Which Foods are Recommended for Adamantinomatous Craniopharyngiomas?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Adamantinomatous Craniopharyngiomas when undergoing chemotherapy or when you determine you have a genetic risk for developing Adamantinomatous Craniopharyngiomas because of BARD1 and NF1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Adamantinomatous Craniopharyngiomas which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Pitanga in my diet” or “Should I reduce consumption of vegetable Potato” or “Can I take Neem Extract and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ADAMANTINOMATOUS CRANIOPHARYNGIOMAS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Adamantinomatous Craniopharyngiomas is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMAS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Adamantinomatous Craniopharyngiomas

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Adamantinomatous Craniopharyngiomas from cBioPortal. The patients enrolled in the studies for Adamantinomatous Craniopharyngiomas are in ages between 3 to 71 with an average age of 40. 50.6% of males and 49.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 77; the top genes with mutations and other abnormalities for Adamantinomatous Craniopharyngiomas include genes DNMT3A, TET2, BARD1, NF1 and NSD1. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Adamantinomatous Craniopharyngiomas are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Adamantinomatous Craniopharyngiomas.

Significance of Nutrition for Adamantinomatous Craniopharyngiomas

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Adamantinomatous Craniopharyngiomas. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Pummelo includes active ingredients Beta-sitosterol, Naringenin, Naringin, Vitamin C, Hesperetin and others. And Pitanga contains active ingredients Quercetin, Vitamin A, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Adamantinomatous Craniopharyngiomas, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, DNA Repair, Oncogenic Cancer Epigenetics, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Adamantinomatous Craniopharyngiomas, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMAS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Adamantinomatous Craniopharyngiomas undergoing chemotherapy treatment

In Adamantinomatous Craniopharyngiomas – the genes DNMT3A, TET2, BARD1, NF1 and NSD1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Adamantinomatous Craniopharyngiomas are RAS-RAF Signaling, DNA Repair, JAK-STAT Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, DNA Repair, JAK-STAT Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Yellow Wax Bean or Scarlet Bean?

Pulses are an important part of many diets. The active ingredients contained in Yellow Wax Bean are Palmitic Acid, Vitamin C, Vitamin A, Ferulic Acid, Butyric Acid among others. While the active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Stigmasterol, Oleic Acid, Linoleic Acid and others.

Palmitic Acid can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and RAS-RAF Signaling. Vitamin A has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Liquiritigenin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinomatous Craniopharyngiomas with chemotherapy Radiation – Foods like Yellow Wax Bean are recommended compared to Scarlet Bean. This is because the active ingredients Citric Acid and Liquiritigenin in Scarlet Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin A contained in Yellow Wax Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER SCARLET BEAN FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMAS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Onion or Potato?

Vegetables are an important part of many diets. The active ingredients contained in Onion are Quercetin, Myricetin, Isorhamnetin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Potato are Beta-sitosterol, Vitamin C, Stigmasterol, Solasodine, Oleic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and JAK-STAT Signaling. Myricetin has biological action on biochemical pathways RAS-RAF Signaling, Epithelial to Mesenchymal Transition and JAK-STAT Signaling.

Isoquercitrin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinomatous Craniopharyngiomas with chemotherapy Radiation – Foods like Onion are recommended compared to Potato. This is because the active ingredients Isoquercitrin and Gallic Acid in Potato interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Myricetin contained in Onion support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ONION IS RECOMMENDED OVER POTATO FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMAS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Pitanga or Pummelo?

Fruits are an important part of many diets. The active ingredients contained in Pitanga are Quercetin, Vitamin A, Vitamin C among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Naringenin, Naringin, Vitamin C, Hesperetin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Oxidative Stress and RAS-RAF Signaling. Quercetin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Epithelial to Mesenchymal Transition.

Naringenin can manipulate biochemical pathways Oxidative Stress. Naringin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinomatous Craniopharyngiomas with chemotherapy Radiation – Foods like Pitanga are recommended compared to Pummelo. This is because the active ingredients Naringenin and Naringin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Pitanga support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PITANGA IS RECOMMENDED OVER PUMMELO FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMAS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Macadamia Nut or Pecan Nut?

Nuts are an important part of many diets. The active ingredients contained in Macadamia Nut are Palmitic Acid, Beta-sitosterol, Lauric Acid, Myristic Acid, Folic Acid among others. While the active ingredients contained in Pecan Nut are Vitamin A, Vitamin E, Delphinidin, Oleic Acid, Linoleic Acid and others.

Palmitic Acid can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress.

Vitamin E can manipulate biochemical pathways Oxidative Stress. Delphinidin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinomatous Craniopharyngiomas with chemotherapy Radiation – Foods like Macadamia Nut are recommended compared to Pecan Nut. This is because the active ingredients Vitamin E and Delphinidin in Pecan Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Beta-sitosterol contained in Macadamia Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MACADAMIA NUT IS RECOMMENDED OVER PECAN NUT FOR ADAMANTINOMATOUS CRANIOPHARYNGIOMAS ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Adamantinomatous Craniopharyngiomas

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BARD1 and NF1 are two genes whose abnormalities are risk factors for Adamantinomatous Craniopharyngiomas. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Adamantinomatous Craniopharyngiomas can be used as a guide for coming up with a recommended personalized nutrition plan. For Adamantinomatous Craniopharyngiomas gene BARD1 has causative impact on biological pathways like DNA Repair. And NF1 has a causative impact on biological pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BARD1 and NF1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BARD1 and NF1 should be avoided.

Eat more pulses, Winged Bean or Soy Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Quercetin, Daidzein, Beta-sitosterol and others.

Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Adamantinomatous Craniopharyngiomas due to abnormalities in genes BARD1 and NF1 – Foods like Winged Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ADAMANTINOMATOUS CRANIOPHARYNGIOMAS DUE TO GENES BARD1 AND NF1

Eat more vegetables, Jicama or Green Bean?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Green Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Apoptosis.

Ferulic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Adamantinomatous Craniopharyngiomas due to abnormalities in genes BARD1 and NF1 – Foods like Jicama are recommended compared to Green Bean. This is because the active ingredients Ferulic Acid and Folic Acid in Green Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER GREEN BEAN FOR REDUCING THE GENETIC RISK OF ADAMANTINOMATOUS CRANIOPHARYNGIOMAS DUE TO GENES BARD1 AND NF1

Eat more fruits, Feijoa or Huckleberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, P-coumaric Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Adamantinomatous Craniopharyngiomas due to abnormalities in genes BARD1 and NF1 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Ferulic Acid in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF ADAMANTINOMATOUS CRANIOPHARYNGIOMAS DUE TO GENES BARD1 AND NF1

Eat more nuts, Pine Nut or Acorn?

The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Quercitrin, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Gallic Acid can manipulate biochemical pathways DNA Repair. Vitamin B2 has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Adamantinomatous Craniopharyngiomas due to abnormalities in genes BARD1 and NF1 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Vitamin B2 in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF ADAMANTINOMATOUS CRANIOPHARYNGIOMAS DUE TO GENES BARD1 AND NF1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Adamantinomatous Craniopharyngiomas by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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