Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Signet Ring Cell Adenocarcinoma Of The Colon And Rectum when undergoing chemotherapy or when you determine you have a genetic risk for developing Signet Ring Cell Adenocarcinoma Of The Colon And Rectum because of SMAD4 and RNF43 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Signet Ring Cell Adenocarcinoma Of The Colon And Rectum which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Raspberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Modified Citrus Pectin and Lycopene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Signet Ring Cell Adenocarcinoma Of The Colon And Rectum
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum from cBioPortal. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 8; the top genes with mutations and other abnormalities for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum include genes TP53, SMAD4, RNF43, KRAS and ERCC4. The occurrence frequency distribution for these genes respectively is 37.5%, 37.5%, 25.0%, 25.0% and 12.5%. These tumor genetic details of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum.
Significance of Nutrition for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Raspberry includes active ingredients Resveratrol, Quercetin, Ellagic Acid, Vitamin C, Vitamin A and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Signet Ring Cell Adenocarcinoma Of The Colon And Rectum, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Adherens junction, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum undergoing chemotherapy treatment
In Signet Ring Cell Adenocarcinoma Of The Colon And Rectum – the genes TP53, SMAD4, RNF43, KRAS and ERCC4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum are RAS-RAF Signaling, Adherens junction, PI3K-AKT-MTOR Signaling and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Adherens junction, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Beta-sitosterol, Daidzein, Vitamin E and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Adherens junction, MYC Signaling and WNT Beta Catenin Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Rutin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Signet Ring Cell Adenocarcinoma Of The Colon And Rectum with chemotherapy Docetaxel – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Rutin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Vitamin E, Linolenic Acid, Vitamin C, Vitamin A and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Kaempferol has biological action on biochemical pathways WNT Beta Catenin Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Signet Ring Cell Adenocarcinoma Of The Colon And Rectum with chemotherapy Docetaxel – Foods like Arugula are recommended compared to Beetroot. This is because the active ingredients Oleic Acid and Linoleic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BEETROOT FOR SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Raspberry?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Raspberry are Resveratrol, Quercetin, Ellagic Acid, Vitamin C, Vitamin A and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Rutin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Signet Ring Cell Adenocarcinoma Of The Colon And Rectum with chemotherapy Docetaxel – Foods like Partridgeberry are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Rutin in Raspberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER RASPBERRY FOR SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Vitamin A, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and NFKB Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Signet Ring Cell Adenocarcinoma Of The Colon And Rectum with chemotherapy Docetaxel – Foods like Pine Nut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER MACADAMIA NUT FOR SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.
Foods for Genetic Risk of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMAD4 and RNF43 are two genes whose abnormalities are risk factors for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum can be used as a guide for coming up with a recommended personalized nutrition plan. For Signet Ring Cell Adenocarcinoma Of The Colon And Rectum gene SMAD4 has causative impact on biological pathways like TGFB Signaling, Inflammation and Cell Cycle. And RNF43 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMAD4 and RNF43 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMAD4 and RNF43 should be avoided.
Eat more pulses, Mung Bean or Pigeon Pea?
The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Vitexin among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Linoleic Acid and others.
Quercetin can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum due to abnormalities in genes SMAD4 and RNF43 – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM DUE TO GENES SMAD4 AND RNF43
Eat more vegetables, Jicama or Parsnip?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Linolenic Acid, Vitamin C, Psoralen, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ferulic Acid can manipulate biochemical pathways Growth Factor Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum due to abnormalities in genes SMAD4 and RNF43 – Foods like Jicama are recommended compared to Parsnip. This is because the active ingredients Ferulic Acid and Linoleic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM DUE TO GENES SMAD4 AND RNF43
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Peach?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Linolenic Acid, Vitamin C, Oleic Acid, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum due to abnormalities in genes SMAD4 and RNF43 – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM DUE TO GENES SMAD4 AND RNF43
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Cianidanol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Linolenic Acid, Vitamin C, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Signet Ring Cell Adenocarcinoma Of The Colon And Rectum due to abnormalities in genes SMAD4 and RNF43 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SIGNET RING CELL ADENOCARCINOMA OF THE COLON AND RECTUM DUE TO GENES SMAD4 AND RNF43
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Signet Ring Cell Adenocarcinoma Of The Colon And Rectum by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Tmb Mskcc 2018
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.