Which Foods are Recommended for Breast Angiosarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Breast Angiosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Breast Angiosarcoma because of PPM1D and AMER1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Breast Angiosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Date in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Damiana and Senna supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BREAST ANGIOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Breast Angiosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR BREAST ANGIOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Breast Angiosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Breast Angiosarcoma from cBioPortal. The top genes with mutations and other abnormalities for Breast Angiosarcoma include genes DNMT3A, TET2, PPM1D, AMER1 and EPHB1. The occurrence frequency distribution for these genes respectively is 42.9%, 35.7%, 14.3%, 7.1% and 7.1%. These tumor genetic details of Breast Angiosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Breast Angiosarcoma.

Breast angiosarcoma is a rare and aggressive type of cancer that develops in the blood vessels of the breast. It is often diagnosed through imaging tests such as MRI or ultrasound and confirmed through biopsy. There can be primary or secondary types of angiosarcoma of the breast. Primary breast angiosarcoma develops in people who have never been treated for breast cancer and it may present with a lump in the breast, discolored rash or bruised appearance on the skin or the breast or arm or a thickened area of skin on the breast. The secondary breast angiosarcoma occurs in patients previously treated for breast cancer and its symptoms can include a painful lump in the breast, a swelling in the breast or arm or a discolored rash similar to the primary breast angiosarcoma. Breast angiosarcomas are diagnosed with mammograms, breast MRI, PET scan or ultrasound and may even require a biopsy. Surgical removal of the tumor is the standard treatment for angiosarcoma of the breast, with a focus on achieving clear margins. Chemotherapy and radiation therapy may be used after surgery as part of the treatment plan. The life expectancy for individuals with angiosarcoma of the breast can vary widely depending on factors such as the stage of the disease and the presence of metastases. In addition, supportive care with optimal nutrition (foods and natural supplements) can help with improving the patients’ well-being. (Ref: https://www.hopkinsmedicine.org/health/conditions-and-diseases/breast-cancer/angiosarcoma-of-the-breast; https://www.cancer.org/cancer/breast-cancer/about/types-of-breast-cancer/angiosarcoma-of-the-breast.html; https://www.medicalnewstoday.com/articles/angiosarcoma-of-the-breast)

Significance of Nutrition for Breast Angiosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Breast Angiosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Strawberry includes active ingredients Ellagic Acid, Vitamin C, Lupeol, Beta-sitosterol, Linolenic Acid and others. And Date contains active ingredients Apigenin, Quercetin, Vitamin C, Protocatechuic Acid, Lupeol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Breast Angiosarcoma, activation or inhibition of selected biochemical pathways like Angiogenesis, Hypoxia, Oncogenic Cancer Epigenetics, JAK-STAT Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Breast Angiosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BREAST ANGIOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Breast Angiosarcoma undergoing chemotherapy treatment

In Breast Angiosarcoma – the genes DNMT3A, TET2, PPM1D, AMER1 and EPHB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Breast Angiosarcoma are Angiogenesis, Hypoxia, JAK-STAT Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Angiogenesis, Hypoxia, JAK-STAT Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Stigmasterol, Vitamin C, Vitexin, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Stigmasterol, Vitamin C, Linolenic Acid, Beta-sitosterol and others.

Quercetin can manipulate biochemical pathways Angiogenesis, MYC Signaling and Hypoxia. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, Angiogenesis and MYC Signaling.

Folic Acid can manipulate biochemical pathways MYC Signaling and JAK-STAT Signaling. And so on.

When treating Breast Angiosarcoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Fava Bean. This is because the active ingredients Folic Acid in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Stigmasterol contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER FAVA BEAN FOR BREAST ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Celery?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Vitamin C, Protocatechuic Acid, Chlorogenic Acid, Beta-carotene among others. While the active ingredients contained in Celery are Quercetin, Apigenin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Quercetin can manipulate biochemical pathways Angiogenesis, MYC Signaling and Hypoxia. Vitamin C has biological action on biochemical pathways Angiogenesis, MYC Signaling and Hypoxia.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

When treating Breast Angiosarcoma with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER CELERY FOR BREAST ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Date or Strawberry?

Fruits are an important part of many diets. The active ingredients contained in Date are Apigenin, Quercetin, Vitamin C, Protocatechuic Acid, Lupeol among others. While the active ingredients contained in Strawberry are Ellagic Acid, Vitamin C, Lupeol, Beta-sitosterol, Linolenic Acid and others.

Apigenin can manipulate biochemical pathways MYC Signaling, Hypoxia and JAK-STAT Signaling. Quercetin has biological action on biochemical pathways Angiogenesis, MYC Signaling and Hypoxia.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Breast Angiosarcoma with chemotherapy Radiation – Foods like Date are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Apigenin and Quercetin contained in Date support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: DATE IS RECOMMENDED OVER STRAWBERRY FOR BREAST ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Stigmasterol, Vitamin E, Resveratrol, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Angiogenesis, MYC Signaling and Hypoxia. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, Angiogenesis and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and JAK-STAT Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and JAK-STAT Signaling. And so on.

When treating Breast Angiosarcoma with chemotherapy Radiation – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR BREAST ANGIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Breast Angiosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PPM1D and AMER1 are two genes whose abnormalities are risk factors for Breast Angiosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Breast Angiosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Breast Angiosarcoma gene PPM1D has causative impact on biological pathways like DNA Repair. And AMER1 has a causative impact on biological pathways . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PPM1D and AMER1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PPM1D and AMER1 should be avoided.

Eat more pulses, Lentils or Common Bean?

The active ingredients contained in Lentils are Esculin, Daidzein, Oleic Acid, Ellagic Acid, Beta-sitosterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Oleic Acid, Vitamin C, Linolenic Acid and others.

Esculin can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Daidzein has biological action on biochemical pathways Hedgehog Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Breast Angiosarcoma due to abnormalities in genes PPM1D and AMER1 – Foods like Lentils are recommended compared to Common Bean. This is because the active ingredients Ferulic Acid and Pelargonidin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Esculin and Daidzein contained in Lentils together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LENTILS IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF BREAST ANGIOSARCOMA DUE TO GENES PPM1D AND AMER1

Eat more vegetables, Cassava or Onion?

The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Onion are Beta-sitosterol, Protocatechuic Acid, Vitamin C, Linolenic Acid, Diallyl Disulfide and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Diallyl Disulfide can manipulate biochemical pathways DNA Repair. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Breast Angiosarcoma due to abnormalities in genes PPM1D and AMER1 – Foods like Cassava are recommended compared to Onion. This is because the active ingredients Diallyl Disulfide and Myricetin in Onion further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER ONION FOR REDUCING THE GENETIC RISK OF BREAST ANGIOSARCOMA DUE TO GENES PPM1D AND AMER1

Eat more fruits, Star Fruit or Raspberry?

The active ingredients contained in Star Fruit are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Epigallocatechin Gallate among others. While the active ingredients contained in Raspberry are Resveratrol, Ellagic Acid, Vitamin C, Quercetin, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Breast Angiosarcoma due to abnormalities in genes PPM1D and AMER1 – Foods like Star Fruit are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Star Fruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: STAR FRUIT IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF BREAST ANGIOSARCOMA DUE TO GENES PPM1D AND AMER1

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Oleic Acid, Vitamin E, Linolenic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Chestnut are Oleic Acid, Ellagic Acid, Vitamin C, Linolenic Acid, Linoleic Acid and others.

Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Breast Angiosarcoma due to abnormalities in genes PPM1D and AMER1 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF BREAST ANGIOSARCOMA DUE TO GENES PPM1D AND AMER1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Breast Angiosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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