Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Follicular Thyroid Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Follicular Thyroid Cancer because of EPHB1 and HRAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Follicular Thyroid Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Neem Extract and Lavender supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO FOLLICULAR THYROID CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Follicular Thyroid Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR FOLLICULAR THYROID CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Follicular Thyroid Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Follicular Thyroid Cancer from cBioPortal. The patients enrolled in the studies for Follicular Thyroid Cancer are in ages between 17 to 70 with an average age of 50. 27.3% of males and 72.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Follicular Thyroid Cancer include genes EPHB1, HRAS, BRAF, TERT and ATP12A. The occurrence frequency distribution for these genes respectively is 10.5%, 10.5%, 10.5%, 10.5% and 5.3%. These tumor genetic details of Follicular Thyroid Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Follicular Thyroid Cancer.
Significance of Nutrition for Follicular Thyroid Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Follicular Thyroid Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Vitamin C, Quercetin, Ferulic Acid, Caffeic Acid, Resveratrol and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Follicular Thyroid Cancer, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, MAPK Signaling, Small Molecule Transport, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Follicular Thyroid Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR FOLLICULAR THYROID CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Follicular Thyroid Cancer undergoing chemotherapy treatment
In Follicular Thyroid Cancer – the genes EPHB1, HRAS, BRAF, TERT and ATP12A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Follicular Thyroid Cancer are RAS-RAF Signaling, MAPK Signaling, Epithelial to Mesenchymal Transition and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, MAPK Signaling, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Stigmasterol, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Vitamin C, Quercetin, Daidzein, Stigmasterol, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Stigmasterol has biological action on biochemical pathways Oxidative Stress, Epithelial to Mesenchymal Transition and MYC Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Follicular Thyroid Cancer with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Cianidanol in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR FOLLICULAR THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Carob?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Phloroglucinol, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways Oxidative Stress, Epithelial to Mesenchymal Transition and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MAPK Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Follicular Thyroid Cancer with chemotherapy Radiation – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Quercetin in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR FOLLICULAR THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Nance or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Huckleberry are Vitamin C, Quercetin, Ferulic Acid, Caffeic Acid, Resveratrol and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Betulin has biological action on biochemical pathways Oxidative Stress, Epithelial to Mesenchymal Transition and MYC Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Delphinidin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Follicular Thyroid Cancer with chemotherapy Radiation – Foods like Nance are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Delphinidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER HUCKLEBERRY FOR FOLLICULAR THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Stigmasterol, Beta-sitosterol, Oleic Acid, Vitamin E, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Oxidative Stress and MYC Signaling. Stigmasterol has biological action on biochemical pathways MAPK Signaling, Epithelial to Mesenchymal Transition and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and MAPK Signaling. And so on.
When treating Follicular Thyroid Cancer with chemotherapy Radiation – Foods like Pistachio are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR FOLLICULAR THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Follicular Thyroid Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EPHB1 and HRAS are two genes whose abnormalities are risk factors for Follicular Thyroid Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Follicular Thyroid Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Follicular Thyroid Cancer gene EPHB1 has causative impact on biological pathways like . And HRAS has a causative impact on biological pathways like Growth Factor Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EPHB1 and HRAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EPHB1 and HRAS should be avoided.
Eat more pulses, Mung Bean or Common Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Vitexin, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Vitamin C, Esculin, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. Vitexin has biological action on biochemical pathways Small Molecule Transport, RAS-RAF Signaling and Apoptosis.
Apigenin can manipulate biochemical pathways TGFB Signaling. Esculin has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Follicular Thyroid Cancer due to abnormalities in genes EPHB1 and HRAS – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF FOLLICULAR THYROID CANCER DUE TO GENES EPHB1 AND HRAS
Eat more vegetables, Arrowroot or Parsnip?
The active ingredients contained in Arrowroot are Protocatechuic Acid, Quercetin, Vitamin C, Beta-carotene, Chlorogenic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Vitamin C, Oleic Acid, Bergapten, Psoralen and others.
Protocatechuic Acid can manipulate biochemical pathways Apoptosis, EPHRIN Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.
Imperatorin can manipulate biochemical pathways Small Molecule Transport. Myristicin has biological action on biochemical pathways Apoptosis. And so on.
For genetic risk of Follicular Thyroid Cancer due to abnormalities in genes EPHB1 and HRAS – Foods like Arrowroot are recommended compared to Parsnip. This is because the active ingredients Imperatorin and Myristicin in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Protocatechuic Acid and Vitamin C contained in Arrowroot together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF FOLLICULAR THYROID CANCER DUE TO GENES EPHB1 AND HRAS
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Peach?
The active ingredients contained in Orange are D-limonene, Linalool, Vitamin C, Hesperidin, Oleic Acid among others. While the active ingredients contained in Peach are Vitamin C, Oleic Acid, Beta-sitosterol, Linolenic Acid, Modified Citrus Pectin and others.
D-limonene can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Follicular Thyroid Cancer due to abnormalities in genes EPHB1 and HRAS – Foods like Orange are recommended compared to Peach. This is because the active ingredients Fisetin and Caffeic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF FOLLICULAR THYROID CANCER DUE TO GENES EPHB1 AND HRAS
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Oleic Acid, Beta-sitosterol, Vitamin E, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin C, Oleic Acid, Beta-sitosterol, Vitamin E and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Apoptosis. Vitamin E has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Follicular Thyroid Cancer due to abnormalities in genes EPHB1 and HRAS – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF FOLLICULAR THYROID CANCER DUE TO GENES EPHB1 AND HRAS
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Follicular Thyroid Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pancan Pcawg 2020
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- [Hemagglutinating activity of diarrhea virus of infant mice (DVIM) (author’s transl)].
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- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
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- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
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- Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
- Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
- Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.