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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Rosai-dorfman Disease?

Aug 13, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Rosai-dorfman Disease when undergoing chemotherapy or when you determine you have a genetic risk for developing Rosai-dorfman Disease because of MAP2K1 and SMC3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Rosai-dorfman Disease which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Quince in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Stevia and Cardamom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ROSAI-DORFMAN DISEASE, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Rosai-dorfman Disease is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ROSAI-DORFMAN DISEASE, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Rosai-dorfman Disease

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Rosai-dorfman Disease from cBioPortal. The top genes with mutations and other abnormalities for Rosai-dorfman Disease include genes KRAS, MAP2K1, KMT2C, SMC3 and NOTCH3. The occurrence frequency distribution for these genes respectively is 20.8%, 12.5%, 5.6%, 4.8% and 4.5%. These tumor genetic details of Rosai-dorfman Disease are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Rosai-dorfman Disease.

Significance of Nutrition for Rosai-dorfman Disease

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Rosai-dorfman Disease. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Strawberry includes active ingredients Ellagic Acid, Pelargonidin, Lupeol, Linolenic Acid, Vitamin C and others. And Quince contains active ingredients Modified Citrus Pectin, Oleic Acid, Vitamin C, Chlorogenic Acid, Linoleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Rosai-dorfman Disease, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Rosai-dorfman Disease, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Rosai-dorfman Disease, activation or inhibition of selected biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ROSAI-DORFMAN DISEASE – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Rosai-dorfman Disease undergoing chemotherapy treatment

In Rosai-dorfman Disease – the genes KRAS, MAP2K1, KMT2C, SMC3 and NOTCH3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Rosai-dorfman Disease are PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling and others. Cladribine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Glucaric Acid, Quercetin, Linolenic Acid, Vitamin C, Oleic Acid among others. While the active ingredients contained in Common Bean are Pelargonidin, Apigenin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Glucaric Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Rosai-dorfman Disease with chemotherapy Cladribine – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR ROSAI-DORFMAN DISEASE ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Eat more vegetables, Tomato or Celery?

Vegetables are an important part of many diets. The active ingredients contained in Tomato are Lycopene, Glucaric Acid, Lupeol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Celery are Glucaric Acid, Apigenin, Quercetin, Linolenic Acid, Oleic Acid and others.

Lycopene can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling.

Luteolin can manipulate biochemical pathways MYC Signaling. Cynaroside has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Rosai-dorfman Disease with chemotherapy Cladribine – Foods like Tomato are recommended compared to Celery. This is because the active ingredients Luteolin and Cynaroside in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Glucaric Acid contained in Tomato support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TOMATO IS RECOMMENDED OVER CELERY FOR ROSAI-DORFMAN DISEASE ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Which Foods are Recommended for Rosai dorfman Disease?

Eat more fruits, Quince or Strawberry?

Fruits are an important part of many diets. The active ingredients contained in Quince are Modified Citrus Pectin, Oleic Acid, Vitamin C, Chlorogenic Acid, Linoleic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Pelargonidin, Lupeol, Linolenic Acid, Vitamin C and others.

Quercitrin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Modified Citrus Pectin has biological action on biochemical pathways RAS-RAF Signaling, MAPK Signaling and MYC Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

When treating Rosai-dorfman Disease with chemotherapy Cladribine – Foods like Quince are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercitrin and Modified Citrus Pectin contained in Quince support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: QUINCE IS RECOMMENDED OVER STRAWBERRY FOR ROSAI-DORFMAN DISEASE ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Eat more nuts, Hazelnut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Oleic Acid, Linolenic Acid, Myricitrin among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.

Vitamin E can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling. And so on.

When treating Rosai-dorfman Disease with chemotherapy Cladribine – Foods like Hazelnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR ROSAI-DORFMAN DISEASE ON TREATMENT WITH CHEMOTHERAPY CLADRIBINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Rosai-dorfman Disease

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MAP2K1 and SMC3 are two genes whose abnormalities are risk factors for Rosai-dorfman Disease. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Rosai-dorfman Disease can be used as a guide for coming up with a recommended personalized nutrition plan. For Rosai-dorfman Disease gene MAP2K1 has causative impact on biological pathways like Angiogenesis, RAS-RAF Signaling and cGMP Signaling. And SMC3 has a causative impact on biological pathways like Cell Cycle and Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MAP2K1 and SMC3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MAP2K1 and SMC3 should be avoided.

Eat more pulses, Winged Bean or Adzuki Bean?

The active ingredients contained in Winged Bean are Vitamin C, Betulinic Acid, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.

Betulinic Acid can manipulate biochemical pathways MAPK Signaling, Angiogenesis and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Rosai-dorfman Disease due to abnormalities in genes MAP2K1 and SMC3 – Foods like Winged Bean are recommended compared to Adzuki Bean. This is because the active ingredients Folic Acid in Adzuki Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR REDUCING THE GENETIC RISK OF ROSAI-DORFMAN DISEASE DUE TO GENES MAP2K1 AND SMC3

Eat more vegetables, Giant Butterbur or Bell Pepper?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Kaempferol, Melatonin, Vitamin A among others. While the active ingredients contained in Bell Pepper are Isorhamnetin, Vitamin E, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Angiogenesis and RAS-RAF Signaling. Beta-sitosterol has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.

Isorhamnetin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Capsaicin has biological action on biochemical pathways MAPK Signaling and MYC Signaling. And so on.

For genetic risk of Rosai-dorfman Disease due to abnormalities in genes MAP2K1 and SMC3 – Foods like Giant Butterbur are recommended compared to Bell Pepper. This is because the active ingredients Isorhamnetin and Capsaicin in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF ROSAI-DORFMAN DISEASE DUE TO GENES MAP2K1 AND SMC3

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Pummelo?

The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Glucaric Acid, Delphinidin among others. While the active ingredients contained in Pummelo are Vitamin C, Naringin, Linolenic Acid, Chlorogenic Acid, Oleic Acid and others.

D-limonene can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling.

Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

For genetic risk of Rosai-dorfman Disease due to abnormalities in genes MAP2K1 and SMC3 – Foods like Orange are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Glucaric Acid contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF ROSAI-DORFMAN DISEASE DUE TO GENES MAP2K1 AND SMC3

Eat more nuts, Almond or Macadamia Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Salicylic Acid, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and Angiogenesis. Quercetin has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways MAPK Signaling, WNT Beta Catenin Signaling and MYC Signaling. Lauric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling. And so on.

For genetic risk of Rosai-dorfman Disease due to abnormalities in genes MAP2K1 and SMC3 – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ROSAI-DORFMAN DISEASE DUE TO GENES MAP2K1 AND SMC3


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Rosai-dorfman Disease by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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