Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Small Cell Bladder Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Small Cell Bladder Cancer because of TERT and TP53 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Small Cell Bladder Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Raspberry” or “Include fruit Date in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Garlic and Chamomile supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SMALL CELL BLADDER CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Small Cell Bladder Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SMALL CELL BLADDER CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Small Cell Bladder Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Small Cell Bladder Cancer from cBioPortal. The patients enrolled in the studies for Small Cell Bladder Cancer are in ages between 54 to 58 with an average age of 56. 62.5% of males and 37.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 7; the top genes with mutations and other abnormalities for Small Cell Bladder Cancer include genes TERT and TP53. The occurrence frequency distribution for these genes respectively is 100.0% and 100.0%. These tumor genetic details of Small Cell Bladder Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Small Cell Bladder Cancer.
Significance of Nutrition for Small Cell Bladder Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Small Cell Bladder Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Raspberry includes active ingredients Vitamin C, Resveratrol, Quercetin, Ellagic Acid, Gallic Acid and others. And Date contains active ingredients Apigenin, Lupeol, Beta-sitosterol, Linolenic Acid, Protocatechuic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Small Cell Bladder Cancer, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, MAPK Signaling, Cytokine Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Small Cell Bladder Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SMALL CELL BLADDER CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Small Cell Bladder Cancer undergoing chemotherapy treatment
In Small Cell Bladder Cancer – the genes TERT and TP53 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Small Cell Bladder Cancer are Cell Cycle Checkpoints, Apoptosis and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Stigmasterol and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Stigmasterol has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Small Cell Bladder Cancer with chemotherapy Doxorubicin – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR SMALL CELL BLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Beta-sitosterol, Linolenic Acid, P-coumaric Acid, Vitamin C, Vitamin B3 and others.
Vitamin A can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. Kaempferol has biological action on biochemical pathways Cell Cycle Checkpoints.
Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.
When treating Small Cell Bladder Cancer with chemotherapy Doxorubicin – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR SMALL CELL BLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Date or Raspberry?
Fruits are an important part of many diets. The active ingredients contained in Date are Apigenin, Lupeol, Beta-sitosterol, Linolenic Acid, Protocatechuic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Resveratrol, Quercetin, Ellagic Acid, Gallic Acid and others.
Apigenin can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Lupeol has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
When treating Small Cell Bladder Cancer with chemotherapy Doxorubicin – Foods like Date are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Apigenin and Lupeol contained in Date support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: DATE IS RECOMMENDED OVER RASPBERRY FOR SMALL CELL BLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Stigmasterol, Linolenic Acid, Vitamin B3 among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
When treating Small Cell Bladder Cancer with chemotherapy Doxorubicin – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR SMALL CELL BLADDER CANCER ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Small Cell Bladder Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. TERT and TP53 are two genes whose abnormalities are risk factors for Small Cell Bladder Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Small Cell Bladder Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Small Cell Bladder Cancer gene TERT has causative impact on biological pathways like Cell Cycle Checkpoints, Apoptosis and DNA Repair. And TP53 has a causative impact on biological pathways like Cell Cycle Checkpoints and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like TERT and TP53 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes TERT and TP53 should be avoided.
Eat more pulses, Common Pea or Fava Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Small Cell Bladder Cancer due to abnormalities in genes TERT and TP53 – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Ferulic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF SMALL CELL BLADDER CANCER DUE TO GENES TERT AND TP53
Eat more vegetables, Giant Butterbur or Endive?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Small Cell Bladder Cancer due to abnormalities in genes TERT and TP53 – Foods like Giant Butterbur are recommended compared to Endive. This is because the active ingredients Quercetin and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF SMALL CELL BLADDER CANCER DUE TO GENES TERT AND TP53
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Quercetin, Hyperoside, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Small Cell Bladder Cancer due to abnormalities in genes TERT and TP53 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF SMALL CELL BLADDER CANCER DUE TO GENES TERT AND TP53
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Small Cell Bladder Cancer due to abnormalities in genes TERT and TP53 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SMALL CELL BLADDER CANCER DUE TO GENES TERT AND TP53
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Small Cell Bladder Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Integrative clinical genomics of metastatic cancer.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Isotretinoin in the treatment of systemic sclerosis.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- HyperFoods/food_compound_original.csv at master • warcraft12321/HyperFoods • GitHub
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.