Which Foods are Recommended for Primary Central Nervous System Lymphoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Primary Central Nervous System Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Primary Central Nervous System Lymphoma because of MYD88 and PIM1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Primary Central Nervous System Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Green Bean” or “Can I take Vitamin E and Tangerine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Primary Central Nervous System Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Primary Central Nervous System Lymphoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Primary Central Nervous System Lymphoma from cBioPortal. The patients enrolled in the studies for Primary Central Nervous System Lymphoma are in ages between 54 to 83 with an average age of 68. 44.4% of males and 55.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 19; the top genes with mutations and other abnormalities for Primary Central Nervous System Lymphoma include genes MYD88, PIM1, CD79B, FAT4 and TCL1A. The occurrence frequency distribution for these genes respectively is 70.0%, 40.0%, 40.0%, 30.0% and 30.0%. These tumor genetic details of Primary Central Nervous System Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Primary Central Nervous System Lymphoma.

Significance of Nutrition for Primary Central Nervous System Lymphoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Primary Central Nervous System Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Linolenic Acid, Stigmasterol, Beta-sitosterol, Oleic Acid and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Primary Central Nervous System Lymphoma, activation or inhibition of selected biochemical pathways like Apoptosis, MAPK Signaling, NFKB Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Primary Central Nervous System Lymphoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Primary Central Nervous System Lymphoma undergoing chemotherapy treatment

In Primary Central Nervous System Lymphoma – the genes MYD88, PIM1, CD79B, FAT4 and TCL1A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Primary Central Nervous System Lymphoma are Apoptosis, MAPK Signaling, Glutathione Metabolism and others. Epirubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, MAPK Signaling, Glutathione Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Moth Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Linolenic Acid, Lupeol, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Stigmasterol, Beta-sitosterol, Oleic Acid, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Stigmasterol can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Glutathione Metabolism, Focal Adhesion and Oxidative Stress. And so on.

When treating Primary Central Nervous System Lymphoma with chemotherapy Epirubicin – Foods like Common Pea are recommended compared to Moth Bean. This is because the active ingredients Stigmasterol and Vitamin A in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER MOTH BEAN FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY EPIRUBICIN FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Green Bean?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Linolenic Acid, Brassinin, Beta-sitosterol, Oleic Acid, Kaempferol among others. While the active ingredients contained in Green Bean are Linolenic Acid, Astragalin, Beta-sitosterol, Ferulic Acid, Oleic Acid and others.

Brassinin can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Oxidative Stress, Glutathione Metabolism and Focal Adhesion. Ferulic Acid has biological action on biochemical pathways Oxidative Stress and Glutathione Metabolism. And so on.

When treating Primary Central Nervous System Lymphoma with chemotherapy Epirubicin – Foods like Kohlrabi are recommended compared to Green Bean. This is because the active ingredients Vitamin A and Ferulic Acid in Green Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER GREEN BEAN FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY EPIRUBICIN FOR SOME CONDITIONS.

Eat more fruits, Saskatoon Berry or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Apricot are Quercetin, Linolenic Acid, Stigmasterol, Beta-sitosterol, Oleic Acid and others.

Delphinidin can manipulate biochemical pathways NFKB Signaling, MYC Signaling and MAPK Signaling. Quercetin has biological action on biochemical pathways Apoptosis, DNA Repair and Cell Cycle.

Rutin can manipulate biochemical pathways Glutathione Metabolism and Focal Adhesion. Stigmasterol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Primary Central Nervous System Lymphoma with chemotherapy Epirubicin – Foods like Saskatoon Berry are recommended compared to Apricot. This is because the active ingredients Rutin and Stigmasterol in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER APRICOT FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY EPIRUBICIN FOR SOME CONDITIONS.

Eat more nuts, Almond or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Stigmasterol, Beta-sitosterol among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Beta-sitosterol, Beta-carotene, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Quercetin has biological action on biochemical pathways DNA Repair, Cell Survival and MYC Signaling.

Gallic Acid can manipulate biochemical pathways Glutathione Metabolism. Beta-carotene has biological action on biochemical pathways Oxidative Stress and MAPK Signaling. And so on.

When treating Primary Central Nervous System Lymphoma with chemotherapy Epirubicin – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY EPIRUBICIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Primary Central Nervous System Lymphoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYD88 and PIM1 are two genes whose abnormalities are risk factors for Primary Central Nervous System Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Primary Central Nervous System Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Primary Central Nervous System Lymphoma gene MYD88 has causative impact on biological pathways like Cytokine Signaling, Inflammation and Antigen Presentation. And PIM1 has a causative impact on biological pathways like Cytokine Signaling and JAK-STAT Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYD88 and PIM1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYD88 and PIM1 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Linolenic Acid, Vitamin C, Stigmasterol, Linoleic Acid, Liquiritigenin among others. While the active ingredients contained in Soy Bean are Quercetin, Ferulic Acid, Linolenic Acid, Vitamin E, Vitamin C and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and Apoptosis. Liquiritigenin has biological action on biochemical pathways NFKB Signaling, Notch Signaling and MAPK Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways Growth Factor Signaling, Apoptosis and MAPK Signaling. And so on.

For genetic risk of Primary Central Nervous System Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Folic Acid in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Liquiritigenin contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA DUE TO GENES MYD88 AND PIM1

Eat more vegetables, Burdock or Carob?

The active ingredients contained in Burdock are Chlorogenic Acid, Linolenic Acid, Dehydrocostus Lactone, Lupeol, Arctigenin among others. While the active ingredients contained in Carob are Quercetin, Gallic Acid, Phloroglucinol, Myricetin, Palmitic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and NFKB Signaling. Caffeic Acid has biological action on biochemical pathways NFKB Signaling and MAPK Signaling.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and Chromatin Remodeling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Primary Central Nervous System Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Burdock are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Caffeic Acid contained in Burdock together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BURDOCK IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA DUE TO GENES MYD88 AND PIM1

Eat more fruits, Raspberry or Plum?

The active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Salicylic Acid, Gallic Acid, Vitamin C among others. While the active ingredients contained in Plum are Quercetin, Chlorogenic Acid, Melatonin, Vitamin C, Betulinic Acid and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Apoptosis and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and Apoptosis.

Myristic Acid can manipulate biochemical pathways Apoptosis, MAPK Signaling and Notch Signaling. Palmitic Acid has biological action on biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and Chromatin Remodeling. And so on.

For genetic risk of Primary Central Nervous System Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Raspberry are recommended compared to Plum. This is because the active ingredients Myristic Acid and Palmitic Acid in Plum further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER PLUM FOR REDUCING THE GENETIC RISK OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA DUE TO GENES MYD88 AND PIM1

Eat more nuts, Pecan Nut or Pumpkin Seeds?

The active ingredients contained in Pecan Nut are Linolenic Acid, Vitamin E, Delphinidin, Linoleic Acid, Cianidanol among others. While the active ingredients contained in Pumpkin Seeds are Salicylic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid, Gamma-linolenic Acid and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and MAPK Signaling. Delphinidin has biological action on biochemical pathways Growth Factor Signaling, NFKB Signaling and MAPK Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling and MAPK Signaling. Cucurbitacin I has biological action on biochemical pathways NFKB Signaling. And so on.

For genetic risk of Primary Central Nervous System Lymphoma due to abnormalities in genes MYD88 and PIM1 – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR REDUCING THE GENETIC RISK OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA DUE TO GENES MYD88 AND PIM1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Primary Central Nervous System Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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