Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Peripheral T-cell Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Peripheral T-cell Lymphoma because of RHOA and IDH2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Peripheral T-cell Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Rambutan in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Wheatgrass and Vitamin C supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PERIPHERAL T-CELL LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Peripheral T-cell Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PERIPHERAL T-CELL LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Peripheral T-cell Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Peripheral T-cell Lymphoma from cBioPortal. 61.5% of males and 38.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 13; the top genes with mutations and other abnormalities for Peripheral T-cell Lymphoma include genes TET2, RHOA, TP53, DNMT3A and IDH2. The occurrence frequency distribution for these genes respectively is 61.5%, 61.5%, 23.1%, 15.4% and 15.4%. These tumor genetic details of Peripheral T-cell Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Peripheral T-cell Lymphoma.
Significance of Nutrition for Peripheral T-cell Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Peripheral T-cell Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Ellagic Acid, Vitamin C, Hyperoside, Quercetin, Resveratrol and others. And Rambutan contains active ingredients Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Peripheral T-cell Lymphoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics, Cytoskeletal Dynamics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Peripheral T-cell Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PERIPHERAL T-CELL LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Peripheral T-cell Lymphoma undergoing chemotherapy treatment
In Peripheral T-cell Lymphoma – the genes TET2, RHOA, TP53, DNMT3A and IDH2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Peripheral T-cell Lymphoma are MAPK Signaling, Cell Cycle Checkpoints, Apoptosis and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Linolenic Acid, Beta-sitosterol, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Survival, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways DNA Repair. And so on.
When treating Peripheral T-cell Lymphoma with chemotherapy Doxorubicin – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR PERIPHERAL T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Vitamin C, Linolenic Acid, Beta-sitosterol, Brassinin, Oleic Acid among others. While the active ingredients contained in Endive are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Brassinin has biological action on biochemical pathways Cell Survival, Cell Cycle Checkpoints and MAPK Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. And so on.
When treating Peripheral T-cell Lymphoma with chemotherapy Doxorubicin – Foods like Kohlrabi are recommended compared to Endive. This is because the active ingredients Vitamin A and Folic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER ENDIVE FOR PERIPHERAL T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Rambutan or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Rambutan are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Vitamin C, Hyperoside, Quercetin, Resveratrol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Linolenic Acid has biological action on biochemical pathways Cell Survival, Notch Signaling and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
When treating Peripheral T-cell Lymphoma with chemotherapy Doxorubicin – Foods like Rambutan are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Linolenic Acid contained in Rambutan support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RAMBUTAN IS RECOMMENDED OVER CRANBERRY FOR PERIPHERAL T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Vitamin C, Linolenic Acid, Rhamnetin, Beta-sitosterol and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Survival and Notch Signaling. Quercetin has biological action on biochemical pathways DNA Repair, Growth Factor Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Peripheral T-cell Lymphoma with chemotherapy Doxorubicin – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR PERIPHERAL T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Peripheral T-cell Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RHOA and IDH2 are two genes whose abnormalities are risk factors for Peripheral T-cell Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Peripheral T-cell Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Peripheral T-cell Lymphoma gene RHOA has causative impact on biological pathways like Cytoskeletal Dynamics, Adherens junction and cGMP Signaling. And IDH2 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RHOA and IDH2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RHOA and IDH2 should be avoided.
Eat more pulses, Common Pea or Yellow Wax Bean?
The active ingredients contained in Common Pea are Lupeol, Vitamin C, Daidzein, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Ferulic Acid, Butyric Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oncogenic Cancer Epigenetics.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Peripheral T-cell Lymphoma due to abnormalities in genes RHOA and IDH2 – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF PERIPHERAL T-CELL LYMPHOMA DUE TO GENES RHOA AND IDH2
Eat more vegetables, Bitter Melon or Yardlong Bean?
The active ingredients contained in Bitter Melon are Vitamin C, Cianidanol, Oleic Acid, Cucurbitacin E, Caffeic Acid among others. While the active ingredients contained in Yardlong Bean are Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Netrin Signaling and MYC Signaling.
Oleic Acid can manipulate biochemical pathways Cytoskeletal Dynamics and Netrin Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Peripheral T-cell Lymphoma due to abnormalities in genes RHOA and IDH2 – Foods like Bitter Melon are recommended compared to Yardlong Bean. This is because the active ingredients Oleic Acid and Folic Acid in Yardlong Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cianidanol contained in Bitter Melon together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BITTER MELON IS RECOMMENDED OVER YARDLONG BEAN FOR REDUCING THE GENETIC RISK OF PERIPHERAL T-CELL LYMPHOMA DUE TO GENES RHOA AND IDH2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Blueberry or Fig?
The active ingredients contained in Blueberry are Resveratrol, Vitamin C, Quercetin, Vitamin E, Cianidanol among others. While the active ingredients contained in Fig are Lupeol, Vitamin C, Beta-sitosterol, Psoralen, Bergapten and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Netrin Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Peripheral T-cell Lymphoma due to abnormalities in genes RHOA and IDH2 – Foods like Blueberry are recommended compared to Fig. This is because the active ingredients Palmitic Acid and Lauric Acid in Fig further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cianidanol contained in Blueberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER FIG FOR REDUCING THE GENETIC RISK OF PERIPHERAL T-CELL LYMPHOMA DUE TO GENES RHOA AND IDH2
Eat more nuts, Pine Nut or Pumpkin Seeds?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Gamma-linolenic Acid, Beta-sitosterol, Linolenic Acid, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, Cytoskeletal Dynamics and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways Cell Junctions, MYC Signaling and Cytoskeletal Dynamics. And so on.
For genetic risk of Peripheral T-cell Lymphoma due to abnormalities in genes RHOA and IDH2 – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR REDUCING THE GENETIC RISK OF PERIPHERAL T-CELL LYMPHOMA DUE TO GENES RHOA AND IDH2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Peripheral T-cell Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Alpha-linolenic acid based nano-suspension protect against lipopolysaccharides induced mastitis by inhibiting NFκBp65, HIF-1α, and mitochondria-mediated apoptotic pathway in albino Wistar rats.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Clinical pharmacodynamics of antihistamines.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Research progress on the anticancer effects of vitamin K2.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Promise of bitter melon (Momordica charantia) bioactives in cancer prevention and therapy.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.