Foods for Dedifferentiated Liposarcoma!

Introduction

Foods for Dedifferentiated Liposarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Dedifferentiated liposarcoma, a subtype of cancer that evolves from well-differentiated liposarcoma, presents a complex challenge in oncology. Pathology outlines of dedifferentiated liposarcoma reveal a distinct transition from a less aggressive to a more aggressive histologic phenotype. The ICD-10 code for dedifferentiated liposarcoma aids in its standardized classification and treatment documentation. Patients with this diagnosis often face a variable prognosis, heavily influenced by factors like the stage of the disease, with stage 4 indicating advanced cancer, and the presence of metastasis. Symptoms can vary, but often include palpable masses or pain, depending on the tumor’s location. The recurrence of dedifferentiated liposarcoma is a significant concern, necessitating close monitoring after initial treatment. Treatment strategies typically include surgery, chemotherapy, and in some cases, immunotherapy, especially for higher-grade tumors like grade 3 liposarcomas or in advanced stages. The role of MDM2, a genetic marker, is increasingly studied for its potential in guiding treatment decisions. The survival rate for dedifferentiated liposarcoma, while generally lower than less aggressive forms, can vary based on early detection, effective treatment, and the individual patient’s overall health. This underlines the importance of personalized treatment plans to improve life expectancy and quality of life for those affected by this challenging cancer.

For Dedifferentiated Liposarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Dedifferentiated Liposarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Dedifferentiated Liposarcoma?

For example does it matter if vegetable Globe Artichoke is consumed more compared to Shallot? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Gram Bean over Moth Bean. And if what I eat matters – then how does one identify foods which are recommended for Dedifferentiated Liposarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Dedifferentiated Liposarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Caffeic Acid, Curcumin, Lycopene, Formononetin. And Red Raspberry contains active ingredients Quercetin, Ellagic Acid, Curcumin, Formononetin, Genistein and possibly others.

A common mistake made when deciding and choosing foods to eat for Dedifferentiated Liposarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Dedifferentiated Liposarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Dedifferentiated Liposarcoma?

Personalized nutrition for cancers like Dedifferentiated Liposarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Dedifferentiated Liposarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Dedifferentiated Liposarcoma

All cancers like Dedifferentiated Liposarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Dedifferentiated Liposarcoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Dedifferentiated Liposarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Dedifferentiated Liposarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Dedifferentiated Liposarcoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ATRX, MUC16, ERBB4, APC and FAT1 are the top ranked reported genes for Dedifferentiated Liposarcoma. ATRX is reported in 2.5 % of the representative patients across all clinical trials. And MUC16 is reported in 2.1 %. The combined population patient data cover ages from 34 to 86. 65.9 % of the patient data are identified as men. The Dedifferentiated Liposarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Dedifferentiated Liposarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GLOBE ARTICHOKE or SHALLOT?

Vegetable Globe Artichoke contains many active ingredients or bioactives such as Myricetin, Caffeic Acid, Curcumin, Formononetin, Genistein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Glucocorticoid Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Globe Artichoke is recommended for Dedifferentiated Liposarcoma when ongoing cancer treatment is Radiation. This is because Globe Artichoke modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Shallot are Myricetin, Caffeic Acid, Curcumin, Formononetin, Genistein. These active ingredients manipulate various biochemical pathways like Oxidative Stress, DNA Repair and Heat Stress Response and others. Shallot is not recommended for Dedifferentiated Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GLOBE ARTICHOKE IS RECOMMENDED OVER SHALLOT FOR Dedifferentiated Liposarcoma AND TREATMENT Radiation.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Formononetin, Genistein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Glucocorticoid Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Red Raspberry is recommended for Dedifferentiated Liposarcoma when ongoing cancer treatment is Radiation. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Caffeic Acid, Curcumin, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Heat Stress Response and others. Pummelo is not recommended for Dedifferentiated Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Dedifferentiated Liposarcoma AND TREATMENT Radiation.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Myricetin, Caffeic Acid, Curcumin, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like Cholesterol Metabolism, Extracellular Matrix Remodelling, Glucocorticoid Signaling and JAK-STAT Signaling and others. Butternut is recommended for Dedifferentiated Liposarcoma when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Myricetin, Caffeic Acid, Curcumin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, DNA Repair and Heat Stress Response and others. European Chestnut is not recommended for Dedifferentiated Liposarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Dedifferentiated Liposarcoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Dedifferentiated Liposarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and P53 Signaling and others. Giant Butterbur is recommended for risk of Dedifferentiated Liposarcoma when associated genetic risk is APC. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Spinach are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Spinach is not recommended when risk of Dedifferentiated Liposarcoma when associated genetic risk is APC because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SPINACH FOR APC GENETIC RISK OF CANCER.

Choose Fruit NANCE or BLACK ELDERBERRY?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and P53 Signaling and others. Nance is recommended for risk of Dedifferentiated Liposarcoma when associated genetic risk is APC. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Black Elderberry are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Extracellular Matrix Remodelling and Stem Cell Signaling and others. Black Elderberry is not recommended when risk of Dedifferentiated Liposarcoma when associated genetic risk is APC because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER BLACK ELDERBERRY FOR APC GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Growth Factor Signaling and P53 Signaling and others. Common Hazelnut is recommended for risk of Dedifferentiated Liposarcoma when associated genetic risk is APC. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Dedifferentiated Liposarcoma when associated genetic risk is APC because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR APC GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Dedifferentiated Liposarcoma. Dedifferentiated Liposarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Dedifferentiated Liposarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Globe Artichoke contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Dedifferentiated Liposarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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