Which Foods are Recommended for Testicular Germ Cell Tumors?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Testicular Germ Cell Tumors when undergoing chemotherapy or when you determine you have a genetic risk for developing Testicular Germ Cell Tumors because of LZTR1 and PIK3C2G gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Testicular Germ Cell Tumors which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Mango” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Prairie Turnip” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO TESTICULAR GERM CELL TUMORS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Testicular Germ Cell Tumors is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR TESTICULAR GERM CELL TUMORS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Testicular Germ Cell Tumors

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Testicular Germ Cell Tumors from cBioPortal. The patients enrolled in the studies for Testicular Germ Cell Tumors are in ages between 14 to 66 with an average age of 28.From a patient sample size of 63; the top genes with mutations and other abnormalities for Testicular Germ Cell Tumors include genes LZTR1, KMT2D, PIK3C2G, KIT and MYH10. The occurrence frequency distribution for these genes respectively is 4.9%, 3.3%, 3.3%, 3.3% and 3.3%. These tumor genetic details of Testicular Germ Cell Tumors are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Testicular Germ Cell Tumors.

Significance of Nutrition for Testicular Germ Cell Tumors

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Testicular Germ Cell Tumors. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Mango includes active ingredients Lupeol, Gallic Acid, Beta-sitosterol, Vitamin C, Vitamin A and others. And Raspberry contains active ingredients Ellagic Acid, Quercetin, Resveratrol, Gallic Acid, Salicylic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Testicular Germ Cell Tumors, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Testicular Germ Cell Tumors, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR TESTICULAR GERM CELL TUMORS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Testicular Germ Cell Tumors undergoing chemotherapy treatment

In Testicular Germ Cell Tumors – the genes LZTR1, KMT2D, PIK3C2G, KIT and MYH10 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Testicular Germ Cell Tumors are Cell Cycle, C-type Lectin Receptor Signaling, Phospholipase Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, C-type Lectin Receptor Signaling, Phospholipase Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Chickpea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Genistein, Vitamin C among others. While the active ingredients contained in Chickpea are Genistein, Vitamin A, Linolenic Acid, Oleic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oxidative Stress and Hypoxia.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Testicular Germ Cell Tumors with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Chickpea. This is because the active ingredients Genistein and Linolenic Acid in Chickpea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER CHICKPEA FOR TESTICULAR GERM CELL TUMORS ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Prairie Turnip?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Isorhamnetin, Beta-sitosterol, Indole-3-carbinol among others. While the active ingredients contained in Prairie Turnip are Selenium, Vitexin, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Cell Survival and Apoptosis.

Selenium can manipulate biochemical pathways Oxidative Stress. Vitexin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Testicular Germ Cell Tumors with chemotherapy Cisplatin – Foods like Cabbage are recommended compared to Prairie Turnip. This is because the active ingredients Selenium and Vitexin in Prairie Turnip interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER PRAIRIE TURNIP FOR TESTICULAR GERM CELL TUMORS ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more fruits, Raspberry or Mango?

Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Gallic Acid, Salicylic Acid among others. While the active ingredients contained in Mango are Lupeol, Gallic Acid, Beta-sitosterol, Vitamin C, Vitamin A and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oxidative Stress and Hypoxia.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Testicular Germ Cell Tumors with chemotherapy Cisplatin – Foods like Raspberry are recommended compared to Mango. This is because the active ingredients Gallic Acid and Citric Acid in Mango interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER MANGO FOR TESTICULAR GERM CELL TUMORS ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Gallic Acid, Betulin, Vitamin C among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Beta-sitosterol, Beta-carotene, Vitamin C and others.

Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Betulin has biological action on biochemical pathways Cell Survival, PI3K-AKT-MTOR Signaling and Oxidative Stress.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Testicular Germ Cell Tumors with chemotherapy Cisplatin – Foods like Chestnut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Betulin contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER ACORN FOR TESTICULAR GERM CELL TUMORS ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Testicular Germ Cell Tumors

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. LZTR1 and PIK3C2G are two genes whose abnormalities are risk factors for Testicular Germ Cell Tumors. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Testicular Germ Cell Tumors can be used as a guide for coming up with a recommended personalized nutrition plan. For Testicular Germ Cell Tumors gene LZTR1 has causative impact on biological pathways like MAPK Signaling and RAS-RAF Signaling. And PIK3C2G has a causative impact on biological pathways like Inositol Phosphate Signaling and Chemokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like LZTR1 and PIK3C2G should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes LZTR1 and PIK3C2G should be avoided.

Eat more pulses, Lentils or Soy Bean?

The active ingredients contained in Lentils are Ellagic Acid, Linoleic Acid, Esculin, Beta-sitosterol, Isoliquiritigenin among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Linoleic Acid, Stigmasterol, Beta-sitosterol and others.

Ellagic Acid can manipulate biochemical pathways Apoptosis, WNT Beta Catenin Signaling and Post Translation Modification. Esculin has biological action on biochemical pathways MAPK Signaling and Apoptosis.

Genistein can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways MAPK Signaling. And so on.

For genetic risk of Testicular Germ Cell Tumors due to abnormalities in genes LZTR1 and PIK3C2G – Foods like Lentils are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Esculin contained in Lentils together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LENTILS IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF TESTICULAR GERM CELL TUMORS DUE TO GENES LZTR1 AND PIK3C2G

Eat more vegetables, Onion or Carob?

The active ingredients contained in Onion are Quercetin, Linoleic Acid, Isorhamnetin, Stigmasterol, Beta-sitosterol among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Phloroglucinol, Myricetin, Gallic Acid and others.

Isorhamnetin can manipulate biochemical pathways Apoptosis, Extracellular Matrix Remodelling and WNT Beta Catenin Signaling. Stigmasterol has biological action on biochemical pathways MAPK Signaling, Oxidative Stress and Apoptosis.

Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Post Translation Modification. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Testicular Germ Cell Tumors due to abnormalities in genes LZTR1 and PIK3C2G – Foods like Onion are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Quercetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Isorhamnetin and Stigmasterol contained in Onion together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ONION IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF TESTICULAR GERM CELL TUMORS DUE TO GENES LZTR1 AND PIK3C2G

Eat more fruits, Cloudberry or Pummelo?

The active ingredients contained in Cloudberry are Ellagic Acid, Vitamin C, Vitamin A, Urolithin B among others. While the active ingredients contained in Pummelo are Naringin, Linoleic Acid, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, WNT Beta Catenin Signaling and MAPK Signaling. Vitamin A has biological action on biochemical pathways Oxidative Stress, WNT Beta Catenin Signaling and Apoptosis.

Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Testicular Germ Cell Tumors due to abnormalities in genes LZTR1 and PIK3C2G – Foods like Cloudberry are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin A contained in Cloudberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CLOUDBERRY IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF TESTICULAR GERM CELL TUMORS DUE TO GENES LZTR1 AND PIK3C2G

Eat more nuts, Pistachio or Peanut?

The active ingredients contained in Pistachio are Linoleic Acid, Stigmasterol, Beta-sitosterol, Vitamin E, Oleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Linoleic Acid, Stigmasterol, Beta-sitosterol, Vitamin E and others.

Beta-sitosterol can manipulate biochemical pathways WNT Beta Catenin Signaling, Apoptosis and Oxidative Stress. Stigmasterol has biological action on biochemical pathways MAPK Signaling, Apoptosis and Oxidative Stress.

Quercetin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Testicular Germ Cell Tumors due to abnormalities in genes LZTR1 and PIK3C2G – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Quercetin and Citric Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF TESTICULAR GERM CELL TUMORS DUE TO GENES LZTR1 AND PIK3C2G

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Testicular Germ Cell Tumors by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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