addonfinal2
What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Gastrointestinal Neuroendocrine Tumors?

Aug 12, 2022

4.6
(29)
Estimated reading time: 15 minutes
Home » Blogs » Which Foods are Recommended for Gastrointestinal Neuroendocrine Tumors?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gastrointestinal Neuroendocrine Tumors when undergoing chemotherapy or when you determine you have a genetic risk for developing Gastrointestinal Neuroendocrine Tumors because of ALK and APC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Gastrointestinal Neuroendocrine Tumors which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Heart Of Palm” or “Can I take Sesamin and Lavender supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GASTROINTESTINAL NEUROENDOCRINE TUMORS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Gastrointestinal Neuroendocrine Tumors is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR GASTROINTESTINAL NEUROENDOCRINE TUMORS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Gastrointestinal Neuroendocrine Tumors

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Gastrointestinal Neuroendocrine Tumors from cBioPortal. 55.0% of males and 45.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Gastrointestinal Neuroendocrine Tumors include genes ALK, APC, DAXX, GNAS and KMT2D. The occurrence frequency distribution for these genes respectively is 16.7%, 16.7%, 16.7%, 16.7% and 16.7%. These tumor genetic details of Gastrointestinal Neuroendocrine Tumors are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gastrointestinal Neuroendocrine Tumors.

Significance of Nutrition for Gastrointestinal Neuroendocrine Tumors

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gastrointestinal Neuroendocrine Tumors. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Vitamin C, Ferulic Acid, Caffeic Acid, Delphinidin, Quercetin and others. And Raspberry contains active ingredients Ellagic Acid, Vitamin C, Salicylic Acid, Quercetin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Gastrointestinal Neuroendocrine Tumors, activation or inhibition of selected biochemical pathways like MAPK Signaling, Oxidative Stress, Oncogenic Histone Methylation, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gastrointestinal Neuroendocrine Tumors, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Gastrointestinal Neuroendocrine Tumors, activation or inhibition of selected biochemical pathways like MAPK Signaling, Oxidative Stress, Oncogenic Histone Methylation, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GASTROINTESTINAL NEUROENDOCRINE TUMORS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Gastrointestinal Neuroendocrine Tumors undergoing chemotherapy treatment

In Gastrointestinal Neuroendocrine Tumors – the genes ALK, APC, DAXX, GNAS and KMT2D have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gastrointestinal Neuroendocrine Tumors are MAPK Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Vitamin A among others. While the active ingredients contained in Fava Bean are Daidzein, Butein, Oleic Acid, Vitamin C, Beta-sitosterol and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, Oxidative Stress and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oxidative Stress.

Quercetin can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastrointestinal Neuroendocrine Tumors with chemotherapy Cyclophosphamide – Foods like Winged Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Cianidanol in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER FAVA BEAN FOR GASTROINTESTINAL NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more vegetables, Giant Butterbur or Heart Of Palm?

Vegetables are an important part of many diets. The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Melatonin, Vitamin A, Vitamin B3 among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Vitamin A, Palmitic Acid, Folic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Oxidative Stress and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oxidative Stress.

Palmitic Acid can manipulate biochemical pathways MYC Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and MAPK Signaling. And so on.

When treating Gastrointestinal Neuroendocrine Tumors with chemotherapy Cyclophosphamide – Foods like Giant Butterbur are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER HEART OF PALM FOR GASTROINTESTINAL NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Science of Right Personalized Nutrition for Cancer

Eat more fruits, Raspberry or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Raspberry are Ellagic Acid, Vitamin C, Salicylic Acid, Quercetin, Vitamin A among others. While the active ingredients contained in Huckleberry are Vitamin C, Ferulic Acid, Caffeic Acid, Delphinidin, Quercetin and others.

Ellagic Acid can manipulate biochemical pathways Oxidative Stress, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Oxidative Stress and MAPK Signaling.

Delphinidin can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastrointestinal Neuroendocrine Tumors with chemotherapy Cyclophosphamide – Foods like Raspberry are recommended compared to Huckleberry. This is because the active ingredients Delphinidin and Quercetin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER HUCKLEBERRY FOR GASTROINTESTINAL NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more nuts, Cashew Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Butyric Acid, Palmitic Acid, Lauric Acid among others. While the active ingredients contained in Acorn are Vitamin C, Beta-sitosterol, Beta-carotene, Quercetin, Vitamin A and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Oxidative Stress and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oxidative Stress.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastrointestinal Neuroendocrine Tumors with chemotherapy Cyclophosphamide – Foods like Cashew Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Quercetin in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cashew Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASHEW NUT IS RECOMMENDED OVER ACORN FOR GASTROINTESTINAL NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Gastrointestinal Neuroendocrine Tumors

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ALK and APC are two genes whose abnormalities are risk factors for Gastrointestinal Neuroendocrine Tumors. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gastrointestinal Neuroendocrine Tumors can be used as a guide for coming up with a recommended personalized nutrition plan. For Gastrointestinal Neuroendocrine Tumors gene ALK has causative impact on biological pathways like Growth Factor Signaling, JAK-STAT Signaling and Immune Checkpoints. And APC has a causative impact on biological pathways like Angiogenesis and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ALK and APC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ALK and APC should be avoided.

Eat more pulses, Scarlet Bean or Hyacinth Bean?

The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Stigmasterol, Vitamin C, Liquiritigenin among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Palmitic Acid, Myristic Acid, Folic Acid and others.

Stigmasterol can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Palmitic Acid can manipulate biochemical pathways MYC Signaling, DNA Repair and MAPK Signaling. Myristic Acid has biological action on biochemical pathways P53 Signaling, RAS-RAF Signaling and MYC Signaling. And so on.

For genetic risk of Gastrointestinal Neuroendocrine Tumors due to abnormalities in genes ALK and APC – Foods like Scarlet Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL NEUROENDOCRINE TUMORS DUE TO GENES ALK AND APC

Eat more vegetables, Brussels Sprout or Radish?

The active ingredients contained in Brussels Sprout are Brassinin, Oleic Acid, Linolenic Acid, Vitamin C, Sulforaphane among others. While the active ingredients contained in Radish are Quercetin, Caffeic Acid, Kaempferol, Oleic Acid, Linolenic Acid and others.

Brassinin can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Quercetin can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Gastrointestinal Neuroendocrine Tumors due to abnormalities in genes ALK and APC – Foods like Brussels Sprout are recommended compared to Radish. This is because the active ingredients Quercetin and Pelargonidin in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Brassinin and Vitamin C contained in Brussels Sprout together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BRUSSELS SPROUT IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL NEUROENDOCRINE TUMORS DUE TO GENES ALK AND APC

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Strawberry?

The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Oleic Acid, Linolenic Acid, Vitamin C and others.

D-limonene can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling. And so on.

For genetic risk of Gastrointestinal Neuroendocrine Tumors due to abnormalities in genes ALK and APC – Foods like Orange are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL NEUROENDOCRINE TUMORS DUE TO GENES ALK AND APC

Eat more nuts, Pine Nut or Brazil Nut?

The active ingredients contained in Pine Nut are Oleic Acid, Linolenic Acid, Vitamin E, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Linolenic Acid, Vitamin E, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and MAPK Signaling. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Gastrointestinal Neuroendocrine Tumors due to abnormalities in genes ALK and APC – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Vitamin E in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF GASTROINTESTINAL NEUROENDOCRINE TUMORS DUE TO GENES ALK AND APC


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Gastrointestinal Neuroendocrine Tumors by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 4.6 / 5. Vote count: 29

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?