Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mantle Cell Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Mantle Cell Lymphoma because of CDC27 and FAT1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mantle Cell Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Squash” or “Can I take Guggul and Vitamin D3 supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MANTLE CELL LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mantle Cell Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MANTLE CELL LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mantle Cell Lymphoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mantle Cell Lymphoma from cBioPortal. 72.7% of males and 27.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 237; the top genes with mutations and other abnormalities for Mantle Cell Lymphoma include genes CDC27, FAT1, RYR3, ASH1L and KMT2C. The occurrence frequency distribution for these genes respectively is 11.4%, 5.9%, 5.9%, 5.9% and 5.5%. These tumor genetic details of Mantle Cell Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mantle Cell Lymphoma.
Significance of Nutrition for Mantle Cell Lymphoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mantle Cell Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Date includes active ingredients Apigenin, Quercetin, Lupeol, Beta-sitosterol, Protocatechuic Acid and others. And Persimmon contains active ingredients Lycopene, Quercetin, Lupeol, Betulinic Acid, Fisetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mantle Cell Lymphoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, Chemokine Signaling, Cell Cycle, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mantle Cell Lymphoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MANTLE CELL LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mantle Cell Lymphoma undergoing chemotherapy treatment
In Mantle Cell Lymphoma – the genes CDC27, FAT1, RYR3, ASH1L and KMT2C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mantle Cell Lymphoma are MAPK Signaling, Chemokine Signaling, Amino Acid Metabolism and others. Vincristine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, Chemokine Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A, Genistein and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Vitamin D Signaling.
Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Linoleic Acid has biological action on biochemical pathways Chemokine Signaling. And so on.
When treating Mantle Cell Lymphoma with chemotherapy Vincristine – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linolenic Acid and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR MANTLE CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Squash?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Squash are Ellagic Acid, Vitamin E, Beta-sitosterol, Oleic Acid, Vitamin C and others.
Kaempferol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and WNT Beta Catenin Signaling. Vitamin A has biological action on biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Vitamin D Signaling. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
When treating Mantle Cell Lymphoma with chemotherapy Vincristine – Foods like Arugula are recommended compared to Squash. This is because the active ingredients Ellagic Acid and Linolenic Acid in Squash interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER SQUASH FOR MANTLE CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Date?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Lycopene, Quercetin, Lupeol, Betulinic Acid, Fisetin among others. While the active ingredients contained in Date are Apigenin, Quercetin, Lupeol, Beta-sitosterol, Protocatechuic Acid and others.
Lycopene can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chemokine Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Apigenin can manipulate biochemical pathways Vitamin D Signaling and PI3K-AKT-MTOR Signaling. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
When treating Mantle Cell Lymphoma with chemotherapy Vincristine – Foods like Persimmon are recommended compared to Date. This is because the active ingredients Apigenin and Gallic Acid in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER DATE FOR MANTLE CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Vitamin A, Cianidanol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chemokine Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, Chemokine Signaling and MYC Signaling. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling. And so on.
When treating Mantle Cell Lymphoma with chemotherapy Vincristine – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Linolenic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Vitamin A contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR MANTLE CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY VINCRISTINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Mantle Cell Lymphoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDC27 and FAT1 are two genes whose abnormalities are risk factors for Mantle Cell Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mantle Cell Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Mantle Cell Lymphoma gene CDC27 has causative impact on biological pathways like Cell Cycle. And FAT1 has a causative impact on biological pathways like Cytoskeletal Dynamics and Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDC27 and FAT1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDC27 and FAT1 should be avoided.
Eat more pulses, Common Pea or Fava Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Genistein, Vitamin C among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Genistein, Vitamin C, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Quercetin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Mantle Cell Lymphoma due to abnormalities in genes CDC27 and FAT1 – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Quercetin in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF MANTLE CELL LYMPHOMA DUE TO GENES CDC27 AND FAT1
Eat more vegetables, Jicama or Chinese Mustard?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Chinese Mustard are Indole-3-carbinol, Isorhamnetin, Quercetin, Kaempferol, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Apoptosis.
Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Mantle Cell Lymphoma due to abnormalities in genes CDC27 and FAT1 – Foods like Jicama are recommended compared to Chinese Mustard. This is because the active ingredients Quercetin and Folic Acid in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF MANTLE CELL LYMPHOMA DUE TO GENES CDC27 AND FAT1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Cranberry?
The active ingredients contained in Kiwi are Vitamin C, Chlorogenic Acid, Quercetin, Fisetin, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Hyperoside, Ellagic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Chlorogenic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Mantle Cell Lymphoma due to abnormalities in genes CDC27 and FAT1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF MANTLE CELL LYMPHOMA DUE TO GENES CDC27 AND FAT1
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Chestnut are Vitamin C, Oleic Acid, Ellagic Acid, Linolenic Acid, Linoleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Mantle Cell Lymphoma due to abnormalities in genes CDC27 and FAT1 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF MANTLE CELL LYMPHOMA DUE TO GENES CDC27 AND FAT1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mantle Cell Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Phenolic Profiles, Antioxidant Capacities, and Inhibitory Effects on Digestive Enzymes of Different Kiwifruits.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.