Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Papillary Thyroid Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Papillary Thyroid Cancer because of HRAS and KMT2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Papillary Thyroid Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Thunder God and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PAPILLARY THYROID CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Papillary Thyroid Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PAPILLARY THYROID CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Papillary Thyroid Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Papillary Thyroid Cancer from cBioPortal. The patients enrolled in the studies for Papillary Thyroid Cancer are in ages between 15 to 89 with an average age of 46. 36.5% of males and 63.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 950; the top genes with mutations and other abnormalities for Papillary Thyroid Cancer include genes BRAF, NRAS, HRAS, MUC16 and KMT2A. The occurrence frequency distribution for these genes respectively is 40.3%, 5.7%, 2.3%, 1.7% and 1.2%. These tumor genetic details of Papillary Thyroid Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Papillary Thyroid Cancer.
Significance of Nutrition for Papillary Thyroid Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Papillary Thyroid Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Ellagic Acid, Hyperoside, Vitamin C, Myricetin and others. And Persimmon contains active ingredients Quercetin, Lupeol, Lycopene, Betulinic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Papillary Thyroid Cancer, activation or inhibition of selected biochemical pathways like Cell Cycle, Nucleotide Metabolism, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Papillary Thyroid Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PAPILLARY THYROID CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Papillary Thyroid Cancer undergoing chemotherapy treatment
In Papillary Thyroid Cancer – the genes BRAF, NRAS, HRAS, MUC16 and KMT2A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Papillary Thyroid Cancer are Cell Cycle, Nucleotide Metabolism, C-type Lectin Receptor Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Nucleotide Metabolism, C-type Lectin Receptor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Vitamin E, Daidzein, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints and Cell Cycle. And so on.
When treating Papillary Thyroid Cancer with chemotherapy Cisplatin – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Aescin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR PAPILLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Beta-carotene, Vitamin C, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Survival.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Vitamin D Signaling and DNA Repair. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Papillary Thyroid Cancer with chemotherapy Cisplatin – Foods like Jicama are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER SPINACH FOR PAPILLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Lupeol, Lycopene, Betulinic Acid, Vitamin C among others. While the active ingredients contained in Cranberry are Quercetin, Ellagic Acid, Hyperoside, Vitamin C, Myricetin and others.
Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.
When treating Papillary Thyroid Cancer with chemotherapy Cisplatin – Foods like Persimmon are recommended compared to Cranberry. This is because the active ingredients Quercetin and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER CRANBERRY FOR PAPILLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Resveratrol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways Inositol Phosphate Signaling, DNA Repair and Cell Cycle.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and NFKB Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Papillary Thyroid Cancer with chemotherapy Cisplatin – Foods like Pistachio are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER MACADAMIA NUT FOR PAPILLARY THYROID CANCER ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Papillary Thyroid Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. HRAS and KMT2A are two genes whose abnormalities are risk factors for Papillary Thyroid Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Papillary Thyroid Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Papillary Thyroid Cancer gene HRAS has causative impact on biological pathways like Growth Factor Signaling and G-protein-coupled Receptor Signaling. And KMT2A has a causative impact on biological pathways like Amino Acid Metabolism and Oncogenic Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like HRAS and KMT2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes HRAS and KMT2A should be avoided.
Eat more pulses, Mung Bean or Moth Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Vitexin among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitexin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Papillary Thyroid Cancer due to abnormalities in genes HRAS and KMT2A – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF PAPILLARY THYROID CANCER DUE TO GENES HRAS AND KMT2A
Eat more vegetables, Giant Butterbur or Green Bean?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Kaempferol, Vitamin B3, Melatonin among others. While the active ingredients contained in Green Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Linoleic Acid can manipulate biochemical pathways TGFB Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Papillary Thyroid Cancer due to abnormalities in genes HRAS and KMT2A – Foods like Giant Butterbur are recommended compared to Green Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Green Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER GREEN BEAN FOR REDUCING THE GENETIC RISK OF PAPILLARY THYROID CANCER DUE TO GENES HRAS AND KMT2A
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Salmonberry or Lingonberry?
The active ingredients contained in Salmonberry are Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A among others. While the active ingredients contained in Lingonberry are Resveratrol, Quercetin, Hyperoside, Vitamin C, Oleic Acid and others.
Protocatechuic Acid can manipulate biochemical pathways Apoptosis, EPHRIN Signaling and MYC Signaling. P-coumaric Acid has biological action on biochemical pathways TGFB Signaling, P53 Signaling and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways P53 Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
For genetic risk of Papillary Thyroid Cancer due to abnormalities in genes HRAS and KMT2A – Foods like Salmonberry are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Caffeic Acid in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Protocatechuic Acid and P-coumaric Acid contained in Salmonberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SALMONBERRY IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF PAPILLARY THYROID CANCER DUE TO GENES HRAS AND KMT2A
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Papillary Thyroid Cancer due to abnormalities in genes HRAS and KMT2A – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF PAPILLARY THYROID CANCER DUE TO GENES HRAS AND KMT2A
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Papillary Thyroid Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
- Integrated genomic characterization of papillary thyroid carcinoma.
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- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Small-molecule inhibitors of NADPH oxidase 4.
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- β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells.
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- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
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- Clinical pharmacodynamics of antihistamines.
- Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer.
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Perturbation of the EphA2-EphrinA1 system in human prostate cancer cells by colonic (poly)phenol catabolites.
- Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.