Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Large Cell Lung Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Large Cell Lung Carcinoma because of KEAP1 and FAT3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Large Cell Lung Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Purslane” or “Can I take Neem Extract and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LARGE CELL LUNG CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Large Cell Lung Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR LARGE CELL LUNG CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Large Cell Lung Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Large Cell Lung Carcinoma from cBioPortal. From a patient sample size of 12; the top genes with mutations and other abnormalities for Large Cell Lung Carcinoma include genes TP53, KMT2D, KEAP1, FAT3 and INHBA. The occurrence frequency distribution for these genes respectively is 77.8%, 22.2%, 22.2%, 22.2% and 22.2%. These tumor genetic details of Large Cell Lung Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Large Cell Lung Carcinoma.
Significance of Nutrition for Large Cell Lung Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Large Cell Lung Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Quercetin, Delphinidin, Resveratrol, P-coumaric Acid, Vitamin C and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Large Cell Lung Carcinoma, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Large Cell Lung Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LARGE CELL LUNG CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Large Cell Lung Carcinoma undergoing chemotherapy treatment
In Large Cell Lung Carcinoma – the genes TP53, KMT2D, KEAP1, FAT3 and INHBA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Large Cell Lung Carcinoma are Growth Factor Signaling, Oncogenic Cancer Epigenetics, Angiogenesis and others. Pemetrexed is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, Oncogenic Cancer Epigenetics, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Yellow Wax Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Yellow Wax Bean are Vitamin C, Ferulic Acid, Cianidanol, Palmitic Acid, Butyric Acid among others. While the active ingredients contained in Pigeon Pea are Genistein, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, Adherens junction and Oxidative Stress. Vitamin A has biological action on biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling.
Genistein can manipulate biochemical pathways Oxidative Stress and Nutrient sensing. Vitamin C has biological action on biochemical pathways Heat Stress Response. And so on.
When treating Large Cell Lung Carcinoma with chemotherapy Pemetrexed – Foods like Yellow Wax Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin C in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER PIGEON PEA FOR LARGE CELL LUNG CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Purslane?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Purslane are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Adherens junction, Oxidative Stress and Cell Cycle.
Vitamin C can manipulate biochemical pathways Heat Stress Response. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Large Cell Lung Carcinoma with chemotherapy Pemetrexed – Foods like Cassava are recommended compared to Purslane. This is because the active ingredients Vitamin C and Citric Acid in Purslane interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin A contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER PURSLANE FOR LARGE CELL LUNG CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Huckleberry are Quercetin, Delphinidin, Resveratrol, P-coumaric Acid, Vitamin C and others.
Resveratrol can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways Adherens junction, Oxidative Stress and Cell Cycle.
Quercetin can manipulate biochemical pathways Oxidative Stress. Delphinidin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Large Cell Lung Carcinoma with chemotherapy Pemetrexed – Foods like Partridgeberry are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Delphinidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER HUCKLEBERRY FOR LARGE CELL LUNG CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Delphinidin, Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and Heat Stress Response.
Ellagic Acid can manipulate biochemical pathways Heat Stress Response, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Large Cell Lung Carcinoma with chemotherapy Pemetrexed – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR LARGE CELL LUNG CARCINOMA ON TREATMENT WITH CHEMOTHERAPY PEMETREXED FOR SOME CONDITIONS.
Foods for Genetic Risk of Large Cell Lung Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KEAP1 and FAT3 are two genes whose abnormalities are risk factors for Large Cell Lung Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Large Cell Lung Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Large Cell Lung Carcinoma gene KEAP1 has causative impact on biological pathways like Antigen Presentation, Post Translation Modification and Oxidative Stress. And FAT3 has a causative impact on biological pathways like Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KEAP1 and FAT3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KEAP1 and FAT3 should be avoided.
Eat more pulses, Scarlet Bean or Chickpea?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Stigmasterol, Linolenic Acid among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Vitamin A, Genistein, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Genistein can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Large Cell Lung Carcinoma due to abnormalities in genes KEAP1 and FAT3 – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Genistein and Linolenic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF LARGE CELL LUNG CARCINOMA DUE TO GENES KEAP1 AND FAT3
Eat more vegetables, Cabbage or Brussels Sprout?
The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Vitamin C, Brassinin, Vitamin B3 among others. While the active ingredients contained in Brussels Sprout are Beta-sitosterol, Vitamin C, Oleic Acid, Brassinin, Linolenic Acid and others.
Glucaric Acid can manipulate biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and PI3K-AKT-MTOR Signaling.
Brassinin can manipulate biochemical pathways Oxidative Stress. Sinapic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Large Cell Lung Carcinoma due to abnormalities in genes KEAP1 and FAT3 – Foods like Cabbage are recommended compared to Brussels Sprout. This is because the active ingredients Brassinin and Sinapic Acid in Brussels Sprout further promote the effects of genes on the biochemical pathways. While the active ingredients Glucaric Acid and Vitamin K contained in Cabbage together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER BRUSSELS SPROUT FOR REDUCING THE GENETIC RISK OF LARGE CELL LUNG CARCINOMA DUE TO GENES KEAP1 AND FAT3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Apricot?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Apricot are Beta-sitosterol, Vitamin C, Oleic Acid, Stigmasterol, Linolenic Acid and others.
Lycopene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Casuarinin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Rutin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Large Cell Lung Carcinoma due to abnormalities in genes KEAP1 and FAT3 – Foods like Feijoa are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Casuarinin contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER APRICOT FOR REDUCING THE GENETIC RISK OF LARGE CELL LUNG CARCINOMA DUE TO GENES KEAP1 AND FAT3
Eat more nuts, Hazelnut or Cashew Nut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Lauric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Large Cell Lung Carcinoma due to abnormalities in genes KEAP1 and FAT3 – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF LARGE CELL LUNG CARCINOMA DUE TO GENES KEAP1 AND FAT3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Large Cell Lung Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.