butyric Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.
Palmitic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Folic Acid can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. And so on.
For genetic risk of Cervical Neuroendocrine Tumor due to abnormalities in genes BRD4 and FAT3 – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF CERVICAL NEUROENDOCRINE TUMOR DUE TO GENES BRD4 AND FAT3
Eat more vegetables, Giant Butterbur or Radish?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Radish are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Salicylic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Cervical Neuroendocrine Tumor due to abnormalities in genes BRD4 and FAT3 – Foods like Giant Butterbur are recommended compared to Radish. This is because the active ingredients Pelargonidin and Salicylic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF CERVICAL NEUROENDOCRINE TUMOR DUE TO GENES BRD4 AND FAT3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Cranberry?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Hyperoside, Vitamin C, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Cervical Neuroendocrine Tumor due to abnormalities in genes BRD4 and FAT3 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF CERVICAL NEUROENDOCRINE TUMOR DUE TO GENES BRD4 AND FAT3
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Quercetin and others.
Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Apoptosis and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Cervical Neuroendocrine Tumor due to abnormalities in genes BRD4 and FAT3 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF CERVICAL NEUROENDOCRINE TUMOR DUE TO GENES BRD4 AND FAT3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Cervical Neuroendocrine Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.