Foods for Extraskeletal Myxoid Chondrosarcoma!

Introduction

Foods for Extraskeletal Myxoid Chondrosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Extraskeletal myxoid chondrosarcoma, a rare soft tissue sarcoma, presents unique diagnostic and therapeutic challenges. The pathology outlines of extraskeletal myxoid chondrosarcoma are critical for accurate diagnosis, revealing its distinctive myxoid matrix and chondroid appearance. A notable feature of this tumor is the presence of specific genetic translocations, often resulting in unique fusion genes that can be diagnostic markers. Treatment typically involves surgical resection, and the role of additional therapies, such as chemotherapy and radiotherapy, is tailored to individual cases. The survival rate and prognosis depend on various factors, including the presence of lung metastasis, which is a significant concern in advanced stages. Symptoms can be non-specific but often include a painless mass or swelling in the affected area. The ICD-10 code for extraskeletal myxoid chondrosarcoma ensures standardized reporting for clinical and research purposes. Radiology, particularly MRI, plays a crucial role in the assessment of the tumor, providing detailed information on its size, extent, and relationship with surrounding structures. The cytology of this tumor can further aid in diagnosis, especially when a biopsy is performed. Understanding the life expectancy for patients with extraskeletal myxoid chondrosarcoma is complex and requires consideration of individual patient factors and the extent of the disease. The management of extraskeletal myxoid chondrosarcoma requires a comprehensive and multidisciplinary approach, focusing on both the local control of the tumor and monitoring for distant spread, to optimize outcomes for affected patients.

For Extraskeletal Myxoid Chondrosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Extraskeletal Myxoid Chondrosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Extraskeletal Myxoid Chondrosarcoma?

For example does it matter if vegetable Yellow Bell Pepper is consumed more compared to Shallot? Does it make any difference if fruit Natal Plum is preferred over Sapodilla? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Winged Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Extraskeletal Myxoid Chondrosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Extraskeletal Myxoid Chondrosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Natal Plum contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Phloretin. And Sapodilla contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Extraskeletal Myxoid Chondrosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Extraskeletal Myxoid Chondrosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Extraskeletal Myxoid Chondrosarcoma?

Personalized nutrition for cancers like Extraskeletal Myxoid Chondrosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Extraskeletal Myxoid Chondrosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Extraskeletal Myxoid Chondrosarcoma

All cancers like Extraskeletal Myxoid Chondrosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Extraskeletal Myxoid Chondrosarcoma. Biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling, Chromatin Remodeling are part of the signature definition of Extraskeletal Myxoid Chondrosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Extraskeletal Myxoid Chondrosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Extraskeletal Myxoid Chondrosarcoma when taking cancer treatment Dexamethasone, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ARID1A, PIK3C3, TERT, KMT2D and NTRK1 are the top ranked reported genes for Extraskeletal Myxoid Chondrosarcoma. ARID1A is reported in 10.0 % of the representative patients across all clinical trials. And PIK3C3 is reported in 10.0 %. The combined population patient data cover ages from to . 77.8 % of the patient data are identified as men. The Extraskeletal Myxoid Chondrosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Extraskeletal Myxoid Chondrosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable YELLOW BELL PEPPER or SHALLOT?

Vegetable Yellow Bell Pepper contains many active ingredients or bioactives such as Curcumin, Lupeol, Lycopene, Linalool, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Yellow Bell Pepper is recommended for Extraskeletal Myxoid Chondrosarcoma when ongoing cancer treatment is Dexamethasone. This is because Yellow Bell Pepper modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dexamethasone.

Some of the active ingredients or bioactives in vegetable Shallot are Apigenin, Curcumin, Lupeol, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Shallot is not recommended for Extraskeletal Myxoid Chondrosarcoma when ongoing cancer treatment is Dexamethasone because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE YELLOW BELL PEPPER IS RECOMMENDED OVER SHALLOT FOR Extraskeletal Myxoid Chondrosarcoma AND TREATMENT Dexamethasone.

Choose Fruit SAPODILLA or NATAL PLUM?

Fruit Sapodilla contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Lycopene, Daidzein. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Sapodilla is recommended for Extraskeletal Myxoid Chondrosarcoma when ongoing cancer treatment is Dexamethasone. This is because Sapodilla modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dexamethasone.

Some of the active ingredients or bioactives in fruit Natal Plum are Apigenin, Curcumin, Lupeol, Lycopene, Phloretin. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. Natal Plum is not recommended for Extraskeletal Myxoid Chondrosarcoma when ongoing cancer treatment is Dexamethasone because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SAPODILLA IS RECOMMENDED OVER NATAL PLUM FOR Extraskeletal Myxoid Chondrosarcoma AND TREATMENT Dexamethasone.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Juglone, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis and MYC Signaling and others. Black Walnut is recommended for Extraskeletal Myxoid Chondrosarcoma when ongoing cancer treatment is Dexamethasone. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Dexamethasone.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Lupeol, Daidzein, Stigmasterol. These active ingredients manipulate various biochemical pathways like MYC Signaling and others. European Chestnut is not recommended for Extraskeletal Myxoid Chondrosarcoma when ongoing cancer treatment is Dexamethasone because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Extraskeletal Myxoid Chondrosarcoma AND TREATMENT Dexamethasone.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Extraskeletal Myxoid Chondrosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or RADISH?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Formononetin, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for risk of Extraskeletal Myxoid Chondrosarcoma when associated genetic risk is ARID1A. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Radish are Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Radish is not recommended when risk of Extraskeletal Myxoid Chondrosarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER RADISH FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or PUMMELO?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for risk of Extraskeletal Myxoid Chondrosarcoma when associated genetic risk is ARID1A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Extraskeletal Myxoid Chondrosarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER PUMMELO FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of Extraskeletal Myxoid Chondrosarcoma when associated genetic risk is ARID1A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended when risk of Extraskeletal Myxoid Chondrosarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR ARID1A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Extraskeletal Myxoid Chondrosarcoma. Extraskeletal Myxoid Chondrosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Extraskeletal Myxoid Chondrosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Yellow Bell Pepper contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Extraskeletal Myxoid Chondrosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
• Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma.
• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
• α-Pinene Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells.
• Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
• Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.