Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Dedifferentiated Liposarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Dedifferentiated Liposarcoma because of ERBB4 and APC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Dedifferentiated Liposarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Neem Extract and Thunder God supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DEDIFFERENTIATED LIPOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Dedifferentiated Liposarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR DEDIFFERENTIATED LIPOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Dedifferentiated Liposarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Dedifferentiated Liposarcoma from cBioPortal. The patients enrolled in the studies for Dedifferentiated Liposarcoma are in ages between 34 to 86 with an average age of 62. 65.9% of males and 34.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 497; the top genes with mutations and other abnormalities for Dedifferentiated Liposarcoma include genes ATRX, MUC16, ERBB4, APC and FAT1. The occurrence frequency distribution for these genes respectively is 2.5%, 2.1%, 1.7%, 1.2% and 1.2%. These tumor genetic details of Dedifferentiated Liposarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Dedifferentiated Liposarcoma.
Significance of Nutrition for Dedifferentiated Liposarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Dedifferentiated Liposarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Geraniin, Beta-sitosterol, Lupeol, Cianidanol and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Dedifferentiated Liposarcoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Dedifferentiated Liposarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DEDIFFERENTIATED LIPOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Dedifferentiated Liposarcoma undergoing chemotherapy treatment
In Dedifferentiated Liposarcoma – the genes ATRX, MUC16, ERBB4, APC and FAT1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Dedifferentiated Liposarcoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A among others. While the active ingredients contained in Pigeon Pea are Genistein, Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Hedgehog Signaling and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. And so on.
When treating Dedifferentiated Liposarcoma with chemotherapy Radiation – Foods like Winged Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER PIGEON PEA FOR DEDIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Lotus?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Beta-carotene, Vitamin C, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Lotus are Quercetin, Beta-sitosterol, Linolenic Acid, Vitamin C, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways Microtubule Dynamics, DNA Repair and TGFB Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Dedifferentiated Liposarcoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Lotus. This is because the active ingredients Citric Acid and Quercetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER LOTUS FOR DEDIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Strawberry are Ellagic Acid, Geraniin, Beta-sitosterol, Lupeol, Cianidanol and others.
Resveratrol can manipulate biochemical pathways Microtubule Dynamics, JAK-STAT Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Oxidative Stress.
Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Oncogenic Cancer Epigenetics and MYC Signaling. Ellagic Acid has biological action on biochemical pathways Heat Stress Response, Epithelial to Mesenchymal Transition and MYC Signaling. And so on.
When treating Dedifferentiated Liposarcoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER STRAWBERRY FOR DEDIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Beta-carotene, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Oxidative Stress. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Dedifferentiated Liposarcoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR DEDIFFERENTIATED LIPOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Dedifferentiated Liposarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERBB4 and APC are two genes whose abnormalities are risk factors for Dedifferentiated Liposarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Dedifferentiated Liposarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Dedifferentiated Liposarcoma gene ERBB4 has causative impact on biological pathways like Growth Factor Signaling and MAPK Signaling. And APC has a causative impact on biological pathways like Angiogenesis and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERBB4 and APC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERBB4 and APC should be avoided.
Eat more pulses, Scarlet Bean or Lima Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Stigmasterol among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Linoleic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Dedifferentiated Liposarcoma due to abnormalities in genes ERBB4 and APC – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF DEDIFFERENTIATED LIPOSARCOMA DUE TO GENES ERBB4 AND APC
Eat more vegetables, Cassava or Beetroot?
The active ingredients contained in Cassava are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Dedifferentiated Liposarcoma due to abnormalities in genes ERBB4 and APC – Foods like Cassava are recommended compared to Beetroot. This is because the active ingredients Linoleic Acid and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF DEDIFFERENTIATED LIPOSARCOMA DUE TO GENES ERBB4 AND APC
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Grape?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Grape are Vitamin E, Lupeol, Resveratrol, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Dedifferentiated Liposarcoma due to abnormalities in genes ERBB4 and APC – Foods like Feijoa are recommended compared to Grape. This is because the active ingredients Pelargonidin and Linoleic Acid in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF DEDIFFERENTIATED LIPOSARCOMA DUE TO GENES ERBB4 AND APC
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Dedifferentiated Liposarcoma due to abnormalities in genes ERBB4 and APC – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Ferulic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF DEDIFFERENTIATED LIPOSARCOMA DUE TO GENES ERBB4 AND APC
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Dedifferentiated Liposarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.