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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Epithelioid Sarcoma?

Aug 21, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Epithelioid Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Epithelioid Sarcoma because of SMARCB1 and CDKN2C gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Epithelioid Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Guggul and Agaricus Mushroom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EPITHELIOID SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Epithelioid Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EPITHELIOID SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Epithelioid Sarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Epithelioid Sarcoma from cBioPortal. 53.3% of males and 46.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 37; the top genes with mutations and other abnormalities for Epithelioid Sarcoma include genes SMARCB1, CDKN2C, FAT1, KMT2C and ABL1. The occurrence frequency distribution for these genes respectively is 12.5%, 6.2%, 6.2%, 6.2% and 6.2%. These tumor genetic details of Epithelioid Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Epithelioid Sarcoma.

Significance of Nutrition for Epithelioid Sarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Epithelioid Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Myricetin, Quercetin, Ellagic Acid, Resveratrol, Vitamin C and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Epithelioid Sarcoma, activation or inhibition of selected biochemical pathways like DNA Repair, MAPK Signaling, PI3K-AKT-MTOR Signaling, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Epithelioid Sarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Epithelioid Sarcoma, activation or inhibition of selected biochemical pathways like DNA Repair, MAPK Signaling, PI3K-AKT-MTOR Signaling, Chromatin Remodeling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EPITHELIOID SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Epithelioid Sarcoma undergoing chemotherapy treatment

In Epithelioid Sarcoma – the genes SMARCB1, CDKN2C, FAT1, KMT2C and ABL1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Epithelioid Sarcoma are DNA Repair, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Etoposide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Oleic Acid, Vitamin C, Beta-sitosterol among others. While the active ingredients contained in Common Bean are Oleic Acid, Vitamin C, Ferulic Acid, Linolenic Acid, Delphinidin and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Apigenin can manipulate biochemical pathways DNA Repair. Esculin has biological action on biochemical pathways DNA Repair. And so on.

When treating Epithelioid Sarcoma with chemotherapy Etoposide – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR EPITHELIOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Glucaric Acid, Quercetin, Benzyl Isothiocyanate, Sulforaphane, Vitamin C among others. While the active ingredients contained in Spinach are Glucaric Acid, Quercetin, Oleic Acid, Vitamin C, Linolenic Acid and others.

Glucaric Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Apigenin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Epithelioid Sarcoma with chemotherapy Etoposide – Foods like Cabbage are recommended compared to Spinach. This is because the active ingredients Apigenin and Folic Acid in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Vitamin C contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SPINACH FOR EPITHELIOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Which Foods are Recommended for Epithelioid Sarcoma?

Eat more fruits, Orange or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Oleic Acid among others. While the active ingredients contained in Cranberry are Myricetin, Quercetin, Ellagic Acid, Resveratrol, Vitamin C and others.

D-limonene can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways DNA Repair. And so on.

When treating Epithelioid Sarcoma with chemotherapy Etoposide – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Glucaric Acid contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR EPITHELIOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Eat more nuts, Almond or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Salicylic Acid, Linolenic Acid among others. While the active ingredients contained in Cashew Nut are Gallic Acid, Vitamin C, Beta-sitosterol, Butyric Acid, Vitamin K and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair, MAPK Signaling and MYC Signaling.

Lauric Acid can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Palmitic Acid has biological action on biochemical pathways MYC Signaling and MAPK Signaling. And so on.

When treating Epithelioid Sarcoma with chemotherapy Etoposide – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Palmitic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR EPITHELIOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY ETOPOSIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Epithelioid Sarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMARCB1 and CDKN2C are two genes whose abnormalities are risk factors for Epithelioid Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Epithelioid Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Epithelioid Sarcoma gene SMARCB1 has causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. And CDKN2C has a causative impact on biological pathways like Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMARCB1 and CDKN2C should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMARCB1 and CDKN2C should be avoided.

Eat more pulses, Winged Bean or Moth Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid and others.

Betulinic Acid can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, P53 Signaling and Cell Cycle Checkpoints.

Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Epithelioid Sarcoma due to abnormalities in genes SMARCB1 and CDKN2C – Foods like Winged Bean are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF EPITHELIOID SARCOMA DUE TO GENES SMARCB1 AND CDKN2C

Eat more vegetables, Giant Butterbur or Lotus?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Melatonin, Vitamin B3, Vitamin A among others. While the active ingredients contained in Lotus are Fisetin, Quercetin, Beta-sitosterol, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Epithelioid Sarcoma due to abnormalities in genes SMARCB1 and CDKN2C – Foods like Giant Butterbur are recommended compared to Lotus. This is because the active ingredients Fisetin and Vitamin B3 in Lotus further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER LOTUS FOR REDUCING THE GENETIC RISK OF EPITHELIOID SARCOMA DUE TO GENES SMARCB1 AND CDKN2C

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Lingonberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Hyperoside, Quercetin, Resveratrol, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and Cell Cycle. Lycopene has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Resveratrol can manipulate biochemical pathways P53 Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Epithelioid Sarcoma due to abnormalities in genes SMARCB1 and CDKN2C – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Linoleic Acid in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF EPITHELIOID SARCOMA DUE TO GENES SMARCB1 AND CDKN2C

Eat more nuts, Pecan Nut or Acorn?

The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Delphinidin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Quercitrin and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and Cell Cycle. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Epithelioid Sarcoma due to abnormalities in genes SMARCB1 and CDKN2C – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF EPITHELIOID SARCOMA DUE TO GENES SMARCB1 AND CDKN2C


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Epithelioid Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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