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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Well Differentiated Liposarcoma?

Aug 25, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Well Differentiated Liposarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Well Differentiated Liposarcoma because of FGFR1 and TNFAIP3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Well Differentiated Liposarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Strawberry Guava” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Arugula” or “Can I take Banaba and Caffeine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO WELL DIFFERENTIATED LIPOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Well Differentiated Liposarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR WELL DIFFERENTIATED LIPOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Well Differentiated Liposarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Well Differentiated Liposarcoma from cBioPortal. 55.2% of males and 44.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 131; the top genes with mutations and other abnormalities for Well Differentiated Liposarcoma include genes FGFR1, TNFAIP3, COL1A1, MDM2 and TGFBR1. The occurrence frequency distribution for these genes respectively is 6.7%, 3.3%, 3.3%, 3.3% and 3.3%. These tumor genetic details of Well Differentiated Liposarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Well Differentiated Liposarcoma.

Significance of Nutrition for Well Differentiated Liposarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Well Differentiated Liposarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Strawberry Guava includes active ingredients Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A and others. And Pomegranate contains active ingredients Ellagic Acid, Apigenin, Methyl Gallate, Beta-sitosterol, Betulinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Well Differentiated Liposarcoma, activation or inhibition of selected biochemical pathways like mRNA Splicing, Cell Cycle, PI3K-AKT-MTOR Signaling, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Well Differentiated Liposarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Well Differentiated Liposarcoma, activation or inhibition of selected biochemical pathways like mRNA Splicing, Cell Cycle, PI3K-AKT-MTOR Signaling, Growth Factor Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR WELL DIFFERENTIATED LIPOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Well Differentiated Liposarcoma undergoing chemotherapy treatment

In Well Differentiated Liposarcoma – the genes FGFR1, TNFAIP3, COL1A1, MDM2 and TGFBR1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Well Differentiated Liposarcoma are mRNA Splicing, Cell Cycle, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers mRNA Splicing, Cell Cycle, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Vitamin A, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Well Differentiated Liposarcoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR WELL DIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Asparagus or Arugula?

Vegetables are an important part of many diets. The active ingredients contained in Asparagus are Isorhamnetin, Quercetin, Oleic Acid, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Arugula are Vitamin A, Kaempferol, Esculin, Vitamin K, Erysolin and others.

Isorhamnetin can manipulate biochemical pathways Cell Cycle, MAPK Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling, Cell Cycle and MAPK Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Esculin has biological action on biochemical pathways DNA Repair and TGFB Signaling. And so on.

When treating Well Differentiated Liposarcoma with chemotherapy Radiation – Foods like Asparagus are recommended compared to Arugula. This is because the active ingredients Vitamin A and Esculin in Arugula interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Isorhamnetin and Quercetin contained in Asparagus support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER ARUGULA FOR WELL DIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Well Differentiated Liposarcoma?

Eat more fruits, Pomegranate or Strawberry Guava?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Ellagic Acid, Apigenin, Methyl Gallate, Beta-sitosterol, Betulinic Acid among others. While the active ingredients contained in Strawberry Guava are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A and others.

Betulinic Acid can manipulate biochemical pathways Cell Cycle, MAPK Signaling and PI3K-AKT-MTOR Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, TGFB Signaling and Cell Cycle.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.

When treating Well Differentiated Liposarcoma with chemotherapy Radiation – Foods like Pomegranate are recommended compared to Strawberry Guava. This is because the active ingredients Vitamin A and Linoleic Acid in Strawberry Guava interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER STRAWBERRY GUAVA FOR WELL DIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways Cell Cycle, MAPK Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling, Cell Cycle and MAPK Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Well Differentiated Liposarcoma with chemotherapy Radiation – Foods like Hazelnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR WELL DIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Well Differentiated Liposarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FGFR1 and TNFAIP3 are two genes whose abnormalities are risk factors for Well Differentiated Liposarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Well Differentiated Liposarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Well Differentiated Liposarcoma gene FGFR1 has causative impact on biological pathways like Angiogenesis, MAPK Signaling and Growth Factor Signaling. And TNFAIP3 has a causative impact on biological pathways like Cytokine Signaling, Antigen Presentation and NFKB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FGFR1 and TNFAIP3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FGFR1 and TNFAIP3 should be avoided.

Eat more pulses, Hyacinth Bean or Chickpea?

The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Myristic Acid, Folic Acid among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.

Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Well Differentiated Liposarcoma due to abnormalities in genes FGFR1 and TNFAIP3 – Foods like Hyacinth Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF WELL DIFFERENTIATED LIPOSARCOMA DUE TO GENES FGFR1 AND TNFAIP3

Eat more vegetables, Cassava or Broccoli?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Broccoli are Vitamin C, Ferulic Acid, Linolenic Acid, Oleic Acid, Brassinin and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and P53 Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Well Differentiated Liposarcoma due to abnormalities in genes FGFR1 and TNFAIP3 – Foods like Cassava are recommended compared to Broccoli. This is because the active ingredients Vitamin A and Folic Acid in Broccoli further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BROCCOLI FOR REDUCING THE GENETIC RISK OF WELL DIFFERENTIATED LIPOSARCOMA DUE TO GENES FGFR1 AND TNFAIP3

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Cloudberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cloudberry are Vitamin C, Ellagic Acid, Urolithin B, Vitamin A and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Well Differentiated Liposarcoma due to abnormalities in genes FGFR1 and TNFAIP3 – Foods like Feijoa are recommended compared to Cloudberry. This is because the active ingredients Vitamin A and Ellagic Acid in Cloudberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CLOUDBERRY FOR REDUCING THE GENETIC RISK OF WELL DIFFERENTIATED LIPOSARCOMA DUE TO GENES FGFR1 AND TNFAIP3

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways Growth Factor Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Notch Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Well Differentiated Liposarcoma due to abnormalities in genes FGFR1 and TNFAIP3 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF WELL DIFFERENTIATED LIPOSARCOMA DUE TO GENES FGFR1 AND TNFAIP3


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Well Differentiated Liposarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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