Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Extraskeletal Myxoid Chondrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Extraskeletal Myxoid Chondrosarcoma because of ARID1A and PIK3C3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Extraskeletal Myxoid Chondrosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Bilberry in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Turmeric and Curcumin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EXTRASKELETAL MYXOID CHONDROSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Extraskeletal Myxoid Chondrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR EXTRASKELETAL MYXOID CHONDROSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Extraskeletal Myxoid Chondrosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Extraskeletal Myxoid Chondrosarcoma from cBioPortal. 77.8% of males and 22.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 18; the top genes with mutations and other abnormalities for Extraskeletal Myxoid Chondrosarcoma include genes ARID1A, PIK3C3, TERT, KMT2D and NTRK1. The occurrence frequency distribution for these genes respectively is 10.0%, 10.0%, 10.0%, 10.0% and 10.0%. These tumor genetic details of Extraskeletal Myxoid Chondrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Extraskeletal Myxoid Chondrosarcoma.
Significance of Nutrition for Extraskeletal Myxoid Chondrosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Extraskeletal Myxoid Chondrosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Fig includes active ingredients Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others. And Bilberry contains active ingredients Resveratrol, Caffeic Acid, Asperuloside, P-coumaric Acid, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Extraskeletal Myxoid Chondrosarcoma, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, Apoptosis, Inositol Phosphate Signaling, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Extraskeletal Myxoid Chondrosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EXTRASKELETAL MYXOID CHONDROSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Extraskeletal Myxoid Chondrosarcoma undergoing chemotherapy treatment
In Extraskeletal Myxoid Chondrosarcoma – the genes ARID1A, PIK3C3, TERT, KMT2D and NTRK1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Extraskeletal Myxoid Chondrosarcoma are PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Oleic Acid, Glucaric Acid, Vitamin C, Linolenic Acid, Vitexin among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Oleic Acid, Vitamin C, Linolenic Acid and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Extraskeletal Myxoid Chondrosarcoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR EXTRASKELETAL MYXOID CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Bamboo or Chicory?
Vegetables are an important part of many diets. The active ingredients contained in Bamboo are Caffeic Acid, Beta-sitosterol, Oleic Acid, Protocatechuic Acid, Vitamin C among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Caffeic Acid, Betulinic Acid and others.
Ferulic Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Caffeic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.
When treating Extraskeletal Myxoid Chondrosarcoma with chemotherapy Radiation – Foods like Bamboo are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ferulic Acid and Caffeic Acid contained in Bamboo support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BAMBOO IS RECOMMENDED OVER CHICORY FOR EXTRASKELETAL MYXOID CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Bilberry or Fig?
Fruits are an important part of many diets. The active ingredients contained in Bilberry are Resveratrol, Caffeic Acid, Asperuloside, P-coumaric Acid, Gallic Acid among others. While the active ingredients contained in Fig are Lupeol, Beta-sitosterol, Bergapten, Psoralen, Vitamin C and others.
Arbutin can manipulate biochemical pathways MYC Signaling. Chlorogenic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MYC Signaling. And so on.
When treating Extraskeletal Myxoid Chondrosarcoma with chemotherapy Radiation – Foods like Bilberry are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Arbutin and Chlorogenic Acid contained in Bilberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BILBERRY IS RECOMMENDED OVER FIG FOR EXTRASKELETAL MYXOID CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Beta-sitosterol, Oleic Acid, Vitamin E, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Extraskeletal Myxoid Chondrosarcoma with chemotherapy Radiation – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR EXTRASKELETAL MYXOID CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Extraskeletal Myxoid Chondrosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID1A and PIK3C3 are two genes whose abnormalities are risk factors for Extraskeletal Myxoid Chondrosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Extraskeletal Myxoid Chondrosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Extraskeletal Myxoid Chondrosarcoma gene ARID1A has causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. And PIK3C3 has a causative impact on biological pathways like Autophagy, Inositol Phosphate Signaling and Antigen Presentation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID1A and PIK3C3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID1A and PIK3C3 should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid, P-coumaric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Extraskeletal Myxoid Chondrosarcoma due to abnormalities in genes ARID1A and PIK3C3 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Folic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF EXTRASKELETAL MYXOID CHONDROSARCOMA DUE TO GENES ARID1A AND PIK3C3
Eat more vegetables, Jicama or Jute?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Jute are Vitamin C, Oleic Acid, Linolenic Acid, Quercetin, Vitamin B3 and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Extraskeletal Myxoid Chondrosarcoma due to abnormalities in genes ARID1A and PIK3C3 – Foods like Jicama are recommended compared to Jute. This is because the active ingredients Quercetin and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF EXTRASKELETAL MYXOID CHONDROSARCOMA DUE TO GENES ARID1A AND PIK3C3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Raspberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Resveratrol, Vitamin C, Quercetin, Ellagic Acid, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Extraskeletal Myxoid Chondrosarcoma due to abnormalities in genes ARID1A and PIK3C3 – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF EXTRASKELETAL MYXOID CHONDROSARCOMA DUE TO GENES ARID1A AND PIK3C3
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Oleic Acid, Linolenic Acid, Quercetin, Ellagic Acid and others.
Vitamin E can manipulate biochemical pathways Inositol Phosphate Signaling, Apoptosis and MYC Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Extraskeletal Myxoid Chondrosarcoma due to abnormalities in genes ARID1A and PIK3C3 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF EXTRASKELETAL MYXOID CHONDROSARCOMA DUE TO GENES ARID1A AND PIK3C3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Extraskeletal Myxoid Chondrosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
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- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.