Which Foods are Recommended for Anorectal Mucosal Melanoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anorectal Mucosal Melanoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anorectal Mucosal Melanoma because of SF3B1 and NF1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Anorectal Mucosal Melanoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Muskmelon in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Arugula and Buckthorn supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANORECTAL MUCOSAL MELANOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Anorectal Mucosal Melanoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANORECTAL MUCOSAL MELANOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Anorectal Mucosal Melanoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Anorectal Mucosal Melanoma from cBioPortal. 44.9% of males and 55.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 109; the top genes with mutations and other abnormalities for Anorectal Mucosal Melanoma include genes SF3B1, NF1, KIT, TP53 and NRAS. The occurrence frequency distribution for these genes respectively is 27.5%, 20.3%, 13.0%, 7.2% and 7.2%. These tumor genetic details of Anorectal Mucosal Melanoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anorectal Mucosal Melanoma.

Significance of Nutrition for Anorectal Mucosal Melanoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anorectal Mucosal Melanoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Ellagic Acid, Hyperoside, Resveratrol, Quercetin, Myricetin and others. And Muskmelon contains active ingredients Lupeol, Cucurbitacin E, Linoleic Acid, Linolenic Acid, Isoliquiritigenin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Anorectal Mucosal Melanoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anorectal Mucosal Melanoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANORECTAL MUCOSAL MELANOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Anorectal Mucosal Melanoma undergoing chemotherapy treatment

In Anorectal Mucosal Melanoma – the genes SF3B1, NF1, KIT, TP53 and NRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anorectal Mucosal Melanoma are Cell Cycle Checkpoints, Apoptosis, Oncogenic Cancer Epigenetics and others. Carmustine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, Oncogenic Cancer Epigenetics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linoleic Acid, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Linoleic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and P53 Signaling.

Genistein can manipulate biochemical pathways Oncogenic Cancer Epigenetics and DNA Repair. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Anorectal Mucosal Melanoma with chemotherapy Carmustine – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR ANORECTAL MUCOSAL MELANOMA ON TREATMENT WITH CHEMOTHERAPY CARMUSTINE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Carob?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Phloroglucinol, Gallic Acid and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Kaempferol has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Anorectal Mucosal Melanoma with chemotherapy Carmustine – Foods like Arugula are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Quercetin in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CAROB FOR ANORECTAL MUCOSAL MELANOMA ON TREATMENT WITH CHEMOTHERAPY CARMUSTINE FOR SOME CONDITIONS.

Eat more fruits, Muskmelon or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Muskmelon are Lupeol, Cucurbitacin E, Linoleic Acid, Linolenic Acid, Isoliquiritigenin among others. While the active ingredients contained in Cranberry are Ellagic Acid, Hyperoside, Resveratrol, Quercetin, Myricetin and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Lupeol has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and P53 Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.

When treating Anorectal Mucosal Melanoma with chemotherapy Carmustine – Foods like Muskmelon are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Lupeol contained in Muskmelon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUSKMELON IS RECOMMENDED OVER CRANBERRY FOR ANORECTAL MUCOSAL MELANOMA ON TREATMENT WITH CHEMOTHERAPY CARMUSTINE FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linoleic Acid, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Linoleic Acid, Linolenic Acid, Vitamin C and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and DNA Repair. Vitamin A has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and Cell Cycle Checkpoints.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

When treating Anorectal Mucosal Melanoma with chemotherapy Carmustine – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Quercetin in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ANORECTAL MUCOSAL MELANOMA ON TREATMENT WITH CHEMOTHERAPY CARMUSTINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Anorectal Mucosal Melanoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SF3B1 and NF1 are two genes whose abnormalities are risk factors for Anorectal Mucosal Melanoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anorectal Mucosal Melanoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anorectal Mucosal Melanoma gene SF3B1 has causative impact on biological pathways like mRNA Splicing. And NF1 has a causative impact on biological pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SF3B1 and NF1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SF3B1 and NF1 should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Vitamin E, Daidzein, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Anorectal Mucosal Melanoma due to abnormalities in genes SF3B1 and NF1 – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ANORECTAL MUCOSAL MELANOMA DUE TO GENES SF3B1 AND NF1

Eat more vegetables, Jicama or Radish?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Apoptosis.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Anorectal Mucosal Melanoma due to abnormalities in genes SF3B1 and NF1 – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF ANORECTAL MUCOSAL MELANOMA DUE TO GENES SF3B1 AND NF1

Eat more fruits, Feijoa or Huckleberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, P-coumaric Acid, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Anorectal Mucosal Melanoma due to abnormalities in genes SF3B1 and NF1 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF ANORECTAL MUCOSAL MELANOMA DUE TO GENES SF3B1 AND NF1

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and mRNA Splicing. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Anorectal Mucosal Melanoma due to abnormalities in genes SF3B1 and NF1 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ANORECTAL MUCOSAL MELANOMA DUE TO GENES SF3B1 AND NF1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Anorectal Mucosal Melanoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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