Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Angioimmunoblastic T-cell Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Angioimmunoblastic T-cell Lymphoma because of IDH2 and RHOA gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Angioimmunoblastic T-cell Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Custard Apple in my diet” or “Should I reduce consumption of vegetable Heart Of Palm” or “Can I take Vitamin C and Wheatgrass supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Angioimmunoblastic T-cell Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Angioimmunoblastic T-cell Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Angioimmunoblastic T-cell Lymphoma from cBioPortal. 30.0% of males and 70.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 12; the top genes with mutations and other abnormalities for Angioimmunoblastic T-cell Lymphoma include genes TET2, DNMT3A, IDH2, RHOA and BRAF. The occurrence frequency distribution for these genes respectively is 75.0%, 58.3%, 33.3%, 25.0% and 8.3%. These tumor genetic details of Angioimmunoblastic T-cell Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Angioimmunoblastic T-cell Lymphoma.
Significance of Nutrition for Angioimmunoblastic T-cell Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Angioimmunoblastic T-cell Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Vitamin C, Resveratrol, Ellagic Acid, Hyperoside, Quercetin and others. And Custard Apple contains active ingredients Vitamin C, Linolenic Acid, Cianidanol, Oleic Acid, Epicatechin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Angioimmunoblastic T-cell Lymphoma, activation or inhibition of selected biochemical pathways like DNA Repair, Hypoxia, Oncogenic Cancer Epigenetics, Energy Metabolism plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Angioimmunoblastic T-cell Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Angioimmunoblastic T-cell Lymphoma undergoing chemotherapy treatment
In Angioimmunoblastic T-cell Lymphoma – the genes TET2, DNMT3A, IDH2, RHOA and BRAF have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Angioimmunoblastic T-cell Lymphoma are DNA Repair, Hypoxia, Apoptosis and others. Azacitidine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Hypoxia, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Vitamin C, Daidzein, Lupeol, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Genistein and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Angioimmunoblastic T-cell Lymphoma with chemotherapy Azacitidine – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Eat more vegetables, Garden Cress or Heart Of Palm?
Vegetables are an important part of many diets. The active ingredients contained in Garden Cress are Vitamin C, Vitamin E, Benzyl Isothiocyanate, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and Apoptosis.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.
When treating Angioimmunoblastic T-cell Lymphoma with chemotherapy Azacitidine – Foods like Garden Cress are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Garden Cress support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GARDEN CRESS IS RECOMMENDED OVER HEART OF PALM FOR ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Eat more fruits, Custard Apple or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Custard Apple are Vitamin C, Linolenic Acid, Cianidanol, Oleic Acid, Epicatechin among others. While the active ingredients contained in Cranberry are Vitamin C, Resveratrol, Ellagic Acid, Hyperoside, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways Hypoxia, MYC Signaling and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Angioimmunoblastic T-cell Lymphoma with chemotherapy Azacitidine – Foods like Custard Apple are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Cianidanol contained in Custard Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CUSTARD APPLE IS RECOMMENDED OVER CRANBERRY FOR ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Vitamin C, Quercetin, Beta-sitosterol, Vitamin B3, Quercitrin and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Cianidanol has biological action on biochemical pathways Hypoxia, PI3K-AKT-MTOR Signaling and MYC Signaling.
Beta-carotene can manipulate biochemical pathways DNA Repair and Notch Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
When treating Angioimmunoblastic T-cell Lymphoma with chemotherapy Azacitidine – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Angioimmunoblastic T-cell Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. IDH2 and RHOA are two genes whose abnormalities are risk factors for Angioimmunoblastic T-cell Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Angioimmunoblastic T-cell Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Angioimmunoblastic T-cell Lymphoma gene IDH2 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. And RHOA has a causative impact on biological pathways like Cytoskeletal Dynamics, Adherens junction and cGMP Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like IDH2 and RHOA should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes IDH2 and RHOA should be avoided.
Eat more pulses, Scarlet Bean or Yellow Wax Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Oleic Acid, Beta-sitosterol, Genistein, Linolenic Acid among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Cianidanol, Ferulic Acid, Butyric Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oncogenic Cancer Epigenetics.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Angioimmunoblastic T-cell Lymphoma due to abnormalities in genes IDH2 and RHOA – Foods like Scarlet Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA DUE TO GENES IDH2 AND RHOA
Eat more vegetables, Jicama or Beetroot?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Beetroot are Vitamin C, Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Hypoxia.
Oleic Acid can manipulate biochemical pathways Cytoskeletal Dynamics and Netrin Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Angioimmunoblastic T-cell Lymphoma due to abnormalities in genes IDH2 and RHOA – Foods like Jicama are recommended compared to Beetroot. This is because the active ingredients Oleic Acid and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA DUE TO GENES IDH2 AND RHOA
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Blueberry or Fig?
The active ingredients contained in Blueberry are Resveratrol, Vitamin C, Quercetin, Vitamin E, Cianidanol among others. While the active ingredients contained in Fig are Lupeol, Vitamin C, Beta-sitosterol, Psoralen, Bergapten and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Netrin Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Angioimmunoblastic T-cell Lymphoma due to abnormalities in genes IDH2 and RHOA – Foods like Blueberry are recommended compared to Fig. This is because the active ingredients Palmitic Acid and Lauric Acid in Fig further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cianidanol contained in Blueberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER FIG FOR REDUCING THE GENETIC RISK OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA DUE TO GENES IDH2 AND RHOA
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Quercetin, Vitamin E, Oleic Acid, Gamma-linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Quercetin can manipulate biochemical pathways Cell Junctions. Lecithin has biological action on biochemical pathways MYC Signaling, Cytoskeletal Dynamics and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Angioimmunoblastic T-cell Lymphoma due to abnormalities in genes IDH2 and RHOA – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA DUE TO GENES IDH2 AND RHOA
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Angioimmunoblastic T-cell Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- Clinical pharmacodynamics of antihistamines.
- Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Research progress on the anticancer effects of vitamin K2.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- New concepts in phospholipase D signaling in inflammation and cancer.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.